Villa vacation rentals in La Mesa

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Top-rated villa rentals in La Mesa

Guests agree: these villas are highly rated for location, cleanliness, and more.

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Guest favorite

Villa in Otay Mesa

4.94 out of 5 average rating, 68 reviews

Grand 5-Bedroom San Diego Home w/ Pool & Views!

Forget your worries in this spacious and serene space. Relax along the private poolside oasis while admiring the horizon ocean & skyline views! This home will be sure to impress with upgraded amenities, plenty of seating for all, & beautiful furnishings. 5 big bedrooms, plus loft room w/ bed & foosball game. Multigenerational families & non-rowdy groups will delight in this grand home. Enjoy all the sights of San Diego and come home for restful slumbers at this beautiful south San Diego retreat.

Guest favorite

Villa in Allied Gardens

4.92 out of 5 average rating, 25 reviews

Fun Get Away, Vaulted Ceiling, Pool, Hot Tub, New.

Enjoy a stylish experience at this centrally-located place. Great place to stay for those seeking an experience close to the beach and mountains and anywhere in San Diego you'd like to visit. 5 min from trails and Cowles Mountain. 15 min to Sea World, Animal Park, beaches, parks, downtown, Balboa park, the Midway museum, Coronado, Torrey Pines, La Jolla Cove, and much more! 2 min to a kid playground. Nice Villa in a really nice and Quiet Neighborhood, but will also accommodate your best party!

Guest favorite

Villa in Hillcrest

4.78 out of 5 average rating, 50 reviews

Vintage Home on the Canyon’s Edge

We’re excited to offer our beautiful home in University Heights- just 5 mins from downtown SD. Perched on the edge of a peaceful canyon, the house is surrounded by nature, offering a serene escape while keeping you close to the city’s best attractions. Home features: • 2 comfortable bedrooms • A dedicated study that can double as a third bedroom • 2 full bathrooms • Fully equipped kitchen • Smart TV, WiFi, washer & dryer • A private balcony overlooking the canyon and our inviting hot tub

Superhost

Villa in Emerald Hills

4.77 out of 5 average rating, 122 reviews

🦄Paradise View SD (Private Escape) 🌄 86'' TV

Escape to beautiful San Diego and experience a vacation like no other! Our luxury vacation rental offers the perfect mix of privacy and convenience, just 12 minutes from downtown, the airport, and San Diego’s top attractions. 🌴✨ From the moment you arrive, you’ll be drawn to our brand-new infinity-style pool — the perfect spot to soak up the California sunshine and unwind in total relaxation. Enjoy complete privacy while staying close to everything the city has to offer, the ultimate retreat!

Guest favorite

Villa in Allied Gardens

4.91 out of 5 average rating, 100 reviews

6-bed Paradise Villa Pool, hot-tub massage chair

*EV charging available Welcome to Casa Cerro-my incredible chic high-tech modern villa in San Diego! This stylish place to stay is perfect for families and group trips. Its open and airy layout can accommodate up to 11 people. This completely remodeled home is furnished with all the luxuries of home and more that is powered by an iPad for you to use. I love technology. But don't worry you don't have to use it to power up the house, everything has traditional switches/remotes if you choose.

Superhost

Villa in Rancho Penasquitos

5 out of 5 average rating, 3 reviews

Dream Home Private Heated Pool Jacuzzi and more!

Kickback and enjoy this dreamy 6-bedroom, 4.5 bath getaway! 🤩 HUGE 50 feet long heated salt water pool, mid 80’s year round!😎 No jacuzzi fees! 😁 Spacious bedrooms, skylights and upstairs laundry. Perfect for family reunions, group retreats, or any crew that loves traveling together. ✈️ FULL HOME ACCESS. Whether you're splashing in the oversized pool, or just chilling in the breezy living spaces, this home is built for fun and comfort, lounging and unforgettable memories! 📸

Guest favorite

Villa in Mission Hills

4.98 out of 5 average rating, 88 reviews

Hidden Villa with Beautiful Furnished Garden Patio

Close to everything, quiet and private. This beautiful 2 Bd Villa seems to be loved by all who stay here. The outdoor private patio feels like your in the forest. Gorgeous custom bath with large marble shower. Full size laundry. Great entertainment system,DVD's, Roku, Amazon Prime. The home has open beam ceilings, lots of light and a fabulous patio fully furnished for guests, outdoor dining and barbecuing. The home is private, fenced, furry friends are welcome.

Guest favorite

Villa in La Mesa

4.92 out of 5 average rating, 39 reviews

TooHotTooSettle• Pool• HotTub• GameRoom•Sleep 14

Luxury Retreat in Mount Helix | Pool • Hot Tub • Games Welcome to your private oasis in beautiful Mount Helix! This stylish 4-bedroom home is designed for relaxation and entertainment, featuring a sparkling pool, a soothing hot tub, and a game area for endless fun. With spacious living areas, modern decor, and a fully equipped kitchen, this home is perfect for families, friends, or a weekend getaway. Book now and experience the best of San Diego in style!

Guest favorite

Villa in Pacific Beach

4.93 out of 5 average rating, 146 reviews

The Crown Jewel Villa with AC!Bikes,Kayak and SUP!

Escape to the peaceful and coveted beach community of Crown Point in San Diego! This highly sought after neighborhood boasts mostly permanent residents, creating a serene and tranquil environment for our guests. Right across the street from the home, you can find Ski Beach and Park, a favorite spot for families and kids. Explore the variety of local eateries and coffee shops, or take a short walk to popular Sail Bay and the ocean.

Guest favorite

Villa in Spring Valley

4.96 out of 5 average rating, 70 reviews

Modern 3-Bedroom Villa, Luxurious Outdoor Oasis

Welcome to Your Perfect Spring Valley Villa! Nestled in the heart of Spring Valley, our charming spacious 3-bedroom, 2-bath home offers the perfect blend of comfort, style, and modern amenities. Whatever your planning, our home provides an ideal setting for a memorable stay. Need a rental car? We have a 2019 Blue Jeep Wrangler Unlimited Sport available via Turo right outside ready for use. Link to book available inside.

Guest favorite

Villa in Mission Hills

5 out of 5 average rating, 84 reviews

1stResorts.com WATER VIEW FAMILY VILLA A w/ HOTTUB

Brand New FAMILY Villa with Water Views from the kitchen / living area! Special reduction for week long stay!! Two level Villa. Large deck attached. Hot Tub, Barbecue Grill, Fire pit! Beautiful sunsets!! Come stay with us and enjoy all of San Diego's finest. We are located close to Balboa Park, Coronado and so many great venues and experiences or just stay on site and enjoy your very own Oasis!

Guest favorite

Villa in Mira Mesa

4.89 out of 5 average rating, 44 reviews

Beautiful house in mira mesa

Get ready to enjoy a bright and spacious home right in the heart of Mira Mesa! Just 20 minutes from downtown, the airport, top attractions, and plenty of shopping, it’s the perfect spot for large families or groups of friends eager to experience the best of San Diego. Here, you’ll feel right at home while soaking up all that sunny San Diego has to offer