Guesthouse vacation rentals in Upstate South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Upstate South Carolina guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Waynesville
4.96 out of 5 average rating, 277 reviews

Cozy studio loft in the Blue Ridge Mountains

EvanRating, 5 stars1 week ago
Great place to see when visiting Pisgah National Forest attractions and/or Great Smoky Mountains. Comfortable, quiet, and clean :)
Top guest favorite
Guesthouse in Athens
4.95 out of 5 average rating, 327 reviews

Great 1 BR house in Normaltown

HollyRating, 5 stars2 weeks ago
Lovely little home with lovely flowers and artistic touches. Perfect quiet location while visiting my son at UGA. Juana was very accommodating when I made a last minute reservation, and had everything ready for us when we arrived.
Top guest favorite
Guesthouse in Donalds
4.99 out of 5 average rating, 371 reviews

Home on the farm

JamesRating, 5 stars2 days ago
Awesome little getaway. From fishing to riding the trails on the property l and splashing around in the pool. It was peaceful. Kids had an awesome time.
Top guest favorite
Guesthouse in Avery Creek
4.99 out of 5 average rating, 315 reviews

Loft in the Countryside

SarahRating, 5 stars2 months ago
Perfect for our quick weekend in Asheville with the pup!
Top guest favorite
Guesthouse in Tryon
4.98 out of 5 average rating, 109 reviews

Historic Jockey Cottage, TIEC 20 mins, Tryon 5

MollyRating, 5 stars4 months ago
My husband and I stayed a week over Christmas to visit family. Terry and Bill met us when we arrived and were super friendly and showed us around, met our dog, and gave us the history of the cottage. The cottage was very cozy and exactly what we needed! Gorgeous scenery and was fun to see the horses every morning. We will be back!
Top guest favorite
Guesthouse in Mills River
4.97 out of 5 average rating, 185 reviews

Rocking chair porch in Mills River! Relax

AndyRating, 5 stars3 months ago
Great hosts , beautiful unique little home with everything that was needed! Highly recommended if you want a quiet place to relax!
Guest favorite
Guesthouse in Salem
4.89 out of 5 average rating, 307 reviews

Mountain Edge Loft

JewelRating, 5 stars3 months ago
Beautiful land and home, cute dogs and chickens, the bread was delicious and i definitely recommend California's Mexican Grill, it was yummy!! The fire pit was so warm. Everything was clean and comfortable, Marsha responded to our messages in a short time and was very kind, will recommend to friends!
Top guest favorite
Guesthouse in Rabun Gap
5 out of 5 average rating, 230 reviews

Betty's Creek Loft in Rabun Gap.

SuzanneRating, 5 stars4 days ago
We thoroughly enjoyed Matthew and Beverly’s Loft. It was perfect! Very peaceful with magnificent views! This was our first AirBNB stay and we couldn’t have been more pleased. We plan to come back to this loft again.

Guest house rentals with a patio

Top guest favorite
Guesthouse in Spartanburg
5 out of 5 average rating, 88 reviews

The Lodge at Pythian Park

SarahRating, 5 stars1 day ago
We loved the peaceful stream and the quiet location. Ginny and Terry are wonderful hosts, along with their well-mannered, beautiful dogs. It is tucked away 10 minutes from everything on a beautiful piece of property. The room is very clean and new. Every detail and need is noticed. Ginny even had ice made for us before we got there! The bed is soooo comfortable and the sheets were super soft. Everything was perfect!
Guest favorite
Guesthouse in Bogart
5 out of 5 average rating, 11 reviews

Classic City Cottage

ErinRating, 5 stars2 weeks ago
Great place to stay - met all of our needs and then some. Perfect for a night before the Georgia G Day scrimmage game. Host was super helpful and responsive.
Guest favorite
Guesthouse in Batesburg-Leesville
5 out of 5 average rating, 8 reviews

Beautiful Lake Front 1 bedroom Guest House

TracyRating, 5 stars6 months ago
Rhonda was always willing to help with anything I needed. During Hurricane Helen we lost power and water. Rhonda traveled to North Carolina and picked up a generator to take care of us. Rhonda is willing to go the extra mile to ensure her guests have a great stay in her guests house. I will definitely stay there again.
Top guest favorite
Guesthouse in Maggie Valley
4.99 out of 5 average rating, 344 reviews

Starswept Studio–Walk to Brewery, Near BRP & GSMNP

ChrisRating, 5 stars1 day ago
Great location, friendly host, clean and very well appointed private space…this is what all other Air BnBs should aspire to!
Top guest favorite
Guesthouse in Greenville
4.95 out of 5 average rating, 37 reviews

Tranquil 2BR Guest House on Pond by Furman

AnnRating, 5 stars1 week ago
Peaceful surroundings with pond and patio. Great location. Close to shopping, swamp rabbit trail, parks, and mountains. Very clean and nicely decorated. Very responsive host. Hope to stay again.
Top guest favorite
Guesthouse in Inman
4.99 out of 5 average rating, 119 reviews

Foothills Favorite

MackRating, 5 stars1 day ago
Our stay was great! Check in was super easy and there were super clear instructions for checking in and out. The space itself was spotless and super comfortable. Would stay again!
Top guest favorite
Guesthouse in Greenville
4.96 out of 5 average rating, 195 reviews

Cozy Downtown GVL Studio

AmyRating, 5 stars2 days ago
This is a great place to stay in Greenville! It was conveniently close to downtown which we found to be perfect for our stay! Jonathan responded quickly to our messages and was a great host!
Top guest favorite
Guesthouse in Greenville
4.97 out of 5 average rating, 130 reviews

Finished Room over Garage (FROG) on Reedy River

JuanitaRating, 5 stars1 week ago
It was so beautiful and peaceful A beautiful view to drink your morning Coffee So quiet no traffic sounds Very very clean Couch and bed very comfortable I really enjoyed the trail great walk I loved everything Bret was a great host Always quick to answer questions Checked to see if we needed anything So friendly I would stay again It was such a great stay😄😄😄😄😄😊

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in Arden, NC 28704, USA
4.93 out of 5 average rating, 397 reviews

Explore the Woods from a Quiet Apartment near Sierra Nevada

SarahRating, 5 stars3 weeks ago
A beautiful, quaint little spot! Perfect for my brother and I while we were attending Arborfest in Fletcher this weekend!
Top guest favorite
Guesthouse in Tuckasegee
4.99 out of 5 average rating, 221 reviews

Wolf Lake Escape - lake & mountain retreat

ChadRating, 5 stars1 week ago
Wolf Lake Escape is a great little remote spot right on the lake. Kathleen is an excellent host and Tilley the dog is a friendly co-host! The apartment is private and the views of the lake from just outside the door are beautiful. Thanks Kathleen, we’ll be back!
Top guest favorite
Guesthouse in Watkinsville
4.98 out of 5 average rating, 196 reviews

Gallery Carriage House DT Watkinsville w EV

BarbaraRating, 5 stars3 days ago
2nd time there, location is close to art, shopping, walking trails and good food
Top guest favorite
Guesthouse in Canton
4.98 out of 5 average rating, 192 reviews

Spring in the Smoky Mountains,Canton (AVL)-amazing

LeoRating, 5 stars10 months ago
Stayed at Gregg & Lynn’s for one night on a road trip. They were super-responsive, and the place had everything I needed—hot shower, laundry, and comfy bed. The views were nice and it was very quiet and private. Be aware that there are many stairs leading up to the front door.
Guest favorite
Guesthouse in Six Mile
4.9 out of 5 average rating, 125 reviews

Camper at Hickory Lodge and Guesthouse

ToriRating, 5 stars3 weeks ago
We had an enjoyable stay in the camper! Our first time to experience staying in a camper. It was a fun experience.
Top guest favorite
Guesthouse in Westminster
4.99 out of 5 average rating, 169 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

SharonRating, 5 stars2 weeks ago
Absolutely loved this little cabin. Very comfortable and would definitely stay again.
Top guest favorite
Guesthouse in Shelby
4.99 out of 5 average rating, 267 reviews

Cabin in the Pines

PamRating, 5 stars3 weeks ago
It was a great place to stay. I would highly recommend this cute little cabin. Thanks, Pam
Top guest favorite
Guesthouse in Athens
4.96 out of 5 average rating, 194 reviews

Five Points Dawg Suite

SherrieRating, 5 stars5 days ago
This guest house was just what I needed. I stayed for a total of 9 nights. The home was clean, private and I felt very safe. If I had anything negative to say it would only be that the guest house needed an iron. Other than that absolutely no complaints.

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