
Guesthouse vacation rentals in Panama City
Find and book unique guesthouse rentals on Airbnb
Quick stats about guesthouse rentals in Panama City

Total vacation rentals
Explore 90 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at ﺩ.ﺇ 37 per night before taxes and fees

Verified guest reviews
Over 1,890 verified reviews to help you choose

Family-friendly vacation rentals
10 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 20 rentals that welcome pets

Vacation rentals with a pool
10 properties feature pools

Rentals with dedicated workspaces
30 properties have a dedicated workspace

Wi-Fi availability
80 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Kitchen, Wifi, and Pool across Panama City rentals

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Top-rated guesthouse rentals in Panama City
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Unique find: central+urban+ huge green yard+safe
Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated to help you feel at home. The space not suitable for children under 12.

Efficiency Bungalow - Metropolitan Natural Park
Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park. A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Chagres River Lodge
You stay in our guest house on the River Chagres, in the village Santa Rosa. it is a stone house with a beautiful Panama rancho over it, so the house stays nice and cool. In our garden you have large trees with many birds such as parrots. We have a sloth in the tree. In the morning you can hear the monkeys on the other side and you can explore the area with the canoe. Or take a dip in the river to cool off. A boat to Gamboa or the Panama Canal is a 20 minute boat ride.

Garden Cottage in Panama City
Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

The Mexican
La Mexicana in Altos de Cerro Azul 🏔️🌵 Rustic 2-story getaway for 16+ people. 5 bedrooms, 4 bathrooms, equipped kitchen, Wi-Fi and TV. Pet friendly! 🐾 Enjoy the extensive garden, terrace with hammocks, barbecue and dominoes table. Campfire nights in the indoor fireplace and adventure days on nearby rivers and trails. The authentic Mexican "vibe" in the coolness of the mountain. Ideal for large groups looking to disconnect in total comfort. Book your trip!

Smart Stay by SS • Budget Studio 5+ Airport & Mall
Affordable studio just 11minutes from Tocumen Airport and very close to the Panapark Free Zone, making it ideal for both business and transit travelers. The space offers Wi-Fi, a TV with Netflix, and is surrounded by supermarkets and stores. It’s a simple, private, and comfortable place to rest. ✅Perfect for engineers and business travelers looking for a good, nice, and affordable place. ✔ Fast Internet ✔ Self check-in ✔ Modern and secure spaces ✔ A/C

Convenient, centrally located suite with parking
This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Ancon Garden Studio - Panama City | Fast WiFi
Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.

Cool Guesthouse + WiFi + Pool + TV + AC @ Panama Canal
✔️Verified Superhost! Your stay will be in the best hands Guest house, Near the City of Knowledge 🇵🇦 📍 In the tropical forest of the old Clayton base, with amenities, parks, sports and gastronomy. Close to the city, shopping malls, the Miraflores Locks and the transoceanic railway🇵🇦 We offer: 💧 Hot Water 📶 Wifi ❄️ AC 🏊♂️ Pool 📺 Smart TV and Cable 🚗Parking This strategic location, with a high level of security in the area.

Apartment in a safe residential area
You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.

For 4 people, 2 separate bedrooms in the park
Quiet sleep surrounded by lush greenery 20 minutes from Panama spacious accommodation suitable for 2 couples or family of 4 people 1 queen bed and 2 twins with each en-suite private bathroom, provision of an umbrella bed Rest room hammock , equipped kitchen dining room, a saltwater pool to entertain you facing the ocean whose only users you are surrounded by a large garden Workspace with fast wifi Water sports, hiking nearby

Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
Popular amenities for Panama City guesthouse rentals
Family-friendly guest house rentals

Casa Relic - Room #4 Mixed Dormitory

Spectacular double room for 4 people

CY7 l Private room with terrace

CY1 l Private-entrance room in Marbella

CY5 l Private room in Marbella

Private Ensuite Room

CY8 l Private room in Marbella

Private Room in Smart Hostel
Guest house rentals with a patio

Guesthouse by the river, 2 full beds

Bedroom#6+kitchen+WiFi+A/C+Close to the subway

Airport Studio 1 by SS-affordable stay 5 min AIRPT

Room+Parking+TV+Kitchen+Work Area+WiFi@PanamáCity

CY4 l Private room in Marbella

Quiet bedroom 15 minutes from the airport

Private suite

Comfortable room with air
Guest house rentals with a washer and dryer

Hot tub | Sauna | BBQ | Hiking

Mountain Haven | Calm & Romance

Where Rosie 500 per month

Private Ocean-View Room in Premium Balboa Building

WHERE YOYI

Smart Stay by SS • Budget Studio 3+ Airport & Mall

Room, nature, sauna and eveything, near the sea.

The Black Studio by SS • near airport & city
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