Guesthouse vacation rentals in San Diego County

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouse rentals in San Diego County

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite

A curving staircase is visible, flanked by white walls and adorned with vibrant blue tiles. Handrails provide support along the ascent, leading to a bright upper space. A potted plant enhances the serene ambiance at the top of the stairs.

Guesthouse in San Diego

5 out of 5 average rating, 210 reviews

Santorini-Inspired Cottage w/ Hot Tub + Views

*CHECK OUT OUR OTHER AIRBNB* Travel 16 steps up a Greek-inspired curving stairway with 2-story high walls to your tucked-away cottage built into the hillside villa of Alta Colina. With spectacular views, step onto the balcony to watch planes take off & boats sail around the harbor. End the night in front of your secluded back patio fireplace or climb the steps of your spiral staircase to the rooftop Jacuzzi. European-inspired design & details, it'll be hard to believe you’re still in San Diego!

Guest favorite

A scenic view captures lush hillsides and a calm lake under a clear sky, with a rainbow arching gracefully over the landscape. Green vegetation sprawls across the area, adding vibrancy to the tranquil scene.

Guesthouse in Escondido

4.91 out of 5 average rating, 789 reviews

Hilltop cabin retreat with lake & mountain views

Rustic hilltop cabin overlooking Lake Hodges. Surrounded by open canyons & mountains, you will feel like you're a million miles away from everything as you take in the views from the cabin, deck or the outside shower, swim in the saltwater pool, or relax by the fire bowl. A short walk to lake with boating, fishing & miles of hiking/mountain biking trails. Property offers swimming pool, fire bowl, and shaded arbor. SD Zoo Safari Park, wineries, breweries, & ocean beaches all within easy reach.

Top guest favorite

A private garden area features two large orange umbrellas shading wicker seating arrangements. Lush greenery and colorful potted plants surround the space, with a stone patio leading to a warm-toned guesthouse wall. A window on the guesthouse reflects natural light, enhancing the serene atmosphere.

Guesthouse in San Diego

4.97 out of 5 average rating, 595 reviews

Central & Serene Secret Garden Guesthouse

My cozy & stylish Garden Guesthouse features colorful decor that gives a fun, relaxed vibe. Relax in style inside or outside in my peaceful garden w a cup of coffee, or glass of wine. I love to say a hi to my guests yet your privacy is #1. Reach me via Airbnb app if I can help! Kensington is a central, 1920’s historic neighborhood w shops & great local eateries. Close to downtown, Gaslamp, Zoo, airport, beaches, Balboa Park. Bus stop, & trolley nearby. Reserved off street parking space too!

Top guest favorite

A green, manicured lawn is highlighted with a white gazebo and ornamental garden seating. Towering palm trees flank the scene, while a staircase leads up to a spacious home nestled in the background. Shadows create a gentle pattern on the grass from surrounding elements.

Guesthouse in Escondido

5 out of 5 average rating, 165 reviews

Infinity Poolside Apt. In San Diego Wine Country

162 Perfect 5.0 Reviews-Amazing views, peaceful and beautiful space in a wine country setting. A perfect setting to celebrate a special occasion and create memories. Amazing sweeping views of wine country, lake, golf course and mountains on the 14th green of a golf course with full access to the estate pool, spa, covered parking, EV charger w/private European park. Large luxury suite with a Kitchen, Sitting Room, Bathroom, Steam shower/Sauna and bedroom with luxurious robes, linens and towels.

Top guest favorite

A broad view captures the coastal landscape of La Jolla, featuring the shimmering ocean, serene bay, and city lights under a clear sky. The horizon displays the iconic pier, with the vibrant residential area blended into the backdrop of rolling hills.

Guesthouse in San Diego

4.98 out of 5 average rating, 222 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

Welcome to your private 1,000 sq. ft. studio apartment, atop a scenic hill in La Jolla. Enjoy views of the ocean, bay, city lights and Sea World fire works display, creating the perfect backdrop for your getaway. Conveniently located just 5 minutes from the beautiful Windansea Beach and only 8 minutes from the vibrant village of La Jolla, where you can explore shops, dining, and cultural attractions. Experience the best of San Diego, with top attractions just minutes away. Your ideal getaway

Top guest favorite

The private bathroom features a modern design with a freestanding bathtub and a dual-sink vanity topped with white countertops. Two circular mirrors are mounted above the sinks, and natural light enters through a window. Soft towels are neatly arranged, contributing to the serene ambiance.

Guesthouse in Vista

4.98 out of 5 average rating, 179 reviews

Birdsong Retreat

This cozy one-bedroom suite has its own private entrance and offers a quiet, comfortable stay. Inside you’ll find a king-size bed, seating area with TV, and a refreshment nook with fridge, microwave, Keurig, and sink. A full-size washer and dryer are included for your convenience. The remodeled bathroom features dual vanities, a soaking tub, walk-in shower, and large closet. Set back from the street, the suite also offers outdoor seating and a peaceful yard with birds and bunnies.

Top guest favorite

The exterior of a renovated guesthouse is presented, featuring a white stucco facade with decorative tiles along the steps. A green door, large windows, and a charming walkway leading to the stairs enhance the inviting appearance of the property.

Guesthouse in San Diego

4.99 out of 5 average rating, 172 reviews

Carrie’s North Park Casita, in Heart of San Diego

Fully renovated stand-alone guesthouse in North Park, consistently voted one of the coolest neighborhoods in the US. Just a few blocks from all the action at 30th and University, but tucked away in a quiet, historically designated residential neighborhood. Walk to Balboa Park or The World Famous San Diego Zoo. Get to Downtown San Diego, San Diego International Airport, Old Town, Little Italy, Coronado, La Jolla, Sea World, multiple beaches & so much more in under 15 minutes.

Top guest favorite

A charming garden patio is highlighted by an outdoor umbrella and cozy seating. Vibrant plants and flowers surround the entrance of the casita, which features double doors framed by soft ambient lighting. A decorative rug adds a colorful touch to the inviting space.

Guesthouse in San Diego

4.95 out of 5 average rating, 179 reviews

1BR Casita in the Heart of Kensington + EV Charger

Just blocks from Adams Avenue, this 1-bedroom San Diego casita is perfect for your vacation. It features a comfy queen bed, a 55" Roku 4K TV, a desk, and a private bathroom. The living area boasts high ceilings, a two-seater sofa, another 55" 4K TV, a bistro table, and a Euro-kitchen. Step out to your private succulent garden patio for a tranquil escape. Enjoy the convenience of a separate entrance and off-street parking. Perfect for exploring all that San Diego has to offer!

Top guest favorite

A bright living area is viewed from the entrance, featuring a gray sofa, a wooden side table, and a striped area rug. Large sliding glass doors provide a view of a private outdoor space with lounge chairs. Modern decor and ceiling fan contribute to the airy ambiance.

Guesthouse in Encinitas

4.98 out of 5 average rating, 163 reviews

Beach Rock Retreat - Private Encinitas Guesthouse

Enjoy San Diego’s North Coast in this tropical PRIVATE Encinitas guesthouse centrally located from beautiful BEACHES, world-class GOLF courses, upscale shopping, and amazing restaurants. Beach Rock Guesthouse offers plenty of PRIVACY in all directions from its SECOND STORY comfortable living space. At 780 sq. ft., it's quiet and airy with lots of LIGHT and everything you need to relax or work in COMFORT during your stay. Short Term Rental City Permit # RNTL-007659-2018

Top guest favorite

The poolside area features a well-maintained saltwater pool reflecting the colors of the sunset. Comfortable seating arrangements, including lounge chairs and a cozy fire pit, are visible. Large umbrellas provide shade, and lush greenery adds to the serene ambiance.

Guesthouse in San Diego

4.96 out of 5 average rating, 123 reviews

Vacation Paradise-Heated Pool+Hot Tub+FirePit+EV

This is the perfect Guest House with a salted & heated pool & hot tub. We are located in a super quiet & very safe neighborhood in beautiful San Diego, 15 minutes drive to Downtown, La Jolla, Beaches, Zoo, Sea World & Convention Center. Hike next door at Mission Trails & Lake Murray. Smart TV, wifi, two zone AC, full kitchen, W/D combo and top quality finishes await you inside. Everything you need for memorable vacation! No smoking or vaping on the property.

Top guest favorite

A spacious outdoor deck features comfortable seating arrangements with light-colored cushions, providing a relaxed space for guests. A wooden coffee table sits in the center, surrounded by potted plants and the entrance to the guest house visible in the background.

Guesthouse in San Diego

4.99 out of 5 average rating, 412 reviews

*Private Canyon Retreat: Your Own Guesthouse*

An airy 1BD guest house at the end of a quiet dead-end street that overlooks a tranquil canyon....and an owner that works hard to create a fabulous experience for each guest; not just “another average rental”. With private entrance, full kitchen & bath, and double french doors opening onto a 400 sq ft deck with canyon views, it's the ideal retreat to come back to after exploring San Diego. Come fall in love with your next home away from home!

Top guest favorite

The exterior of the barn is shown, featuring a clean white facade with a sloped roof. A sizable driveway leads to a garage with multiple doors. Lush greenery surrounds the building, contributing to a serene environment.

Guesthouse in Vista

4.99 out of 5 average rating, 297 reviews

New Tranquil Barn Retreat on a Peaceful Half Acre

The Buena Vista barn is a clean, quiet, and upgraded detached barn in Vista with everything you need for a peaceful and comfortable stay! Only 10 minutes to downtown Vista, you'll find great restaurants, breweries, shops, and a movie theater. Points of interest: • Downtown Vista: 10 minutes • Cal State San Marcos: 15-17 minutes • Beach: 20 minutes • Legoland: 22 minutes • Temecula and Wine Tasting: 30-40 minutes • Sea World: 47 minutes