Hotels in Upstate South Carolina

Find and book unique hotels on Airbnb

Top-rated hotels in Upstate South Carolina

Guests agree: these hotels are highly rated for location, cleanliness, and more.

1 of 1 pages1 / 1
Guest favorite
A cozy interior space is showcased with natural wood paneling. A spiral staircase leads to an upper level. A modern kitchen with bar seating features a sleek countertop and contemporary appliances. Soft seating is provided by a light-colored sofa, inviting relaxation.
Hotel room in Cashiers
4.96 out of 5 average rating, 120 reviews

Log Suite at our Boutique Bed & Brewery

Our Two-Story log suites are the perfect basecamp for couples and families alike. They offer two bedrooms with two spacious bathrooms, along with a small kitchen, equipped with induction cook top and refrigerator. Great for extended weekends or a quick trip to enjoy the beauty of Cashiers, North Carolina. Be sure to take a quick hike over to our on-site brewery, Whiteside Brewing Co., and enjoy the great food and drink selection they have to offer. This suite is sure to cure what “ales” you! ;)

Superhost
Hotel room in Sapphire
New place to stay

1‑Bedroom Retreat at Fairfield Sapphire Valley

From winter thrills to summer adventures, your one‑bedroom is the perfect base to explore Western North Carolina. Hit groomed ski runs, chase waterfalls (including the highest in the East), or stay active with canoe/kayak rentals, miniature golf, footgolf, tennis, golf, and basketball. Prefer relaxation? Enjoy indoor/outdoor pools or visit a local winery. Hike, fish, or tour the Biltmore Estate’s gardens and architecture, then return to a cozy, well‑appointed one‑bedroom for restful evenings.

Guest favorite
Two glasses of red wine sit on a wooden table, accompanied by a plate of snacks. In the background, a cozy gathering occurs around a firepit, with people enjoying food and each other's company, surrounded by a warm ambiance.
Hotel room in Highlands
4.85 out of 5 average rating, 13 reviews

Outpost Inn Highlands

The Petite is our 170 SF Queen hotel room with all of the bells and whistles of larger rooms but in a cozier footprint- luxury Queen mattress, Italian linens, vintage Appalachian textiles, Pendleton Blankets, coffeemaker, minibar with NC goodies, minifridge, luxury bathroom with robe, luxury toiletries and amazing walk in shower with the best water pressure. Please note this Room has since been painted Hague Blue by Farrow and Ball (pics on the way!). Outside your door is our newest firepit!

Hotel room in Seneca
5 out of 5 average rating, 3 reviews

Boutique Hotel. Room # 1, Q/K combo.

You’ll love the stylish decor of this charming place to stay. While maintaining the distinct character of this historic building, our recent renovations included upgrades that create the homey feel and Southern charm that makes our hotel your "home away from home." You can choose between a luxurious King/Queen or Queen/Queen bed combo, both of which are complete with plush latex mattresses, lavish furnishings and bedding, and state of the showers, all steeping you in relaxation.

Guest favorite
A spacious room is depicted, featuring a king bed with crisp white linens. Dark blue walls are complemented by framed artwork. A large TV is mounted on the wall, and a seating area is visible. A closet and mini-fridge are arranged in the corner.
Hotel room in Clayton
5 out of 5 average rating, 7 reviews

King Room at Bridge Creek Inn

Settle into comfort in our Standard King Room at Bridge Creek Inn—perfect for solo travelers or couples. This stylish room features a plush king bed, smart TV, mini-fridge, and a modern bathroom with a walk-in shower. Natural light fills the space, creating a warm and relaxing atmosphere. Enjoy high-speed Wi-Fi and a cozy layout ideal for work or rest. Don’t miss Vandiver, our onsite restaurant and bar, serving up Southern-inspired cuisine and craft cocktails daily.

Superhost
A spacious bedroom features a king-sized bed with an ornate wooden headboard and matching posts. A lighted ceiling fan circulates air, while a television is mounted on the wall. Natural light streams through the plantation shutters, enhancing the neutral-toned walls.
Hotel room in Lake Lure
5 out of 5 average rating, 3 reviews

Swayze Suite at Lake Lure Inn

Experience vintage elegance and modern comfort in the Swayze Suite at The Lake Lure Inn and Spa. This luxurious retreat features a king-sized bed, spa-inspired bathroom, and a cozy living area with old Hollywood charm. Guests enjoy access to the inn’s pool, on-site dining, and spa. Explore Lake Lure's scenic beauty and iconic "Dirty Dancing" locations. Perfect for romance or relaxation, this suite offers an unforgettable getaway. Book now for timeless memories!

Superhost
An aerial view of the property reveals a spacious outdoor area featuring a large swimming pool surrounded by lounge chairs. Neatly arranged seating areas are situated on lush green lawns, framed by trees, providing a serene environment for relaxation.
Hotel room in Sapphire

Resort at Fairfield Sapphire Valley 1 Bedroom Unit

From exhilarating winter recreation to summer vacation thrills, there's always something to do at this picture-perfect destination. You can start by discovering the natural beauty of western North Carolina. Whether you seek well-groomed ski runs or the highest waterfall in the East, Sapphire delivers it all — and then some. It's easy to stay active with canoe and kayak rentals, miniature golf, footgolf, tennis, golf, and basketball courts ready for you.

Superhost
Hotel room in Waynesville
5 out of 5 average rating, 3 reviews

Stylishly Updated Room | Charming Couples Stay

Step into a slower, sweeter way of living at Wildrest Hotel. A 1946 mountain retreat where time stretches, worries fade, and real connection returns. Hidden beneath a canopy of old-growth trees and wrapped in the timeless beauty of stone and timber, this historic property invites you to trade the noise of everyday life for something more meaningful, quiet mornings, long conversations, and the kind of peace you forgot you were missing.

Hotel room in Greenville
4.73 out of 5 average rating, 145 reviews

Near GSP Airport | Bar & Dining + Shuttle

Experience the best of Greenville at our conveniently located Cambria Hotel, just off I-85 and I-385. We’re minutes from downtown dining, shops at Greenridge, and local favorites like Frankie's Fun Park and Roper Mountain Science Center. Enjoy free WiFi, an outdoor pool, airport shuttle service, and on-site dining at Woodside Grill. Greenville-Spartanburg Airport is just 8 miles away with complimentary shuttle access.

Hotel room in Greenville
4.67 out of 5 average rating, 6 reviews

Modern Comfort • Near GSP • Pool Access

Enjoy a freshly renovated room just minutes from GSP Airport. Designed for comfort, this updated space features modern finishes, plush bedding, & spacious layout. Start your morning with complimentary hot breakfast, unwind by our refreshed pool, and enjoy free parking throughout your stay. Convenience and comfort — all in one place.

Guest favorite
A spacious room features a large bed with soft bedding and a decorative pillow. A comfortable sofa is positioned in front of the bed. A dining area with a round table and chairs is visible, along with a kitchenette in the background.
Hotel room in Clemson
5 out of 5 average rating, 57 reviews

The Abernathy

The Abernathy is located one block from The Rock and offers guests large rooms with 445 sq. ft. to stretch out and enjoy their stay in Clemson. Bicycles are available for guests to take on a leisurely pedal through Clemson's campus at their own pace. There is also an on-site bar to enjoy after a long day of exploring.

Superhost
A spacious hotel room features a king bed with clean white linens and wooden furniture. A large window allows natural light to enter, revealing a shared balcony that overlooks green foliage. A desk and chair are positioned nearby, along with a mirror reflecting the room's layout.
Hotel room in Hendersonville
4.58 out of 5 average rating, 24 reviews

Kanuga Lake Inn - King Shared Balcony

Traditional hotel accommodation that includes a king bed, private bathroom and air conditioning/heating. These rooms feature a shared balcony with the adjacent room that overlooks into a courtyard area or a parking lot. Our hotel rooms do not have a view of the lake. Please note there is not a TV in the room.

Popular amenities for Upstate South Carolina hotels

Destinations to explore