Mansion vacation rentals in Panama
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Top-rated mansion rentals in Panama
Guests agree: these mansions are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Panama mansion rentals
Mansion rentals with a pool
Home in Playa Bluff
5.0 out of 5 average rating, 15 reviewsJungle House 100m from the beach
Jun 16 – 23
Villa in Río Hato
5.0 out of 5 average rating, 38 reviewsLuxury 4BR Villa + Guesthouse & Pool @Buenaventura
Jun 12 – 19
Cottage in Altos del Maria
4.93 out of 5 average rating, 96 reviewsCabin with Spectacular Mountain View
Jun 20 – 27
Home in Gamboa
4.86 out of 5 average rating, 88 reviewsBirdHouse@ Gamboa Panamá Canal
Aug 5 – 12
Villa in Playa Venao
4.98 out of 5 average rating, 61 reviewsCasa Aqua: Amazing beach front house - Playa Venao
Aug 4 – 11
Villa in Panamá
5.0 out of 5 average rating, 30 reviewsBreathtaking Views Mansion w/King Beds
Sep 29 – Oct 6
Home in Río Hato
4.95 out of 5 average rating, 75 reviewsSpectacular beachfront house in Buenaventura!
Oct 12 – 19
Villa in Portobelo
5.0 out of 5 average rating, 42 reviewsEntire Villa with pool in front of beach!
Apr 12 – 19
Luxury mansion rentals
Apartment in Maria Chiquita
5.0 out of 5 average rating, 5 reviews4 recamaras Playa Escondida
Nov 24 – Dec 1
Villa in Bejuco
4.96 out of 5 average rating, 78 reviewsBeach house in Punta Chame, Villa frente al mar
Jul 19 – 26
Villa in Punta Chame
4.93 out of 5 average rating, 14 reviewsFREE NIGHT Amazing Beachfront Villa - Palm House
Nov 26 – Dec 3
Home in San José
5.0 out of 5 average rating, 12 reviewsαlkeyler | Luxury Mini Resort 20 PERS @Punta Barco
Nov 21 – 28
Villa in Río Hato
4.92 out of 5 average rating, 73 reviews(Panama) Beach house with golf course.
Sep 3 – 10
Villa in Río Hato
4.91 out of 5 average rating, 22 reviewsSecluded Villa in Buenaventura Golf and Resort
May 19 – 26
Apartment in Panamá
4.67 out of 5 average rating, 139 reviewsEcleptic apartment with 4 rooms and amazing pool
Jan 14 – 21
Cabin in Panama
4.92 out of 5 average rating, 12 reviewsCasa de Playa Portobelo Caribe
Mar 30 – Apr 6
Pet-friendly mansion rentals
Villa in Bocas del Toro
5.0 out of 5 average rating, 56 reviewsCasa del Mar - eco aqua villa
Nov 25 – Dec 2
Apartment in San Carlos District
4.99 out of 5 average rating, 78 reviewsAmazing Oceanfront apartment in San Carlos
Sep 24 – Oct 1
Villa in Costa Esmeralda
4.97 out of 5 average rating, 68 reviews#1 Villa with pool, jacuzzi, pool table, ping pong.
Feb 5 – 12
Villa in Costa Esmeralda
5.0 out of 5 average rating, 13 reviewsSpectacular 600-meter oceanfront beach house
Oct 5 – 12
Home in Panamá
5.0 out of 5 average rating, 7 reviewsWonderful House with Terrace and Sea View
Oct 5 – 12
Apartment in El Chirú
4.94 out of 5 average rating, 83 reviewsBuenaventura Golf & Beach Resort Lux Apartment
Aug 27 – Sep 3
Home in Pedasí
4.83 out of 5 average rating, 6 reviewsOcean View From The Jungle!
Oct 16 – 23
Home in Provincia de Panamá Oeste
4.88 out of 5 average rating, 16 reviewsLuxurious beach front home in Veracruz
Mar 24 – 31
Destinations to explore
- Waterfront rentals Panama
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