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Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

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An outdoor area features a private plunge pool surrounded by wooden decking and sun loungers. A blue shade sail offers protection from the sun. Lush greenery and a vibrant blue fence enhance the tropical ambiance, with glimpses of the water visible in the background.

Home in Bastimentos Island

4.82 out of 5 average rating, 126 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

A spacious villa exterior is highlighted, featuring a long private swimming pool and lounge chairs arranged along the poolside. The surrounding landscaped garden is well-maintained, with palm trees providing shade and the villa's architecture showcasing a classic roof design.

Villa in Farallon

4.9 out of 5 average rating, 229 reviews

4 Bedroom villa Costa Blanca Golf-Beach Decamerom

Spacious villa, with 4 bedrooms all on one level, each with an en-suite bathroom. 250sq m detached villa overlooking the 7th putting green on Mantaraya Golf Course. Accommodation is provided for up to 12 people within the 4 bedrooms. The villa is within a 15 minute walk to the Pacific Coast sandy beach where guests have access to the Property Owners Beach Club restaurant and carpark. There is a 15m long swimming pool plus shallow area for children in the rear garden which is totally private.

A spacious outdoor deck features modern furniture arranged for relaxation, overlooking a lush mountainous landscape. Verdant hills and a colorful sky at dawn create a tranquil environment, inviting guests to enjoy the natural beauty and serenity of the surroundings.

Earthen home in El Cope, Penonome

4.92 out of 5 average rating, 179 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

The exterior of the three-story beach house is showcased, featuring terracotta roofs and lush landscaping. Palm trees and colorful flowers enhance the vibrant surroundings, while the ocean is visible in the background, complementing the peaceful neighborhood setting.

Home in San Carlos

4.95 out of 5 average rating, 123 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Top guest favorite

The image shows a bright outdoor area featuring a clear blue swimming pool bordered by light stone paths and lush green grass. A tall palm tree provides shade in the foreground, while the backyard includes a single-story house and an open patio area under a roof.

Villa in Punta Chame

4.97 out of 5 average rating, 126 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

The outdoor area features a private pool, illuminated with soothing blue tones, alongside sun loungers partially submerged in the water. Soft lighting highlights the modern architecture of the house and its spacious terrace, providing a relaxing ambiance under the evening sky.

Home in Vista Mar Golf, Beach & Marina

4.89 out of 5 average rating, 256 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Top guest favorite

A private pool area is framed by lush tropical plants and trees, with lounge chairs situated nearby. The pool’s clear blue water reflects the surrounding greenery and the structure in the background, which includes a covered patio for relaxation.

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 214 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Top guest favorite

A bright dining area features a round wooden table surrounded by six turquoise chairs. Large windows allow natural light to fill the space, showcasing a cozy atmosphere. A wooden dresser and potted plants add touches of comfort. Arched openings lead to other rooms.

Home in El Valle de Antón

4.95 out of 5 average rating, 163 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

An inviting infinity pool is positioned on a spacious patio, overlooking a sweeping mountain view. Two lounge chairs are arranged on the deck, facing the water, while lush greenery and colorful blooms enhance the serene environment surrounding the pool area.

Cottage in Altos del Maria

4.94 out of 5 average rating, 158 reviews

Mountain Cottage with Great View

Mountain Cottage, with spectacular views of the Altos del María Mountains, perfect for relaxing or spending time with the family. It features a infinity pool, spacious outdoor spaces, Smart TV and A/C in all rooms and living room, Wi-Fi throughout the property, and is fully equipped. Includes Prime Video service. It also has a fire pit and a gas BBQ. Complimentary late checkout is available for rentals departing on Sundays.

A private pool area is illuminated with soft purple lighting, creating a serene ambiance during the evening. The spacious pool is complemented by a relaxing jacuzzi, both surrounded by lush greenery. A modern house is visible in the background with large glass doors.

Home in Playa Coronado

4.74 out of 5 average rating, 119 reviews

Coronado. Luminosa piscina y jacuzzi, casa entera

Diviértete con toda tu familia en este espacio familiar y divertido dentro de Coronado con garita de seguridad. La casa cuenta con una hermosa piscina luminosa con playa, jacuzzi acompañada de su kiosko y barbacoa. La casa tiene 4 recamaras y 4 baños remodelados 2 recamaras cuentan con salida a la piscina Cocina moderna y amplia sala comedor Cerca a la playa, restaurantes y supermercados

The outdoor area features a large swimming pool surrounded by lounge chairs, with a separate jacuzzi nearby. Inside, a game room comprises a pool table and a ping pong table, with expansive glass doors allowing natural light and views of the greenery.

Villa in Costa Esmeralda

4.97 out of 5 average rating, 101 reviews

#1 Villa con piscina, jacuzzi, billar, pin pon.

Spectacular villa a few minutes from the beach by car, super spacious, ideal to share with family, friends or corporate meetings. The property is full of surprises and with many things to do including its swimming pool, jacuzzi, pool table, ping pong table, domino table, hammocks, large green areas, gas BBQ, variety of board games and a fully equipped kitchen.

A spacious living area features large glass doors opening to a private terrace, allowing natural light to fill the room. A comfortable sectional sofa and stylish dining table are complemented by a large television on an accent wall. Tropical plants enhance the inviting ambiance.

Condo in Buenaventura, El Chirú

4.92 out of 5 average rating, 134 reviews

Modern | Steps to Beach Club & Shops | Sleeps 10

★ A Proper Rents Experience ★ • Beautiful design • Excellent location • Steps to the La Mansa Beach Club! • Spacious & luxurious • Luxury Bedding • 75 inches TV • Beautiful views! • Half a block from restaurants & convenience store! • Fully equipped • High speed internet • Buenaventura, best luxury beach resort in Panama

Vacation rentals for every style

Get the amount of space that is right for you

Chalets

Adventure-ready homes with après-ski style

Bungalows

Intimate homes. inviting architecture

Cottages

Quaint homes, peaceful surroundings

Popular amenities for Panama mansion rentals

Free parking on premises

Air conditioning

Luxury mansion rentals

Top guest favorite

A sparkling blue pool with a circular spa features surrounding lounge chairs shaded by tall umbrellas. Lush greenery is visible in the background, enhancing the tranquil ambiance. Light reflects off the water, creating an inviting setting for relaxation.

Villa in Rio Hato

5 out of 5 average rating, 9 reviews

Villa Solara 5 - Luxury 5 Bedroom Pool Villa

A serene outdoor space features a gentle curve of water surrounded by lush greenery. Terraced steps lead down to the water's edge, and a variety of trees and plants create a tranquil atmosphere, while a structure is positioned on the hillside in the background.

Home in Panamá

5 out of 5 average rating, 4 reviews

La Casa de la Cascada

An outdoor pool area is framed by well-maintained gardens and palm trees, illuminated by warm lights. Multiple lounge beds under a shaded pergola provide relaxation spots. The pool features a circular design, surrounded by landscaped greenery, creating a serene atmosphere at dusk.

Condo in Buenaventura, El Chirú

4.97 out of 5 average rating, 127 reviews

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

A lakeside gazebo with a tiled roof is situated among lush greenery. Kayaks in vibrant colors await on a wooden dock extending over the water. Comfortable seating is arranged on the platform, providing a serene space for relaxation by the lake.

Cottage in Panama City

5 out of 5 average rating, 21 reviews

Hacienda La Perezosa en Cerro Azul

A spacious pool area is featured in the foreground, showcasing a large pool with a shallow entry and a clear blue surface. Multiple sun loungers are positioned around the pool, while palm trees provide a touch of greenery. The villa's exterior and covered terrace are visible in the background.

Villa in Rio Hato

4.91 out of 5 average rating, 65 reviews

Luxury 4BR Villa + Guesthouse & Pool @Buenaventura

Top guest favorite

A serene outdoor space features a private pool surrounded by blue lounge chairs. The area is paved with bricks, and an outdoor dining setup is visible in the background, along with a barbecue area. The sky is illuminated with vibrant sunset colors.

Home in Rio Hato

4.95 out of 5 average rating, 40 reviews

Villa Santorini | Playa Blanca

Top guest favorite

A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.

Villa in Panamá

4.98 out of 5 average rating, 56 reviews

Breathtaking Views Mansion w/King Beds

A spacious single-story home is surrounded by lush, manicured gardens. Colorful flowers bloom along stone pathways, leading to the entrance. A covered patio provides shaded seating, while vibrant greenery surrounds the property, creating a tranquil outdoor atmosphere.

Home in Boquete

5 out of 5 average rating, 5 reviews

NEW! Luxury Home in 5-Star Resort | King | Garden

Pet-friendly mansion rentals

Lush palm trees are featured along a well-maintained pathway leading to the beach. Green coconuts hang among the fronds, while vibrant greenery and white stone walls add a fresh touch. The sandy shore is visible in the background, framed by a clear blue sky.

Vacation home in San Carlos

4.92 out of 5 average rating, 51 reviews

Bienvenidos a nuestra casa de Playa Corona

An inviting outdoor kitchen area equipped with a grill and dining set overlooks a lush garden. A cozy indoor living space features a plush sofa and a large TV. The private pool, framed by lounge chairs and greenery, offers a tranquil oasis for relaxation.

Condo in El Chirú

4.91 out of 5 average rating, 43 reviews

Laguna Fun and Sun: Your Escape Awaits

The estate features a two-story structure with orange and stone accents, surrounded by lush greenery. A covered porch extends along the front, providing a shaded spot to enjoy nature. The backdrop of rolling hills adds to the serene environment of this secluded retreat.

Villa in El Valle de Antón

4.91 out of 5 average rating, 46 reviews

Quinta El Bosque

A hammock is suspended under a covered terrace, overlooking a serene beach. Yellow chairs are positioned nearby on a wooden deck, complemented by a coastal view featuring calm blue waters and a clear sky. The scene is tranquil and inviting for relaxation.

Chalet in Juan Hombron

5 out of 5 average rating, 4 reviews

Casa con encanto acceso a playa

A spacious pool area is surrounded by lush greenery and vibrant palm trees. The pool features a blue mosaic tile design, reflecting the clear sky above. A covered terrace with seating and umbrellas is visible, along with hammocks nearby, providing ample relaxation space.

Villa in Rio Hato

4.86 out of 5 average rating, 44 reviews

La Casa de las Uvas un oasis con vistas al mar

Top guest favorite

A calm swimming pool reflects the surrounding buildings, with lush palm trees providing greenery. A spacious gazebo is positioned at the pool's edge, accompanied by several shaded lounge chairs for relaxation.

Apartment in Buenaventura

4.99 out of 5 average rating, 109 reviews

Exclusivo apartamento a pasos del mar en Puntarena

Top guest favorite

Home in Rio Hato

4.98 out of 5 average rating, 125 reviews

Spacious Vacation Home in a Tourist Area

A modern outdoor pool reflects the surrounding structures, with large glass windows visible in the background. Palm trees line the edges of the pool area, providing a touch of greenery. Lounge chairs are positioned nearby, enhancing the inviting space for relaxation.

Home in Playa Malibú

4.91 out of 5 average rating, 11 reviews

MoMa Malibu, Beach front

Mansion rentals with a pool

The inviting outdoor area features a swimming pool bordered by a spacious deck. Sun loungers and comfortable seating are arranged nearby, creating a relaxed atmosphere. The backdrop includes a row of wooden doors leading to the house, framed by palm trees under an overcast sky.

Villa in Las Lajas

4.84 out of 5 average rating, 37 reviews

Casa de Playa Donde Emy

A serene outdoor area is showcased, featuring a swimming pool surrounded by well-maintained grass and a decorative fountain in the foreground. Lounge chairs are positioned near the pool, while lush greenery offers a sense of privacy.

Home in Panama City

4.95 out of 5 average rating, 40 reviews

Agradable Casa Duplex con piscina.

A spacious outdoor terrace features a large swimming pool surrounded by potted plants. The area offers stunning views of the ocean and greenery. Comfortable lounge chairs are positioned on the deck, providing a relaxing space to enjoy the scenery under a clear blue sky.

Villa in Mariato

4.79 out of 5 average rating, 19 reviews

Villa Papagayo, Playa Morrillo, Veraguas

Top guest favorite

A spacious living area features a comfortable sectional sofa adorned with decorative pillows. Large windows provide a view of the ocean, while a dining table is visible in the background. Stylish light fixtures hang from the ceiling, adding to the open and airy feel.

Condo in Maria Chiquita

5 out of 5 average rating, 47 reviews

Playa Escondida. Apartamento con vista al mar.

A well-lit bedroom features a spacious bed with white linens and colorful accent pillows. Two nightstands with green lamps are positioned beside the bed. Natural light enters through a window with sheer curtains, and a ceiling fan is mounted above, enhancing ventilation.

Condo in El Chirú

4.97 out of 5 average rating, 32 reviews

Buenaventura | Luxury Beach Apartment | Panama

A serene outdoor space features a tranquil water fountain set against a backdrop of palm trees. The fountain's gentle spray is visible, with paved walkways leading toward the water's edge. Comfortable seating arrangements are situated nearby, enhancing the open atmosphere.

Condo in El Chirú

4.9 out of 5 average rating, 145 reviews

Beach apartment in BUENAVENTURA

A modern living and dining area features a glass dining table with upholstered chairs, accompanied by a comfortable sectional couch. Large windows allow natural light to illuminate the space, and decorative elements include a vase with flowers and artwork on the white walls.

Apartment in Panamá

4.91 out of 5 average rating, 46 reviews

140 m2 apartment down town Panama-City

Top guest favorite

A nighttime view showcases a vibrant city skyline, with numerous tall buildings illuminated against the dark sky. The urban landscape features a mix of modern architecture, highlighting the dynamic energy of the city.

Apartment in Panamá

4.98 out of 5 average rating, 40 reviews

Top Floor Condo 6 bedroom with amazing views

Destinations to explore