Guesthouse vacation rentals in South Carolina
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Top-rated guesthouse rentals in South Carolina
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
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Popular amenities for South Carolina guesthouse rentals
Family-friendly guest house rentals
Guesthouse in Greenville
4.92 out of 5 average rating, 581 reviewsHistoric 19th Century Cabin/Guest House
Mar 4 – 11
Guesthouse in Bluffton
4.98 out of 5 average rating, 355 reviewsHickory Trace Carriage House
Nov 20 – 27
Guesthouse in Townville
4.88 out of 5 average rating, 230 reviewsLisa’s Lodge
Aug 3 – 10
Guesthouse in Pawleys Island
4.95 out of 5 average rating, 219 reviewsPrivate Studio Apt - (Pets/beach/pool/golf)
Sep 22 – 29
Guesthouse in Summerville
4.98 out of 5 average rating, 643 reviews★Delightful guest house near historic plantations★
Dec 16 – 23
Guesthouse in Charleston
4.92 out of 5 average rating, 302 reviewsMother in Law in James Island Riverland Terrace
Jan 17 – 24
Guesthouse in Lexington
4.94 out of 5 average rating, 247 reviewsCome Pause and Relax!
Aug 11 – 18
Guesthouse in Mount Pleasant
4.98 out of 5 average rating, 214 reviewsBungalow Under The Oaks
Sep 21 – 28
Guest house rentals with a patio
Guesthouse in Fort Mill
4.95 out of 5 average rating, 132 reviewsCarriage House Suite on Lake Wylie
Jul 24 – 31
Guesthouse in Charleston
4.93 out of 5 average rating, 172 reviewsQuaint Cottage Studio in Ashley Forest (Avondale)
Mar 28 – Apr 4
Guesthouse in Columbia
4.95 out of 5 average rating, 147 reviewsRenovated One Bedroom Guest House by UofSC
Jul 14 – 21
Guesthouse in North Charleston
5.0 out of 5 average rating, 110 reviewsThe Park Circle Clerestory Studio Guest House
Jul 2 – 9
Guesthouse in Charleston
4.98 out of 5 average rating, 122 reviewsPrivate Backyard With Fire Pit, 15 Min to Downtown
Feb 26 – Mar 5
Guesthouse in Johns Island
4.91 out of 5 average rating, 105 reviewsCozy Cottage! 5 mins from Kiawah!
Aug 2 – 9
Guesthouse in Charleston
4.97 out of 5 average rating, 127 reviewsStudio Apartment Minutes to Downtown Charleston
Dec 25 – Jan 1
Guesthouse in Spartanburg
5.0 out of 5 average rating, 39 reviewsThe Lodge at Pythian Park
Sep 21 – 28
Guest house rentals with a washer and dryer
Guesthouse in Florence
4.92 out of 5 average rating, 125 reviewsMidtown Retreat - Guest House in heart of Florence
Sep 21 – 28
Guesthouse in Lyman
4.99 out of 5 average rating, 123 reviewsBlue Heron Hideaway Lakeside Retreat
Jul 7 – 14
Guesthouse in Summerville
4.97 out of 5 average rating, 216 reviewsTiny Oak Cottage in Historic Downtown Summerville
Nov 27 – Dec 4
Guesthouse in Florence
4.99 out of 5 average rating, 666 reviewsBoho Private Downtown Stay Near I-95 & Hospital
Jul 20 – 27
Guesthouse in Mount Pleasant
4.97 out of 5 average rating, 406 reviewsGuesthouse Convenient to Charleston, Shem Creek, and Beaches
Feb 10 – 17
Guesthouse in Bluffton
4.96 out of 5 average rating, 322 reviewsOld Town Bluffton Carriage Apt.
Mar 25 – Apr 1
Guesthouse in Charleston
4.98 out of 5 average rating, 244 reviewsDetached Guest Suite
Jan 6 – 13
Guesthouse in Westminster
4.99 out of 5 average rating, 148 reviewsLit'l Bit O' Heaven- Rocky Top Lodge
Oct 6 – 13
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