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Apartment vacation rentals in Panama

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Top-rated apartment rentals in Panama

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in Panamá
4.96 out of 5 average rating, 256 reviews

In the heart of Casco, remodeled and with parking

Escape and discover the old town in this remodeled, comfortable and central accommodation in the heart of Casco Viejo. Our location is the best, it will make you come back. Close to restaurants, bars, impressive churches, and museums. The property dates back to the 17th century (1756) history and good atmosphere. You can explore the area on foot, fully equipped kitchen, European king bed, you will feel right at home, surrounded by the famous calicanto walls. -A large living room -Fully-equiped kitchen

Top guest favorite
A comfortable seating area features a wooden couch adorned with light-colored pillows. Large windows provide a view of the lush greenery outside, while a warm light fixture adds a soft glow to the room. The space is complemented by a simple wooden table and concrete flooring.
Apartment in Provincia de Veraguas
4.93 out of 5 average rating, 131 reviews

Casa Melina Torio Cozy upscale 2b jungle apartment

Stylish jungle two bedroom apartment Walking distance 5 restaurants. attractions: waterfall, jungle trails, River, Beach & Morrillo Surf break. Fully equipped with everything you need & want (Drinking water filter, Hot water, AC, Starlink WiFi & TV). Perfect for a couple/family seeking to blend work and play. Designed so our guests can fully experience our Torio culture. Cook with local fresh ingredients, discover Torio on foot & return to rest in the coziest rental you have ever experienced.

Guest favorite
A spacious living room features a comfortable brown sofa and an armchair beside a decorative coffee table. Natural light enters through large glass doors draped with sheer curtains, illuminating the warm wood floors and elegant decor.
Apartment in Panama City
4.96 out of 5 average rating, 113 reviews

Luxury Mid-Century Apartment In Casco Viejo

Luxury mid-century one bedroom Boutiqe 72 m2 apartment. Step into the elegant, functional and comfortable place that we offer with love. The apartment located within a beautiful two-floors antique building in the heart of Casco Viejo. The apartment includes a well equipped brand new kitchen, a dining area and a spacious living room, also a balcony with a view of the lively streets below. The tranquil bedroom has an ensuite bathroom and a walking closet that fitting perfectly to your needs.

Guest favorite
A spacious terrace features four hammocks suspended between columns, inviting relaxation with a view of the serene ocean. A dining table with surrounding chairs is positioned nearby, overlooking calm waters and lush greenery, enhancing the outdoor living experience.
Apartment in Juan Gallego
4.88 out of 5 average rating, 220 reviews

Pebos Reef Apt 1 · Beachfront · Sea View Terrace

This spectacular beachfront property is ideally situated with an incredible view of neighboring islands, fishing friendly waters, and mesmerizing snorkeling spots for children and adults to enjoy. Monkey greetings from the jungle adjacent, octopus and colorful native fish inhabited waters, and lazy bear sloth sightings are all part of your daily experiences here at Pebos Reef! If you are lucky you will even see dolphins from the terrace ! A terrace on the sea is all you need.

Top guest favorite
Apartment in Panama City
4.98 out of 5 average rating, 126 reviews

The View of Casco: Designer Loft with best Balcony

Sip your morning coffee or evening wine on the balcony, taking in a stunning, panoramic view of the city skyline! ​Experience the absolute best of Casco Viejo from this elegant, fully remodeled 1-bedroom loft. Nestled inside a beautifully restored 1850 colonial building—featuring historic, original calicanto walls—this stylish space puts the entire city at your doorstep. ​You are just steps away from world-class dining, vibrant cafes, museums, and Casco's legendary nightlife

Top guest favorite
Apartment in Panamá
4.97 out of 5 average rating, 35 reviews

Walk to Everything | Luxury Stay in Casco Viej

Wake up overlooking one of the last historic bastions of Casco Viejo, sip your morning cofee on a private balcony, and step directly into Panama City most vibrant and wakable neighboorhood. Surrounded by colonial architecture, charming plazas, and a vibrant culinary scene, this space invites you to experience Panama with style and tranquility. Ideal for those seeking an exclusive, walkable, and characterful environment in one of the city's most iconic areas.

Guest favorite
Apartment in Panamá
4.92 out of 5 average rating, 53 reviews

Casco Antiguo Apartment with Balcony & Stone Wall

Elegante apartamento en el corazón de Casco Antiguo. Disfruta de un espacio colonial con paredes de piedra expuesta, iluminación cálida y un encantador balcón con vista a calles vibrantes. Ubicado en Avenida B, a pasos de restaurantes, cafeterías, rooftop bars y lugares históricos. Capacidad para hasta 5 huéspedes. Perfecto para vivir la cultura y energía de Casco Viejo. Debido al ambiente animado del área, puede escucharse ruido nocturno los fines de semana.

Superhost
A spacious living area is highlighted by a large sectional sofa and a low wooden shelf displaying modern decor. Glass doors open to a balcony showcasing outdoor seating, with natural light illuminating the room. The tile floor adds a warm touch to the ambiance.
Apartment in Panamá
4.81 out of 5 average rating, 133 reviews

Stunning Terrace Among Ruins in Casco Viejo

Welcome to your Casco Viejo retreat! This spacious apartment, perfect for up to 8 guests, offers a unique blend of modern comfort and historic charm in Panama City’s most iconic neighborhood. Located in the heart of Casco Viejo. The highlight of this beautiful space is the stunning terrace nestled among historic ruins, where you can relax, enjoy a meal, or simply take in the timeless atmosphere. This is more than a stay – it’s an unforgettable experience.

Top guest favorite
Apartment in Panamá
5 out of 5 average rating, 35 reviews

Private parking & rooftop | Studio Casco Center

This beautiful restored studio from the 1870s blends history with modern design. Enjoy a private rooftop terrace with seating and BBQ, plus private PARKING—ideal after exploring Casco's best restaurants, galleries, and nightlife steps away. ✨ Highlights: - Historic Charm: Original tile floors and exposed colonial stone walls. - Comfort: King bed, living room, and full kitchen. - Amenities: Private rooftop & private PARKING. - Great location

Top guest favorite
Apartment in Panamá
4.96 out of 5 average rating, 130 reviews

Spectacular views, pool, and ideal location

Disfruta una experiencia inolvidable en una ubicación privilegiada de Ciudad de Panama. Despierta con impresionantes vistas de los edificios, el mar. Relajate en la piscina o el rooftop y siéntete como en casa gracias a nuestra hospitalidad. A pocos minutos del Casco Antiguo, Cinta Costera, Metro, Restaurantes, bares y centros comerciales, Albrook Mall, Multiplaza Mall, Soho Mall. Ideal para vacaciones o viajes de negocios.

Guest favorite
A cozy sitting area is highlighted by a large window offering views of the vibrant plaza and cathedral. Two comfortable armchairs are positioned beside a small coffee table on a textured rug. Natural light fills the space, enhancing the warm tones of the wooden floor.
Apartment in Panama City
4.91 out of 5 average rating, 122 reviews

The best view of the Old Town

Welcome to this charming accommodation located in the heart of Casco Viejo, on the third floor facing one of the most iconic squares in Panama, Plaza Catedral! Thanks to its privileged location, you will enjoy a unique view of the square and the imposing Cathedral Church. Right in this lively square, you will have at your disposal a wide variety of restaurants and shops where you can buy souvenirs of this wonderful trip.

Guest favorite
Apartment in Panamá
4.98 out of 5 average rating, 159 reviews

Full apartment in Panama

This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

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