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House vacation rentals in Panama City

Find and book unique houses on Airbnb

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Superhost
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panamá
4.87 out of 5 average rating, 105 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Top guest favorite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Cerro Ancón
4.89 out of 5 average rating, 104 reviews

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.98 out of 5 average rating, 81 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost
An inviting entryway leads into a spacious dining area with a large table surrounded by upholstered chairs. Natural light floods in from windows, illuminating the light-colored stone floors and emphasizing the open design of the modern kitchen visible in the background.
Home in Panamá
5 out of 5 average rating, 4 reviews

Designer Canal Home - Med or Longterm

Welcome to our little oasis in Panama City's historic Canal Zone! Our home has recently undergone a spectacular renovation with features that set it apart from other canal homes: luxury stone floors, tall ceilings, and an open, modern kitchen. It's the perfect retreat for someone who wants to be in the city but still surrounded by parks and wildlife. Note that we are ideally looking for guests who will stay for a month or more and would consider longer term tenancies if the fit were right.

Guest favorite
A spacious living room features a bright yellow sofa and a flat-screen TV. An open-concept layout leads to a dining area with a table and chairs, alongside a well-equipped kitchen visible in the background. Large windows provide natural light and views of the lush surroundings.
Home in Panamá
4.87 out of 5 average rating, 15 reviews

Family-Friendly Panama Canal Home with Fenced Yard

Welcome to our 3-bedroom vacation rental in Cardenas, Panama Canal area! Perfect for families, this home boasts a kitchen with quality appliances, including a 6-burner gas stove and a large fridge. Relax in stylish bedrooms, featuring a king suite with a private bath, and enjoy the lush surroundings filled with wildlife. Located next to a park with sports courts, this kid-friendly neighborhood offers outdoor fun. Experience the unique blend of comfort and nature right at your doorstep!

Guest favorite
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in Punta Paitilla
4.77 out of 5 average rating, 115 reviews

Large Private Residence in an Excellent Area

House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Guest favorite
A spacious bedroom is highlighted by a large bed featuring neutral bedding. Natural light flows through expansive windows that provide views of the surrounding greenery. Two bedside lamps and a seating area with a chair add functionality to the space, creating a serene retreat.
Home in Panamá
4.92 out of 5 average rating, 13 reviews

House of the waterfalls

Your ideal escape: A hidden refuge in the Panamanian capital. Harmony between waterfalls and urban comfort. Rest in a natural environment, minutes away from everything. Wake up to birdsong and the relaxing sound of water. To make your stay more pleasant, we offer a swimming pool, pool table, board games, campfire area, spacious and equipped kitchen, three cozy rooms with private bathrooms. Enjoy a country experience to contemplate, share, or simply disconnect.

Superhost
Home in Panamá
4.86 out of 5 average rating, 72 reviews

Spacious Family House Airport

Just 6 minutes from Tocumen International Airport, our comfortable house is an excellent option to rest and relax, a safe and quiet place, you have a 24-hour Supermarket with a Restaurant and Pharmacy 2 minutes away, 3 minutes from Tocumen Hospital and the Metro Station, 10 minutes from Los Pueblos Shopping Center and Metromall. In our house you can enjoy 3 bedrooms, 2 bathrooms, A/C, a large terrace, private parking, an equipped kitchen, Wi-Fi and Netflix.

Superhost
A lush green lawn showcases well-maintained grass, framed by tropical plants with vibrant yellow leaves. In the background, a spacious outdoor area is visible, featuring a covered seating area. Hammocks are gently swaying, inviting relaxation amidst the natural surroundings.
Home in Panamá
4.81 out of 5 average rating, 53 reviews

Wonderful nature

Enjoy a family retreat in the heart of nature, where tranquility envelops you. This cozy accommodation, surrounded by a beautiful garden in the Metropolitan Natural Park, offers you a unique escape just 3 minutes from Albrook Mall and 5 minutes from downtown. Wake up to birdsong and a visit from the ñeques (agoutis), while relaxing in an exclusive and lively atmosphere. The perfect getaway to disconnect and enjoy nature with all the amenities!

Top guest favorite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in Panama City
4.83 out of 5 average rating, 123 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in Panamá
4.92 out of 5 average rating, 163 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favorite
Home in Panamá
4.94 out of 5 average rating, 411 reviews

Private Studio 10 Min from the Airport!

Apartamento Entero 10 MINUTES FROM the Airport! The apartment is fully furnished, including appliances and kitchenware, toiletries, a living/dining room, a work table, and more. Only a few minutes' walk to the SAN ANTONIO METRO Station and METROMALL. We offer tours to San Blas - Tours to Monkey Island and the Panama Canal to help you make the most of your trip. Our home is Your home in Panama 🇵🇦

Popular amenities for Panama City house rentals

Quick stats about house rentals in Panama City

  • Total vacation rentals

    Explore 490 vacation rentals in Panama City

  • Verified guest reviews

    Over 7,960 verified reviews to help you choose

  • Family-friendly vacation rentals

    200 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 170 rentals that welcome pets

  • Vacation rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    230 properties have a dedicated workspace

  • Wi-Fi availability

    460 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Destinations to explore

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