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Vacation rentals in Panama City

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Top-rated vacation rentals in Panama City

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in San Felipe
4.97 out of 5 average rating, 235 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Top guest favorite
Apartment in Panamá
4.94 out of 5 average rating, 110 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
An indoor garden is showcased, featuring lush greenery and soft lighting. A glass roof allows natural light to illuminate the space, which is accented by warm-toned stone walls. Two stylish chairs are positioned nearby, creating a comfortable seating area.
Condo in San Felipe
4.91 out of 5 average rating, 130 reviews

CASA SAEMA -PRESTIGIOUS DUPLEX PENTHOUSE WITH TERRACES

Espectacular ático Duplex en Panamá Casco antiguo, de 265 M2 con balcones, terrazas privadas exterior, cuenta con una salón jardín interior, un comedor, 3 hab. (+ sofá cama en studio), recientemente reformado con concepto Loft, diseño exclusivo único y confortable, en la mejor zona del Casco viejo, perfecto para relajarse y desconectar, cocina , lavavajilla, sala con lavadora. piscina compartida, asc, portero 24-7, no se permiten niños que no sepan nadar, gran variedad de ocio en la zona.

Top guest favorite
Apartment in San Felipe
4.97 out of 5 average rating, 102 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Guest favorite
A spacious living area features light wood flooring and a modern open kitchen. Two light-colored sofas surround a marble coffee table, while a dining area with a stylish table sits nearby. A spiral staircase leads to the upper level, and decorative artwork adorns the walls.
Loft in San Felipe
4.92 out of 5 average rating, 114 reviews

Loft 3b Old Town Best! It's 150 m2 (492 feet)

Immerse yourself in the historic charm and modern elegance of our 3-bedroom, 150 m2 loft in the heart of the Old Town. With wooden floors that radiate warmth and a modern open-plan kitchen ideal for sharing, this space guarantees a memorable vacation. Located on Avenida A, you'll find yourself just a few steps away from exquisite restaurants, museums, colonial churches, and the Casco's coveted rooftops, making every day an adventure.

Superhost
A spacious living area features patterned tiled flooring and large windows that invite natural light. A brown leather sofa is paired with a wooden coffee table and a round ottoman. A dining area with tall chairs is visible, enhancing the open layout.
Apartment in San Felipe
4.87 out of 5 average rating, 138 reviews

Bright and spacious 1BR Apt @CascoViejo w/terrace

Welcome to Casa Bandera, your retreat in the heart of the Old Town! This elegant 200m² apartment combines history and comfort. It features one bedroom, two private bathrooms, a fully equipped kitchen, a living room, a dining room, a laundry room, and an exclusive rooftop terrace with 360° views of the entire Old Town, perfect for two people. Enjoy an unforgettable stay in a cozy and fully equipped setting.

Guest favorite
The image captures a stunning view from a balcony, overlooking a historic cathedral with intricate architectural detailing. The white buildings frame the scene, and cloudy skies add a soft contrast to the vibrant structure of the cathedral, highlighting its grandeur.
Loft in San Felipe
4.9 out of 5 average rating, 278 reviews

Amazing Loft with the Best view of Casco viejo for

Beautiful loft located in the center of Casco Antiguo, the most touristic area of Panama. This spacious loft comfortably accommodates up to 6 guests, making it perfect for families or groups of friends. Come, enjoy and relax in this impressive loft, featuring an incredible view of the Panama Cathedral. You can easily visit museums, bars, restaurants, and historic churches located just a few meters away.

Superhost
A private terrace features a jacuzzi surrounded by lush greenery against an exposed stone wall. Wooden decking creates a warm ambiance, complemented by two lounge chairs designed for relaxation, offering an inviting outdoor space for guests.
Apartment in San Felipe
4.9 out of 5 average rating, 166 reviews

Jacuzzi in colonial ruins in beautiful apartment

Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.

Guest favorite
Guesthouse in Panama City
4.88 out of 5 average rating, 248 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

Superhost
The studio apartment features a historic stone wall contrasted by modern furnishings, including a queen-size bed and sofa-bed. A dining table and working desk are present, with warm wood flooring enhancing the spacious feel. Natural light enters through large windows, illuminating the inviting space.
Apartment in San Felipe
4.92 out of 5 average rating, 398 reviews

Mola Studio | Design By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.

Superhost
The interior showcases a cozy seating area with a brown sofa and two clear chairs around a glass table. A spacious bed with warm bedding is positioned against the wall. Natural light enters through large windows adorned with soft curtains, highlighting decorative shelves and artwork.
Home in Santa Ana
4.88 out of 5 average rating, 182 reviews

Golden Space | Design By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.

Guest favorite
A private balcony features woven chairs and a glass-topped table. Green ferns are visible hanging from the wall, while the tiled roof of nearby buildings adds a traditional touch to the view.
Loft in San Felipe
4.87 out of 5 average rating, 200 reviews

Corcho rooms #1 - queen rom with a balcony

Enjoy charming “Corcho rooms” in the heart of touristic Casco Viejo district of Panama City. We carefully restored old colonial building and converted it to the restaurant and apartments upstairs. “Corcho” is luckily situated in the central, restored part of Casco. Most of the buildings around are restored and the neighborhood is safe.

Popular amenities for Panama City vacation rentals

Frequently Asked Questions

  • What are the best places to stay in Panama City?

    Panama City has stays in vibrant neighborhoods like Casco Viejo, known for historic charm, and Punta Pacifica, often suggested for modern towers and city views. Many visitors also enjoy options around El Cangrejo for its mix of cafes and local culture.

  • What are the best things to do in Panama City with kids?

    Explore the Biomuseo’s interactive exhibits, walk the Amador Causeway for city and canal views, or visit parks like Parque Natural Metropolitano to spot wildlife. Many families enjoy boat tours or learning about the canal’s history.

  • What are some of the best things to do in Panama City?

    Wander historic streets in Casco Viejo, explore exhibits at the Panama Canal Museum, and stroll the Cinta Costera waterfront. Food and markets, canal tours, and cultural centers are frequently suggested for first-time visitors.

  • How is the weather in Panama City?

    Panama City has a tropical climate with warm temperatures year-round, often around 75–88°F (24–31°C). Visitors can expect higher humidity, with occasional rain, especially during the wet season.

  • What are the best places to visit in Panama City?

    Casco Viejo’s historic architecture, the Panama Canal, and the Biomuseo are often highlighted for visitors. The Amador Causeway is also suggested for scenic walks and views over the bay.

  • What are some hiking trails in Panama City?

    Parque Natural Metropolitano has trails through tropical forest with city vistas and wildlife. The Sendero El Gaital path and walking routes around Cerro Ancón are also frequently suggested for those who want a nature escape near urban sights.

  • What are some family activities we can do in Panama City?

    Families often enjoy the interactive displays at Biomuseo, relaxing on the Amador Causeway, and wildlife spotting in Parque Natural Metropolitano. Parks with playgrounds and canal boat tours are also popular with kids.

  • What are some of the best day trip ideas from Panama City?

    Day trips from Panama City often include hiking in nearby rainforest reserves, visiting Gamboa for canal views and nature tours, or relaxing on beaches around the Pearl Islands. Guided excursions introduce travelers to indigenous cultural sites as well.

  • Are there any pet friendly accommodations available in Panama City?

    Panama City has pet-friendly stays, especially in neighborhoods like El Cangrejo and San Francisco, where parks and walkable streets make it easy to enjoy the city with your pet. Many hosts welcome dogs and cats with advance notice.

  • What are some local tips for visiting Panama City?

    When exploring Panama City, lightweight clothing helps with humidity, and a reusable water bottle is useful. Street murals around Casco Viejo show local talent, while trying fresh seafood in city markets gives a taste of regional flavors.

  • What is Panama City known for?

    Panama City is known for the Panama Canal, mix of colonial and modern architecture, and vibrant culinary scene. Its waterfront walks and lively festivals celebrate a crossroads of cultures.

  • What are the best hidden gems to explore in Panama City?

    Panama City has tucked-away art galleries in Casco Viejo, quiet gardens at Mi Pueblito, and street food stands in Santa Ana that attract locals. Seek out small museums and indie coffee shops for a neighborhood experience.

  • What are the best foods to try in Panama City?

    Local favorites include sancocho chicken stew, patacones (fried plantains), and ceviche from city markets. Panamanian seafood, fresh tropical fruits, and pastries filled with local flavors are frequently suggested.

  • What should I bring for a trip to Panama City?

    Bring lightweight, breathable clothing for the tropical climate, comfortable walking shoes, and sun protection like hats and sunscreen. A rain jacket and an adapter for electronics are also practical for your stay.

  • What is the nightlife in Panama City like?

    Panama City has a vibrant nightlife scene, with lively rooftop bars, salsa venues, and music lounges in Casco Viejo. Neighborhoods like Calle Uruguay and El Cangrejo are known for dance clubs, craft cocktail spots, and casual pubs. Visitors often explore a mix of local rhythms and international influences after dark.

  • What are the most popular events or festivals in Panama City?

    Carnival is one of the most popular celebrations, filling Panama City with music, parades, and color before Lent. Jazz festivals, local art fairs, and folklore events also draw crowds throughout the year.

  • Are there family friendly vacation rentals in Panama City?

    Panama City has family-friendly vacation rentals, especially in areas near parks and cultural attractions like El Cangrejo, San Francisco, and Casco Viejo. Many hosts provide amenities for children and groups traveling together.

  • When is the best time to visit Panama City?

    The drier season is often recommended for clearer skies and outdoor activities. Many travelers prefer visiting when major cultural events and festivals enliven the city’s atmosphere.

Quick stats about vacation rentals in Panama City

  • Total vacation rentals

    Explore 4,860 vacation rentals in Panama City

  • Verified guest reviews

    Over 124,900 verified reviews to help you choose

  • Family-friendly vacation rentals

    1,530 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,800 rentals that welcome pets

  • Vacation rentals with a pool

    2,660 properties feature pools

  • Rentals with dedicated workspaces

    2,930 properties have a dedicated workspace

  • Wi-Fi availability

    4,620 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Self check-in, Gym, and BBQ grill across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore

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