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House vacation rentals in Panama City

Find and book unique houses on Airbnb

Quick stats about house rentals in Panama City

  • Total vacation rentals

    Explore 490 vacation rentals in Panama City

  • Verified guest reviews

    Over 7,960 verified reviews to help you choose

  • Family-friendly vacation rentals

    200 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 170 rentals that welcome pets

  • Vacation rentals with a pool

    90 properties feature pools

  • Rentals with dedicated workspaces

    230 properties have a dedicated workspace

  • Wi-Fi availability

    460 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • 4.7 Average rating

    Panama City stays receive an average rating of 4.7 out of 5 from guests

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite
The exterior of a two-story residence is shown, featuring a classic design with a stone façade and wooden accents. Lush greenery surrounds the entrance, where steps lead to the upper level. Two friendly dogs can be seen in the foreground, adding a welcoming touch to the scene.
Home in Panamá
4.88 out of 5 average rating, 104 reviews

Central|Confort|surrounded by nature|Wifi|parking

Conectar con la ciudad y la maravillosa naturaleza al mismo tiempo. Descansar en una hamaca en el balcón lo hace único. Te quedará genial si deseas visitarnos de placer, trabajo (WiFi de alta velocidad); en familia o en grupos de amigos. Casa de la Antigua Zona del Canal, Primer Alto; desde aquí para explorar lugares turísticos y restaurantes. (Cerca Terminal de Buses, Metro Tren, Albrook Mall, parque Metropolitano, Aeropuerto Marcos Gelabert, Casco Antiguo, Coast Way de Amador, Canal de 🇵🇦)

Top guest favorite
The image showcases the exterior of a two-story house, framed by lush greenery. Sunlight filters through trees, highlighting the white façade and green shutters. A covered area is visible at the front, along with a gated fence that adds security to the property.
Home in Panamá
4.89 out of 5 average rating, 103 reviews

3BR Home in Ancon Hill - Urban Oasis

Discover our home at Ancon Hill in Panama City, steps from Supreme Court. The hill offers scenic hiking trails to the top with city views, lush greenery, and wildlife. 5 min to Albrook Mall. 10 min to Casco Viejo (UNESCO site, restaurants, museums, nightlife), Amador Causeway, Cinta Costera, Metropolitan Park, Panama Convention Center, and Albrook Airport. 20 min to Panama Canal Miraflores Locks and Veracruz beach (across Bridge of Americas, gateway to countryside). 35 min to Tocumen Airport.

Guest favorite
A stone pathway leads through lush tropical foliage toward a welcoming entrance. Tall trees and vibrant greenery frame the path, creating a serene approach to the property, which is partially visible in the background, surrounded by nature's tranquility.
Home in Panama City
4.98 out of 5 average rating, 80 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost
A stack of large wooden blocks is positioned in the backyard, complemented by a cheerful yellow rubber duck atop the structure. Lush greenery and ornamental plants line the background, creating a vibrant atmosphere in the well-maintained garden.
Home in Bethania
4.84 out of 5 average rating, 44 reviews

King Beds | 4BR | BBQ & Garden | pets ok!

Nestled in a prime central location, this lovely house offers guests unparalleled convenience and uniqueness. Find yourself just a swift 10-minute Uber ride away from the bustling heart of downtown, making exploration and nightlife easily accessible. One of the standout features of our home is the exclusive view of the Metropark, which you can relish from both the backyard and balcony – a serene panorama that's hard to beat. Finally sleep in supreme comfort with king-sized beds featured.

Guest favorite
A spacious living room features a bright yellow sofa and a flat-screen TV. An open-concept layout leads to a dining area with a table and chairs, alongside a well-equipped kitchen visible in the background. Large windows provide natural light and views of the lush surroundings.
Home in Panamá
4.87 out of 5 average rating, 15 reviews

Family-Friendly Panama Canal Home with Fenced Yard

Welcome to our 3-bedroom vacation rental in Cardenas, Panama Canal area! Perfect for families, this home boasts a kitchen with quality appliances, including a 6-burner gas stove and a large fridge. Relax in stylish bedrooms, featuring a king suite with a private bath, and enjoy the lush surroundings filled with wildlife. Located next to a park with sports courts, this kid-friendly neighborhood offers outdoor fun. Experience the unique blend of comfort and nature right at your doorstep!

Superhost
Home in Panama City
4.73 out of 5 average rating, 15 reviews

Villa Flor house

Welcome to Casa Villa Flor — a comfortable and peaceful home located in the quiet San Antonio neighborhood. Conveniently located just 15 minutes from the airport, and within walking distance to MetroMall and the train station, making it easy to explore the area and travel around the city. Perfect for families or groups of up to 6 guests, the home includes: • Air conditioning • High-speed WiFi & Internet • Comfortable living spaces • Quiet residential atmosphere • No smoking

Guest favorite
A two-story residence features a light-colored facade with large windows allowing ample natural light. A spacious garage with a multi-car door is prominently displayed in front. The surrounding area is neatly paved, with a tranquil atmosphere suggested by the absence of heavy traffic.
Home in San Francisco
4.77 out of 5 average rating, 114 reviews

Large Private Residence in an Excellent Area

House in the best area of the country. Very quiet street, central, close to restaurants, pharmacies, mall among others. Large comfortable residence for groups or families. Private parking for up to 2 cars 4 spacious bedrooms, 2 comfortable studios, living room, breakfast room, large terrace. *Kosher Option Available* House in one of the best areas of the country. Very quiet street, central, close to restaurants, pharmacies, mall, and more. Large, comfortable residence for groups.

Guest favorite
A spacious bedroom is highlighted by a large bed featuring neutral bedding. Natural light flows through expansive windows that provide views of the surrounding greenery. Two bedside lamps and a seating area with a chair add functionality to the space, creating a serene retreat.
Home in Panamá
4.92 out of 5 average rating, 13 reviews

House of the waterfalls

Your ideal escape: A hidden refuge in the Panamanian capital. Harmony between waterfalls and urban comfort. Rest in a natural environment, minutes away from everything. Wake up to birdsong and the relaxing sound of water. To make your stay more pleasant, we offer a swimming pool, pool table, board games, campfire area, spacious and equipped kitchen, three cozy rooms with private bathrooms. Enjoy a country experience to contemplate, share, or simply disconnect.

Superhost
Home in Panamá
4.86 out of 5 average rating, 71 reviews

Spacious Family House Airport

Just 6 minutes from Tocumen International Airport, our comfortable house is an excellent option to rest and relax, a safe and quiet place, you have a 24-hour Supermarket with a Restaurant and Pharmacy 2 minutes away, 3 minutes from Tocumen Hospital and the Metro Station, 10 minutes from Los Pueblos Shopping Center and Metromall. In our house you can enjoy 3 bedrooms, 2 bathrooms, A/C, a large terrace, private parking, an equipped kitchen, Wi-Fi and Netflix.

Top guest favorite
A spacious living and dining area is depicted, featuring a blue sectional sofa with yellow accent pillows. A glass dining table with yellow placemats and black chairs is shown. Natural light enters through windows, revealing a glimpse of greenery outside.
Home in San Francisco
4.83 out of 5 average rating, 123 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Guest favorite
A private rooftop terrace offers expansive views of the ocean and skyline. Comfortable seating arrangements include a coffee table and lounge chairs beneath a shaded umbrella. Decorative plants enhance the outdoor space, while string lights provide a warm ambiance during evenings.
Home in San Felipe
4.92 out of 5 average rating, 162 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favorite
Home in Panamá
4.94 out of 5 average rating, 408 reviews

Private Studio 10 Min from the Airport!

Apartamento Entero 10 MINUTES FROM the Airport! The apartment is fully furnished, including appliances and kitchenware, toiletries, a living/dining room, a work table, and more. Only a few minutes' walk to the SAN ANTONIO METRO Station and METROMALL. We offer tours to San Blas - Tours to Monkey Island and the Panama Canal to help you make the most of your trip. Our home is Your home in Panama 🇵🇦

Popular amenities for Panama City house rentals

Destinations to explore

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