
Apartment vacation rentals in Panama City
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Top-rated apartment rentals in Panama City
Guests agree: these apartments are highly rated for location, cleanliness, and more.

Modern apartment in the heart of Obarrio
This apartment stands out for its privileged location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The convenience of having two bathrooms makes it unique. Ideal for travelers looking for tranquility and functionality. Located within walking distance of 50th Street and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area for walking and enjoying the city.

The Penthouse Annex
Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Luxury Mid-Century Apartment In Casco Viejo
Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Tropicool Loft w/rooftop steps from Casco
This historic 1941 loft is located at the entrance of Casco Viejo where you’re steps from the fish market and all the cool cafés, rooftops, and trendy restaurants that make up the neighborhood. Fully equipped kitchen, washer/dryer combo, 1.5 bath, bedroom on 2nd floor, 2 balconies + communal rooftop, projector w/Netflix, fast internet, and great AC. You’re also directly in front of the Cinta Costera park for running, biking, tennis courts. Near local airport for flights to Bocas!

2BR King Suite Ocean View, Casco, Canal 500MB WIFI
Experience Yoo Panama by world renown architect Philippe Starck. Massive unit 155 m2 / 1,700 ft2 ocean view apartment with an unobstructed view of Panama City/Pacific Ocean overlooking the Panama Canal, Casco Viejo & Cinta Costera. Views & location don’t get better than this. Each bedroom is a King Bed suite. The apartment is located on the prestigious Avenida Balboa. There is a grocery store and 3 of PA's most renown restaurants in the building. Blazing fast wifi at 500mgbs.

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Amazing loft with an iconic view of Casco Viejo
Enjoy a unique experience, in this elegant and centrally-located loft. Fully remodeled 1 bedroom apartment, in a central location in Casco Viejo (the old city). You will be just steps away from many restaurants, cafes, museums, and the existing night life casco has to offer. Located in “Jeronimo,” this restored- colonial building was built in the year 1850, and features unique crafted wall décor, as well as some of the original "calicanto" walls.

Impressive with ocean and Panama city views
Experience a unique, modern apartment with its own style, where every sunrise and sunset becomes a show. Enjoy breathtaking views of Panama City, the bay, and the Old Town from the comfort of your accommodation. Location Unbeatable Located just 5 minutes from the charming Old Town and the famous seafood market, and 10 minutes from the banking area. In addition, you will have a metro station and several bus stops just a few steps from the building

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

k*| Delightful 1 BR w/King Bed in Calle 50
Calle 50 es el Times Square de la Ciudad de Panamá. Esta emblemática calle resguarda a la concurrida Area Bancaria. La ubicación del apartamento es excepcional y céntrica, cercana a: ->Estación Iglesia del Carmen [Línea 1 del Metro de Panamá] ->Cinta Costera ->Parque Urracá ->Supermercado Rey ->F&F Tower (Edificio del "Tornillo") ->Nightlife en Calle Uruguay Desde el piso 19 se ofrecen vistas a la ciudad y a la selva.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Jacuzzi in colonial ruins in beautiful apartment
Welcome to Casa Marquez Portazgo! This cozy apartment in the heart of Panama City offers comfort and convenience, ideal for your stay. With one bedroom and capacity for two people, you'll enjoy a relaxing atmosphere in 70 m². Located in the San Felipe neighborhood, just steps from the entrance to the Casco Antiguo, it offers a unique experience. You can also unwind in the jacuzzi.
Popular amenities for Panama City apartment rentals
Weekly apartment rentals

Beautiful apartment in Casco Viejo ST. George D

new apartment in the heart of Panama

Best location & Rooftop Pool Apto with elevator

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Suite Luxury 30th View , Cinta Costera Panama

Ocean View private Studio Apartment

Modern City Escape Nice Views & Great Location!

2-Bedroom Apt Ocean Views PH Yoo
Private apartment rentals

A cozy Casco Viejo apartment

Ocean view with industrial design

Apartamento Av. Balboa, Yoo&Arts

YOO Panama · Luxury signature ocean view. 57th fl

w* | Luxury 2BR in Old Town

Exclusivo Apto/Av Balboa/Pool/Gym/AC/View/Parking

A resort-style apartment with an ocean view

Modern skyscraper, free breakfast, pool, gym
Apartment rentals with a hot tub

3 bedroom penthouse with spectacular views!

Apartamento entre oceano y selva

Luxury Apartment in Panama | 2BR + Views + Pool

Luxury Beachfront Apartment Near Panama City

Modern Furnished Studio with Ocean Views in Panama

Spacious Oceanfront Apartment

Luxurious Apartment Oceanfront View

Tropical Paradise at Playa Bonita
Quick stats about apartment rentals in Panama City

Total vacation rentals
Explore 2,770 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

Verified guest reviews
Over 71,040 verified reviews to help you choose

Family-friendly vacation rentals
850 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 990 rentals that welcome pets

Vacation rentals with a pool
1,730 properties feature pools

Rentals with dedicated workspaces
1,720 properties have a dedicated workspace

Wi-Fi availability
2,640 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
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- Things to do Panama
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- Nature and outdoors Panama
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