Pet-friendly vacation rentals in Upstate South Carolina

Find and book unique pet-friendly homes on Airbnb

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Popular amenities for Upstate South Carolina pet-friendly home rentals

Pet-friendly house rentals

Top guest favorite
Home in Hendersonville
4.99 out of 5 average rating, 136 reviews

Modern Private cabin | WiFi| | Hot Tub | Fire Pit

VickyRating, 5 stars6 days ago
I had a little trouble getting in with the keypad, but that is probably more about my lack of knowledge with keypad entries. 😂 The home was spotless when we arrived and we filled it with lots of laughter and fun! The back deck was amazing - even in a gentle rain. And, our last night there we enjoyed a fire in the fire pit. Mike and Cate were INCREDIBLY helpful and communicative. They answered every question within minutes and made us feel well taken care of. Departure was easy and they requested minimal prep for departure. They made staying at their home easy and comfortable. 👍
Superhost
Home in Greenville
4.82 out of 5 average rating, 147 reviews

Fenced in Yard, 2 Queen Beds, Downtown!

ChaseRating, 5 stars2 weeks ago
We enjoyed staying here. Lots to do around the area. Would definitely stay here again
Top guest favorite
Home in Anderson
4.99 out of 5 average rating, 198 reviews

Lake Escape

NicoleRating, 5 stars4 weeks ago
Our family was fortunate enough to stay at Marissa’s lovely Lake Escape to celebrate our daughter’s graduation from Clemson. It was a beautiful way to enjoy being together. We loved Marissa’s beautiful lake house. It reminded us of our family cabin in upstate New York. Thank you very much Marissa for opening up your lovely home to the Giebelhaus House.💜🧡💜🧡
Top guest favorite
Home in Greenville
4.98 out of 5 average rating, 124 reviews

Family & Pet Friendly Home - Sleeps 8

DawnRating, 5 stars1 week ago
The house was perfect for our needs!! It had everything we needed and then some! The communication from the hosts was fast and clear which is completely appreciated. Thank you all for a great place to stay during our time in South Carolina.
Superhost
Home in Seneca
4.85 out of 5 average rating, 221 reviews

Cozy Lake House 5 miles from Clemson w Dock

HonorioRating, 5 stars1 month ago
It is a very nice and comfortable house. I recommend it if you are looking for a house, it is the best option.
Top guest favorite
Home in Seneca
4.99 out of 5 average rating, 209 reviews

The Cozy Cottage

DonnaRating, 5 stars3 weeks ago
Mara’s place was extremely clean, the beds were so comfortable and the kitchen was well stocked. The neighborhood felt safe and location was ideal for us going to a Clemson rowing event. We hope to visit again.
Guest favorite
Home in Duncan
4.98 out of 5 average rating, 128 reviews

Cozy modern home near Tyger River Park

JasonRating, 5 stars1 week ago
Had a great stay! Exactly what we needed for the weekend! Quiet and close to the softball fields.
Top guest favorite
Home in Fountain Inn
4.96 out of 5 average rating, 114 reviews

Spacious 3 BR house with private backyard oasis.

CindyRating, 5 stars3 months ago
Another great stay at Jesses. We were able to explore downtown fountain Inn with its restaurants and boutiques. The house is near the Swamp River Trail so that you can walk your dog , the house has comfortable beds and is outfit fitted with all the essentials you need for a great stay

Pet-friendly home rentals with a pool

Top guest favorite
Guest suite in Clinton
4.99 out of 5 average rating, 234 reviews

College View Cottage & Saltwater Pool

ToniRating, 5 stars1 week ago
Lisa is a great host. She goes over and above, making sure her guests are comfortable and communicates very clearly. We will definitely book with her again.
Top guest favorite
Home in Westminster
4.99 out of 5 average rating, 121 reviews

Lakefront Oasis, Dog-Friendly Fenced in Yard.

CharlotteRating, 5 stars6 days ago
I couldn't be more pleased with my first AirBnB stay. The place was clean, inviting, and well-stocked. I wasn't expecting spices, dog toys, dog bowls, dog cot, etc. The fully fenced in yard, lake access, available kayaks, and privacy are the only things I wanted and this place sure supplied! the hot tub, outdoor shower, and firepit were huge bonuses. Also, met and talked with the neighbor who is super friendly 😉 I stayed alone the first half with my dogs and got my peace in. The second half a couple girl friends joined and we thoroughly enjoyed paddling out the this little island and throwing rocks, trying to fish, etc. Enjoying using the coloring supplies, games, and grill as well! It did storm most of the week, but even that was enjoyable! 10/10 experience for us all.
Guest favorite
Cottage in Greer
4.91 out of 5 average rating, 124 reviews

Country Retreat

JonathanRating, 5 stars1 week ago
What a wonderful little place to stay. Private, clean, and close enough to town. Some parts of the cottage (pool, bathroom, and part of kitchen) were recently renovated and were even nicer than the photos. Harry was very responsive with any questions. It was a pleasure staying here and I hope to visit again.
Guest favorite
Cabin in Six Mile
4.95 out of 5 average rating, 120 reviews

Beautiful cabin retreat at Lake Keowee

JaredRating, 5 stars3 days ago
Just a great time Honestly! Place was fun and perfect for my brother’s fishing and kayaking getaway trip. Just the right size and the best recommendations for everything. Great host, great home, and great location! Couldn’t have been more perfect. P.S. The shower pressure and temperature was like luxury at the end of a day at the lake. Highly recommend
Top guest favorite
Guest suite in Rutherfordton
4.99 out of 5 average rating, 119 reviews

Modern Studio on a Private Horse Farm with a Pool

SueRating, 5 stars1 week ago
Lovely, well designed space with a fireplace, overlooking the pool on one side and beautiful horses on the other. Great mini kitchen and creatively furnished with a mix of new and vintage pieces. Definitely five stars!
Top guest favorite
Home in Campobello
4.97 out of 5 average rating, 230 reviews

POOL HOT TUB Sleeps 11 Luxury Getaway Gameroom

DennyRating, 5 stars1 month ago
Wow this place was absolutely amazing the pool and the hot tub were definitely the highlight of the stay but the house was also very homey and clean and it’s was a fun time
Superhost
Home in Greenville
4.82 out of 5 average rating, 102 reviews

Pet + Family Friendly 4BR Pool House Near Furman

KamyRating, 5 stars1 week ago
We enjoyed this home. It was comfortable, roomy, and suited our needs perfectly. It looked like the pictures. Renee was a great host with checking in on us and making sure everything was good. We would definitely consider staying again!
Top guest favorite
Home in Roebuck
4.99 out of 5 average rating, 112 reviews

A quiet place in the country

DonaldRating, 5 stars2 weeks ago
Very homey, well stocked, roomy, in-law apartment in a quiet, country setting. Garage parking with direct handicap ramp entrance from inside of garage to the apartment.

Private, pet-friendly home rentals

Top guest favorite
Cabin in Franklin
4.98 out of 5 average rating, 248 reviews

Mountain Top Hideaway

TimRating, 5 stars1 week ago
One of the most scenic rentals out there! We had a perfect stay at Wayne’s place. Instructions on how to get to the cabin were very clear and GPS surprisingly took us right to the front door. You get incredible privacy but only 20 minutes to get into town if you need anything. Would absolutely return here!
Top guest favorite
Shipping container in Clarkesville
5 out of 5 average rating, 37 reviews

Oakey Mountain Mirror Haus

NathanRating, 5 stars1 week ago
Sauna, cold plunge & hot tub were perfect after hiking nearby. Hosts were very responsive & we had an excellent time, thank you!
Guest favorite
Farm stay in Rutherfordton
4.92 out of 5 average rating, 106 reviews

Grain Cottage on Highland Cow Farm

AutrinaRating, 5 stars2 months ago
This was my daughter’s birthday weekend and we had a Mommy/daughter weekend on the farm. This was literally one of the best experiences of our life. My daughter is an animal lover; especially cows and she was in heaven. Sheri and her family were amazing, welcoming and some of the sweetest people we’ve ever met! If you love stay here you won’t regret it! We’re grateful that we found New Beginnings Historic Farms!!!
Top guest favorite
Guesthouse in Franklin
4.95 out of 5 average rating, 496 reviews

Ol Skool Cabin ( tiny home)

VeldaRating, 5 starstoday
The cabin was great! In a beautiful location, not far from town. Beth had plenty of information about things to do. I was there to go gem mining and she had a map for most of them. I prefer maps to using GPS so it was right up my alley. It rained every night and on the tin roof it made me feel right at home.
Top guest favorite
Shipping container in Walhalla
4.96 out of 5 average rating, 26 reviews

Valhalla Sky Suite at Hisaw Gap

LindaRating, 5 stars5 days ago
We had a great time! Brannon was very responsive and replied within a reasonable time. We enjoyed every bit of it especially the nature. We will definitely come back and will recommend to family and friends. Thank you again for the experience!
Top guest favorite
Dome in Sylva
4.98 out of 5 average rating, 142 reviews

Ramantic Getaway In The Clouds W/Hot Tub & Views!

JoseRating, 5 stars3 days ago
Our recent stay in this one-of-a-kind dome near the Smoky Mountains was a breath of fresh air—literally and figuratively. Tucked into a quiet patch of forest, the dome offered a beautiful, peaceful escape from everyday life. The outdoor deck was our favorite spot—perfect for sipping coffee in the crisp mountain air or stargazing at night. The hot tub outside was the cherry on top—relaxing in warm water while surrounded by nature was pure magic. The fire pit added a great touch for unwinding in the evenings. Location-wise, it struck the perfect balance—remote enough to feel off-the-grid, but still a short drive from trails, waterfalls, and charming mountain towns. The hosts were friendly, responsive, and made everything easy. If you’re looking for a cozy, beautiful, and totally different kind of stay, this dome is the way to go. Highly recommend for couples or solo travelers looking to recharge in nature.
Top guest favorite
Cabin in Zirconia
4.96 out of 5 average rating, 45 reviews

Parke's Stand- Treehouse

AustinRating, 5 stars2 weeks ago
Staying in this tree house was an absolute dream! It was private, spotlessly clean, and truly one-of-a-kind—such a peaceful and unique experience. You can tell a lot of care and attention went into making it special. Hartwell was an amazing host—super helpful and quick to respond to any questions. I couldn’t have asked for a better stay. Highly recommend!
Top guest favorite
Cottage in Travelers Rest
4.99 out of 5 average rating, 133 reviews

The Little Big House

StephanieRating, 5 stars3 weeks ago
Quick getaway to the upstate while our daughter attended a camp function. Home was very very clean, well stocked kitchen. Simply decorated, zero clutter. A/C gets five stars all to itself!!! Quiet at night, close to everything we needed. 15 minute drive to downtown Greenville. Husband loved the blackout blinds in bedroom. Solid WiFi.

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