
Guesthouse vacation rentals in La Mesa
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Top-rated guesthouse rentals in La Mesa
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Popular amenities for La Mesa guesthouse rentals
Family-friendly guest house rentals

Lovely Guesthouse in garden setting
We are so grateful to have been able to stay at Gwynn's place, it is so peaceful and lovely. Like a secret garden getaway. We loved all the small touches, and beauty of the space. Gwynn made us feel very welcome and comfortable! The pool is amazing and the outdoor spaces are delightful. Can't wait to stay here again.

Fig Tree Bungalow
This place was great and the owner was very helpful.

BEAUTIFUL Private Studio
My husband and I stayed at Sean's place to help our daughter move to San Diego, our stay was absolutely perfect! Super clean, fun decor, nice unexpected treats for guests, sheets, towels, bed all comfy. I actually want to replicate some of the decor! Location is great and quiet. Loved having a designated parking space. For our future visits we won't have to look any further, I know this will be our place to stay. Sean's instructions for check-in is very thorough, making check-in so easy. We really appreciated the recommendations he provided with places to eat, to grab a coffee and even the local farmers market. I find so many checkout's so complicated and cumbersome, Sean's is very very reasonable. I highly recommend booking with Sean, you won't be disappointed.

New Guest House - North Park
Lynae’s place was wonderful, as was Lynae! Balboa park right nearby, with gorgeous trails and scenery. Walkable to North Park area which had a fun variety of bars, shops, and restaurants. Lynae was a wonderful host - responsive, kind, flexible - and the home was bright, airy, with gorgeous views. We couldn’t say enough good things about the wall of jasmine walking in. Thank you Lynae for having us in your home!

Retreat house. Nature, Hot Tub, Views!
This was my second stay at Meaghan and Derek’s property, just me and my dog, Oreo. It’s the perfect place to rest and slow down. The quiet, combined with the beauty of the surroundings, truly helps to cultivate a peaceful mind and leave you feeling recharged. Meaghan and Derek are wonderful hosts—you can genuinely feel the love and care they put into tending their property. It’s a special place, and I’m grateful to have returned. I can’t wait for the next time!

Cosy quiet Guesthouse near SDSU
Desiree is such a sweet host! My husband, five month old, and I stayed in her Airbnb and we very much enjoyed our time. The place was well kept and clean. She had the guest house stocked with all the essentials which made it so nice and convenient. Anytime we had a question or request, she was quick to respond and resolve. The location is close to many great coffee shops, restaurants, and things to do. Glad we found this place and would definitely book it again in the future!!

Charming North Park Cottage
My wife and I stayed here with our nearly 6mo old son. Check in was a breeze. Place was perfect for the 3 of us. May have been too small if it were 4 adults. The neighborhood is great. Really felt like home for us. Plenty of street parking and very walkable to many restaurants and bars.

Private Casita in Great Eastlake Neighborhood
Wonderful spot and perfect for a little weekend visiting family. Super safe and beautiful neighborhood! The bed and linens were extremely comfortable and I slept like a baby. I would definitely stay here again when I’m the area. Thanks David!
Guest house rentals with a patio

Gorgeous Guesthouse Poway w/Private Yard
We had a great stay. The place was very clean, private, and beautifully decorated. It felt comfortable and welcoming. Would happily stay here again.

La Jolla Oasis: Ocean, City and Fire Works Views
The space is stunning, spacious with modern decor and beautiful views. Atoosa has anticipated everything you will need to enjoy your vacation, from coffee to complimentary snacks to free weights and gear for the beach. The bed is cozy, and the sheets silky soft. The view from the terrace is lovely and peaceful. Parking is easy, and you are just a quick drive from the cafes and beaches of La Jolla. This gorgeous apartment will surpass your expectations.

New! Beautiful Private Casita- King Bed & Office
My wife and I had a wonderful stay. Place was clean, host was responsive to any questions, the bed was comfortable, and it was close to many tourist locations. Would definitely recommend!

Cozy, Quiet and Private Backyard Studio Escape
I had an absolutely wonderful stay at Stephanie's place! The space was spotless and made me feel right at home. The location was fantastic and the check-in process was incredibly easy. Stephanie was an outstanding host, always quick to respond to any questions. I especially loved the rain shower! I highly recommend this Airbnb to anyone visiting San Diego and would definitely love to stay here again!

Heart of SD | Zoo Nearby | Private Patio | Central
Alexandra was extremely accommodating, with a great private space that matched the description and photos well. The studio was clean and neat, additionally they had a guest streaming account as well as other great amenities!

New (2022) North Park Abode w/ Roof Deck
A fantastic location in North Park near Balboa Park with gorgeous views from the 2nd floor deck. It made for a gorgeous backdrop for graduation family photos! There are ample nearby restaurant choices for this safe and quiet neighborhood. Comes with a very comfortable bed, and a variety of pillows with an efficient kitchenette.. only wish the shower head streamed more water. Hosts were very gracious and responsive to our requests. I definitly plan to stay here again and have already recommended this awesome place to friends.

Loft Cabin-Night Cinema+Hot Soaking Tub+Views!
We loved staying at Allison & James’s off-grid cabin stay! They were extremely accommodating to our late check in time due to a late flight and communication was easy. The cabin itself is one of a kind and makes for such a unique experience. We took full advantage of everything it has to offer — outdoor cinema + the fire pit + the outdoor soaking tub. Although it’s considered off grid, the cabin didn’t miss a beat. I will say, the ride down to the cabin is a bit steep (due to an unfortunate flash flood years ago), but when staying in a spot like this, you’re signing up for an adventure and it definitely was one riding down the hill in the solar powered golf cart! Overall, we were really pleased with this stay and agreed it was the neatest place we’ve stayed yet! Thank you again Allison and James for your hospitality. Highest recommendation!

Central studio w/ private outdoor space & parking
Very nice and clean place to stay. Lauren was super responsive and helpful. 10 mins from downtown and the beach so a great location, I would stay at this place again if I was in town.
Guest house rentals with a washer and dryer

Private Guest House for 2 with Kitchen + Laundry
The place was exactly as described! Paid for a place with far less amenities for the exact same price range so definitely recommend this one!

Modern mountain guest house. Incredible views
This was a great house! The kitchen is stocked with the basics plus plenty of coffee, creamer, etc. and a basket of snacks! Water dispenser is also great. Loved everything and would absolutely stay here again and highly recommend it! Thank you Bonnie!

Rancho Relaxo / Spacious Detached Guest House
my daughter and I stayed at Susie and Britt's poolhouse for 6 nights when we were in the San Diego area for a wedding. At first we thought we would look for a beach rental but then heard that it can be foggy on the coast during May and June and going 5 miles inland can make a big difference with weather. we looked in Rancho Sante Fe because that we where the wedding venue was located and we really hit the jackpot! Everything is just as described- very relaxing times in the jacuzzi and by the fire pit in the evenings. The travel to the surrounding SanDiego sights was super easy. Highly recommend this rental!!!

Central San Diego! Your home away from home!
OUR HOME AWAY FROM HOME! what can we say that we haven’t already? It’s our maybe 5th time staying here and we love it. Even our pup walks right up to the door ready to get in. Shaun is such an amazing host, very communicative, sweet and overall amazing. The space itself is a dream, it has all the amenities you cab think of and if you need anything just ask. The location is great. And did we mention we get amazing workouts with the workout area they allow u to utilize! Book it!

Clean Cozy Private Guesthouse - Central San Diego
This airbnb was very nice for two people. It was a perfect space with a spot on the driveway for one car. Walking in, the airbnb was clean and smelled really good. There was plenty of amenities and our host Frank was friendly and responsive. We would book again!

Cozy Cottage 1/2 mile to North Park close to dtwn
Excellent place. We loved the location relative to the sites we wanted to see. Free parking, laundry, very well stocked kitchen, comfortable bed. We were very comfortable and happy here. And as a host Wendy was phenomenal. One of the most responsive hosts I’ve had the pleasure of connecting with on Airbnb. Thank you Wendy!!!

Mt Helix Studio Loft with Mountain Views
I definitely recommend this place, Josh was amazing! The house was very comfortable and clean. He also checked on us if we needed anything and was responsive to any questions we had. The surroundings are amazing and sunrises look beautiful.. We will definitely book again!

Modern Sweet Home Stay, Hillcrest, A/C Parking W/D
Nicole is really nice!!! The Apartment has everything you need - clean and modern , good quality by products and towels and so on. Parking place was directory next to the door. We also saw her cats :) We would recommend it!! The neoghbourhood is clean and you have everyrhing you need.
Quick stats about guesthouse rentals in La Mesa
Total rentals
80 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
5.2K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with a pool
10 properties have a pool
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- Rosarito Beach
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- USS Midway Museum
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