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Apartment vacation rentals in Panama City

Find and book unique apartments on Airbnb

Top-rated apartment rentals in Panama City

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Top guest favorite
Apartment in San Felipe
4.97 out of 5 average rating, 238 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Guest favorite
Apartment in Panamá
4.93 out of 5 average rating, 116 reviews

Apto 4 min from Tocumen Airport | 24-hr check-in

Layover in Panama? Stay where everything is easy and comfortable Just 4 minutes from Tocumen International Airport – perfect for early flights or quick stopovers A modern, comfortable, and secure apartment with: • Fast WiFi and air conditioning • Smart lock and flexible check-in • 24/7 security • Pool, gym, and fully equipped kitchen • Steps from the ITSE Metro station Ideal for layover travelers, curious tourists, or business trips. 🌴 Just arrive — everything’s ready for you. We’ll be waiting!

Guest favorite
A charming historic building features ornate white architecture with teal accents. Arched windows and balconies are visible on the upper levels, showcasing decorative wrought-iron railings. The entrance showcases double doors, inviting passersby to explore the structure's elegance.
Apartment in San Felipe
4.85 out of 5 average rating, 170 reviews

Best location - Unique and charming loft

Relax and enjoy the elegance of a bygone era when you stay in this charming Loft. Carefully built with wooden floors, calicanto walls, high beamed ceilings and antique details for a luxurious yet charming feel. Take an early morning walk and enjoy the ruins, churches, and museums of Casco Viejo. Stroll through the historic streets while the city sleeps, then return for morning coffee in this classic and elegant Loft with a dreamy terrace. This apartment is located in the heart of Casco Viejo!

Superhost
A spacious outdoor area features wooden dining tables surrounded by potted plants. The space includes a plunge pool, comfortable seating, and a hammock for relaxation, with views of the nearby structures and the sky above.
Apartment in San Felipe
4.87 out of 5 average rating, 383 reviews

Casco Viejo 360° View Old Tower Penthouse

Located in one of the oldest buildings in Panama and set over 3 stories with unrivaled panoramic views over the historical Casco Viejo, the skyline of Panama City and views of the causeway, our gorgeous penthouse is the ideal space to take in the local sights, sounds, art, culture, socialize with your friends and family, or simply relax in a cozy love nest! Top speed wifi, excellent location, and fully equipped with all the home comforts, the penthouse is the perfect spot to explore Panama.

Guest favorite
A balcony features two red chairs on a patterned tile floor, overlooking the vibrant Main Plaza. The wrought-iron railing provides a classic touch, while trees and buildings can be seen in the background, under a partly cloudy sky.
Apartment in San Felipe
4.94 out of 5 average rating, 147 reviews

Elegant Apt - View to Main Plaza of Casco Viejo

Experience the charm of Casco Viejo with this beautiful apartment, located in the heart of the historic neighborhood - close to many dining options, cafes, supermarkets and attractions. Enjoy the stunning views of the Main Plaza from the comfort of your balcony or rest easy inside with the soundproof doors and strong WIFI connection. We provide a water biden throughout your stay for hydration and Panamanian coffee renowned as one of the best in the world, at the moment of check in.

Guest favorite
A spacious master bedroom features a king-size bed with a soft grey comforter. Two elegant benches are positioned at the foot of the bed. A ceiling fan distributes air throughout the room, while light fixtures provide a warm glow. An open layout leads to a dressing area and private bathroom.
Apartment in San Felipe
4.83 out of 5 average rating, 178 reviews

Lovely Spacious 3BR in Casco Viejo w/Balcony

Welcome to Casa Bandera, your retreat in the heart of Casco Viejo! Located in Panama's iconic Casco Antiguo, this elegant apartment combines the area's historic charm with modern comfort. It features three cozy bedrooms, each with a private bathroom; an in-house laundry center, a fully equipped kitchen, a living room, and a dining room, perfect for sharing in an exclusive setting. Perfect for up to six people. Enjoy an unforgettable stay in a cozy and fully equipped environment.

Guest favorite
An open living space features a large gray sectional sofa paired with a round wooden coffee table. A patterned rug lies beneath, complementing the light wooden flooring. The kitchen area is visible in the background, showcasing modern appliances and a breakfast bar with stools.
Apartment in San Felipe
4.94 out of 5 average rating, 173 reviews

Cozy 2 Bedroom w/ Splash Pool

Our place is a 3-story apartment located on the quiet side of Casco Viejo. It has a very private feel to it, which allows for an incredible afternoon of sunbathing or bbqing on our private rooftop. The splash pool allows for a refresh and fits 2 people at a time. This place has so much character from with original exposed stone walls, to the sweeping view of the Arto Chato ruins. It also has a great work space, all the necessities to stay in and cook, watch a movie, etc.

Top guest favorite
Apartment in San Felipe
4.97 out of 5 average rating, 106 reviews

Amazing loft with an iconic view of Casco Viejo

Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Superhost
Apartment in San Felipe
4.78 out of 5 average rating, 179 reviews

Studio apartment in the heart of Casco

Welcome to Casa Pérez, your retreat in the heart of the Old Town! Enjoy a prime location and the best views from a spectacular private balcony facing the most iconic square in the Casco. Ideal for 3 people, this cozy and bright one-bedroom apartment includes Wi-Fi, air conditioning, living room, dining room, equipped kitchen, washing machine and elevator for your comfort. Enjoy an unforgettable stay in a warm and fully equipped atmosphere.

Top guest favorite
A modern living area features a white sectional sofa adorned with colorful cushions. A sleek coffee table sits in front of a mounted television. Large windows provide expansive views of the city skyline, enhancing the bright and airy feel of the space.
Apartment in Marbella
4.89 out of 5 average rating, 165 reviews

Beautiful Apt, Best Location 2BR

Beautiful apartment, high floor up, with 2 bedrooms, 2 bathrooms, walking closet, and essential closet for the second bedroom. Extra twin bed available in the apartment. High speed internet, 300Mbps by Wifi aprox. , 600Mbps by cable. Social area on the roof with swimming pool, gym, sauna and bbq area. The building location is excellent, We are walking distance for grocery stores, restaurants, bank, Hilton Hotel&Casino.

Guest favorite
A cozy sitting area is highlighted by a large window offering views of the vibrant plaza and cathedral. Two comfortable armchairs are positioned beside a small coffee table on a textured rug. Natural light fills the space, enhancing the warm tones of the wooden floor.
Apartment in San Felipe
4.91 out of 5 average rating, 103 reviews

The best view of the Old Town

Welcome to this charming accommodation located in the heart of Casco Viejo, in front of one of the most emblematic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Guest favorite
Apartment in San Francisco
4.99 out of 5 average rating, 144 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Popular amenities for Panama City apartment rentals

Quick stats about apartment rentals in Panama City

  • Total vacation rentals

    Explore 2,890 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

  • Verified guest reviews

    Over 79,200 verified reviews to help you choose

  • Family-friendly vacation rentals

    900 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 1,090 rentals that welcome pets

  • Vacation rentals with a pool

    1,840 properties feature pools

  • Rentals with dedicated workspaces

    1,770 properties have a dedicated workspace

  • Wi-Fi availability

    2,760 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

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