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Apartment vacation rentals in La Mesa

Find and book unique apartments on Airbnb

Top-rated apartment rentals in La Mesa

Guests agree: these apartments are highly rated for location, cleanliness, and more.

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Top guest favorite
A serene bedroom is highlighted by tropical leaf-patterned wallpaper. A comfortable bed is layered with neutral-colored pillows and fresh linens. Natural light filters through sheer curtains, illuminating two accent chairs and a small side table, creating a peaceful and inviting atmosphere.
Apartment in Greater North Park
4.99 out of 5 average rating, 114 reviews

Designer Rental w/ FirePit- Petco Park, DT, + Zoo

Welcome to Our 1920s Designer Craftsman Apartment in San Diego’s Best Neighborhood! *Unbeatable Location! Minutes Petco Park, Downtown, Zoo, + Conv Center :) *Washer&Dryer *High end Bedding *Easy Parking *Boutique hotel-like experience Fire pit, grills, and a cocktail/reading den! This stylish apartment is on the edge of the iconic Balboa Park, a short walk from the lively North Park scene, & 5-minute drive to the Gaslamp Quarter and airport. Beaches and Convention Center are only minutes away.

Guest favorite
A lush garden path leads through vibrant greenery, featuring blooming roses and various colorful flowers. Tropical palm trees rise in the background, and the exterior of the house is painted in a soft hue, creating a welcoming atmosphere in the outdoor space.
Apartment in Cherokee Point
4.88 out of 5 average rating, 253 reviews

Private Studio close by North Park

Fast fiber WIFI, twin bed, TV (Roku & Netflix), microwave, fridge, hotplate, toaster, coffee maker, desk, office chair, armchair, folding table, W/D, iron & board. No pets please. Quiet, clean, central location. Free offstreet parking. Walk to University Ave eateries, shops, buses. See Host Guidebook. 1 mi to 30th St/North Park, 10 min drive to Balboa Park, Downtown, Airport. #7, 10 & 215 bus to downtown. Near I-I5, 805, I-8 freeways. Check-in: Lockbox. Cleaned & Disinfected for Your Safety.

Top guest favorite
An expansive outdoor patio is showcased, featuring a comfortable sectional sofa with soft cushions and a stylish coffee table. Bi-folding doors connect to a modern kitchen area adorned with sleek cabinetry. The distant view reveals the San Diego coastline under a clear blue sky.
Apartment in Little Italy
4.94 out of 5 average rating, 231 reviews

Calm Luxury Penthouse Getaway With Panoramic Views

Welcome to the most relaxing and luxurious penthouse condo in Little Italy! Featuring 2 expansive balconies with sweeping views, my condo sleeps 4-6 comfortably and is situated right in the heart of San Diego's most desirable neighborhood, Little Italy. Enjoy an area that is rich in exquisite cuisine, boutiques, patio cafés, exciting bars and local breweries. Area amenities nearby feature the famous San Diego Zoo, beautiful Balboa Park, Waterfront Park, the Convention Center and much more!

Superhost
Apartment in City Heights
4.96 out of 5 average rating, 323 reviews

Hot Tub & Sauna | San Diego Getaway

Looking for a place to thoroughly relax and reset, while soaking into a private hot tub and infrared sauna? Looking for a peaceful home with a dedicated workspace, A/C, HD monitor, and high-speed WiFi? Looking to stay central to San Diego's eclectic neighborhoods while being tucked away on a quiet residential street? Looking for an efficient apartment with brand new appliances? This is the place for you! Petco Park / Downtown ~ 10 min. Pacific Beach/La Jolla ~ 20 min. Old Town ~ 13 min.

Top guest favorite
The open-concept living space features a dining area with wooden chairs and a round table, a comfortable couch facing expansive glass doors, and views of Mission Bay. A tray with sliced fruit and drinks rests on the kitchen counter, welcoming relaxation and enjoyment.
Apartment in Bay Park
4.99 out of 5 average rating, 104 reviews

Stunning Bay View Getaway

Spacious one bedroom with large deck overlooking Mission Bay. This second-floor space is all yours, with a private entrance, hot tub, and expansive view of the bay, neighboring beach communities, and even a strip of the ocean. Perfect for a romantic and luxurious getaway, even if one or both of you need to do a little remote work. Only minutes to public transportation, Sea World, beaches, and all that Mission Bay Park offers (boat rentals, biking, jet-skiing, parasailing, kayaking, etc.)

Top guest favorite
A bedroom is equipped with a metal bed frame featuring a floral-patterned quilt. Two bedside lamps cast soft light, and wall art in calming colors adds a touch of design. Sliding glass doors reveal outdoor access to a private patio area with furniture.
Apartment in La Mesa
4.98 out of 5 average rating, 185 reviews

Lovely Hideaway Studio by Village-Private Patio

Enjoy the cool vibe at this unique rustic getaway tucked back on a tree-lined hill 5 minutes above City of La Mesa Village, 20 minutes from downtown San Diego. The studio is on the ground floor of our two-story house. We live on the 2nd floor, and the studio is it's own completely private space. 5 miles to San Diego State University; 16-20 miles to San Diego beaches; 10 miles to Downtown San Diego; 15 miles to Sea World San Diego; and 13 miles to the World Famous San Diego Zoo!

Top guest favorite
A light-filled bedroom features a spacious bed dressed in neutral linens. A cozy blanket is layered at the foot of the bed, and a decorative pillow adds a pop of color. A window with a light-filtering shade overlooks a cozy living area with a chess set.
Apartment in Greater North Park
4.96 out of 5 average rating, 168 reviews

Eco | Filtered Air | Modern | North Park | patio |

Ground level apartment in the heart of one of the hippest neighborhoods of San Diego - North Park. We're in a quiet area and still walking distance to Balboa Park as well as coffee, breweries, restaurants, etc. Welcome to @CasaMiranDiego ⭐Queen memory-foam Tuft & Needle ⭐Filtered air ⭐Blackout curtains (bdrm) ⭐AC/Heat ⭐Fiber internet ⭐Solar panels ⭐Smart TV ⭐97 walkscore ⭐Edible garden ⭐Private patio ⭐Washer/Dryer ⭐Easy free street parking ⭐We welcome people from all backgrounds

Guest favorite
A spacious lounge area features a large, L-shaped gray couch, a contemporary glass coffee table, and a flat-screen TV mounted on the wall. A fireplace with a dark mantel adds warmth, and light enters through the black-framed windows that lead to a private outdoor space.
Apartment in La Mesa
4.93 out of 5 average rating, 364 reviews

A Little Bit of Luxury in La Mesa! Private & Gated

Relax and stretch out on your king size bed or take a short stroll to La Mesa Village to take in the new shops, bars & restaurants. Enjoy your large lounge with smart tv & fireplace and while away the evening on your fully lit deck. The delights of downtown San Diego, beaches, zoo & airport are only a 15-20 minute drive away. Within walking distance to La Mesa Blvd Tolley stop. Apartment & parking for 1 vehicle is private & gated with plenty of on-street parking.

Guest favorite
A serene sunset view is captured with soft hues of purple, pink, and orange streaking the sky. Silhouetted hills create a calming backdrop, while the dimming light gently transitions the scenery into evening.
Apartment in Spring Valley
4.89 out of 5 average rating, 175 reviews

Comfy, Cozy Flat With Pool & Spa!

Our flat has a patio that enjoys great sunsets. We are freeway close to all, easy in and easy out!! You’ll love the place because of the comfy bed, space, patio and access to pool and spa. Also, the yard can be enjoyed for relaxing, eating, bonfires, horseshoes and cornhole. An adjoining space is also an AIRBNB studio suite. Great for traveling friends or as an alternative place to consider for your stay. Look for Foemer man Cave with Pool And Spa.

Superhost
An open living space is highlighted by a large sectional sofa and a round coffee table. The neutral-toned decor includes a colorful area rug. A dining table with two chairs is visible, while the kitchen area features a minimalist design with essential appliances.
Apartment in Little Italy
4.89 out of 5 average rating, 231 reviews

State & Fir (Little Italy Loft, Free Parking)

Ultra Minimal, Sunlit Bi-Level Loft In The Heart Of Little Italy—A Bright, Aesthetic Escape For Slow Mornings And Cozy Evenings. Enjoy Exposed Brick, High Ceilings, Beautiful Art, And An Airy Open Floor Plan. Step Outside To Trendy Cafés, Restaurants, Wine Bars, Farmers Markets, And Waterfront Park. Just Minutes To The Convention Center, Concerts, And The Trolley. Includes One Free On-Site Parking Spot And Free Laundry. Live Like A Local.

Guest favorite
A serene courtyard features a prominent tree with sprawling branches, offering shade over a wooden deck. A Zen Buddha statue sits peacefully on the deck, surrounded by lush greenery and decorative plants, creating a calming atmosphere. Stairs lead to the upper levels of the property.
Apartment in Hillcrest
4.96 out of 5 average rating, 539 reviews

Hillcrest #2 Cozy Private Balcony ZenGarden Garage

Heat up the cherry red kettle or a complementary coffee, sit back and enjoy, on your private balcony, overlooking the serene, Zen garden, while listening to the zen fountain. Zen Buddha, awaits your exit and every arrival to the property, whether retuning from the eclectic Hillcrest nightlife, or a scenic stroll through Balboa Park, with its many museums, gardens, fountains, restaurants and coffee shops.

Superhost
A spacious living area features large windows that fill the room with natural light. A plush white sofa and bright red chairs provide seating, while a round coffee table sits centrally on a red carpet. A wall-mounted TV is visible for entertainment.
Apartment in San Diego
4.88 out of 5 average rating, 1,783 reviews

At Mine | Spacious Suite in the Gaslamp Quarter

This meticulously renovated historical hotel suite, designed by Pininfarina, is located in Downtown San Diego’s vibrant Gaslamp Quarter, surrounded by restaurants and nightlife. It offers private, spacious accommodations for both business and leisure travelers, featuring a king bed, smart TV, central AC, and mini-fridge. Please note: an adjoining bar operates until midnight, and some noise is expected.

Popular amenities for La Mesa apartment rentals

When is the best time to visit La Mesa?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceﺩ.ﺇ408ﺩ.ﺇ393ﺩ.ﺇ408ﺩ.ﺇ397ﺩ.ﺇ404ﺩ.ﺇ404ﺩ.ﺇ422ﺩ.ﺇ404ﺩ.ﺇ400ﺩ.ﺇ400ﺩ.ﺇ422ﺩ.ﺇ411
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Quick stats about apartment rentals in La Mesa

  • Total vacation rentals

    Explore 30 vacation rentals in La Mesa

  • Nightly prices starting at

    La Mesa vacation rentals start at ﺩ.ﺇ110 per night before taxes and fees

  • Verified guest reviews

    Over 1,420 verified reviews to help you choose

  • Family-friendly vacation rentals

    10 properties offer extra space & kid-friendly amenities

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    30 of La Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across La Mesa rentals

  • 4.8 Average rating

    La Mesa stays are highly rated by guests—averaging 4.8 out of 5!

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