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Vacation home rentals in Upstate South Carolina

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Upstate South Carolina

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious exterior view of the building is shown, featuring a distinctive pink facade and a textured roof. A wooden staircase leads to an upper deck, while two chairs are positioned on a gravel area beside the entrance. Lush greenery surrounds the structure.
Vacation home in Pisgah Forest
4.99 out of 5 average rating, 107 reviews

Wake surrounded by views of the beautiful Blue Ridge Mountains in this lovely 1 bedroom vacation home.

Forget your worries in this spacious and serene space with indoor fireplace,full kitchen,laundry room,air, covered parking,large deck and outdoor fire pit/dining area. Minutes from hiking,biking,fishing,golf, 200+ waterfalls, dining, downtown Brevard, shopping,local breweries. Located between Pisgah National and DuPont State Forests. 30 minutes from Asheville airport and 20 minutes from historic Hendersonville. Brevard Music Center, Cradle of Forestry,Flat Rock Playhouse, Biltmore House nearby

Top guest favorite
Vacation home in Greenville
4.94 out of 5 average rating, 214 reviews

City Dream Spacious 2BR-2BA Walk the Heart of GVL

A comfy & spacious escape for work or vacay. 2 FULL BATHROOMS. Prime location by Main St. to walk,trolley,bike downtown or to trail.This gem is 5 min walk to Bcycle/trolley & Fluor Field. 12 min walk to Falls.Uber friendly.See shops-art galleries-museums-tours-eateries-breweries-outdoor activities.Newly remodeled spacious historic bldg w 10’ ceilings, wood floors & new baths.1300 sq.ft entire 1st floor.1 King &1 Queen bed.Large private patio,full kitchen/living/dining. Games & records.PARK FREE

Guest favorite
The modern cabin is nestled among trees, elevated on stilts, and features a spacious covered deck that invites outdoor enjoyment. Large windows reflect the greenery, allowing for natural light to enhance the welcoming design. A serene forest backdrop complements the structure.
Vacation home in Pisgah Forest
4.86 out of 5 average rating, 109 reviews

PILOT COVE Studio - Modern Luxury w/ Nature!

Directly bordering Pisgah National Forest at the Highway 276 gateway, Pilot Cove offers unrivaled access to Pisgah's renowned trails, roadways, rock walls, and trophy waters. Our luxury forest lodging cabins feature these amenities: - Modern Design - Upscale Finishes - Full Kitchen - Full Bathroom - Washer / Dryer - Perfect Sleeper Mattresses - Luxury Microfiber Linens - 48″ Flatscreen TV - Cable w/ 200+ Channels - Free Wi-Fi - Parking at each unit - Spacious Covered Deck - Bike Wash Station

Top guest favorite
Vacation home in Seneca
4.93 out of 5 average rating, 60 reviews

Cozy cottage 15 mins from Clemson, 7 mins from Lake Keowee

Has Stairs This efficiency apt has it all. Kitchen with convection micro, fridge, coffee maker & hot plate. Not a full size home, it’s an apartment. Space surrounded by Oconee County Country Club golf course. 1 mile to Walmart and shopping. 30 mins to the Blue Ridge Mountains. We are 7 mins to beautiful Lake Keowee. Please note 5 people should be family as it is tight. The person booking the property must be staying on the property. No construction equipment or trucks allowed on the property.

Top guest favorite
Vacation home in Bryson City
4.97 out of 5 average rating, 97 reviews

Nantahala River 2BR - Bear Cave Boat Parade

Closest rental to the Nantahala Outdoor Center! 1.5 miles upriver. Trains daily. Read this: NO SMOKING, NO PETS, no exceptions, please don't ask. Service animal excepted. Read CANCELLATION POLICY before booking and house rules before booking. NO TRASH SERVICE in area, guest must remove when checking out. NO TRAILERS. Parking too small Two vehicles MAX. NOT SAFE for small children due to powerful water. WI-FI provided. CELL Coverage: Verizon = Excellent. T Mobile = None. ATT = Outdoors only.

Guest favorite
A modern kitchen features stainless steel appliances, including a refrigerator and oven. A round dining table with four wooden chairs is centered in the space, inviting meals together. Natural light filters through a window, brightening the neutral-colored cabinetry and wooden flooring.
Vacation home in Roebuck
4.9 out of 5 average rating, 105 reviews

Patriot Point B, an inviting studio apartment

This patriot themed studio apartment sleeps 5. The apartment includes a queen, pull out queen sofa bed, optional roll out full bed, a full kitchen, 1 bathroom, full laundry area, with areas for relaxing, bonfire and a gas grill. The apartment offers cozy patriotic decor including several historic homes in the area. It's charming and includes a large room with designated areas for the bed and living area, a kitchen and separate bath. We are minutes from downtown Spartanburg. Kerri & Brian

Top guest favorite
An outdoor seating area is depicted with comfortable chairs arranged around a decorative area rug. Potted plants and greenery surround the space, providing a natural and serene ambiance. A wooden railing outlines the area, enhancing the connection to the surrounding landscape.
Vacation home in Tryon
4.99 out of 5 average rating, 136 reviews

Sandy Plains Fountain Home | King Bed | 3 MI TIEC

2 Bedrooms - 1 king bed & 1 queen, 1 bath Efficiency kitchen ( we are testing an additional space that we have recently added as another bedroom as an extra bonus room ) there will be an extra 100$ added separately by the host for use of 3rd bedroom- 2 night minimum Detached Laundry facility on property where nature surrounds you with additional outside seating & dining . Peaceful and centrally-located 3 miles from Tryon International Equestrian Center TIEC & local wineries .

Top guest favorite
Vacation home in Anderson
4.99 out of 5 average rating, 117 reviews

Lake House and Dock Upscale and Immaculate

Our immaculate 2020 built water-themed home is a luxury furnished lakefront 1.1 acre property on Lake Hartwell with a large boat dock. Our house enjoys amazing lake views and is perfect for the tournament fisherman, the boating enthusiast, golfers, families and those just needing to relax. We are down the street from Stonecreek Cove Golf Course in a countryside atmosphere and are comfortably close to the renowned Green Pond Landing, host to many national fishing tournaments.

Superhost
A private hot tub is shown, situated on a patio with views of a flowing stream and surrounding trees. The water's surface is gently bubbled, reflecting the natural greenery nearby, creating a serene atmosphere for relaxation.
Vacation home in Bryson City
4.5 out of 5 average rating, 62 reviews

Eagle's Nest

Eagle's Nest is a comfortable and spacious two- bedroom cottage featuring a large great room with a view overlooking the rushing waters of Alarka Creek. One bedroom with one queen-sized bed features a Victorian theme. The second bedroom with one queen-sized bed is decorated with a rustic wildlife look. Take in the cool mountain air while sitting on the private porch. There is a large grassy area in the front, it's the perfect place for children to play and explore.

Guest favorite
A covered dock with two boat slips is positioned over calm waters. Surrounding trees reflect in the lake, enhancing the natural scenery. A clear sky with scattered clouds provides a serene backdrop for an enjoyable waterfront experience.
Vacation home in Fair Play
4.93 out of 5 average rating, 76 reviews

Lakefront Hartwell Home w/NEW Dock + NEW Fire Pit

This 5 bedroom/3.5 bath house sleeps 14 and is perfect if you enjoy all of the amenities of a resort + the perks of a quiet, private home. Resort-style amenities include: a new covered dock with two boat slips, kayak, paddleboards, stone fire pit, NEW Hot Tub, stacked porches with ample seating and dining spaces, two indoor fireplaces, a full kitchen and a kichenette, comfortable beds, a serene gazebo - all nestled in the natural beauty of Lake Hartwell.

Top guest favorite
Vacation home in Hendersonville
5 out of 5 average rating, 82 reviews

Bike from House! Rocky Ridge Base Camp at DuPont

Escape to our quiet 6.5-acre retreat at DuPont State Forest! Perfect for bikers & hikers, this updated home comfortably sleeps 5. Enjoy a fully equipped kitchen, cozy wood stove, and a large covered deck with a grill. A dedicated garage with a bike stand makes this the ultimate basecamp for exploring Brevard and Pisgah. Hidden away near Sky Valley Road, experience peaceful solitude with easy access to world-class trails.

Top guest favorite
Vacation home in Seneca
4.99 out of 5 average rating, 70 reviews

Lakefront Clemson Retreat - 4 bedroom & 4 bathroom

Enjoy a light and modern lakefront retreat - 4 bedrooms and 4 bathrooms near Clemson's Memorial Stadium (Death Valley) and downtown Clemson. Harts Cove is 1 mile from Hartwell Village with restaurants and shopping on Clemson Blvd! There is a pool, work-out room, pool table and two docks on Lake Hartwell! There is a basketball and volleyball court and an outdoor fireplace for your enjoyment!

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