Private suite vacation rentals in Upstate South Carolina

Find and book unique private suite rentals on Airbnb

Top-rated private suite rentals in Upstate South Carolina

Guests agree: these private suite rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A private patio area features two striped chairs positioned around a circular table. Sliding glass doors provide access to the guest suite, framed by a well-maintained green lawn and lush trees in the background.
Guest suite in Brevard
4.94 out of 5 average rating, 556 reviews

Private guest suite in heart of Cedar Mountain

NO CLEANING FEE Newly constructed private guest suite conveniently located in the heart of Cedar Mountain. 8 miles from Pretty Place Chapel. Queen bed, tiled shower, kitchenette that includes convection oven, sink, microwave, small refrigerator, coffee pot, tea kettle, small table and chairs, private patio and fire pit(advanced notice required & bring your own wood please). Room is very well stocked with coffee, snacks & toiletries. If you’re planning to visit Pretty Place- check website first

Top guest favorite
A classic brick two-story house is showcased, featuring a covered front porch with decorative columns. Green landscaping surrounds the home, complemented by well-maintained grass and trees. A pathway leads to the house, inviting guests to explore the entrance further.
Guest suite in Anderson
4.99 out of 5 average rating, 168 reviews

Backyard Hideaway - Anderson, SC

Enjoy a stylish comfy experience at this lovely private suite w/king bed. Located in the Linley Park Historic District of Anderson, SC. One block from acres of green space, walking paths, playground, and shopping. Enter the gated courtyard with an inviting covered porch and lush outdoor space. Less than one mile to downtown restaurants, breweries, and shopping. One mile to Anderson University, AnMed Health. 15 miles to Clemson University. Includes private suite and access to back porch/yard.

Top guest favorite
A stone facade house is displayed against a vibrant sunset, with lush landscaping adorned in colorful flowerbeds. The entrance features arched windows and a spacious driveway leading to two garages. The surrounding trees add to the serene natural setting.
Guest suite in Woodruff
4.96 out of 5 average rating, 220 reviews

Luxurious river front nature retreat on 120 acres

Privacy, luxury and nature-for you! Luxurious apartment in our home (owner-occupied) - on 120 private acres overlooking the Enoree river. Visitors are blown away by the view and the sound of the river. Beautiful walking trail and 2 kayaks available for use. There is a beautiful waterfall located only 600 yards upriver, by kayak. There are bald eagles, turtles, herons, etc.. 15 miles to GSP airport and 21 miles to downtown Greenville and Spartanburg. (No pets, smoking/vaping inside, or guns!)

Top guest favorite
A private outdoor Jacuzzi is illuminated by soft blue lights, nestled on a covered patio surrounded by natural wood and balcony railings. Trees can be seen in the background, creating a serene and tranquil atmosphere.
Guest suite in Athens
4.97 out of 5 average rating, 188 reviews

River Bottom Bungalow

Pamper yourself with a very private Bungalow in the peaceful woods of west Athens (approx. 15 min from UGA). This newly renovated SPA-like space is a haven for wellness and relaxation. Situated on the Oconee River in the lovely River Bottom neighborhood, you'll enjoy the rejuvenating benefits of your own private custom-built cedar sauna, spacious marble shower, outdoor Jacuzzi, king bed & more. The Bungalow is part of the main house with a separate, PRIVATE entrance through the backyard.

Superhost
A sturdy wooden staircase leads up to a private entrance, framed by an attractive wooden exterior. Softly glowing string lights outline the steps, enhancing the welcoming ambiance. A small seating area is visible at the top, surrounded by lush greenery and flower beds.
Guest suite in Greenville
4.86 out of 5 average rating, 416 reviews

Lakefront modern private guest suite 6mi to DT

MINI PRIVATE OASIS. 6 MILES TO DOWNTOWN GREENVILLE! LAKEFRONT + PRIVATE DOCK NY Times #1 AMERICAN CITY! Experience modern luxury in your serene mini suite. Please note: the suite is located as an extension attached to a classical Scandinavian chalet. The suite is private. No shared spaces, shared soundproofed wall. 6mi downtown Greenville Amenities include: - Private entrance & patio - Private dock - 43” Roku TV - Charcoal grill, fire pit - Luxury toiletries - Blackout curtains

Top guest favorite
Guest suite in Simpsonville
4.96 out of 5 average rating, 159 reviews

Upstate Bungalow @ Five Forks

Small modern rustic studio located in a quiet neighborhood in the heart of Five Forks. Less than 1 mile from Woodruff Road for endless restaurant and shopping options. Also, just a quick drive to downtown Greenville, Simpsonville, and Mauldin. Perfect for locals or tourists to enjoy and explore all the Upstate has to offer! (Please note- there is an in-ground swimming pool that is not included in the listing. It’s fenced and locked at all times. Signed liability waiver required).

Top guest favorite
A cozy patio area is designed with two wooden Adirondack chairs positioned around a circular firepit. Surrounding the space are vibrant flowers and greenery, creating a natural and peaceful atmosphere. The stone floor adds a rustic charm to the inviting outdoor setting.
Guest suite in Greenville
4.97 out of 5 average rating, 230 reviews

Woodland Retreat Just 10min to Downtown or Furman

Your secluded retreat on Paris Mountain, this small private suite with separate entrance includes one bedroom, one bathroom, and an adjoining kitchenette. The space is newly-renovated and immaculately clean. Located just 10min from downtown Greenville, yet on the privacy of a 3-acre wooded lot. You will have exclusive access to a patio dining area and firepit. Explore hiking paths and native plant gardens. Separate entrance and your own driveway. Children welcome.

Guest favorite
Two individuals sit on a dock overlooking the calm lake, draped in colorful beach towels. Adirondack chairs provide comfortable seating, positioned to enjoy the serene water views and surrounding greenery. A potted plant adds a touch of color to the peaceful scene.
Guest suite in Seneca
4.96 out of 5 average rating, 126 reviews

Hartwell Escape 6 mi to Clemson Beautiful views

We recently purchased this gorgeous home on Lake Hartwell, in a secluded cul-de-sac in a quiet neighborhood (6 miles to Clemson..ALL BACKROADS) You will have the entire bottom floor with separate entrance . Enjoy beautiful lake views on the covered porch or from our dock. A Private Neighborhood Boat ramp is 25 feet from our home. Bring your boat, use our dock, space for multiple trailers. Driveway parking. Dogs Welcome! ($25 pet fee/entire stay)

Top guest favorite
Guest suite in Abbeville
5 out of 5 average rating, 134 reviews

Walk in studio w laundry and fast wifi

Unwind in your private suite just 5 minutes from Historic Abbeville Square. Sip coffee on the patio, stream shows on the smart TV and sleep soundly in a plush queen bed. What you’ll love: Fast Wi-Fi & keypad self-check-in Fire-pit, creek-side seating & driveway parking Mini-fridge, microwave & starter toiletries Exploring Uptown, mining, catching a show at the Opera House or hiking Lake Russell? We’re the perfect base. Book your stay today!

Top guest favorite
A charming entrance to the guest suite features a pink door and a pathway lined with decorative stones. Lush greenery and flowering plants frame the entrance, while a wooden deck with chairs can be seen in the background, inviting relaxation in the outdoor space.
Guest suite in Greenville
5 out of 5 average rating, 248 reviews

Backyard guest suite near downtown

Welcome to our charming guest suite, Studio B, near the heart of downtown Greenville, South Carolina! Nestled in a quiet neighborhood, our Airbnb offers the perfect blend of comfort, convenience, and Southern hospitality. Whether you're in town for a weekend getaway, a business trip, or exploring all Greenville has to offer, Studio B is the ideal home away from home. Studio B is a private oasis designed with your comfort in mind.

Top guest favorite
Guest suite in Candler
4.97 out of 5 average rating, 562 reviews

Huge Hot Tub! 21 min to Asheville

Come visit Above the Clouds! You're at 3200 feet on 9 private acres, with amazing views of our beautiful Western NC mountains. Everything you need is in your separate and private 650 sqft floor, which is the lower level of our home on top of the mountain. We're in the middle of nature, so be prepared to share space with deer, bear, coyotes, fireflies, and lady bugs. Mini-Frig, Microwave, Keurig coffee with coffee supplies.

Top guest favorite
A serene pool area is surrounded by lush greenery. A group of bright pink lounge chairs is positioned alongside the sparkling water. Decorative shrubs and flowers enhance the laid-back ambiance, while a concrete patio provides ample space for relaxation.
Guest suite in Clinton
4.99 out of 5 average rating, 278 reviews

College View Cottage & Saltwater Pool

Spacious Private Apartment in Lovely Home. You will enjoy the entire lower level of the main house (apprx. 876 sq. ft.) that has a separate, private entrance. Just a block from the campus of Presbyterian College in a quiet, safe neighborhood. My home is also steps from the campus of the Thornwell Home for Children and Thornwell's Lush Acres Farm.

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