
Guesthouse vacation rentals in Upstate South Carolina
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Top-rated guesthouse rentals in Upstate South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Upstate South Carolina guesthouse rentals
Family-friendly guest house rentals

Bright & Cheerful Garage Apt, Perfect Location!

Firefly: Walk to Main St Hendersonville, NC

The Nest; private tiny home @Reblooming Rose

Cozy Studio Apartment

Bungalow on a 3 acre mini farm

Lit'l Bit O' Heaven- Rocky Top Lodge

Cabin in the Pines

Charming Tiny House by the Biltmore Village
Guest house rentals with a patio

Firefly Cove Guesthouse

Modern Studio near downtown

Yes please we need you! Spacious w/ amazing view!

Starswept Studio–Walk to Brewery, Near BRP & GSMNP

1 bedroom guest house on horse property in Tryon

Downtown guest house with private hot tub & deck

Cozy guest cottage at The Black Walnut Chateau

The Woodlen: Studio with Views/Hot tub/ fire pit
Guest house rentals with a washer and dryer

The Spring Valley Retreat

Guest House at Lake Hartwell

Gallery Carriage House DT Watkinsville w EV

MeadowHill Guesthouse - Mountain view-3 mi to town

⭐️⭐️⭐️⭐️⭐️Casita Blanca 🚶🏽➡️Dining, BREWS,SHOPS📍DTWN📍LUX

The Guest House By The River

Gorgeous Downtown Studio & Dog Friendly!

Hickory Hill Guesthouse
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- Blue Ridge Parkway
- Gorges State Park
- Chimney Rock State Park
- Table Rock State Park
- The North Carolina Arboretum
- Tryon International Equestrian Center
- Lake Lure Beach and Water Park
- Ski Sapphire Valley
- Wade Hampton Golf Club
- Jump Off Rock
- Victoria Valley Vineyards
- Discovery Island
- Haas Family Golf
- Carl Sandburg Home National Historic Site
- Saint Paul Mountain Vineyards
- Wellborn Winery
- Burntshirt Vineyards
- City Scape Winery
- Overmountain Vineyards
- Russian Chapel Hills Winery