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Guesthouse vacation rentals in Panama City

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Top-rated guesthouse rentals in Panama City

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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A modern living area features a stylish grey sofa adorned with colorful cushions, providing comfort and visual interest. A wooden bookshelf with various decorative items and books is positioned nearby. Soft lighting emanates from a cluster of candles on a round table, creating a soothing atmosphere.
Guesthouse in El Cangrejo
4.75 out of 5 average rating, 20 reviews

Rare City Oasis with Private Green Space

No more construction. Wake up to the sound of birds in this peaceful retreat in the heart of trendy "El Cangrejo". Housed on the ground-floor apartment of a 2-story building built in the 50's. Features a private green yard — perfect for relaxing or spotting hummingbirds. There is an outdoor dining set. Steps from cafés, galleries, parks, metro, and nightlife, yet quiet and tucked away. Only one neighbor on site. Private parking. Thoughtfully decorated with pieces from local artisans.

The bungalow is nestled among lush greenery, with tall trees and vibrant plants surrounding its entrance. A private parking space is visible in front, and the structure features a light-colored exterior with a welcoming porch. The clear blue sky adds to the serene atmosphere.
Guesthouse in Panama City
4.74 out of 5 average rating, 84 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park.  A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the  privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

A modern living space is outlined with light colors and simple furnishings. A wall-mounted TV is positioned above a low cabinet, while a cozy sofa bed is accompanied by a decorative pillow. Large sliding glass doors invite natural light and provide views of the outdoor patio area.
Guesthouse in Panamá

Trendy Tiny Apartment in Ancon

Nestled in the former Canal Zone, this cozy apartment offers comfort, nature, and city access. Near the City of Knowledge, The Panama Canal and Albrook, it’s perfect for exploring history and culture. We proudly welcome LGBTQ+ travelers and allies to a safe, inclusive space where you can relax and feel at home. Whether you're a solo traveler, a couple, or a digital nomad, you’ll find a warm, affirming environment here. Enjoy tropical hikes, city views, and local events. 🌈

Superhost
A cozy sleeping area features a spacious bed with neutral-toned bedding, complemented by a textured throw. A small workspace with a table and chair is positioned nearby. A wardrobe provides storage, and light enters through a window with simple coverings. Air conditioning unit is mounted on the wall.
Guesthouse in Panamá
4.71 out of 5 average rating, 7 reviews

The Black Studio by SS • near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Top guest favorite
Guesthouse in Panamá
4.76 out of 5 average rating, 246 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Superhost
The kitchen features modern appliances, including a stainless steel gas stove and a white refrigerator. A compact sink is positioned beneath a small window, while kitchen essentials are arranged along a shelf above. Counter space is available for meal preparation, complemented by subtle wall tiles.
Guesthouse in Panamá
4.5 out of 5 average rating, 16 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

A small private pool is surrounded by lush greenery, creating a serene atmosphere. Large glass doors lead into the interior space, framed by decorative vases on either side. The pool area features a textured concrete deck, enhancing the connection with the tropical environment.
Guesthouse in Panamá
4.8 out of 5 average rating, 85 reviews

Cool Guesthouse + WiFi + Pool + TV + AC @ Panama Canal

✔️Superhost Verified! Your stay will be in the best hands Guest House, Close to the City of Knowledge 🇵🇦 📍 In the tropical forest of the ancient Clayton base, with amenities, parks, sports and gastronomy. Close to town, shopping malls, Miraflores Locks and the Transoceanic Railway🇵🇦 We offer: 💧 Hot Water 📶 Wi-Fi. ❄️ AC 🏊‍♂️ Swimming pool 📺 TV Smart y Cable 🚗Carport This strategic location, with a high level of security in the area.

Guest favorite
A small seating area is visible outside the entrance, featuring two black metal chairs positioned on tiled flooring. Nearby, a plant is displayed on a low table, while decorative plants add a green touch to the surrounding space. A large window lets in natural light.
Guesthouse in Panamá
4.93 out of 5 average rating, 42 reviews

CASA PINO, a forest in the city

Excellent independent studio apartment with everything you need, private bathroom, kitchenette, fridge, and WiFi. Very safe. You can use machines in the park to exercise. We are located in a privileged area on the banks of the Canal, with lots of vegetation and forests, but very close to all the recreational amenities of the City of Knowledge. Very central, 10 minutes by metro-bus to Albrook Mall, 10 minutes from the Panama Canal.

A cozy studio area features a spacious bed with a striped blanket. A small round table with two chairs is situated near a window adorned with dark curtains. A television stands on a dresser, and a door leads to a closet space. An air conditioning unit is mounted on the wall.
Guesthouse in Panamá
4.79 out of 5 average rating, 19 reviews

Private studio-type annex near Costa del Este

Very nice little annex and cozy studio type (all in a single area) very cozy super nice, clean. Adjacent to our house, private and independent with all the comforts inside it for your stay , with split air conditioning, smart TV, wifi,spacious shower bathroom with hot water, kitchen with all its appliances, parking area. Located in a very quiet residential area, very good area. Great location. A few minutes from the East Coast.

Guest favorite
The image captures a tranquil sunset above the ocean, with the sun casting golden reflections on the water. A small, dark table and two chairs sit beside a salt-water pool, surrounded by tropical foliage, creating a serene and peaceful setting.
Guesthouse in Veracruz
4.94 out of 5 average rating, 18 reviews

2 bedrooms in tropical garden

Quiet sleep surrounded by lush greenery 20 minutes from Panama spacious accommodation suitable for 2 couples or family of 4 people 1 queen bed and 2 twins with each en-suite private bathroom, provision of an umbrella bed Rest room hammock , equipped kitchen dining room, a saltwater pool to entertain you facing the ocean whose only users you are surrounded by a large garden Workspace with fast wifi Water sports, hiking nearby

Guest favorite
A well-lit bedroom features a spacious bed dressed in a light quilt. Two bedside tables with lamps sit on either side. Blue decorative pillows add a pop of color against the neutral walls, while an air conditioning unit and a vibrant artwork piece enhance the atmosphere.
Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City
5 out of 5 average rating, 27 reviews

Apartment in a safe residential area

You will be Close to everything when you stay in this central home. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, on the way to Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether traveling for business, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We're available if you need any additional information.

Guest favorite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Gamboa
4.87 out of 5 average rating, 71 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet and central accommodation. Close to sights such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

Popular amenities for Panama City guesthouse rentals

Quick stats about guesthouse rentals in Panama City

  • Total vacation rentals

    Explore 80 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

  • Verified guest reviews

    Over 1,490 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    70 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore