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Guesthouse vacation rentals in Panama City

Find and book unique guesthouse rentals on Airbnb

Quick stats about guesthouse rentals in Panama City

  • Total vacation rentals

    Explore 90 vacation rentals in Panama City

  • Nightly prices starting at

    Panama City vacation rentals start at ﺩ.ﺇ 37 per night before taxes and fees

  • Verified guest reviews

    Over 2,070 verified reviews to help you choose

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Vacation rentals with a pool

    20 properties feature pools

  • Rentals with dedicated workspaces

    30 properties have a dedicated workspace

  • Wi-Fi availability

    80 of Panama City vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across Panama City rentals

  • Nearby attractions

    Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)

Top-rated guesthouse rentals in Panama City

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Guest favorite
Guesthouse in El Cangrejo
4.77 out of 5 average rating, 31 reviews

Unique find: central+urban+ huge green yard+safe

Wake up to the sound of birds in this hidden retreat in the heart of the trendy & safe "El Cangrejo" neighborhood. Housed on the ground-floor of a 2-story building built in the 50's. Features a HUGE private green yard, perfect for relaxing or spotting hummingbirds and local critters with an outdoor dining set. Steps from cafés, galleries, parks, metro, nightlife & restaurants. Free Private parking & Fast WiFi. Thoughtfully decorated for a home feel . The space not suitable for children under 10.

A wooden deck is surrounded by tall trees, offering a view of lush green mountains veiled in mist. The area features two benches, inviting guests to enjoy the serene natural surroundings.
Guesthouse in Panama City
4.85 out of 5 average rating, 26 reviews

La cabaña de Alci-Los Altos de cerro Azul" Niebla"

🏡 El Refugio de Alci – “Niebla” Planta baja central de un acogedor chalet familiar, ubicado en el Parque Nacional Chagres, rodeado de ríos, cascadas y bosque. “Niebla” aloja 7 personas+4,+4, en las otras secciones,cuenta con 2habitaciones, 2baños, cocina equipada y rancho central. Balcones con vista al bosque y al riachuelo, sonido relajante. 🌿 Lado derecho 1 casa de huéspedes:(bungalow,Rio)2 hab para 4personas . La casa de huéspedes izq Bosque para 4 personas Objetivo: pagar lo utilizado

Guest favorite
Guesthouse in Panama City
5.0 out of 5 average rating, 16 reviews

Acogedor estudio privado cerca del aeropuerto

Bienvenido a El Rincón de Glenda, un estudio privado acogedor y bien equipado en Vía Tocumen, a pasos del Metro Don Bosco (Línea 2). Ideal para viajeros. Cuenta con 2 camas individuales, sofá, aire acondicionado, TV, mininevera, minicocina con hervidor y estufa, y baño privado con ducha de agua caliente. Se aceptan mascotas. Check-in desde las 3:00 PM y check-out antes de las 12:00 AM. No se permiten fiestas ni fumar en interiores. Tu espacio cómodo, tranquilo y céntrico en Panamá.

Superhost
Guesthouse in Panama City
4.76 out of 5 average rating, 92 reviews

Efficiency Bungalow - Metropolitan Natural Park

Casita Curundu is located in a quiet and beautiful neighborhood next to the Metropolitan Natural Park.  A naturalist delight right in the city, surrounded by an urban jungle forest teeming with birds and wildlife. An amazing place for a couple to stay - you’ll have all the  privacy you need but still be close to all the great attractions and the large shopping and transportation hub Albrook Mall, Airport, Bus & Metro Station and yet removed from the hustle and bustle of the city.

Top guest favorite
Guesthouse in San Francisco
4.77 out of 5 average rating, 263 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Guesthouse in Panama City
5.0 out of 5 average rating, 3 reviews

La mexicana

La Mexicana en Altos de Cerro Azul 🏔️🌵 Escapada rústica de 2 pisos para 16+ personas. 5 habs, 4 baños, cocina equipada, Wi-Fi y TV. ¡Pet friendly! 🐾 Disfruta del jardín extenso, terraza con hamacas, asador y mesa de dominó. Noches de fogata en la chimenea interior y días de aventura en ríos y senderos cercanos. El auténtico "vibe" mexicano en el frescor de la montaña. Ideal para grupos grandes que buscan desconectarse con total comodidad. ¡Reserva tu trip!

Guest favorite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Panama City
4.86 out of 5 average rating, 143 reviews

Casa de huésped privada en Ancón

Disfruta de la sencillez de este acogedor alojamiento tranquilo y céntrico. Cerca de lugares de interés como el edificio de la Administración del Canal de Panamá, Amador Causeway, Albrook Mall, y varios restaurantes. Personalmente decorado para proporcionar comodidad... grandes ventanales en el dormitorio proporcionan iluminación natural y una vista del jardín y el área verde a través de las ventanas; aun así mantiene la privacidad y la tranquilidad deseada.

The kitchen features modern appliances, including a stainless steel gas stove and a white refrigerator. A compact sink is positioned beneath a small window, while kitchen essentials are arranged along a shelf above. Counter space is available for meal preparation, complemented by subtle wall tiles.
Guesthouse in Bethania
4.53 out of 5 average rating, 17 reviews

Conveniente Suite céntrica y con estacionamiento

This special place is close to everything, making it easy to plan your visit. 5-10 minutes to any attraction in Panama City. Assigned parking and two blocks from major bus stop that can take you anywhere in the city or accross the country. You will have the entire place for yourself with independent entry, air conditioning and kitchen. There are four grocery stores walking distance. You can exercise daily at a park located behind the property.

Superhost
Guesthouse in Ancon
5.0 out of 5 average rating, 4 reviews

Ancon Garden Studio - Panama City | Fast WiFi

Nestled in the historic former Canal Zone, this cozy studio is ideal for remote work and easy city access. Enjoy fast WiFi, a dedicated workspace, and a peaceful green setting near Cerro Ancón, the Panama Canal Railway Station, City of Knowledge, and Albrook Metro. Just a short walk away is Los Ríos Pool, a popular swimming facility perfect for lap swimming, exercise, or cooling off after a day of exploring. Also, bikes are available upon request.

Guest favorite
Guesthouse in San Miguelito
5.0 out of 5 average rating, 31 reviews

Apartamento en área residencial segura

Estarás cerca de todo cuando te quedes en este alojamiento céntrico. Alrededor de 20 minutos del aeropuerto de Tocumen, 15minutos de Estadio Romel, de paso para Zona Libre Colón cerca de comercios, restaurantes, farmacias, supermercados, cines, facilidad de transporte. Si el viaje es de trabajo, de turista, o en tránsito por Panamá en este apartamento podrás estar con comodidad. Estamos a su disposición si requiere información adicional.

Guest favorite
Guesthouse in Rufina Alfaro
4.88 out of 5 average rating, 268 reviews

Boho Studio - terraza Privada 9 km aeropuerto

Perfecto para 1–2 huéspedes, Wifi, Terraza privada, studio independiente, cuenta con A/C , y su baño pequeño, entrada autónoma. Ubicado cerca del Aeropuerto Internacional de Tocumen, de 10 a 13 minutos en auto. El Studio está Cerca de 2 Centros Comerciales, Metromall y Los Pueblos OUTLET. La zona residencial es segura al caminar, calles organizadas y limpias. Tenemos la estación del Metro de Cerro Viento afuera en Metromall.

Guest favorite
A tranquil outdoor area showcases a salt-water pool surrounded by lush tropical vegetation. Various palm trees and shrubs provide a natural backdrop. The clear blue sky peeks through the greenery, creating a serene atmosphere for relaxation.
Guesthouse in Veracruz
4.91 out of 5 average rating, 64 reviews

Logement de charme,végétation tropicale,face océan

Détente face a l’océan dans une végétation tropicale, 20 minutes de Panama, proche commerces et transports, chambre spacieuse avec salle de bains individuelle, cuisine équipée, salon extérieur, piscine eau salée.Vous apprécierez de prendre votre petit déjeuner en observant des dizaines d’oiseaux.Pour les amoureux de la nature , calme et décontraction mais aussi randonnées ,plages et sports nautiques.Aucun animal accepté

Popular amenities for Panama City guesthouse rentals

Destinations to explore