Hotel vacation rentals in Panama City

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama City

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in San Felipe

5 out of 5 average rating, 33 reviews

4. Heart of the Old Town: Boutique Apart-Hotel

ChelseaRating, 5 stars15 months ago

This place is gorgeous and has all the amenities. We wish we could have stayed longer. we arrived with a car and had prepaid to park in their small ramp. We thought the car would have GPS but it didn't so we realized we needed SIM cards to get around the country. Rodrigo checked us in and it was five star service from the start. He then walked us to shops until we found and purchased a SIM for our phones. The instructions were in Spanish so he then helped us set up the SIM cards. He did an informal walking tour and showed us some recommended restaurants so we could have dinner. The location is awesome and surrounded by great restaurants and shops in the heart of Casco Viejo. The rooms are gorgeous and the balcony's are fantastic for watching the bustling town. We couldn't recommend this place more!

Colorful doors featuring whimsical character illustrations create a playful atmosphere. The vibrant artwork includes a varied cast of creatures, enhancing the lively ambiance of the shared spaces. Each door stands out with unique designs, inviting guests into a creative and welcoming environment.

Private room in Marbella

4.88 out of 5 average rating, 8 reviews

El Tornillo semi-private space.

KendraRating, 5 stars4 weeks ago

The pool and breakfast are a huge bonus for this place. I was in the semi-private room, you can still hear people on the other side, but it was so much better than being in a dorm as I could get changed and leave my stuff out without any concern. They also provided me with a lock for my door because I didn’t have one. Definitely worth it for the price. I also walked around at night after meeting people at a bar and felt very safe in this neighborhood.

Vacation rentals for every style

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Villas

Luxurious estates for the ultimate escape

Apartments

Convenient locations with everyday essentials

Houses

A space thats all yours, with room for everyone

Popular amenities for Panama City hotel rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

Family-friendly hotel rentals

A bedside table is positioned next to a spacious bed, featuring a simple lamp with a circular base that casts a soft glow. An elegant vase with a flower adds a touch of nature, complementing the soothing color palette of the room.

Hotel room in San Felipe

4.9 out of 5 average rating, 40 reviews

3. Apart-Hotel Boutique- Heart of the Old City

TomasRating, 5 stars43 months ago

Absolutely amazing. Place was spaciouse, clean, well equipped. Location was right in the heart of Caso Viejo and Andres was a true gentlemen our whole stay there. I would highly recommend this place to anyone looking to stay in the heart of Casco Viejo. Dining, entertainment, sight seeing walking all walking distance. truly 5 out of 5 review.

A spacious bed is presented with white bedding and decorative green pillows. Two rolled towels are neatly placed at the foot of the bed. Natural light filters into the room through two windows, adorned with sheer curtains and dark drapes, alongside a small nightstand with a floral arrangement.

Private room in Panamá

4.25 out of 5 average rating, 4 reviews

Hostal Villa Grande - Room 4

JessieRating, 5 stars64 months ago

Great place for a great price! We had a little trouble when we checked in but I think it was airbnb's fault (we had 3 reservations under the same account) but the hostal was super accommodating and helpful and made sure we were all comfortable! Great staff and definitely would recommend to everyone.

A spacious living area features a deep blue sofa positioned across from a large wooden coffee table. A sleek kitchen with wooden cabinetry and a granite bar offers modern appliances. Natural light floods the space, highlighting the elegant chandelier above.

Hotel room in San Felipe

4.9 out of 5 average rating, 48 reviews

6. Beautiful Boutique Apart-Hotel Views & Services

LeeRating, 5 stars27 months ago

Wonderful Airbnb in Casco. La Isabella Suites was located in the heart of CV. Apartment was very spacious and comfortable. A balcony overlooked a beautiful park. Great stay. Highly recommended!

A modest bedroom is equipped with two sets of bunk beds, each featuring a simple design. Light wood flooring complements the neutral walls. An air conditioning unit is visible on the wall, contributing to the room's comfort.

Private room in Panama City

3.86 out of 5 average rating, 7 reviews

Private Five Guest Room. Hab. #2

JeimmyRating, 5 stars15 months ago

The young man at the front desk is very friendly. Just check that the location is correct as I used the one that was on the reservation and it took me somewhere else. We spent the night quietly. The smallest space I thought of. I recommend it.

A well-appointed sleeping area features an intricate black iron headboard with circular accents. The spacious bed is dressed in navy linens, complemented by two bedside tables with stylish reading lamps. Fresh flowers add a touch of color to one side, enhancing the overall decor.

Hotel room in San Felipe

4.92 out of 5 average rating, 49 reviews

5. Beautiful Boutique Apart-Hotel-Views & Services

JeffRating, 5 stars27 months ago

The place was gorgeous and the staff was super friendly, helpful, and attentive. The location couldn't be any better for exploring Casco Viejo.

Hotel room in San Felipe

4.89 out of 5 average rating, 38 reviews

2. Boutique Apart-Hotel- Heart Old City

AndreaRating, 5 stars25 months ago

isabella Suites is a lovely apartment, comfortable and very well situated. Andres and all the staff were friendly and very helpful. My family and I really enjoyed our stay at Isabella Suites and the Casco Antiguo of Ciudad de Panama.

A metal bunk bed with a simple design occupies a minimalist space. The upper and lower sleeping areas feature neutral-colored bedding. A small glass table is positioned nearby, enhancing the functionality of the room.

Private room in Panamá

4.33 out of 5 average rating, 3 reviews

Private Room #4. 3 people

RobertoRating, 5 stars25 months ago

Comfortable place and quite focused for backpackers. The photographs match the place. A good price.

A bright and airy bedroom features a metal bunk bed with a neatly made top bunk and a simple bottom bed. A small chair is placed nearby, complemented by a pillow adorned with colorful patterns. Natural light filters through the large window, enhancing the space's openness.

Private room in Panamá

3.86 out of 5 average rating, 7 reviews

Hostal Villa Grande - MIXED DORM 7

PepeRating, 5 stars27 months ago

I like hostels. You always meet crazy people. This one just adds up. It is sufficient

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Hotel rentals with a pool

A clear swimming pool reflects the surrounding high-rise buildings and blue sky. Sunlight illuminates the water, while a white table and chairs are positioned nearby, providing a calm area for relaxation.

Hotel room in Marbella

4.67 out of 5 average rating, 64 reviews

Your second home in Panama.

MarlenRating, 5 stars1 week ago

The truth is that I really liked it, I recommend it and I would come back. The clean facilities have the option of restaurants nearby, a swimming pool, the area is quiet at night and you can rest well. The only thing is that the customer should be given the option of whether or not they want daily cleaning in the room, otherwise everything is excellent.

Hotel room in Panamá

4.44 out of 5 average rating, 18 reviews

Rainforest Suite with Breakfast! 15 min from city

RogelioRating, 5 stars13 months ago

peacefully and beautiful place...

Hotel room in El Cangrejo

4.75 out of 5 average rating, 12 reviews

Double Suite-Apartment Hotel Príncipe

DiegoRating, 5 stars25 months ago

Super attention and check-in

An outdoor terrace features several lounge chairs and tables shaded by large umbrellas. A swimming pool extends along one side, with a backdrop of modern high-rise buildings under a partly cloudy sky. Lush greenery is present in planters, adding a touch of nature.

Hotel room in Marbella

New place to stay

In the heart of the city.

CristinaRating, 5 stars1 week ago

My stay at Hotel Mío in Panama City was wonderful. The place is simply unbeatable - it's incredibly located, right in front of the city's most iconic skyscrapers and buildings, offering a spectacular view. The pool on the rooftop is beautiful and perfect for relaxing. Also, breakfast is included and is delicious. The hotel itself is beautiful, modern and cozy; I would definitely always come back to stay here every time I visit Panama. I want to make a special mention to Josué, from the restaurant area, whose attention was excellent and really made my experience even better. I highly recommend this hotel!

A well-lit bedroom features a spacious bed with neutral-toned bedding. Two bedside lamps provide soft lighting, while a small nightstand holds essentials. A window allows natural light to enter, and the minimalist decor emphasizes a calm ambiance.

Hotel room in Panamá

3.33 out of 5 average rating, 3 reviews

Hotel Room with one full bed

RobertoRating, 5 stars3 months ago

Excellent

Private room in Panamá

5 out of 5 average rating, 14 reviews

Mandalas Ecolodge, Altos de Cerro Azul

JaironRating, 5 stars1 month ago

We loved the peace and privacy, we managed to share as a couple with a beautiful view and surrounded by nature. Highly recommended

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Hotel rentals with a patio

Lush greenery surrounds the entrance, featuring hanging plants and colorful decorations. Ferns cascade from hanging baskets, creating a vibrant and inviting entrance to the hostal.

Private room in Balboa

4 out of 5 average rating, 3 reviews

Nice hostel, ideal for family trips.

DanielRating, 5 stars5 months ago

Helped us in need of a place to stay very quick and in national holiday

A path of smooth stones leads through a lush garden, flanked by vibrant green plants. The pathway is bordered by concrete edges, guiding towards a gated entrance. Natural light filters through the foliage, creating a serene atmosphere within the outdoor space.

Private room in Panamá

3.8 out of 5 average rating, 5 reviews

Kakún Room 12, Cable TV, Refrigerator, Air Conditioning.

JimmyRating, 5 stars38 months ago

Awesome place in a very nice neighbourhood. One of the most spacious rooms I had so far with a private bathroom and a fridge. Shared kitchen has everything you need and grocery stores and restaurants at walking distance. Friendly staff, fast and stable internet. Highly recommended great value for your money.