House vacation rentals in La Mesa

Find and book unique houses on Airbnb

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Popular amenities for La Mesa house rentals

House rentals with a pool

Guest favorite

Home in La Mesa

4.93 out of 5 average rating, 107 reviews

Updated TownHome, Great Location, Fantastic Views

Jan 15 – 22

ﺩ.ﺇ749 per night
Superhost

Home in La Mesa

4.81 out of 5 average rating, 133 reviews

Sunny SD/La Mesa Updated '24-Pool-4 bed-Sleeps 10

Oct 20 – 27

ﺩ.ﺇ1,581 per night
Guest favorite

Home in La Mesa

4.87 out of 5 average rating, 131 reviews

The Queen House

Nov 23 – 30

ﺩ.ﺇ1,785 per night
Guest favorite

Home in San Diego

5.0 out of 5 average rating, 140 reviews

Midcentury Lux 4BR home with Pool, Spa & Cabana

Feb 12 – 19

ﺩ.ﺇ3,438 per night
Guest favorite

Home in San Diego

4.9 out of 5 average rating, 117 reviews

San Diego Getaway W/Pool & Hot tub! Sleeps 8!

Apr 12 – 19

ﺩ.ﺇ1,476 per night
Superhost

Home in San Diego

4.87 out of 5 average rating, 143 reviews

Bright and spacious home with views, pool & spa.

Aug 18 – 25

ﺩ.ﺇ2,910 per night
Guest favorite

Home in El Cajon

4.97 out of 5 average rating, 134 reviews

Beautiful 3,000 Sq Ft Tropical Oasis

Oct 4 – 11

ﺩ.ﺇ1,697 per night
Guest favorite

Home in San Diego

4.98 out of 5 average rating, 240 reviews

Resort Style Living with Pool, Spa, and Bay Views!

Oct 23 – 30

ﺩ.ﺇ3,031 per night

Quick stats about house rentals in La Mesa

  • Total rentals

    280 properties

  • Rentals with dedicated workspaces

    170 properties have a dedicated workspace

  • Rentals with a pool

    80 properties have a pool

  • Pet-friendly rentals

    90 properties allow pets

  • Family-friendly rentals

    190 properties are a good fit for families

  • Total number of reviews

    9.5K reviews

Destinations to explore

  1. Airbnb
  2. United States
  3. California
  4. San Diego County
  5. La Mesa
  6. House rentals