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House vacation rentals in La Mesa

Find and book unique houses on Airbnb

Quick stats about house rentals in La Mesa

  • Total vacation rentals

    Explore 320 vacation rentals in La Mesa

  • Nightly prices starting at

    La Mesa vacation rentals start at ﺩ.ﺇ 110 per night before taxes and fees

  • Verified guest reviews

    Over 14,030 verified reviews to help you choose

  • Family-friendly vacation rentals

    210 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 110 rentals that welcome pets

  • Vacation rentals with a pool

    80 properties feature pools

  • Rentals with dedicated workspaces

    190 properties have a dedicated workspace

  • Wi-Fi availability

    320 of La Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across La Mesa rentals

  • 4.9 Average rating

    La Mesa stays are highly rated by guests—averaging 4.9 out of 5!

Top-rated house rentals in La Mesa

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
An outdoor seating area is equipped with sectional sofas arranged around a fire pit, featuring a grassy lawn surrounded by lush greenery. A large tree provides shade, while a spacious porch is visible in the background, contributing to the serene atmosphere.
Home in La Mesa
4.93 out of 5 average rating, 152 reviews

Family Fun! Game Garage + Big Yard + Free Parking

Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

Guest favorite
The property features a spacious backyard with a heated pool surrounded by lounge chairs. Palm trees line the perimeter, and soft lighting illuminates the outdoor area during sunset. The two-story house overlooks the pool, creating an inviting atmosphere for relaxation and gatherings.
Home in La Mesa
4.94 out of 5 average rating, 244 reviews

Family Pool Retreat + Gym, Fire Pits, Views (Sleep

Find your family's dream spot in San Diego! Our cozy house sits on a quiet hill, offering privacy and amazing sunset views. Dive into our pool year-round (heating at an additional cost), roast marshmallows by the fire, and cook up fun meals together. With 3 bedrooms and 2 bathrooms, it’s perfect for families, accommodating up to 9 guests. Plus, we're close to all the best attractions. Want a vacation you'll always remember? Send us a message to make it happen! 🌅🏠 We have 3 comfy beds that can

Guest favorite
A contemporary casita is featured with a neatly landscaped front yard and stone pathway leading to the entrance. A garage is visible to the left, and large windows allow natural light to illuminate the welcoming exterior, which is surrounded by lush greenery.
Home in La Mesa
4.92 out of 5 average rating, 130 reviews

Sunnyside Resort Spa, Beach, Zoo, Arcade

SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe, stylish casita. Check in contactless and enjoy! Cozy, comfy, and a perfect base for exploring the city. Cook your own meal in the alluring kitchen or enjoy your meal at the cute dining area outside. Great for family's or trips with friends! The entire guest house is is 5 minutes from SDSU, 15 minutes from the beach and 15 minutes from downtown San Diego! Enjoy

Superhost
A serene bedside scene features a spacious bed topped with crisp white linens. A modern nightstand stands beside it, holding a decorative white vase with greenery and a stylish lamp providing soft light.
Home in La Mesa
4.87 out of 5 average rating, 273 reviews

5 Bed Zen Oasis | Fire Pit, BBQ, Laundry, Parking

Capture the essence of San Diego in our 3 bedroom house hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 10 guests with beautiful outdoors and garden, fire pit table, BBQ grill, FREE laundry, central A/C and heating, 5 comfortable king and queen size beds, plenty of sheets and towels, 4 large HDTVs, Netflix, Max, Hulu, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

Top guest favorite
A spacious living room features a large sectional sofa with orange accent pillows, complemented by a round coffee table. An island with bar stool seating is visible, along with modern kitchen appliances. Natural light enters through the nearby window, highlighting the warm wood tones of the decor.
Home in La Mesa
4.98 out of 5 average rating, 102 reviews

Cozy Mid-Century Charmer | Huge Backyard | Firepit

Welcome to our renovated mid-century home in La Mesa! Perfect for family or friend getaways, this quiet retreat offers a spacious living room, full kitchen, and a huge private backyard. Enjoy shooting hoops, playing corn hole, or relaxing by the fire pit under the stars. No shared walls between bedrooms ensure added privacy and comfort. Ideal location close to San Diego’s top attractions while nestled in a peaceful neighborhood. 15 minutes drive to Downtown, Zoo, La Mesa Village & beaches

Top guest favorite
A cozy living area features a sleek sofa adorned with decorative pillows. A stylish coffee table is positioned in front of the seating. A light yellow wall provides a warm backdrop, with a shelf displaying decorative plates and art, illuminated by subtle lighting.
Home in La Mesa
4.9 out of 5 average rating, 200 reviews

Classic Mid-Century Mount Helix Home with Views

Located in the exclusive Mount Helix neighborhood of La Mesa, this property is conveniently located near the 8 and 94 freeways for easy access to explore the greater San Diego area. Attractions like the historic Balboa Park with the San Diego Zoo or Sea World are a 15-25 minute drive away. With spacious interior and exterior spaces at the property, though, you may not want to leave. The property includes 4 bedrooms and 2.5 bathrooms with furnished living room, family room and kitchen.

Top guest favorite
A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.
Home in La Mesa
4.93 out of 5 average rating, 242 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

Guest favorite
Home in La Mesa
4.94 out of 5 average rating, 142 reviews

Palm Cottage San Diego

Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

Guest favorite
A comfortable living area with a gray sofa and patterned accent pillows is highlighted by a ceiling fan. Armchairs in a light blue pattern provide additional seating. A coffee table sits centrally on a light area rug, with natural light entering through the window and reflecting off the walls.
Home in La Mesa
4.94 out of 5 average rating, 222 reviews

Charming La Mesa Home

**Home cleaned and disinfected following COVID-19 guidelines provided by CDC/Airbnb** Charming 3 bed, 1 bath. Feel at home with your own private laundry, full size kitchen, spa like bathroom and private office/workspace. This place is perfect for both work and leisure getaways. Walking distance from stores, shops, restaurants, and parks. 3 minutes from Highways 125, 94, and 8. Centrally located and less than 15 minutes from downtown San Diego.

Guest favorite
A private pool is surrounded by a spacious patio, featuring a built-in spa and floating pool accessories. Lounge chairs are arranged by the poolside, while the nearby house is complemented by green shrubbery and playful palm trees. Bright sunlight highlights the inviting blue water.
Home in La Mesa
4.89 out of 5 average rating, 104 reviews

QUIET HOME -3 Bedroom & Den, + POOL, sleep 8 plus

Welcome to the La Mesa Pool House! Our cozy house in La Mesa is the perfect place to relax and recharge with the family. This house is walking distance to many great La Mesa eateries such as Terra Restaurant and Surf and Soul. We are also located just 10 minutes away from San Diego State University and we are less than 20 minutes from all major attractions in San Diego: downtown, Little Italy, Zoo, Sea World, beaches and more!

Top guest favorite
An open-concept living area is highlighted by vaulted ceilings and natural light from large windows. A spacious L-shaped sofa is positioned around a coffee table, facing a wall-mounted TV above a modern fireplace. Nearby, a dining area can be seen through an archway.
Home in El Cajon
4.99 out of 5 average rating, 124 reviews

Spacious & Fun | 5br, 4.5ba | Hot Tub | Views

Experience sunny San Diego from this 5 bedroom, 4.5 bathroom foothill home. Wake up to panoramic views of the surrounding hillsides and gather in the spacious living and dining rooms. The home is conveniently located just 15-20 minutes from San Diego's famous beaches and top attractions. After a day of exploration, unwind in the backyard area featuring a hot tub, fire pit, pool table, and life-sized chessboard.

Top guest favorite
A spacious living area features a large leather sectional sofa positioned around a circular wooden coffee table. A wall-mounted TV is visible above a decorative fireplace, while natural light streams through a large window adorned with sheer curtains. A dining area is seen in the background.
Home in La Mesa
4.89 out of 5 average rating, 130 reviews

Sunny & Spacious 3BR Retreat w/ Parking & A/C

Discover your La Mesa retreat! This newly refurbished home offers a perfect blend of comfort and convenience. Enjoy a gourmet kitchen, stylish dining, three bedrooms, two modern bathrooms, and an expansive yard. Explore nearby attractions like the Grossman Center (10-min walk) with shopping and dining, or venture to San Diego's heart (20-min drive). Perfect for families and groups seeking a relaxing getaway.

Popular amenities for La Mesa house rentals

When is the best time to visit La Mesa?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceﺩ.ﺇ 679ﺩ.ﺇ 720ﺩ.ﺇ 786ﺩ.ﺇ 661ﺩ.ﺇ 676ﺩ.ﺇ 786ﺩ.ﺇ 918ﺩ.ﺇ 775ﺩ.ﺇ 679ﺩ.ﺇ 690ﺩ.ﺇ 720ﺩ.ﺇ 731
Avg. temp15°C15°C16°C17°C18°C20°C21°C22°C22°C20°C17°C14°C

Destinations to explore

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