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House vacation rentals in Panama City

Find and book unique houses on Airbnb

Quick stats about house rentals in Panama City

  • Total vacation rentals

    Explore 480 vacation rentals in Panama City

  • Verified guest reviews

    Over 8,400 verified reviews to help you choose

  • Family-friendly vacation rentals

    200 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 160 rentals that welcome pets

  • Vacation rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    240 properties have a dedicated workspace

  • Wi-Fi availability

    440 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern living space features large floor-to-ceiling windows revealing lush green views of the surrounding forest. A light wood floor enhances the open layout, which includes a sleek dining area and comfortable seating. A potted plant adds a natural touch to the interior.
Home in Los Altos De Cerro Azul, Panama
4.95 out of 5 average rating, 22 reviews

Welcome to Zola Sierra! Your Escape Into Nature.

Welcome to Zola Sierra. Your Private Escape Into the Heart of Nature. Step into the serenity of Zola Sierra, a one-of-a-kind 3-bedroom, 3-bath sanctuary nestled deep within the protected highlands of Cerro Azul, Panama. Designed for dreamers, seekers, and soul-restorers, this home is more than a stay — it’s a nature-immersive experience that effortlessly blends modern luxury with untamed wilderness. Come for the views. Stay for the stillness. Fall in love with the wild magic of Zola Sierra!

Superhost
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panamá
4.85 out of 5 average rating, 109 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Top guest favorite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Panamá
4.9 out of 5 average rating, 111 reviews

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Superhost
A spacious bedroom is highlighted by a large bed featuring neutral bedding. Natural light flows through expansive windows that provide views of the surrounding greenery. Two bedside lamps and a seating area with a chair add functionality to the space, creating a serene retreat.
Home in Panamá
4.75 out of 5 average rating, 16 reviews

Casa de las cascadas

Tu escape ideal: Un refugio oculto en la capital panameña. Armonía entre cascadas y comodidad urbana. Descansa en un entorno natural, a pocos minutos de todo. Despierta con el canto de las aves y el relajante sonido del agua. Para que tu estadía sea más placentera te ofrecemos piscina, mesa de billar, juegos de mesa, área de fogata, cocina amplia y equipada, tres acogedoras habitaciones con baño privado. Vive una experiencia campestre para contemplar, compartir o simplemente desconectarte.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.97 out of 5 average rating, 86 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in San Francisco
4.76 out of 5 average rating, 120 reviews

Amplia Residencia Privada en Excelente Zona

Casa en las mejores zona del país. Calle muy tranquila, céntrico, cerca de Restaurantes, Farmacias, Mall entre otros. Amplia Residencia cómoda para grupos o Familias. Estacionamiento Privado de hasta 2 autos 4 Recamaras espaciosas , 2 cómodos estudios, Sala Comedor, Desayunador, Amplia Terraza. *Opcion Kosher Disponible* House in one of the best area of ​​the country. Very quiet street, central, close to restaurants, pharmacies, mall and more. Large comfortable residence for groups.

Guest favorite
A spacious living room features a bright yellow sofa and a flat-screen TV. An open-concept layout leads to a dining area with a table and chairs, alongside a well-equipped kitchen visible in the background. Large windows provide natural light and views of the lush surroundings.
Home in Panamá
4.88 out of 5 average rating, 17 reviews

Family-Friendly Panama Canal Home with Fenced Yard

Welcome to our 3-bedroom vacation rental in Cardenas, Panama Canal area! Perfect for families, this home boasts a kitchen with quality appliances, including a 6-burner gas stove and a large fridge. Relax in stylish bedrooms, featuring a king suite with a private bath, and enjoy the lush surroundings filled with wildlife. Located next to a park with sports courts, this kid-friendly neighborhood offers outdoor fun. Experience the unique blend of comfort and nature right at your doorstep!

Superhost
A lush green lawn showcases well-maintained grass, framed by tropical plants with vibrant yellow leaves. In the background, a spacious outdoor area is visible, featuring a covered seating area. Hammocks are gently swaying, inviting relaxation amidst the natural surroundings.
Home in Panamá
4.82 out of 5 average rating, 55 reviews

Naturaleza maravillosa

Disfruta de un retiro familiar en plena naturaleza, donde la tranquilidad te envuelve. Este acogedor alojamiento, rodeado de un hermoso jardín en el Parque Natural Metropolitano, te ofrece un escape único a solo 3 minutos del Albrook Mall y 5 minutos del centro. Despierta con el canto de las aves y la visita de ñeques, mientras te relajas en un ambiente exclusivo y lleno de vida. ¡La escapada perfecta para desconectar y disfrutar de la naturaleza con todas las comodidades!

Superhost
A serene courtyard features a small pool surrounded by terracotta tiles and smooth wooden planks. Lush green plants are displayed throughout the space, enhancing the tranquil environment. The walls are adorned with original stonework, blending history with nature.
Home in San Felipe
4.78 out of 5 average rating, 124 reviews

Acogedora casa en Casco Viejo con piscina privada

Histórico alojamiento en el corazón del Casco Viejo Vive una experiencia única en este alojamiento ubicado en el centro del Casco Viejo. La propiedad ha sido restaurada cuidadosamente en varias ocasiones por reconocidos arquitectos panameños, incluyendo a Sebastián Paniza. Entre sus características más destacadas se encuentra un pozo histórico dentro de la propiedad, además de paredes y pisos originales que conservan el espíritu y la autenticidad del lugar.

Guest favorite
A charming facade displays three balcony areas adorned with greenery, enhancing the welcoming appearance of the building. The entrance features decorative signage alongside floral accents, while the muted color palette and architectural details of the windows contribute to the overall harmonious design.
Home in San Felipe
4.88 out of 5 average rating, 33 reviews

Cómodo y lujoso apartamento

Disfruta de una experiencia con estilo en nuestro alojamiento en el Casco Antiguo, aprovecha la ubicación cercana a galerías de arte, restaurantes, artesanías,etc. Nuestra casa cuenta con tres habitaciones cada una con balcón, baño y closet, con una bonita cocina contemporánea equipada; una amplia sala y comedor , zona de labores. Cuentas con un area total de 326 mts² Toda la casa rodeada de balcónes donde puedes disfrutar de las vistas panorámicas.

Top guest favorite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in San Francisco
4.83 out of 5 average rating, 127 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favorite
Home in Panamá
4.94 out of 5 average rating, 428 reviews

Estudio Privado a 10 Min del Aeropuerto !

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO y METROMALL. Ofrecemos Tours a San Blas -Tours a Monkey Island y el Canal de Panamá para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Popular amenities for Panama City house rentals

Destinations to explore

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