Hotel vacation rentals in Panama

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Superhost

Large windows provide a panoramic view of the lush green landscape outside, featuring a mix of trees and colorful foliage. A comfortable sofa is positioned nearby, accompanied by a coffee table adorned with a floral arrangement, adding a touch of nature to the inviting indoor space.

Hotel room in Boquete

4.89 out of 5 average rating, 111 reviews

Villa Alejandro - Tastefully Furnished Room

Just 5 minutes walk to centre, calmly situated and close to town located in an extraordinary mansion. Lovely furnished bedroom (King-Size/Orthopedic mattress) with private bathroom and walk-in closet . Affectionately decorated living room with spectacular view to the Boquete valley by large windows and large, full equipped kitchen can be shared with other guests. Lot of space for dining/reading in the living room. Lovely garden and terrace can be used. Gated carport. Fast WiFi, CableTV, Netflix

Guest favorite

A lush landscape frames the view of the ocean, with trees casting gentle shadows over the sandy area. The shoreline is visible in the distance, revealing a calm blue sea that meets the horizon, enhancing the natural beauty of the surroundings.

Hotel room in Palo Seco

5 out of 5 average rating, 10 reviews

Waterfront | Fish restaurant | Room #3 Duo

Notre hotel Ocekepala vous accueille au coeur du village de pêcheurs de Palo Seco (entre Mariato et Torio). Situé en front de mer, les plages sauvages vous attendent pour de belles aventures. Le soir, rendez vous au bout du ponton pour admirer le soleil se coucher sur l'île de Cebaco. Venez ensuite déguster de délicieux produits de la mer (poisson entier, langoustes, burger poisson et notre spécialité la paella) cuisinés par notre équipe. Nous avons hâte de vous accueillir! Karine & Brice.

Guest favorite

A spacious bedroom features a wooden bed with a blue patterned blanket. Large windows offer views of the lush greenery outside. A wooden desk with a chair is situated nearby, and warm hardwood flooring complements the natural light that fills the room.

Hotel room in PA

4.9 out of 5 average rating, 29 reviews

Treetop views of the Pacific in a boutique cabaña

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Guest favorite

A light and airy room is shown with large glass doors leading to a lush outdoor area. A wide-brimmed hat rests on a bed, while a figure stands at the door, showcasing a flowy floral skirt and a simple top amid greenery.

Hotel room in PA

4.91 out of 5 average rating, 34 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Guest favorite

A wooden table is set with bowls of vibrant fruit topped with flowers, alongside two small cups and mugs. A French press coffee maker is included. The background features tall greenery and palm trees visible through a screened porch.

Hotel room in Bastimentos Island

4.95 out of 5 average rating, 64 reviews

Casa Florecer- bungalow at the edge of the sea

Welcome to Casa Florecer, a bungalow at the edge of the sea. Your space is simple and elegant. A studio apartment with plenty of room to enjoy a quiet & peaceful time on the island. The bungalow boasts a screened in porch, gorgeous views, and pristine coral reef for your front yard. All stays include a locally sourced vegetarian breakfast served in our over the water eatery, Juntos. For fun closer to home: we have snorkel gear, paddle boards, and yoga mats available for your enjoyment.

Guest favorite

A spacious outdoor deck area is illuminated by the golden light of the setting sun. Relaxing daybeds are arranged under wooden structures, surrounded by lush palm trees. Rustic wooden tables and benches create a welcoming gathering space with views of the Caribbean sea.

Private room in Bastimentos Island

4.94 out of 5 average rating, 47 reviews

The Firefly B&B oceanfront bungalow w/ pool

Our b&b is a little off the beaten path but we love it that way. Listing is for one of our two private, oceanfront bungalows. We can let you know which one is available at time of booking. We are an eco lodge & describe our vibe as "hip, rustic beach house". Our rooms are fan cooled & have in room safes. Pool is shared by all five rooms. Breakfast is included. If a "resort" or 4 star place is your vibe, we are probably not for you :) We accept guests 15 and up.

Superhost

An outdoor seating area features wooden barstools and dining tables, situated beneath a covered patio. Natural light filters through, casting soft shadows on the polished floor. Lush greenery is visible in the background, enhancing the tranquil ambiance of the space.

Hotel room in Cambutal

4.94 out of 5 average rating, 17 reviews

Boutique Inn_The Hill 2_Private Entry_Tripple_+16

The Hill Panama, our Boutique Inn Adult Only (16+) is proud to be featured on Architectural Digest Magazine, located in the heart of enchanted Cambutal Beach, just a 5 five-minute walk to the beach, surrounded by several surf spots, balance between mountain and sea, hidden amongst the jungle canopy. This listed Room 2 was designed as a boutique hotel room with separated private entry and communal kitchen.

A black scorpion is positioned among dried leaves and foliage. Its prominent pincers and segmented body are clearly visible, blending subtly with the natural surroundings. The texture of the leaves and the scorpion's surface can be observed, illustrating a typical forest floor habitat.

Nature lodge in Darién Province

4.7 out of 5 average rating, 20 reviews

La Chunga

La Chunga is in a difficult access indigenous community without electricity or roads. Come see this gem of a community and the indigenous way of life. You’ll love this place because of the nature walks, the wildlife, the gastronomy, and the people. We have a number of guided tours and adventures. My place is good for adventurers trying to see something new and exciting.

Guest favorite

A flowing river cuts through lush greenery, flanked by buildings on either side. The mountains rise in the background, partially covered by clouds. Blue skies with scattered clouds create an appealing contrast to the earthy tones of the water and surrounding foliage.

Hotel room in Boquete

4.78 out of 5 average rating, 133 reviews

Private Room in Boquete

Enjoy the simplicity of this quiet and central accommodation in town, just a few steps from grocery stores, restaurants, bars, coffee shops, with easy access to public or private transportation. This room has a comfortable bed, private bathroom with hot water ample space, the kitchen is perfectly equipped to share with two other rooms, the garden is beautiful.

Top guest favorite

Tall palm trees frame a view of the ocean, with a green lawn leading down to the water. Colorful buildings are visible on either side, creating a serene environment. The sky is bright and clear, enhancing the relaxed atmosphere of the space.

Private room in Santa Catalina

4.95 out of 5 average rating, 20 reviews

Casa Manila Doble Room with terrace

Welcome to our calm place in front of the ocean. The place is perfect for relaxing on your private terrace and offers breathtaking views of the pacific ocean. In our freshly renovated rooms with A/C you can enjoy a cold breeze after a sunny day. At the end of the day you will be surprised by the best sunset in Santa Catalina.

Guest favorite

A spacious patio area features multiple black wicker chairs arranged along a colorful stone pathway. The outdoor space offers unobstructed views of the sandy beach and ocean beyond, with a wooden railing providing a sense of enclosure. People can be seen enjoying the beach in the distance.

Hotel room in Las Tablas Abajo

4.82 out of 5 average rating, 79 reviews

Blue Room for 2 at Casa Lassini - Oceanfront!

Blue Room - possibly our best room but you can decide. Queen bed, sleeps 2 and comes with everything you need to enjoy yourselves at the beach. A spectacular view overlooking the Pacific Ocean. Room is upstairs; includes A/C, smart TV, Netflix, full size refrigerator, microwave, toaster, coffee & coffeemaker.

Casa particular in Contadora Island

5 out of 5 average rating, 3 reviews

Ocean Front House on exclusive Contadora Island

Whale season has begun! July-October 🐳 Welcome to your paradise on Contadora Island, a hidden gem in the heart of Panama's Pearl Islands. This stunning Ocean Front house offers unparalleled views of the turquoise waters providing the perfect escape for those seeking both tranquility and adventure.