House vacation rentals in South Carolina

Southern Comfort

Vacation in the heart of Myrtle Beach! Situated in a quiet neighborhood just .5 miles to Broadway at the Beach and .75 miles to the ocean. Fully renovated home features 4 bedrooms, 4 bathrooms, comfortably sleeps 8 and boasts a brand-new billiards room perfect for evening entertainment. The private, secluded backyard offers an inground pool, outdoor kitchen, TV, and firepit, with plenty of sun and a covered patio for shade. Several golf courses within 10 minutes. Location...Location...Location!

Value · Location · Grill

Lake Front/firepit/kayaks/ game room & pool table

Welcome to our sweet lake retreat! Relax with the whole family in our peaceful lakefront home. This is a newer construction home with custom upgrades and sleeps up to 14 people. This is in the BEST location on Lake Greenwood! We are located on the main water and close to Harris landing, Twin rivers, Break on the lake, and the 'sandbar'. Enjoy your morning coffee or evening cocktails on our peaceful porch and watch all the wildlife this lake offers. We would love to have you (NO EVENTS/PARTIES!)

Family · Value · Layout

Luxury Retreat & Heated Pool Downtown Simpsonville

Luxury Pool House in the Heart of Simpsonville – Perfect for Gatherings! Designed for comfort, fun, and relaxation. 2 minutes from Downtown Simpsonville and 15 minutes from Downtown Greenville, this luxury retreat feels like a private resort with all the warmth of home. With nature views and countless amenities, you’ll have everything you need for an unforgettable stay. Up to 8 guests with 4 Spacious Beds and 2.5 Baths. Indoor & Outdoor Entertainment, Well-Equipped Kitchen, Cozy Living Room!

Family · Value · Outdoor spaces

Pear Tree Farm-pets welcome! Stables/paddocks too!

Relax with the family at this peaceful place with GORGEOUS sunsets. When we say family, we mean pets & horses as well! We have 12 stables, 7 paddocks. Fenced yard & in ground pool. 5 fireplaces & heart pine floors. 3 living/family rooms. Once owned by the DuPont family (yes that DuPont family), the main part of the home is 96 yrs old and has many charming details. The 4 car garage was also the site of building race cars for the DuPonts. Pear Tree Farm offers the best in country quaintness.

Value · Location · Quiet

Black River Refuge on the Water

The first guest comment I hear is "Wow - pictures don't do this place justice - the house is incredible and the views are spectacular! The next comment is "I thought we were way out in the country but it's only 20 minutes to the waterfront town of Georgetown, with shops, dining, museums and more. Looking to get away? This place is truly a retreat- a 3 bedroom house on the beautiful Black River in Georgetown. Four kayaks provided, swim or fish off the dock just a few steps from the house.

Value · Location · Bathroom

Clemson Lake Hartwell Waterfront, Pontoon Rental

Come and enjoy a relaxing family vacation on beautiful Lake Hartwell in this spacious 2 level home. Plenty of room for multiple families to share. This 7600 sq. ft lakefront home sleep up to 18 featuring 7 bedrooms with 1 additional rooms with sofa beds; 5 full-sized bathrooms; 1 laundry area with 2 washers & 2 dryers. Each level boasts a fully furnished kitchen along with a large entertainment area. Breakfast area off main kitchen in addition to a spacious dining room that seats up to 10.

Value · Family · Hospitality

Sunset Cove-Beautiful Lake views

Your home away from home on Lake Murray! Spacious, modern clean, home with 3 levels of living -3 spacious decks, screen porch, and sunroom all with massive lake views! Plenty to do at Sunset Cove relaxing with family and friends and toys galore! "Wow just wow, best Airbnb ever..Sarah, June 2026. "..clean, beautiful view and so many fun games..Lisa, Oct 2025."Perfect setting for a quiet getaway. The house was amazing, clean, and had all the amenities we were looking for.."Jay, Sept 2025

Family · Value · Parking

Waterfall Views, Lake Hartwell, Highland Architect

Come and enjoy nature with 100+ acres to roam. Architect James Fox designed this cantilevered cliffside home overlooking a beautiful waterfall. Feel like you are in the trees, in an area much as it was when inhabited by Cherokee Indians. Stream feeds into Lake Hartwell. In the summer months on the weekends and holidays kayaks, jet skis and small boats visit the falls. This property is in the foothills of the Appalachian Mountains. Please respect our pet policy, only service animals.

Value · Family · Pool

Pumpkintown Mountain View Cottage

Welcome to Pumpkintown Mountain view Cottage, a 2 bedroom with 1 bath with a large porch and great views of Table Rock and Caesar's Head ridge line. Great location to stay for year-round outdoor activities from hiking (5 miles to Table Rock State Park) to swimming and festivals. We are located 20 minutes to Easley, City of Pickens and Travelers rest. This place has a mix of country, farm and Mountain life in one location so come and relax after a good day of outdoor activities.

Location · Family · Breakfast

Big Water Sunset at Lake it Easy

Escape to Beautiful Lake Wateree for a relaxing weekend away with friends or family. This updated house features 2 bedrooms & 2 bathrooms. Enjoy the cozy vibes of a tastefully decorated space, perfect for unwinding after a day on the lake. Step outside to a serene screened in porch, a fire pit, and stunning big water sunsets that will take your breath away. Whether you're into fishing, kayaking, or simply relaxing by the water, this lakefront house has something for everyone!

Location · Family · Walkability

Cozy Treehouse

Situated at the back of a wooded 2 acre lot, only 10 minutes from downtown Greenville, this is a little oasis in the city! While most treehouses take you on a "roughing it" adventure, Cozy Treehouse is the glamping version of treehouses, boasting 9' ceilings, 1.5 baths, 3 LED TV's and many outdoor living options. If you are looking for a unique getaway just minutes from one of the top growing cities in the south, Cozy Treehouse is the perfect destination for you.

Location · Value · Condition

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

Family · Location · Sleep quality