Hotel vacation rentals in Panama

Find and book unique hotel rentals on Airbnb

Top-rated hotel rentals in Panama

Guests agree: these hotel rentals are highly rated for location, cleanliness, and more.

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Guest favorite

Hotel in Bajo Boquete

5.0 out of 5 average rating, 24 reviews

La Residencia - Suite Bella Vista

This Impressive, extravagant, light flooded Suite with breathtaking view to the Baru Volcano is located just a 10-minute walk from the center of Boquete. Modern and contemporary style with a high sense of detail, located in the second floor of an extraordinary mansion. Luxurious 80m² suite (King-Size/Orthopedic mattress) with spacius private bathroom, huge walkin closet, private full equipped kitchenette, panoramic window, 2 air conditioners, free parking, fast Wifi, cable TV, Netflix, Spotify.

Guest favorite

Hotel in La Enea

4.86 out of 5 average rating, 14 reviews

Private apartment with pool/beach access!

Looking for a private apartment with pool and beach access? The apartment has a queen size bed, bunk bed, and sofa bed with private bathroom. The 2nd floor balconies have pool/ocean views. The apartment is located at Playa Guarare, but is only a 20 minute drive to Las Tablas and 35 minutes to Chitre. On-site restaurant can provide daily meals. 2 minute walk to the beach and 3 minute walk to the port where you can hire a boat for fishing/whale watching. Hammocks and picnic tables available too!

Superhost

Nature lodge in Bastimentos Island

5.0 out of 5 average rating, 4 reviews

Dolphin Serenity - Tropical Suite with Pool

Indulge in tropical luxury at Dolphin Serenity, a two-story suite with a plush king bed. Our eco-lodge features a pool with panoramic views and family rooms. Our Lodge invites you to an unique experience—where boutique elegance meets B&B warmth. Unwind in comfort, surrounded by nature. Rooms offer free WiFi, private bathrooms, and terraces. Enjoy daily continental, American, or vegetarian breakfast. Exclusively for adults, this is your invitation to serenity. Book now for an exclusive escape.

Superhost

Hotel room in Bocas del Toro Province

4.86 out of 5 average rating, 112 reviews

Cozy Loft Hideaway with Double Bed

Welcome to our tropical paradise, where Caribbean vibes meet cozy comfort at our Bed & Breakfast! Get ready for sunsets that'll take your breath away, marine life marvels, and breakfast bliss on our breezy terrace. Tucked just outside the hustle of Bocas Town, we're your chill-out haven! Grab one of our bikes and pedal your way through town, or hop on a kayak for a watery adventure! Oh, and we're strictly for the over 18 crowd, 'cause we know how to keep it cool and classy. 🌅🌴🚴‍♂️🚣‍♀️🍳

Superhost

Boutique hotel in PA

4.84 out of 5 average rating, 43 reviews

Rancho Cabaña- Private Porch, Loft, 1 min to beach

No detail left unnoticed…our boutique cabañas are nestled in jungle gardens with private porches overlooking the Pacific, hammocks for lounging, indoor/outdoor concept bathrooms, stunning hardwood floors, and custom-made furniture. Each of our three cabañas has its own unique charm where comfort meets luxury. We are steps from the beach and minutes from consistent surf breaks and community yoga classes. A shared kitchen is on site, with individual cooking utensils provided for each room.

Superhost

Boutique hotel in PA

4.9 out of 5 average rating, 29 reviews

Villa Coco King Room

Villa Coco is a beautiful boutique hotel in Santa Catalina, only footsteps away of the world known surf break “La Punta” and Unesco world heritage Coiba island. The carefully designed cabañas, provide a space of tranquility and a sense of timelessness. Unwind in the hammocks and canvas chairs on your private terrace, dwell on reading your favorite book or sip on a cool drink from the bar. Our Restaurant “Ai Mamita” offers different kinds of meat, fresh seafood and other tasty delights.

Guest favorite

Hotel room in Bocas del Toro Province

4.92 out of 5 average rating, 71 reviews

Economy Oceanview Room - Bird Island Bungalows

Bird Island Bungalows is a hidden, secluded beach hotel surrounded by pristine private beaches, jungle and a 3.5ha lush tropical garden. From breathtaking sunsets from our 360 degree view roof top bar, silent meditation on our oceanview yoga deck, kayak tours to the bird watcher's paradise Bird Island to educational jungle walks to explore all the unique tropical flora and fauna - there is something for everyone or you just enjoy the beautiful silent sounds of nature and waves.

Superhost

Nature lodge in Taboga Island

4.91 out of 5 average rating, 54 reviews

Eco Lodge Garden Room 5 Oceanview Plunge Pool

Experience Cerrito Tropical Eco Lodge. Relax. Enjoy our refreshing plunge pool. Natural hillside location, interpretive garden. Jaw dropping oceanview from pool/deck (pool chairs, UV umbrellas). Walk to the beach. Comfortable ground floor room with bathroom, airconditioning, free Wifi and local TV. Exterior oceanview /gardenview balcony. Birdwatchers can spot up to 124 species recorded on Taboga. Artisanal pizza made onsite. Local taxes 10%. No pets in the Garden Rooms.

Guest favorite

Nature lodge in Bastimento

4.92 out of 5 average rating, 36 reviews

The Firefly B&B oceanfront bungalow w/ pool

Our b&b is a little off the beaten path but we love it that way. Listing is for one of our two private, oceanfront bungalows. We can let you know which one is available at time of booking. We are an eco lodge & describe our vibe as "hip, rustic beach house". Our rooms are fan cooled & have in room safes. Pool is shared by all five rooms. Breakfast is included. If a "resort" or 4 star place is your vibe, we are probably not for you :) We accept guests 15 and up.

Superhost

Hotel in Las Lajas

5.0 out of 5 average rating, 9 reviews

Beach Apartament Villa Deluxe

Disfruta de una estancia inolvidable en los apartamentos Villa Deluxe de playa Las Lajas. Estos acogedores apartamentos te brindan comodidad y estilo, con vistas espectaculares y un acceso directo a la playa. Relájate en su balcón privado o sumérgete en la piscina tropical para refrescarte. Con una ubicación privilegiada y servicios de primera clase, los apartamentos Villa Deluxe son el lugar perfecto para disfrutar de unas vacaciones de ensueño.

Guest favorite

Casa particular in Bocas del Toro

4.96 out of 5 average rating, 83 reviews

Urania House

Casa con hermosa vista al mar en donde puedes disfrutar de bellos atardeceres mientras se mece en las hamacas del balcon. La casa consta de tres amplias habitaciones, dos baños con agua caliente, Sala, comedor, cosina, terraza y balcon. La casa esta completamente equipada y amueblada para su comfort; TV cable, Internet-wifi.

Guest favorite

Hotel room in Panamá

4.93 out of 5 average rating, 61 reviews

BarrBra / Double Bed / Priv. Bath. / Ac

- house built right over the Caribbean sea - bedroom with double sized bed & Balcony - private bathroom (hot water shower) - AC included - a la carte breakfast included (between 8 - 9:30 a.m.) - guest kitchen - sunset orientated (yes, we're facing west! :)) - ocean access from our private dock - gay-friendly place