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Guesthouse vacation rentals in South Carolina

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for South Carolina guesthouse rentals

Family-friendly guest house rentals

Guest favorite
A serene outdoor living space is observed, featuring a fenced in-ground pool surrounded by a paved patio. Comfortable seating is arranged near the pool, complemented by vibrant flowers in planters. A trampoline is visible in the background, set amidst lush greenery.
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 246 reviews

Studio Apt - (Pets/beach/pool/golf)

MetinRating, 5 stars4 months ago
TJ was a very helpful, responsive, and friendly. The space was very enjoyable, great location
Top guest favorite
A well-maintained lawn features a manicured, artificial turf area leading to a charming guest house. Surrounding greenery and a path of gravel create a welcoming entry. The guest house displays a simple entrance, framed by lush foliage, contributing to a private, tranquil setting.
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 244 reviews

Bungalow Under The Oaks

SandrineRating, 5 stars4 days ago
We stayed here for a long weekend and will 100% be back! Along with a very clean house, Jessica had everything needed in the kitchen along with extra bathroom products in case we forgot anything. Even had necessities if you brought your pet! Location was very close to everything and felt very private and a cute getaway for 2.
Top guest favorite
Two classic cars are parked in front of a detached garage, showcasing a vintage white convertible and a sleek gray vehicle. The garage features two closed doors, framed by light green siding and surrounded by trees, adding to the serene environment.
Guesthouse in Summerville
4.88 out of 5 average rating, 796 reviews

New Loft in Historic Summerville

AmyRating, 5 stars4 days ago
We loved our stay at Jacquelynn's! We had to travel with our two older, yet anxious, dogs for a wedding and it turned out to be the perfect place for us. The loft is detached from the home, making it much more private to go to and from. The place was spotless with cute decor. Even though it is a smaller space, she has everything you need to make your stay comfortable. Lots of towels and blankets as well as silverware, coffee pot, and mugs. I was pleasantly surprised at how the bathroom was actually quite spacious for the small space. The most important and best part for us was the peace and quiet. We typically have to worry about outside noise as our dogs will bark at any and every noise they hear. But the loft is nestled in such a quiet and quaint neighborhood, making it perfect for anyone with anxiety ridden dogs. I highly recommend Jacquelynn's loft!
Guest favorite
A serene bedroom features a spacious bed with a white coverlet and decorative pillows. Natural light enters through a window, illuminating a bedside lamp and a small table. A dresser complements the decor, while artwork adds a touch of color to the muted green walls.
Guesthouse in North Charleston
4.93 out of 5 average rating, 394 reviews

Cozy Park Circle, Charleston Guest House

CaitlynRating, 5 stars1 month ago
Very convenient place to Park Circle and the major highways in Charleston.
Top guest favorite
A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.
Guesthouse in Donalds
4.99 out of 5 average rating, 371 reviews

Home on the farm

JamesRating, 5 stars4 days ago
Awesome little getaway. From fishing to riding the trails on the property l and splashing around in the pool. It was peaceful. Kids had an awesome time.
Superhost
A charming yellow cottage is framed by lush greenery, with a cozy seating area featuring bright blue chairs. A colorful hammock hangs nearby, creating an inviting space for relaxation. Sliding glass doors lead into the cottage, promoting a cheerful and welcoming atmosphere.
Guesthouse in Charleston
4.84 out of 5 average rating, 118 reviews

Romantic Beach Style Cottage close to everything!

NatalieRating, 5 stars3 days ago
Clean & conscious hosts! Mindful of needs that may crop up, lovely home & family. Flexible! Perfect oasis away from the bustle of Charleston.
Guest favorite
The open loft features a spacious bed and a striped couch adorned with decorative pillows. Natural light floods through large windows that frame views of the surrounding woods. Natural wood floors and a small side table complete the cozy atmosphere.
Guesthouse in Salem
4.89 out of 5 average rating, 307 reviews

Mountain Edge Loft

JewelRating, 5 stars3 months ago
Beautiful land and home, cute dogs and chickens, the bread was delicious and i definitely recommend California's Mexican Grill, it was yummy!! The fire pit was so warm. Everything was clean and comfortable, Marsha responded to our messages in a short time and was very kind, will recommend to friends!
Guest favorite
A charming log cabin is nestled among lush greenery, featuring wooden walls and a sloping roof. The front door is framed by two windows adorned with flower boxes. Two white chairs sit on a stone pathway, inviting relaxation in the serene outdoor setting.
Guesthouse in Greenville
4.92 out of 5 average rating, 662 reviews

Historic 19th Century Cabin/Guest House

MelisaRating, 5 stars1 week ago
Tony was welcoming and accommodating. One reviewer mentioned traffic noise, and while the cabin does sit next to a busy thoroughfare, I didn’t find the noise too disturbing. Overall, worth the price for the convenient location, private parking, and full kitchen. Bonus: Very close to the Swamp Rabbit Trail—we were dropped off at the Ingle’s grocery on Geer Highway and rode to the cabin to from the trail. Approximately 22 miles.

Guest house rentals with a patio

Guest favorite
An outdoor lounge area features a spacious sectional sofa in dark upholstery, surrounding a low wooden coffee table. Potted plants add greenery around the space. A shed with blue siding and double glass doors sits in the background, framed by tall trees and a wooden fence.
Guesthouse in Charleston
4.94 out of 5 average rating, 236 reviews

Quaint Cottage Studio in Ashley Forest (Avondale), New Zealand

JenniferRating, 5 stars1 week ago
John and his family offer a cozy place to rest after exploring the nearby neighborhoods by foot and the region by car. A comfy bed, a responsive host, a central location and great local recommendations were highlights.
Top guest favorite
Guesthouse in Campobello
4.97 out of 5 average rating, 116 reviews

Bungalow on a 3 acre mini farm

MichaelRating, 5 stars4 days ago
This was an excellent place to stay. It was beautiful. The smell of the air outside was amazing having lived a city for 5 years. Just absolutely gorgeous!
Guest favorite
A vibrant rainbow appears against a backdrop of lush green trees, with a serene lake visible in the distance. The colors of the rainbow contrast harmoniously with the surrounding foliage, creating a peaceful natural scene.
Guesthouse in Batesburg-Leesville
5 out of 5 average rating, 8 reviews

Beautiful Lake Front 1 bedroom Guest House

TracyRating, 5 stars6 months ago
Rhonda was always willing to help with anything I needed. During Hurricane Helen we lost power and water. Rhonda traveled to North Carolina and picked up a generator to take care of us. Rhonda is willing to go the extra mile to ensure her guests have a great stay in her guests house. I will definitely stay there again.
Superhost
A cottage exterior is shown, featuring a covered patio with three colorful chairs in green, blue, and yellow. The front door is framed by greenery and a decorative lamp, creating a welcoming entry. A gated area is visible alongside the house.
Guesthouse in Myrtle Beach
5 out of 5 average rating, 10 reviews

Cozy 1 Bdrm Cottage~ 1mi to beach~Sleeps4

CarissaRating, 5 stars4 months ago
Very nice and cozy cottage. The bed was very comfortable! We loved that we could bring our dog and that it was fenced in! They were very accommodating and let us stay a little past check out so we could spend more time with our family.
Top guest favorite
The interior features a cozy living area with a dark gray sectional sofa, complemented by decorative pillows. A circular coffee table sits in front, holding a tray with books and a remote. The kitchen appears in the background, showcasing a modern design with white cabinetry.
Guesthouse in Inman
4.99 out of 5 average rating, 119 reviews

Foothills Favorite

MackRating, 5 stars3 days ago
Our stay was great! Check in was super easy and there were super clear instructions for checking in and out. The space itself was spotless and super comfortable. Would stay again!
Top guest favorite
A light-filled living area features a comfortable sectional sofa and a ceiling fan. Two windows provide natural light, while a TV is mounted on the wall. A decorative painting adds color above the sofa, and a woven area rug lies underfoot.
Guesthouse in Johns Island
4.97 out of 5 average rating, 115 reviews

Driftwood Cottage

MeriRating, 5 stars4 days ago
Terry made staying at the Driftwood Cottage easy. Everything was clean and comfortable. Nice placce about 25 minutes outside of Charleston. Perfect place for exploring the area. Terry introduced himself and made sure everything was ok. Then I had complete privacy. Perfect host. Would stay at again.
Guest favorite
A shaded outdoor seating area is furnished with a comfortable couch and chairs, surrounded by tropical plants. A flat-screen TV is mounted on the wall, while a dining table awaits nearby. The entrance door adds a touch of charm to the inviting space.
Guesthouse in North Charleston
4.92 out of 5 average rating, 131 reviews

My Happy Place

BridgetRating, 5 stars3 days ago
We loved our stay at the pool house! It had everything we needed and the location was great. I would highly recommend it!
Top guest favorite
A well-maintained outdoor pool is surrounded by a concrete patio, featuring a railing and steps for easy access. Lush greenery and landscaping provide a natural backdrop, with a shed visible in the distance. Outdoor seating is arranged nearby for relaxation.
Guesthouse in Greenville
4.97 out of 5 average rating, 131 reviews

Finished Room over Garage (FROG) on Reedy River

DeniseRating, 5 stars1 week ago
Very clean and all the amenities I needed. Felt very safe and will be back.

Guest house rentals with a washer and dryer

Guest favorite
The tranquil pool area is softly illuminated, showcasing a clear water surface reflecting the evening sky. Surrounding the pool, a well-maintained white fence provides privacy. Lounge chairs are positioned nearby, creating a relaxing outdoor space for guests to enjoy.
Guesthouse in Charleston
4.85 out of 5 average rating, 121 reviews

CHS Guest house w/ Pool on Golf Course

KarenRating, 5 stars3 weeks ago
The home was neat & clean, conveniently located, private, and quiet. We had so much fun visiting many parts of Charleston with the guest house as our homebase. The home had everything our small family needed for our stay and more! Alicia was a gracious, respectful, and responsive host. She even brought extra supplies to us in case we needed them! We would welcome the opportunity to be a guest with her again.
Top guest favorite
A detached two-car garage is visible, featuring brown doors and white siding. Above the garage, a cozy guest house is present, capped with a pitched roof and adorned with multiple windows. Lush greenery surrounds the structure, enhancing the outdoor space.
Guesthouse in Mount Pleasant
4.99 out of 5 average rating, 147 reviews

Groves Carriage House, near Shem Creek

JimiRating, 5 stars1 week ago
Wonderful, responsive hosts. This above garage unit has everything you need. The neighborhood is very accessible to anywhere you want to go. 5 minutes from Shem Creek. 15 minutes to Sullivan’s Island or Isles of Palms. Roughly 10-15 minutes from Downtown Charleston. The hosts were very helpful with any of my simple needs. I would definitely stay here again.
Top guest favorite
The exterior of a raised wooden structure is framed by palm trees and a carpet of fallen leaves. A spacious staircase leads to the main entrance, which is adorned with hanging plants. The house features several dormer windows under a sloped roof.
Guesthouse in Johns Island
4.95 out of 5 average rating, 100 reviews

Leisure Lane-Private Apt on 22 acre Horse Farm

ChristineRating, 5 stars3 days ago
Absolutely amazing place! It’s quiet and a nice getaway from the city, but yet not too far to still see the sights. What you see in the photos is exactly what you get. We were so happy with the apartment, it’s clean, very comfortable and well thought out. A perfect place if you want some quiet after seeing Charleston for the day. Don’t hesitate, this place is perfect! Thanks Megan, you were an incredible host!
Top guest favorite
Guesthouse in Beaufort
4.98 out of 5 average rating, 408 reviews

The Wren Guest House

BerkleyRating, 5 stars1 week ago
Absolutely charming! Would definitely come back and recommend to others! Had everything we needed! Beaufort is a hidden gem and The Wren was perfect! Thank you! 😍 Berkley and Martha Gray
Top guest favorite
A scenic view captures a dock extending over calm waters, surrounded by lush greenery. The setting sun casts a warm glow, enhancing the tranquil scene. Boats are visible at the dock, with trees providing a natural frame to this picturesque moment.
Guesthouse in Bluffton
4.96 out of 5 average rating, 359 reviews

Old Town Bluffton Carriage Apt.

JustinRating, 5 stars1 week ago
Great location near Bluffton, was in town for a wedding and the rates were way better than in town lodging. Very nice studio with everything we needed.
Top guest favorite
A charming cabin features rustic wooden exteriors accented by bear carvings on two outdoor chairs. In front, a stone fire pit is surrounded by fallen leaves, with a warm fire flickering inside. Soft lights adorn the covered porch, enhancing the cozy ambiance.
Guesthouse in Westminster
4.99 out of 5 average rating, 169 reviews

Lit'l Bit O' Heaven- Rocky Top Lodge

SharonRating, 5 stars2 weeks ago
Absolutely loved this little cabin. Very comfortable and would definitely stay again.
Top guest favorite
A modern kitchen features stainless steel appliances, including a refrigerator and a gas range. Light-colored cabinetry contrasts with dark countertops. A large kitchen sink is complemented by a stylish faucet. Natural light enters through a window adorned with white blinds, enhancing the space's functionality.
Guesthouse in Bluffton
4.98 out of 5 average rating, 130 reviews

Carriage House at 12 Lawrence

KathyRating, 5 stars3 weeks ago
We enjoyed our stay at Kristin and Tyler’s bungalow very much! The location was perfect for our nephew’s wedding in Old Town Bluffton, and the bungalow was clean, nicely decorated, and well equipped. We would definitely stay again if in the area, and highly recommend it to others!
Top guest favorite
A serene courtyard area is surrounded by lush greenery, featuring two wooden lounge chairs and a small table. Flower pots add vibrant touches, while a trellis structure enhances the space. The light-colored paving stones provide a welcoming path for guests.
Guesthouse in Charleston
4.99 out of 5 average rating, 293 reviews

Spacious Daniel Island Apartment

NelleRating, 5 stars3 days ago
We had a wonderful stay at David’s. The space was exactly what we were looking for - clean, quiet, and comfortable. Daniel Island is beautiful, and downtown Charleston and Mount Pleasant are both very accessible by car/Uber. David was very communicative and a great host - we would love to stay here again!

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