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Vacation home rentals in Upstate South Carolina

Find and book unique vacation home rentals on Airbnb

Top-rated vacation home rentals in Upstate South Carolina

Guests agree: these vacation home rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A spacious living area features a comfortable sofa with a light-colored fabric, paired with a wooden coffee table adorned with greenery. A sloped ceiling adds dimension, while a warm neutral palette and natural light enhance the inviting feel of the space.
Vacation home in Pisgah Forest
4.99 out of 5 average rating, 107 reviews

Wake surrounded by views of the beautiful Blue Ridge Mountains in this lovely 1 bedroom vacation home.

Forget your worries in this spacious and serene space with indoor fireplace,full kitchen,laundry room,air, covered parking,large deck and outdoor fire pit/dining area. Minutes from hiking,biking,fishing,golf, 200+ waterfalls, dining, downtown Brevard, shopping,local breweries. Located between Pisgah National and DuPont State Forests. 30 minutes from Asheville airport and 20 minutes from historic Hendersonville. Brevard Music Center, Cradle of Forestry,Flat Rock Playhouse, Biltmore House nearby

Superhost
The cabin is nestled among lush trees, featuring a spacious covered deck that extends outward. Large windows provide glimpses of the modern interior. The entrance is framed by greenery, enhancing the connection with nature.
Vacation home in Pisgah Forest
4.89 out of 5 average rating, 110 reviews

PILOT COVE 2 BR - Modern Luxury w/ Nature!

Directly bordering Pisgah National Forest at the Highway 276 gateway, Pilot Cove offers unrivaled access to Pisgah's renowned trails, roadways, rock walls, and trophy waters. Our luxury forest lodging cabins feature these amenities: - Modern Design - Upscale Finishes - Full Kitchen - Full Bathroom - Washer / Dryer - Perfect Sleeper Mattresses - Luxury Microfiber Linens - 48″ Flatscreen TV - Cable Package - Free Wi-Fi - Parking at each unit - Spacious Covered Deck - Bike Wash Station

Top guest favorite
Vacation home in Greenville
4.94 out of 5 average rating, 214 reviews

City Dream Spacious 2BR/2BA Walk the Heart of GVL

A comfy & spacious escape for work or vacay. 2 FULL BATHROOMS. Prime location by Main St. to walk,trolley,bike downtown or to trail.This gem is 5 min walk to Bcycle/trolley & Fluor Field. 12 min walk to Falls.Uber friendly.See shops-art galleries-museums-tours-eateries-breweries-outdoor activities.Newly remodeled spacious historic bldg w 10’ ceilings, wood floors & new baths.1300 sq.ft entire 1st floor.1 King &1 Queen bed.Large private patio,full kitchen/living/dining. Games & records.PARK FREE

Guest favorite
An efficiency kitchen is visible, featuring a convection microwave, refrigerator, and coffee maker on a smooth countertop. A small dining area with a table and four chairs is nearby. A cozy armchair occupies a corner, while a doorway leads to a bathroom space with a shower.
Vacation home in Seneca
4.93 out of 5 average rating, 60 reviews

Cozy cottage 15 mins from Clemson, 7 mins from Lake Keowee

Has Stairs This efficiency apt has it all. Kitchen with convection micro, fridge, coffee maker & hot plate. Not a full size home, it’s an apartment. Space surrounded by Oconee County Country Club golf course. 1 mile to Walmart and shopping. 30 mins to the Blue Ridge Mountains. We are 7 mins to beautiful Lake Keowee. Please note 5 people should be family as it is tight. The person booking the property must be staying on the property. No construction equipment or trucks allowed on the property.

Top guest favorite
A cozy riverfront cabin with a green metal roof is visible, situated beside a gentle flow of water. An outdoor seating area features a wooden deck, with several chairs positioned for relaxation. The surrounding landscape includes trees and a rocky bank.
Vacation home in Bryson City
4.97 out of 5 average rating, 99 reviews

Nantahala River 2BR - Bear Cave Boat Parade

Closest rental to the Nantahala Outdoor Center! 1.5 miles upriver. Trains daily. Read this: NO SMOKING, NO PETS, no exceptions, please don't ask. Service animal excepted. Read CANCELLATION POLICY before booking and house rules before booking. NO TRASH SERVICE in area, guest must remove when checking out. NO TRAILERS. Parking too small Two vehicles MAX. NOT SAFE for small children due to powerful water. WI-FI provided. CELL Coverage: Verizon = Excellent. T Mobile = None. ATT = Outdoors only.

Superhost
A cottage with a metal roof is set against a backdrop of trees and rolling hills. A gravel pathway leads to the front porch, flanked by landscaped flower beds and a tall evergreen. A clear creek can be seen in the distance, enhancing the serene environment.
Vacation home in Bryson City
4.78 out of 5 average rating, 83 reviews

Bear Kottage

This cottage is so cozy, most people call it the "Honeymoon Kottage." Bear Kottage sits right on the beautiful Alarka Creek; you can walk out your door and fish right in your back yard. This is a great little cottage for those wishing to do a little fishing, wading in the creek, or simply relax beside the beauty of the water from the comfort of their porch rockers or hot tub. Bear Kottage is located about seven miles from downtown Bryson City, which is about a 20-minute drive. WIFI available

Guest favorite
A welcoming blue front door is set against light beige siding. Flanking the door are two decorative planters containing lush greenery. A vertical sign reading 'WELCOME' stands beside the door, enhancing the inviting entrance.
Vacation home in Roebuck
4.9 out of 5 average rating, 105 reviews

Patriot Point B, an inviting studio apartment

This patriot themed studio apartment sleeps 5. The apartment includes a queen, pull out queen sofa bed, optional roll out full bed, a full kitchen, 1 bathroom, full laundry area, with areas for relaxing, bonfire and a gas grill. The apartment offers cozy patriotic decor including several historic homes in the area. It's charming and includes a large room with designated areas for the bed and living area, a kitchen and separate bath. We are minutes from downtown Spartanburg. Kerri & Brian

Guest favorite
Vacation home in Appling
4.95 out of 5 average rating, 65 reviews

Luxe Studio Vaulted Ceilings-Private Entry-Parking

Welcome to our stylish and cozy studio, just minutes from scenic lakes, golf courses, and Augusta National Golf Course. The Luxe Studio features modern amenities like a fireplace, 75-inch Smart TV, high-speed Wi-Fi, and a luxurious queen bed for a relaxing stay. The spacious roundabout driveway offers ample parking for boats or trailers, with outdoor charging outlets available for $25/day per boat. Perfect for the Masters Golf Tournament, fishing trips, remote work, or a peaceful retreat.

Top guest favorite
A gravel driveway leads to a charming detached building surrounded by trees, with a rustic exterior and a welcoming pathway. Natural light filters through the leaves, creating a serene atmosphere that invites exploration.
Vacation home in Tryon
4.99 out of 5 average rating, 137 reviews

Sandy Plains Fountain Home | King Bed | 3 MI TIEC

2 Bedrooms - 1 king bed & 1 queen, 1 bath Efficiency kitchen ( we are testing an additional space that we have recently added as another bedroom as an extra bonus room ) there will be an extra 100$ added separately by the host for use of 3rd bedroom- 2 night minimum Detached Laundry facility on property where nature surrounds you with additional outside seating & dining . Peaceful and centrally-located 3 miles from Tryon International Equestrian Center TIEC & local wineries .

Top guest favorite
Two coasters with a personalized design are placed on a detailed map of the lake area. The map displays various waterways and terrain features, inviting exploration and adventure in the surroundings.
Vacation home in Anderson
4.99 out of 5 average rating, 118 reviews

Lake House and Dock Upscale and Immaculate

Our immaculate 2020 built water-themed home is a luxury furnished lakefront 1.1 acre property on Lake Hartwell with a large boat dock. Our house enjoys amazing lake views and is perfect for the tournament fisherman, the boating enthusiast, golfers, families and those just needing to relax. We are down the street from Stonecreek Cove Golf Course in a countryside atmosphere and are comfortably close to the renowned Green Pond Landing, host to many national fishing tournaments.

Top guest favorite
Vacation home in Morganton
4.85 out of 5 average rating, 103 reviews

Mountain Views w/ Hot Tub + Fire Pit – World’s Inn

Come escape to this newly-renovated 2/2, close to Morganton, Lake James, several breweries and wineries, a wedding venue and all the hiking and other outdoor activities in the state park the property backs up against. The house boasts every modern comfort you would need to work or play if you don’t want to unplug, but this house was meant to be enjoyed outdoors. The hot tub, screened porch, and fire-pit offer the perfect setting to enjoy the tranquility this house provides.

Guest favorite
The living area features a cozy sofa and recliner, with a wooden coffee table positioned on a patterned rug. A stone fireplace is complemented by a flat-screen TV. Natural light floods in through the glass doors leading to the balcony, and an open-area Jacuzzi tub is visible in the corner.
Vacation home in Gatlinburg
4.77 out of 5 average rating, 148 reviews

Stream side condo*Peaceful views+sounds*

154 Village Stream in Chalet Village - A romantic getaway, perfect for couples who want a peaceful, natural setting with easy access to Gatlinburg and the Smokies. It’s one of my favorite places to be on the private back deck listening to the sounds of water & nature. Our space is clean & cozy. Nothing fancy. Perfectly meant for simple people:) We did do upgrades, new decor, and furnishings since photos! Brand new larger water heater installed Dec 2023.

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