Guesthouse vacation rentals in La Mesa

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Popular amenities for La Mesa guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Talmadge
4.98 out of 5 average rating, 209 reviews

Lovely Guesthouse in garden setting

RamonaRating, 5 stars6 months ago
We are so grateful to have been able to stay at Gwynn's place, it is so peaceful and lovely. Like a secret garden getaway. We loved all the small touches, and beauty of the space. Gwynn made us feel very welcome and comfortable! The pool is amazing and the outdoor spaces are delightful. Can't wait to stay here again.
Guest favorite
Guesthouse in La Mesa
4.93 out of 5 average rating, 239 reviews

Fig Tree Bungalow

DeshawnRating, 5 stars5 days ago
This place was great and the owner was very helpful.
Guest favorite
Guesthouse in Greater North Park
4.96 out of 5 average rating, 701 reviews

BEAUTIFUL Private Studio

TraceyRating, 5 stars4 days ago
My husband and I stayed at Sean's place to help our daughter move to San Diego, our stay was absolutely perfect! Super clean, fun decor, nice unexpected treats for guests, sheets, towels, bed all comfy. I actually want to replicate some of the decor! Location is great and quiet. Loved having a designated parking space. For our future visits we won't have to look any further, I know this will be our place to stay. Sean's instructions for check-in is very thorough, making check-in so easy. We really appreciated the recommendations he provided with places to eat, to grab a coffee and even the local farmers market. I find so many checkout's so complicated and cumbersome, Sean's is very very reasonable. I highly recommend booking with Sean, you won't be disappointed.
Top guest favorite
Guesthouse in Greater North Park
4.97 out of 5 average rating, 186 reviews

New Guest House - North Park

KrystenRating, 5 stars2 weeks ago
Lynae’s place was wonderful, as was Lynae! Balboa park right nearby, with gorgeous trails and scenery. Walkable to North Park area which had a fun variety of bars, shops, and restaurants. Lynae was a wonderful host - responsive, kind, flexible - and the home was bright, airy, with gorgeous views. We couldn’t say enough good things about the wall of jasmine walking in. Thank you Lynae for having us in your home!
Top guest favorite
Guesthouse in Jamul
4.95 out of 5 average rating, 222 reviews

Retreat house. Nature, Hot Tub, Views!

FloraRating, 5 stars1 week ago
This was my second stay at Meaghan and Derek’s property, just me and my dog, Oreo. It’s the perfect place to rest and slow down. The quiet, combined with the beauty of the surroundings, truly helps to cultivate a peaceful mind and leave you feeling recharged. Meaghan and Derek are wonderful hosts—you can genuinely feel the love and care they put into tending their property. It’s a special place, and I’m grateful to have returned. I can’t wait for the next time!
Guest favorite
Guesthouse in San Diego
4.93 out of 5 average rating, 195 reviews

Cosy quiet Guesthouse near SDSU

SandyRating, 5 stars2 weeks ago
Desiree is such a sweet host! My husband, five month old, and I stayed in her Airbnb and we very much enjoyed our time. The place was well kept and clean. She had the guest house stocked with all the essentials which made it so nice and convenient. Anytime we had a question or request, she was quick to respond and resolve. The location is close to many great coffee shops, restaurants, and things to do. Glad we found this place and would definitely book it again in the future!!
Guest favorite
Guesthouse in Greater North Park
4.86 out of 5 average rating, 115 reviews

Charming North Park Cottage

BrandyRating, 5 stars1 day ago
My wife and I stayed here with our nearly 6mo old son. Check in was a breeze. Place was perfect for the 3 of us. May have been too small if it were 4 adults. The neighborhood is great. Really felt like home for us. Plenty of street parking and very walkable to many restaurants and bars.
Top guest favorite
Guesthouse in Chula Vista
4.95 out of 5 average rating, 560 reviews

Private Casita in Great Eastlake Neighborhood

EricaRating, 5 stars1 week ago
Wonderful spot and perfect for a little weekend visiting family. Super safe and beautiful neighborhood! The bed and linens were extremely comfortable and I slept like a baby. I would definitely stay here again when I’m the area. Thanks David!

Guest house rentals with a patio

Top guest favorite
Guesthouse in Poway
4.98 out of 5 average rating, 107 reviews

Gorgeous Guesthouse Poway w/Private Yard

ToniRating, 5 stars4 days ago
We had a great stay. The place was very clean, private, and beautifully decorated. It felt comfortable and welcoming. Would happily stay here again.
Top guest favorite
Guesthouse in La Jolla
4.98 out of 5 average rating, 208 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

MarrisRating, 5 stars2 weeks ago
The space is stunning, spacious with modern decor and beautiful views. Atoosa has anticipated everything you will need to enjoy your vacation, from coffee to complimentary snacks to free weights and gear for the beach. The bed is cozy, and the sheets silky soft. The view from the terrace is lovely and peaceful. Parking is easy, and you are just a quick drive from the cafes and beaches of La Jolla. This gorgeous apartment will surpass your expectations.
Guest favorite
Guesthouse in Chula Vista
4.94 out of 5 average rating, 145 reviews

New! Beautiful Private Casita- King Bed & Office

OscarRating, 5 stars2 weeks ago
My wife and I had a wonderful stay. Place was clean, host was responsive to any questions, the bed was comfortable, and it was close to many tourist locations. Would definitely recommend!
Guest favorite
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 105 reviews

Cozy, Quiet and Private Backyard Studio Escape

JoeeRating, 5 stars1 week ago
I had an absolutely wonderful stay at Stephanie's place! The space was spotless and made me feel right at home. The location was fantastic and the check-in process was incredibly easy. Stephanie was an outstanding host, always quick to respond to any questions. I especially loved the rain shower! I highly recommend this Airbnb to anyone visiting San Diego and would definitely love to stay here again!
Superhost
Guesthouse in City Heights
4.86 out of 5 average rating, 263 reviews

Heart of SD | Zoo Nearby | Private Patio | Central

RyanRating, 5 stars2 days ago
Alexandra was extremely accommodating, with a great private space that matched the description and photos well. The studio was clean and neat, additionally they had a guest streaming account as well as other great amenities!
Top guest favorite
Guesthouse in Greater North Park
4.98 out of 5 average rating, 125 reviews

New (2022) North Park Abode w/ Roof Deck

KimRating, 5 stars3 weeks ago
A fantastic location in North Park near Balboa Park with gorgeous views from the 2nd floor deck. It made for a gorgeous backdrop for graduation family photos! There are ample nearby restaurant choices for this safe and quiet neighborhood. Comes with a very comfortable bed, and a variety of pillows with an efficient kitchenette.. only wish the shower head streamed more water. Hosts were very gracious and responsive to our requests. I definitly plan to stay here again and have already recommended this awesome place to friends.
Top guest favorite
Guesthouse in Spring Valley
4.98 out of 5 average rating, 168 reviews

Loft Cabin-Night Cinema+Hot Soaking Tub+Views!

MadelynRating, 5 stars1 week ago
We loved staying at Allison & James’s off-grid cabin stay! They were extremely accommodating to our late check in time due to a late flight and communication was easy. The cabin itself is one of a kind and makes for such a unique experience. We took full advantage of everything it has to offer — outdoor cinema + the fire pit + the outdoor soaking tub. Although it’s considered off grid, the cabin didn’t miss a beat. I will say, the ride down to the cabin is a bit steep (due to an unfortunate flash flood years ago), but when staying in a spot like this, you’re signing up for an adventure and it definitely was one riding down the hill in the solar powered golf cart! Overall, we were really pleased with this stay and agreed it was the neatest place we’ve stayed yet! Thank you again Allison and James for your hospitality. Highest recommendation!
Guest favorite
Guesthouse in San Diego
4.89 out of 5 average rating, 216 reviews

Central studio w/ private outdoor space & parking

NicRating, 5 stars3 weeks ago
Very nice and clean place to stay. Lauren was super responsive and helpful. 10 mins from downtown and the beach so a great location, I would stay at this place again if I was in town.

Guest house rentals with a washer and dryer

Guest favorite
Guesthouse in City Heights
4.98 out of 5 average rating, 135 reviews

Private Guest House for 2 with Kitchen + Laundry

ArleneRating, 5 stars4 weeks ago
The place was exactly as described! Paid for a place with far less amenities for the exact same price range so definitely recommend this one!
Top guest favorite
Guesthouse in El Cajon
4.99 out of 5 average rating, 187 reviews

Modern mountain guest house. Incredible views

HollyRating, 5 stars1 week ago
This was a great house! The kitchen is stocked with the basics plus plenty of coffee, creamer, etc. and a basket of snacks! Water dispenser is also great. Loved everything and would absolutely stay here again and highly recommend it! Thank you Bonnie!
Top guest favorite
Guesthouse in Rancho Santa Fe
4.99 out of 5 average rating, 165 reviews

Rancho Relaxo / Spacious Detached Guest House

JaneRating, 5 stars2 weeks ago
my daughter and I stayed at Susie and Britt's poolhouse for 6 nights when we were in the San Diego area for a wedding. At first we thought we would look for a beach rental but then heard that it can be foggy on the coast during May and June and going 5 miles inland can make a big difference with weather. we looked in Rancho Sante Fe because that we where the wedding venue was located and we really hit the jackpot! Everything is just as described- very relaxing times in the jacuzzi and by the fire pit in the evenings. The travel to the surrounding SanDiego sights was super easy. Highly recommend this rental!!!
Top guest favorite
Guesthouse in City Heights
4.96 out of 5 average rating, 386 reviews

Central San Diego! Your home away from home!

AraceliRating, 5 stars3 weeks ago
OUR HOME AWAY FROM HOME! what can we say that we haven’t already? It’s our maybe 5th time staying here and we love it. Even our pup walks right up to the door ready to get in. Shaun is such an amazing host, very communicative, sweet and overall amazing. The space itself is a dream, it has all the amenities you cab think of and if you need anything just ask. The location is great. And did we mention we get amazing workouts with the workout area they allow u to utilize! Book it!
Guest favorite
Guesthouse in San Diego
4.94 out of 5 average rating, 149 reviews

Clean Cozy Private Guesthouse - Central San Diego

MoniqueRating, 5 stars1 week ago
This airbnb was very nice for two people. It was a perfect space with a spot on the driveway for one car. Walking in, the airbnb was clean and smelled really good. There was plenty of amenities and our host Frank was friendly and responsive. We would book again!
Guest favorite
Guesthouse in City Heights
4.95 out of 5 average rating, 150 reviews

Cozy Cottage 1/2 mile to North Park close to dtwn

JasonRating, 5 stars1 week ago
Excellent place. We loved the location relative to the sites we wanted to see. Free parking, laundry, very well stocked kitchen, comfortable bed. We were very comfortable and happy here. And as a host Wendy was phenomenal. One of the most responsive hosts I’ve had the pleasure of connecting with on Airbnb. Thank you Wendy!!!
Guest favorite
Guesthouse in El Cajon
4.97 out of 5 average rating, 165 reviews

Mt Helix Studio Loft with Mountain Views

Antonio OrtizRating, 5 stars1 month ago
I definitely recommend this place, Josh was amazing! The house was very comfortable and clean. He also checked on us if we needed anything and was responsive to any questions we had. The surroundings are amazing and sunrises look beautiful.. We will definitely book again!
Guest favorite
Guesthouse in San Diego
4.95 out of 5 average rating, 483 reviews

Modern Sweet Home Stay, Hillcrest, A/C Parking W/D

JenniferRating, 5 stars2 weeks ago
Nicole is really nice!!! The Apartment has everything you need - clean and modern , good quality by products and towels and so on. Parking place was directory next to the door. We also saw her cats :) We would recommend it!! The neoghbourhood is clean and you have everyrhing you need.

Quick stats about guesthouse rentals in La Mesa

  • Total rentals

    80 properties

  • Nightly prices starting at

    ﺩ.ﺇ184 before taxes and fees

  • Total number of reviews

    5.2K reviews

  • Family-friendly rentals

    10 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with a pool

    10 properties have a pool

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