
Hotel vacation rentals in Upstate South Carolina
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Top-rated hotel rentals in Upstate South Carolina
Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Upstate South Carolina hotel rentals
Family-friendly hotel rentals

Hike, Breathe, Unplug & Take a Step Back in Time

Inn at Mill Creek Suite 5 - In the Clouds

Direct Golf Course View + Pool. Gym. Dining.

Minutes From Lake Murray Views | Free Parking

Relax in beach themed room.

Double King Room at our Boutique Bed & Brewery

2BD/2BA Condo Near Biltmore Estate and Downtown

Newly Renovated Hotel - Harbison
Hotel rentals with a pool

Spacious 2BD/2BA - Blue Ridge Mountains

Lodges at Trillium- 2 bedrooms

Lodge 06 Pool View

Perfect Downtown Stay for Business or Leisure

Fairfield Mountains Resort - 2 Bedroom Deluxe

Near GSP Airport | Bar & Dining + Shuttle

Wingate by Wyndham Greenville Airport (K)

Quaint Airbnb village with gorgeous views!
Hotel rentals with a patio

Cat Creek Lodge - Nantahala

Outpost Inn Highlands

Resort at Fairfield Sapphire Valley 1 Bedroom Unit

Swayze Suite at Lake Lure Inn

Resort at Fairfield Sapphire Valley 1 Bedroom Unit

Spruce Bungalow | Deluxe Mountain View

Charming Double Queen Retreat

The Inn at Southern Oaks
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- Nature eco lodge rentals Upstate South Carolina
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- Hotel rentals United States
- Blue Ridge Parkway
- Gorges State Park
- Table Rock State Park
- Chimney Rock State Park
- The North Carolina Arboretum
- Tryon International Equestrian Center
- Ski Sapphire Valley
- Lake Lure Beach and Water Park
- Jump Off Rock
- Wade Hampton Golf Club
- Victoria Valley Vineyards
- Discovery Island
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Wellborn Winery
- Burntshirt Vineyards
- City Scape Winery
- Russian Chapel Hills Winery
- Overmountain Vineyards
- Saint Paul Mountain Vineyards