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Bed and breakfast vacation rentals in Upstate South Carolina

Find and book unique bed and breakfast rentals on Airbnb

Top-rated bed and breakfast rentals in Upstate South Carolina

Guests agree: these bed and breakfast rentals are highly rated for location, cleanliness, and more.

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Superhost
Home in Waynesville
4.85 out of 5 average rating, 26 reviews

The Historic Herren House

The Herren House is a historic home built in 1897. This grand house, just 2 short blocks from Main St, provides a peaceful, spacious setting right in the heart of town. Each bedroom has a private en-suite bathroom. Central air & heat, Ceiling fan, WiFi. Also enjoy the shared dining room with large dining table + Keurig coffee machine, living room + board games, additional bathrooms off the 1st floor entry hall, the back-garden courtyard, gazebo with dining table, & the wrap-around front porch.

Guest favorite
The modern cottage features a striking dark exterior complemented by an orange front door. A stone pathway leads to the entrance, framed by windows that provide ample natural light. Lush greenery surrounds the home, enhancing its welcoming presence.
Home in Tryon
4.87 out of 5 average rating, 114 reviews

Private Family Cottage 3BR 2 BATH - 2 min to TIEC

A private modern family cottage in the heart of horse country and in TIEC's back door! Superb hi-quality details with beautiful light and an artistic feel. 3 mins to the front gate, close to Landrum, Columbus, Tryon, Asheville, Greenville, Lake Lure, and Charlotte. Has a boutique hotel feel and amenities, PEACE & QUIET, full kitchen, office space, fireplace, cute bathrooms, and deck with view. Available for short stays or long-term seasonal rentals. Extr. charge for each add guest over 4.

Top guest favorite
An inviting outdoor space features a large in-ground saltwater pool surrounded by lush greenery. Comfortable lounge chairs and umbrellas provide shade, while a gazebo stands in the background. The neatly manicured lawn enhances the tranquil setting, creating an ideal area for relaxation.
Home in Greenville
4.99 out of 5 average rating, 173 reviews

Palmetto Escape - Serene- Pool- 6.6 mi DTWN GVL

Beautiful, updated 2 story home on secluded fenced in resort-like half acre. In-ground saltwater pool (seasonally). Gazebo with mosquito netting, ceiling fans and lighting. Keyless entry. All bedrooms are upstairs, & include Smart TVs and workspaces. High-speed Internet. Bathrooms w/a variety of amenities. Laundry Room. Fully stocked kitchen and propane grill. Perfect for family escapes, working professionals, outdoor adventurers, sports fans, child friendly. Quite, residential neighborhood.

Guest favorite
Home in Shelby
4.95 out of 5 average rating, 21 reviews

The Hunt House Bed and Breakfast

The Hunt House was the beautiful home of Dr. Robert Lee Hunt of Lattimore, NC. It is on 6 acres of pasture and only 3.8 miles from the Washburn Switch Industrial Park. The house is fully furnished with 5 Handmade heart pine, cherry, and walnut bedroom suites, and has 5 bathrooms. The house has hardwood floors in most rooms, and antique furniture throughout the house. The house has a functional fireplace, and a large porch with 8 rocking chairs, that overlook the yard.

Guest favorite
Private room in Waynesville
5 out of 5 average rating, 46 reviews

Green Room at Love Lane B & B, walk to Main St.

Lovely room with private bath in an historic home at 55 Love Lane. Only steps to Frog Level (1 block) and Main St. (4 blocks). Continental breakfast from 8:00 to 9:30. Our Green Room is a private room on the 2nd floor for 2 guests. Victorian queen bed, antique settee, and unique furnishings. Private en suite bath. Central air and heat. WiFi. And check out all of our room listings. We have the Rosemary Room, the Green Room, the Hugh Love Room, and the Easy Suite.

Guest favorite
The interior features a spacious kitchen with rustic cabinetry, a large island, and vintage appliances. Natural light floods through the windows, illuminating the unique ceiling beams and wood flooring. The outdoor patio is visible, offering dining options and a serene mountain backdrop.
Cabin in Waynesville
4.98 out of 5 average rating, 308 reviews

One-of-a-Kind Rustic Mountain Studio-Private Quiet

This mountain cabin is a true escape! Nestled on 16 acres in the mountains overlooking a 6088ft peak, it's the perfect get-a-way. Inspired with a rustic Italian Villa in mind. Private & quiet- The cabin is 7 min. from shops & restaurants of Waynesville & 30 mins to Asheville. Our brand new restored studio cabin is custom designed by local artisans & is a place you can come to unwind, decompress (really), & explore the beautiful mountains of the Great Smokies!

Superhost
A tiny home is located on a gently sloping hillside, framed by trees. The structure features a peaked roof and light-colored exterior, with a small porch area visible. A gravel driveway leads up to the home, enhancing its serene outdoor setting.
Tiny home in Bryson City
4.82 out of 5 average rating, 17 reviews

"ZEN" luxury tiny home on park-like 11 acre Farm

Farmstay Bed and Breakfast. Wing & Hoof Mountain Escape Child & Pet friendly (pets with a fee). Quick 5 minute drive to town and grocery store. 11 acres of Tranquility. Interaction with guests to your preference. Very unique experience. Check out all of our listings. Hot Breakfast included. Fires, grills, complementary drinks, cookies, snacks & fixings for Smores. Ask about snacking the animals. Indoor and outdoor games and toys. Easy access year round.

Guest favorite
Private room in Clemson
5 out of 5 average rating, 11 reviews

Master Suite and Breakfast in Private Dining Room

Our house is located in a safe, upscale neighborhood. The master bedroom suite includes a spacious room with a queen-size bed, a large bathroom with a jacuzzi and a shower, as well as double sinks. The guests have access to a private dining room on the same floor, where breakfast is served daily, at a time of the guests' choice. Guests have access to a 2-mile nature trail through woods and a creek and a retirement community, from the house's backyard.

Guest favorite
Home in Whittier
4.97 out of 5 average rating, 32 reviews

Great Smoky Mtns- Casino- Outdoor Adventures

Luxury home with detached guest. Quiet, secluded with beautiful wooded surroundings. Paved road. Accessible to motorcycles. 1 hour West of Asheville Airport 10 minutes to Dillsboro and Tuckaseegee River 15 minutes to -Sylva and Bryson City -shopping districts, local restaurants & breweries -Harrah’s Casino & Family Multiplex -Great Smokey Mountain National Park 30 minutes to -Nantahala Outdoor adventure area -Cataloochee Ski area-Maggie Valley

Top guest favorite
The exterior of the property is showcased, featuring a charming single-story house surrounded by lush greenery. Large windows allow natural light to fill the space, while a neatly maintained garden with blooming flowers is visible in the foreground.
Private room in Greenville
4.97 out of 5 average rating, 285 reviews

B & B/Downtown/Furman/BJU/1

Minutes to DOWNTOWN GREENVILLE 🌷SPRING SPECIALS🌼Do you LOVE NORTH Greenville? Then come visit our Homey 4 Room B & B we would love to host you along with other guests!Comfy Queen room & loaded tv! Enjoy self serve Continental Breakfast/Fresh Brewed Coffee/Hot Tea Bar. Minutes to Downtown, Bon Secour, Swamp Rabbit Trail, Furman & Bob Jones University’s. 🚨Secure parking. Our property is completely fenced in. You may have to open the gate to access.

Guest favorite
A spacious riverfront inn is positioned on the banks of a flowing whitewater river. Surrounding greenery includes lush trees and varied foliage, enhancing the natural setting. Decks extend towards the water, providing outdoor relaxation areas alongside the scenic river views.
Private room in Sylva
4.99 out of 5 average rating, 68 reviews

Cabin Suite at the Dillsboro Inn

This post & beam 1-room cabin has a mountain feel. Our Riverfront Inn is on a whitewater river with sights and sounds of flowing immediately in front of each suite. We have nightly campfires and are within walking distance to our town's fine dining options and craft shops. Our region has some of the finest eco-tourism opportunities in the eastern US and our neighborhood is ' Where the Blue Ridge Mountains meets the Smokies '.

Top guest favorite
The exterior of a large, wooden house is framed by lush greenery and colorful flowers. A flag is displayed prominently at the entrance, and a gravel driveway leads to the three-car garage. An outdoor dog is visible, exploring the serene surroundings.
Private room in Irmo
4.99 out of 5 average rating, 101 reviews

Lake Murray Retreat

Our house is situated on Lake Murray, just 15 miles from Columbia. We have a canoe for use. We live on a quiet dead end street, but have marinas, restaurants and basic shopping within 2 miles. Our property has gardens, chickens, cats and dogs. We welcome guests who are completely vaccinated against Covid-19. We have elderly relatives with health issues and we do not want to risk any exposure.

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