
House vacation rentals in Panama
Find and book unique houses on Airbnb
Top-rated house rentals in Panama
Guests agree: these houses are highly rated for location, cleanliness, and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.

Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.

Spacious, Over the Water Home with Plunge Pool
Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

2 Bedroom Apartment with Panoramic Caribbean View
Manta Raya Apartment is a very luminous, well constructed 2 stories apartment over the water in "Saigon Bay" on Isla Colón, the main island of the archipelago of Bocas del Toro. With our unique location on the Isthmus of Isla Colón. we enjoy nice sea breezes from both sides of the Caribbean and breathtaking views especially during sunrise and sunset (see pictures). We are a 60 cent taxi ride or 5 minute bike ride from all downtown attractions and just enough out of town enjoy the serenity.

OceanView-Rooftop Jacuzzi&Pool | Concierge Service
Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 8.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base rate covers up to 4 guests, with a $40 charge per additional person, per night.

Spacious 3BR walking distance, close to everything
Enjoy the comfort of this spacious and centrally located private home, located just a two-minute walk from downtown Boquete. Spectacular design with 3 bedrooms, work area, comfortable living-dining room, fully equipped kitchen, bathroom with hot water and parking with electric gate. Beautiful views of the Boquete valley from the balconies and the lookout point. House surrounded by a bamboo forest just a few steps from the best restaurants and attractions, in a quiet environment.

Modern House with Great Views and Heated Pool
Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.

Orange House - Over The Water Rentals
Enjoy golden sunsets across the bay from the Orange House at Over The Water Rentals. Home away from home in a tropical paradise. Relax on your outdoor lounge or explore the bay. The house has snorkel gear, SUP's & kayaks for guests to use for free. Located close to town & airport in a quiet local neighborhood. The house features a king size master bedroom & queen guest room, spacious hot water shower, handmade organic toiletries, fully equipped kitchen & high speed wifi

El Palmar, beach 50 meters away
Listen to the waves from the privacy of our terrace and create unforgettable memories in this unique and family-friendly accommodation just steps from the beach with a private pool. El Palmar is a quiet community with several restaurants available a few steps from the house. The property is fully fenced for the tranquility and safety of children and their pets. In addition, you have wifi, cable TV in both rooms and air conditioning in the dining room and in all the bedrooms

Casa Rosie - Dream Home on Tabogá Island
Casa Rosie is a gorgeous villa on Taboga island with an intimate vibe and spectacular views of the ocean. The perfect place for couples, small groups, and families to unwind and make magical memories! . With great wifi, fully equipped kitchen, 3 inviting bedrooms, and a spacious yet personal feel… Casa Rosie is your home away from home. Included in every stay is free pick up and drop off to the ferry terminal - please let us know the details of your arrival.

Villa Acuario
Relaxation is guaranteed in this one-of-a-kind glass house nestled in the lush mountains of Altos del María. Surrounded by nature and designed with floor-to-ceiling glass walls on all sides— as if you’re living inside a crystal ball. With no direct neighbors, panoramic forest views, it is perfect for a family getaway, a quiet reset, or an extended stay. The home offers light-filled interiors during the day and unforgettable stargazing nights from the rooftop.

Tropical Haven with Pickleball/Yoga Platform
Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.
Popular amenities for Panama house rentals
House rentals with a pool

Luxury beachfront villa!

Mountain Retreat

Playa Malibu Beach House.

The Bird's Nest in the Clouds

villa in contadora, las perlas

Villa GiGi - Beach Home Panama Santa Clara

Private House | Beach | Quiet Stays | Wi-Fi | A/C

3 min to Pedasi, 5 min to the Beach, Private Pool!
Weekly house rentals

Modern Home with Coffee Plantation & Volcano Views

Private Beachfront Getaway

Your perfect mountain escape

Off-Grid Bluff Beach Home for Families or Couples

CASA STARE | Frente al mar: Playa, Jacuzzi y Surf

Entire house with private pool facing beach !

Modern Luxury Beach Front House in Coronado

Bluff Beach Jungle House
Private house rentals

La Florecita - Country house in Valle de Antón

Casa Divi Divi Punta Chame

New Luxury Villa - Solar powered

Private Villa at Red Frog Beach Resort

CasAna

Palmar Eco House Hills

Bay Of The Floating Palms - Beach Front Home

Casa Coco - Beautiful Mountain Villa With AC
Destinations to explore
- Boat rentals Panama
- Fitness-friendly rentals Panama
- Chalet rentals Panama
- Family-friendly rentals Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Smoking-friendly rentals Panama
- Serviced apartment rentals Panama
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- Aparthotel rentals Panama
- Hotel rooms Panama
- Condo rentals Panama
- Rentals with pools Panama
- Guesthouse rentals Panama
- Rentals with a washer and dryer Panama
- Rentals with a home theater Panama
- Loft rentals Panama
- Rentals with lake access Panama
- Farmstay rentals Panama
- Dome rentals Panama
- Treehouse rentals Panama
- Villa rentals Panama
- Rentals with a hot tub Panama
- Pet-friendly rentals Panama
- Rentals with breakfast Panama
- Rentals with beach access Panama
- Lakehouse rentals Panama
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- Tiny house rentals Panama
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- Earth house rentals Panama
- Mansion rentals Panama
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- Beach house rentals Panama
- Rentals with an accessible height bed Panama
- Nature eco lodge rentals Panama
- Rentals with a sauna Panama
- Boutique hotels Panama
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- Shipping container rentals Panama
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- Apartment rentals Panama
- Cabin rentals Panama
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- Bed and breakfasts Panama




