House vacation rentals in La Mesa

An outdoor seating area is equipped with sectional sofas arranged around a fire pit, featuring a grassy lawn surrounded by lush greenery. A large tree provides shade, while a spacious porch is visible in the background, contributing to the serene atmosphere.

4.94 out of 5 average rating, 163 reviews

Family Fun! Game Garage + Big Yard + Free Parking

Embodying the epitome of cool! This home has the perfect blend of a vintage feel with a modern touch. Stepping inside, you’re greeted by an atmosphere of fun & creativity. A large private serene retreat in the backyard w/abundant seating and fire pit. Huge 3-car garage bonus space with games. Located just minutes from downtown La Mesa, many dining options & conveniences. Everything you need & more! Distance to: San Diego Zoo: 18 min Sea World: 23 min SDSU: 13 min Airport: 19 min Gaslamp: 18 min

A contemporary casita is featured with a neatly landscaped front yard and stone pathway leading to the entrance. A garage is visible to the left, and large windows allow natural light to illuminate the welcoming exterior, which is surrounded by lush greenery.

4.89 out of 5 average rating, 142 reviews

Sunnyside Resort Spa, Beach, Zoo, Arcade

SEND US A MESSAGE FOR SPECIAL OFFER! Imagine booking the most memorable experience with your party! Kick back and relax in a safe, stylish casita. Check in contactless and enjoy! Cozy, comfy, and a perfect base for exploring the city. Cook your own meal in the alluring kitchen or enjoy your meal at the cute dining area outside. Great for family's or trips with friends! The entire guest house is is 5 minutes from SDSU, 15 minutes from the beach and 15 minutes from downtown San Diego! Enjoy

A serene bedside scene features a spacious bed topped with crisp white linens. A modern nightstand stands beside it, holding a decorative white vase with greenery and a stylish lamp providing soft light.

4.85 out of 5 average rating, 283 reviews

5 Bed Zen Oasis | Fire Pit, BBQ, Laundry, Parking

Capture the essence of San Diego in our 3 bedroom house hosted by Ethos Vacation Homes. The peaceful property features elite comfort for up to 10 guests with beautiful outdoors and garden, fire pit table, BBQ grill, FREE laundry, central A/C and heating, 5 comfortable king and queen size beds, plenty of sheets and towels, 4 large HDTVs, Netflix, Max, Hulu, Disney+, Apple+, and ESPN+. This spacious San Diego vacation rental home has everything you need for your California Dreaming Vacation!

4.83 out of 5 average rating, 131 reviews

Large Home Heated Pool Spa | Game Room (Sleeps 30)

Gather your friends and family for the ultimate getaway at this spacious paradise! Featuring a sparkling pool, soothing spa, BBQ pit, and cozy fire pit, there’s endless fun for everyone. The game room is packed with entertainment options, perfect for some friendly competition or unwinding after a day in the sun. Designed to host large groups comfortably, this home is ideal for reunions, celebrations, or just a relaxing escape! This home offers everything you need for an unforgettable stay!

4.91 out of 5 average rating, 105 reviews

A grassy backyard features a shaded hammock suspended between trees and a dining set positioned on the lawn. Sunlight filters through the branches, creating playful shadows on the ground. The surrounding landscape includes tiered stone steps leading to elevated areas, enhancing the outdoor space.

Home in Spring Valley

Beautiful Mid-Century Home on Tree Lined Street!

Beautiful, furnished pet-friendly mid-century 3 bedroom 2 bathroom house in Casa de Oro area on a tree-lined street with stunning views of Mount Helix, less than 2 miles from downtown La Mesa with shops, restaurants, coffee shops, parks, and more. Wood-burning fireplace, new appliances (including dishwasher), laundry room with washer and dryer, central A/C and heat, master suite with private bathroom, large grass front yard and turf back yard with fire pit, BBQ, market lights, and more.

A welcoming living area features a spacious beige sectional sofa adorned with patterned throw pillows. Natural light filters through a large window, complemented by soft, flowing curtains. A dark ottoman with decorative details adds a contrasting element to the cozy space.

4.96 out of 5 average rating, 143 reviews

Zen Retreat: 3-Bedroom Oasis near La Mesa Village

Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

A view into a modern living space reveals a sleek kitchen with bar seating and a spacious dining area. Natural light floods the room through large glass doors, showcasing lush greenery outside. A cozy area is completed with a colorful rug beneath and a inviting seating arrangement.

4.94 out of 5 average rating, 251 reviews

Cottage in the Garden! New! Modern!

COTTAGE IN THE GARDEN - New! Modern! Find beauty and serenity in this special guest house in one of San Diego's most desirable areas! Flowering bushes, plants, olive tree and fruit trees seen from all windows. All amenities: WiFi, Cable, serving dishes and tableware, full coffee bar, Ninja Blender, Flat screen TVs, 100% Egyptian Cotton Sheets or Boll and Branch Sheets (used by 3 Presidents), Japanese Toilette and more. 15 minutes to Downtown San Diego and 20 minutes to the beach!

A colorful studio space features turquoise walls and a ceiling fan. A comfortable sofa with decorative pillows is paired with a coffee table. A bed with a floral-patterned comforter sits against a window, while a TV and white refrigerator complete the modern setup.

4.99 out of 5 average rating, 360 reviews

SDCannaBnB #2 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental! Our studio is newly remodeled with luxury ammenities. We proudly cater to the cannabis community and non-users alike. Our studio has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest. This ensures that every guest checks into a clean, fresh-smelling place that feels like home. Our studio is located in our quiet, fully fenced in backyard, close to San Diego's attractions

A spacious outdoor area features a swimming pool, accompanied by colorful lounge chairs and a large umbrella for shade. A unicorn float is visible in the water, with potted flowers adding a touch of vibrancy. The home's façade offers multiple windows and seating options nearby.

4.99 out of 5 average rating, 205 reviews

Mid-Century Style Family House with Spa

This home is the epitome of 1950’s luxury. A perfect family oasis, you won’t even want to leave the property. Beautiful Mt. Helix mid-century modern family home with incredible views, designed by architect of original Las Vegas Desert Inn situated on nearly an acre. Less than 20 minute drive to beaches/Zoo/Sea World/Downtown. With a swimming pool, jacuzzi, and AC. Surrounded by orange, lemon, pomegranate trees and herb garden. No loud parties please, this is a quiet community.

4.94 out of 5 average rating, 150 reviews

Palm Cottage San Diego

Palm Cottage sits in the heart of La Mesa Village, San Diego. Enjoy the charm of a historic home with a fully remodeled and stylish interior featuring both Dutch & French doors letting in plenty of sunshine. A large private yard w/ covered outdoor living area creates the ultimate indoor/outdoor lifestyle. You're steps from the local grocery store, village shopping, coffee shops, restaurants, bars and the trolley. You could not ask for a better location!

4.97 out of 5 average rating, 401 reviews

A spacious backyard is illuminated by string lights, creating a warm ambiance. Lush greenery, including tall palm trees and banana plants, frames the area. A wooden deck provides an outdoor seating space, while comfortable patio furniture is visible nearby. The sky displays soft pastel colors at twilight.

Home in Del Cerro

SDSU Beach Cottage

Welcome to our charming SDSU Beach Cottage! Centrally located in a desirable San Diego neighborhood, you're just 10 minutes from many of the city's top attractions. Steps away, you'll find popular local dining, a wine bar, pub, natural market, pizza shop, nail salon, liquor store, and Einstein Bros. Bagels. Enjoy San Diego's best or unwind in our tropical backyard featuring outdoor games and ping pong. Minimum age to book: 25.

An open-concept living area is highlighted by vaulted ceilings and natural light from large windows. A spacious L-shaped sofa is positioned around a coffee table, facing a wall-mounted TV above a modern fireplace. Nearby, a dining area can be seen through an archway.

4.99 out of 5 average rating, 133 reviews

Spacious & Fun | 5br, 4.5ba | Hot Tub | Views

Experience sunny San Diego from this 5 bedroom, 4.5 bathroom foothill home. Wake up to panoramic views of the surrounding hillsides and gather in the spacious living and dining rooms. The home is conveniently located just 15-20 minutes from San Diego's famous beaches and top attractions. After a day of exploration, unwind in the backyard area featuring a hot tub, fire pit, pool table, and life-sized chessboard.

Popular amenities for La Mesa house rentals

Kitchen

Wifi

Pool

Free parking on premises

Air conditioning

House rentals with a pool

A private pool is surrounded by a spacious patio, featuring a built-in spa and floating pool accessories. Lounge chairs are arranged by the poolside, while the nearby house is complemented by green shrubbery and playful palm trees. Bright sunlight highlights the inviting blue water.

4.9 out of 5 average rating, 115 reviews

QUIET HOME -3 Bedroom & Den, + POOL, sleep 8 plus

4.92 out of 5 average rating, 102 reviews

A dining area is highlighted by a round wooden table surrounded by six wooden chairs. A cozy blue sofa is positioned nearby, with large glass doors opening to a pool area. Natural light enhances the space, complemented by a modern pendant light overhead.

Home in San Diego

San Diego Oasis- A Retro Retreat w/ King Size Bed!

4.9 out of 5 average rating, 116 reviews

*NO TAX*/Heated Pool/Hot Tub/Pizza Oven/Playground

4.96 out of 5 average rating, 179 reviews

Beautiful 3,000 Sq Ft Tropical Oasis

A spacious outdoor area features a clear blue pool surrounded by palm trees. Lounge chairs are positioned nearby, and a shaded table with chairs offers a spot for relaxation. The backyard showcases a privacy fence and ample sunlight.

4.85 out of 5 average rating, 264 reviews

San Diego Pool | Fire Pit | Sunshine | Sleeps 10

The property features a spacious backyard with a heated pool surrounded by lounge chairs. Palm trees line the perimeter, and soft lighting illuminates the outdoor area during sunset. The two-story house overlooks the pool, creating an inviting atmosphere for relaxation and gatherings.

4.93 out of 5 average rating, 252 reviews

Family Pool Retreat + Gym, Fire Pits, Views (Sleep

A serene outdoor pool area features a refreshing blue pool surrounded by terracotta tiles. Two lounge chairs are positioned nearby, inviting relaxation. A wooden fence offers privacy while views of the landscape and sky are visible in the background, creating a tranquil atmosphere.

4.81 out of 5 average rating, 104 reviews

The Agave House | Mountain Views & Pool

4.96 out of 5 average rating, 227 reviews

A dining space features a round table with four white chairs, complemented by a potted plant. Large glass doors slide open to reveal expansive views of the backyard, pool, and surrounding hills, with soft evening light illuminating the scene.

Home in Spring Valley

Upscale Resort House /Views, Saltwater Pool/Spa !

Weekly house rentals

4.9 out of 5 average rating, 126 reviews

Home in San Diego

Sleeps 16 | Hot Tub & Fire Pit | 5BR Reunion Home

4.85 out of 5 average rating, 427 reviews

Cozy 4bd Family Home near all SD Attractions!

An outdoor patio area features a round table with four chairs, all adorned with colorful cushions. A large red umbrella provides shade, and a decorative rug adds vibrancy to the stone surface. Surrounding greenery and blooming plants create a serene environment.

4.98 out of 5 average rating, 341 reviews

Travel Writer's Pad

4.99 out of 5 average rating, 156 reviews

The exterior of a modern two-story home is displayed, featuring solar panels on the roof. Brightly lit outdoor spaces are landscaped with greenery, leading to a cozy seating area near a stylish outdoor fireplace.

Home in San Diego

Newly Built Upscale Home with 5 Bedrooms/6 Baths

4.98 out of 5 average rating, 105 reviews

A serene outdoor seating area features two cushioned chairs and a small table, overlooking a panoramic view of the landscape. Lush greenery is framed by palm trees, enhancing the tranquil atmosphere under a clear blue sky.

Home in Del Cerro

The Home with The View

An inviting game room is highlighted by a polished pool table, surrounded by warm wooden beams overhead. A modern kitchen area is visible, featuring sleek appliances. Nearby, a laundry area is equipped with stacked machines, creating a functional and comfortable space for relaxation and entertainment.

4.96 out of 5 average rating, 101 reviews

San Diego Retreat ·Jacuzzi + Billiards +Sleeps 12!

The kitchen area features modern black cabinetry and stainless steel appliances, including a microwave and compact refrigerator. A smart TV is mounted on the wall, complementing the wooden counter workspace equipped with essential cooking utensils. A dining table with two chairs is positioned nearby.

4.86 out of 5 average rating, 273 reviews

Newer "Manor Studio"

A cozy living area features a sleek sofa adorned with decorative pillows. A stylish coffee table is positioned in front of the seating. A light yellow wall provides a warm backdrop, with a shelf displaying decorative plates and art, illuminated by subtle lighting.

4.9 out of 5 average rating, 206 reviews

Classic Mid-Century Mount Helix Home with Views

Private house rentals

A welcoming porch area features comfortable outdoor seating, with a sleek coffee table placed between black wicker couches. Potted plants add greenery to the space, while a ceiling fan hangs above. The porch is accessible and provides a view of the surrounding area.

4.92 out of 5 average rating, 60 reviews

Oliver House in La Mesa

4.97 out of 5 average rating, 29 reviews

Sunny La Mesa Home w/ Pool & Spa | Family Friendly

A cozy outdoor seating area features two white Adirondack chairs positioned beside a small round table. The inviting entryway of the tiny home is visible, surrounded by lush greenery and trees, creating a peaceful and refreshing environment.

5.0 out of 5 average rating, 55 reviews

Tiny Home with a View

4.94 out of 5 average rating, 85 reviews

Downtown La Mesa gem

4.92 out of 5 average rating, 37 reviews

Panoramic Ocean View Retreat - Family Friendly

5.0 out of 5 average rating, 28 reviews

Bali-Style Tropical Retreat w/sauna & Cabana Bar

5.0 out of 5 average rating, 24 reviews

La Mesa Retreat | Hot Tub | Fire Pit | Longer stay