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Guesthouse vacation rentals in Panama City

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in Panama City

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guesthouse in El Cangrejo
4.77 out of 5 average rating, 30 reviews

Unique find: central+urban+ huge green yard+safe

Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated to help you feel at home. The space not suitable for children under 12.

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Guesthouse in Panama City
4.76 out of 5 average rating, 91 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park.  A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the  privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Top guest favorite
Guesthouse in Panamá
4.77 out of 5 average rating, 259 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Guesthouse in Panamá
5 out of 5 average rating, 3 reviews

The Mexican

La Mexicana in Altos de Cerro Azul 🏔️🌵 Rustic 2-story getaway for 16+ people. 5 bedrooms, 4 bathrooms, equipped kitchen, Wi-Fi and TV. Pet friendly! 🐾 Enjoy the extensive garden, terrace with hammocks, barbecue and dominoes table. Campfire nights in the indoor fireplace and adventure days on nearby rivers and trails. The authentic Mexican "vibe" in the coolness of the mountain. Ideal for large groups looking to disconnect in total comfort. Book your trip!

Guest favorite
Guesthouse in Panamá
4.8 out of 5 average rating, 5 reviews

Smart Stay by SS • Budget Studio 5+ Airport & Mall

Affordable studio just 11minutes from Tocumen Airport and very close to the Panapark Free Zone, making it ideal for both business and transit travelers. The space offers Wi-Fi, a TV with Netflix, and is surrounded by supermarkets and stores. It’s a simple, private, and comfortable place to rest. ✅Perfect for engineers and business travelers looking for a good, nice, and affordable place. ✔ Fast Internet ✔ Self check-in ✔ Modern and secure spaces ✔ A/C

The kitchen features modern appliances, including a stainless steel gas stove and a white refrigerator. A compact sink is positioned beneath a small window, while kitchen essentials are arranged along a shelf above. Counter space is available for meal preparation, complemented by subtle wall tiles.
Guesthouse in Panamá
4.53 out of 5 average rating, 17 reviews

Convenient, centrally located suite with parking

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Superhost
Guesthouse in Ancon

Ancon Garden Studio - Panama City | Fast WiFi

Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.

A spacious outdoor area is presented with artificial grass, illuminated by soft string lights above. A partially covered section features a portable mat on the ground, surrounded by tropical plants and pathways, creating a serene environment for relaxation.
Guesthouse in Panamá
4.76 out of 5 average rating, 87 reviews

Cool Guesthouse + WiFi + Pool + TV + AC @ Panama Canal

✔️Verified Superhost! Your stay will be in the best hands Guest house, Near the City of Knowledge 🇵🇦 📍 In the tropical forest of the old Clayton base, with amenities, parks, sports and gastronomy. Close to the city, shopping malls, the Miraflores Locks and the transoceanic railway🇵🇦 We offer: 💧 Hot Water 📶 Wifi ❄️ AC 🏊‍♂️ Pool 📺 Smart TV and Cable 🚗Parking This strategic location, with a high level of security in the area.

Guest favorite
A welcoming porch features two light-colored chairs placed on a textured tiled floor. Elegant columns support a covered entryway, and green plants in pots add a touch of nature. A wooden door with a decorative design is centered behind the columns.
Guesthouse in Distrito San Miguelito, Brisas del Golf, Panama City
5 out of 5 average rating, 30 reviews

Apartment in a safe residential area

You'll be close to everything when you stay at this centrally located accommodation. About 20 minutes from Tocumen Airport, 15 minutes from Romel Stadium, passing through Colon Free Zone near shops, restaurants, pharmacies, supermarkets, cinemas, easy transportation. Whether the trip is for work, as a tourist, or in transit through Panama, you can be comfortable in this apartment. We are available if you need additional information.

Guest favorite
Guesthouse in Balboa
4.84 out of 5 average rating, 122 reviews

Private guest house in Ancón

Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.

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Guesthouse in Panama City
4.88 out of 5 average rating, 256 reviews

Boho Studio - Private Terrace 9 km from airport

Perfect for 1–2 guests, Wifi, quiet terrace, separate room, has A/C, and its small bathroom. Located near Tocumen International Airport, 10 to 13 minutes by car. The Studio is close to 2 Shopping Centers, Metromall and Los Pueblos OUTLET. The residential area is safe to walk, organized and clean streets. We have the Cerro Viento Metro station outside in Metromall.

A relaxing hot tub is set in a serene outdoor space, surrounded by lush greenery. Soft lighting hangs above, creating a calming ambiance. A wooden deck complements the tub, enhancing the inviting feel of the area.
Guesthouse in Rousseau
4.58 out of 5 average rating, 31 reviews

Cozy apartment with a hot tub

In this accommodation you can breathe tranquility: relax with the whole family! It is located 20 minutes from the Miraflores Locks of the Panama Canal, In the residential complex we have the Riba Smith supermarket, restaurants such as Nacion Sushi, Farmacias Arrocha and activities such as a pleasant ecological walk. This is the second floor

Popular amenities for Panama City guesthouse rentals

Quick stats about guesthouse rentals in Panama City

  • Total vacation rentals

    Explore 90 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

  • Verified guest reviews

    Over 1,890 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Vacation rentals with a pool

    10 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    80 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore