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Villa vacation rentals in Panama City

Find and book unique villas on Airbnb

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Popular amenities for Panama City villa rentals

Private villa rentals

Top guest favorite
The outdoor area features a private swimming pool surrounded by a spacious patio. The house is showcased with large glass doors that open to the poolside, and tropical plants enhance the serene atmosphere. A stairway leads to the upper level, offering additional views.
Villa in Punta Pacifica
4.99 out of 5 average rating, 78 reviews

Beautiful House in Panama w/ King Beds + Pool

SandeepRating, 5 stars3 weeks ago
We stayed at Jonathan’s place for 5 nights. We were group of 8 friends. The place is right in downtown next to everything and it was easy to get around. Secure gates, walk to groceries, cafe and restaurants. Ample parking and huge refreshments and sofas for all of us. We would highly recommend this place
Villa in Panamá
4.8 out of 5 average rating, 50 reviews

Villa La Vista-Panama's majestic mountain hideaway

SarahRating, 5 stars1 week ago
This house is an absolute dream! It’s spacious and well-appointed, and the views are simply breathtaking! Do not hesitate to make your reservation here- I am already dreaming of the time when I can return! Jenny was incredibly helpful and super quick to respond- we were well cared for, which let us relax and enjoy ourselves even more- thank you Jenny!
An outdoor patio area is featured next to a private pool, surrounded by lush greenery. A dining set with six chairs and a large umbrella provides shade, with poolside lounge chairs arranged nearby. Natural stone elements complement the serene atmosphere.
Villa in Panamá
4.5 out of 5 average rating, 6 reviews

In the Last Place in the World (6 guests)

LuigyRating, 5 stars25 months ago
A place and a house that would unquestionably come back and recommend. The house is cozy, the weather is perfect, the divine pool... in the end what it takes to spend a few days totally relaxed.
Top guest favorite
An outdoor swimming pool is surrounded by a spacious deck featuring lounge chairs and a shaded umbrella. Lush greenery and tropical plants provide a serene backdrop, while a smaller spa pool is visible adjacent to the main pool, enhancing the tranquil ambiance.
Villa in Panamá
5 out of 5 average rating, 13 reviews

Villa Helena Studio 1 Apt Cerro Azul

KhaleelRating, 5 stars1 month ago
Very Very super great host will fully recommend 💯 percent great location nice clean surroundings lovely pool ,beautiful scenery thank you ms Helen for taking care of me and my wife looking forward to doing it again you are a wonderful person keep up the good work 👏 🙌
Superhost
An outdoor pool area features a sparkling pool surrounded by lounge chairs. Umbrellas provide shade over seating areas, while tropical foliage and trees create a natural backdrop. A gas grill is positioned nearby for outdoor cooking.
Villa in Panamá
5 out of 5 average rating, 5 reviews

Villa Helena 2 Bedrooms Cerro Azul

AlexRating, 5 stars4 months ago
The stay was nothing but awesome, Ms Helen energy is absolutely amazing and her place outstanding, would definitely recommend , I felt right at home, I would definitely come back
Top guest favorite
A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.
Villa in Panamá
4.98 out of 5 average rating, 49 reviews

Breathtaking Views Mansion w/King Beds

RaeRating, 5 stars1 week ago
Great place. My kids enjoyed the pool, theater and pool table. I enjoyed the BBQ and the views
A two-story villa is set amid trees and greenery, showcasing a vibrant exterior with decorative accents. A clear sky is visible above, and ornamental plants and terracotta pots are placed around the entrance, enhancing the natural surroundings of the property.
Villa in Panamá
4 out of 5 average rating, 5 reviews

Tranquility and peace connect with Nature 🌤

IlianisRating, 5 stars8 months ago
We felt right at home. And Juan Pablo the best always attentive and very thoughtful with everything. We will definitely be back The house is highly organized and clean. I recommend the full to spend their family days and with friends. They will want to stay many more days like us. I repeat it, we will definitely be back
Top guest favorite
Villa in Punta Pacifica
5 out of 5 average rating, 13 reviews

5BR House in Panama City w/ Pool & King Beds

MeeraRating, 5 stars4 days ago
Our stay at this villa in Panama was absolutely amazing! The property was beautiful and had everything we needed—from spacious rooms to a stunning backyard and pool area where our group loved hanging out. It truly felt like our own private oasis right in the heart of the city. The location was perfect—super central and just minutes away from both Casco Viejo and the newer parts of the city. We were surrounded by great restaurants, bars, and cafes, most within walking distance or a quick 5-minute drive. What really made the experience exceptional was the hospitality. Jonathan and his team were outstanding—so responsive, helpful, and accommodating. When we had a small issue with the AC in the upstairs hallway, Jonathan showed up within minutes and had a repair technician there right away. The level of service was truly impressive. I would 100% recommend staying at this villa, and I’d book any property hosted by Jonathan and his team without hesitation. They made our trip so memorable!

Villa rentals with a pool

Top guest favorite
The outdoor area features a private swimming pool surrounded by a spacious patio. The house is showcased with large glass doors that open to the poolside, and tropical plants enhance the serene atmosphere. A stairway leads to the upper level, offering additional views.
Villa in Punta Pacifica
4.99 out of 5 average rating, 78 reviews

Beautiful House in Panama w/ King Beds + Pool

SandeepRating, 5 stars3 weeks ago
We stayed at Jonathan’s place for 5 nights. We were group of 8 friends. The place is right in downtown next to everything and it was easy to get around. Secure gates, walk to groceries, cafe and restaurants. Ample parking and huge refreshments and sofas for all of us. We would highly recommend this place
Villa in Panamá
4.8 out of 5 average rating, 50 reviews

Villa La Vista-Panama's majestic mountain hideaway

SarahRating, 5 stars1 week ago
This house is an absolute dream! It’s spacious and well-appointed, and the views are simply breathtaking! Do not hesitate to make your reservation here- I am already dreaming of the time when I can return! Jenny was incredibly helpful and super quick to respond- we were well cared for, which let us relax and enjoy ourselves even more- thank you Jenny!
An outdoor patio area is featured next to a private pool, surrounded by lush greenery. A dining set with six chairs and a large umbrella provides shade, with poolside lounge chairs arranged nearby. Natural stone elements complement the serene atmosphere.
Villa in Panamá
4.5 out of 5 average rating, 6 reviews

In the Last Place in the World (6 guests)

LuigyRating, 5 stars25 months ago
A place and a house that would unquestionably come back and recommend. The house is cozy, the weather is perfect, the divine pool... in the end what it takes to spend a few days totally relaxed.
Top guest favorite
An outdoor swimming pool is surrounded by a spacious deck featuring lounge chairs and a shaded umbrella. Lush greenery and tropical plants provide a serene backdrop, while a smaller spa pool is visible adjacent to the main pool, enhancing the tranquil ambiance.
Villa in Panamá
5 out of 5 average rating, 13 reviews

Villa Helena Studio 1 Apt Cerro Azul

KhaleelRating, 5 stars1 month ago
Very Very super great host will fully recommend 💯 percent great location nice clean surroundings lovely pool ,beautiful scenery thank you ms Helen for taking care of me and my wife looking forward to doing it again you are a wonderful person keep up the good work 👏 🙌
Superhost
An outdoor pool area features a sparkling pool surrounded by lounge chairs. Umbrellas provide shade over seating areas, while tropical foliage and trees create a natural backdrop. A gas grill is positioned nearby for outdoor cooking.
Villa in Panamá
5 out of 5 average rating, 5 reviews

Villa Helena 2 Bedrooms Cerro Azul

AlexRating, 5 stars4 months ago
The stay was nothing but awesome, Ms Helen energy is absolutely amazing and her place outstanding, would definitely recommend , I felt right at home, I would definitely come back
Top guest favorite
A multi-story mansion is showcased overlooking a vibrant swimming pool, adorned with inflatable toys including a pink flamingo and a whale. Bright umbrellas provide shade over red loungers, all set against a backdrop of lush greenery and a partially cloudy sky.
Villa in Panamá
4.98 out of 5 average rating, 49 reviews

Breathtaking Views Mansion w/King Beds

RaeRating, 5 stars1 week ago
Great place. My kids enjoyed the pool, theater and pool table. I enjoyed the BBQ and the views
Top guest favorite
Villa in Punta Pacifica
5 out of 5 average rating, 13 reviews

5BR House in Panama City w/ Pool & King Beds

MeeraRating, 5 stars4 days ago
Our stay at this villa in Panama was absolutely amazing! The property was beautiful and had everything we needed—from spacious rooms to a stunning backyard and pool area where our group loved hanging out. It truly felt like our own private oasis right in the heart of the city. The location was perfect—super central and just minutes away from both Casco Viejo and the newer parts of the city. We were surrounded by great restaurants, bars, and cafes, most within walking distance or a quick 5-minute drive. What really made the experience exceptional was the hospitality. Jonathan and his team were outstanding—so responsive, helpful, and accommodating. When we had a small issue with the AC in the upstairs hallway, Jonathan showed up within minutes and had a repair technician there right away. The level of service was truly impressive. I would 100% recommend staying at this villa, and I’d book any property hosted by Jonathan and his team without hesitation. They made our trip so memorable!
A serene pool area features a gently flowing waterfall surrounded by stone walls, with a hot tub positioned nearby. Lush greenery envelops the space, adding to the tranquil ambiance. A brightly colored structure stands in the background, enhancing the outdoor experience.
Villa in Panamá
4.75 out of 5 average rating, 8 reviews

Summit View Guest House Cerro Azul Panama

ChiaraRating, 5 stars3 months ago
The experience was spectacular from start to finish. I loved the house. Our host Jenny is fantastic; she provided all the information and details The place itself is breathtaking—the house is stunning, meticulously crafted with love and attention to detail. The cleanliness of the house was impeccable, and it is equipped with everything you could possibly need for a comfortable stay. The amenities provided were top-notch, including high-speed internet and a smart TV with a variety of streaming options. The beds are exceptionally comfortable, offering a perfect night's sleep. The bathroom deserves special mention as well; it is gorgeous and spotless. The owners are great people; their genuine hospitality added a personal touch that made our stay even more memorable. I 100% recommend this beautiful place to anyone looking for a top-tier Airbnb experience that exceeds expectations. For my family, it is our new escape from the city!

Quick stats about villa rentals in Panama City

  • Total rentals

    10 properties

  • Nightly prices starting at

    ﺩ.ﺇ294 before taxes and fees

  • Total number of reviews

    370 reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with a pool

    10 properties have a pool

Destinations to explore

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  2. Panama
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