
House vacation rentals in La Mesa
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Top-rated house rentals in La Mesa
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Popular amenities for La Mesa house rentals
House rentals with a hot tub

Your Modern Lux Pool Resort in the Heart of SD
Wonderful location, 12-14 minutes or less to everything we wanted to do. Expansive patio and pool area. Bedroom layout worked okay for our group of five - three adults and two kids. Property managers were very responsive when we contacted them. The house was spotless. We were there for two weeks and never ran out of things to do in San Diego and environs. We’ll be back.

Modern Home - Rooftop Hot Tub with Ocean Views!
Beautiful and modern house, organized supplies and everything. Owner is super responsive and friendly. Very safe and quiet neighborhood. Also Roof top hot tub is always hot and running. Thank you so much for the hospitality! Larissa & Dave

Canyon View: One-of-a-kind outdoor retreat
We had a splendid weekend trip to Elise’s rental. Was the perfect relaxing getaway. The Airbnb was a close drive to attractions and restaurants! The gem of this stay is the backyard. Such a serene atmosphere perfect for couples & families. Would definitely recommend this stay.

Bright and spacious home with views, pool & spa.
Beautiful home. Great host. Would highly recommend.

University Heights Oasis Getaway
Great place with a very central location, close to the airport and zoo. We really enjoyed our stay and the amenities offered at the home. Lacee was very responsive and accommodating.

Luxury 4-Bed Home - Fantastic Views 15-min from DT
I cannot say enough about this place. I loved staying here and would 1000% stay again. Everything was spotless, the view was amazing, I’ve never been more relaxed and at peace. They have everything you could need,everything was thoughtfully put together. If I could give it 10 stars I would.

Luxury Getaway•Hot Tub Harbor Views•Chef’s Kitchen
We had a long girls’ weekend (a bunch of 40-yr old moms!) - this space was great and had plenty of space. There was a beautiful open living room, kitchen, and dining room. The large window from the kitchen opened so we could have an indoor/outdoor vibe. The yard area was great - plenty of seating and an incredible view. Point Loma and Shelter Island are an easy walk down the hill (going back up is another story!). We had everything we needed - full kitchen to cook, beach towels, etc.

Charming Mid-Century Craftsman: Hot Tub~Serene Yrd
Tasha’s home was beautiful and located in a beautiful neighborhood. Our family needed a place that would also accommodate our dogs and this was the perfect spot. It is in a great location for walking to restaurants and exploring North Park. Tasha is a perfect host and answered any questions that we had in a timely manner. She was extremely courteous and we would definitely stay at her home again. Highly recommend if you are looking for a great home from which to explore San Diego.
House rentals with free parking

Modern Bungalow * Entire Home * Excellent Location
Perfect little bungalow for our stay. Comfortable space for our family of three. Loved the original details of the home like the built ins, picture ledges and window transoms. We had everything we needed for the weekend and were close to great restaurants and coffee shops! Lively neighborhood with residents out walking their dogs in the daytime and peaceful quiet in the evening.

Clean 1BR/1BA Guest House Peaceful Private Casita
Mihn was a great host and very communicative before check-in and on check-out. The guest house was as described: clean, quiet, and convenient to many great local places. Would definitely recommend this place.

Ac home with lots outside space
Amazing airbnb with plenty to offer such as 4 beds as well as kitchenwares and toiletries! My friends and I felt right at home with this airbnb. Melissa was great at communicating too, which made the check in and check out processes much easier!

Stunning Ocean Beach Gem - has everything!
Really enjoyed this stay! Didn't know much about ocean beach beforehand so was pleasantly surprised! Lots of places very walkable from airbnb which was awesome. Also, having a parking spot ended up being so convenient. There is a lot of noise from the airplanes and I can be sensitive to light/noise but found myself being able to sleep soundly. I appreciated hosts being upfront about these things in listing so I could accurately choose this place. Would definitely stay again!

Hillcrest 2 bed 2 en-suite baths garage zen garden
My friends and I Loved staying here! Would love to be back again! Thanks again!

4. Family Reunion Historic Sherman Height
Sheri’s place is great. She is very nice and reply all our questions.. the place worth the price..

🌵King Bed | Queen bed | Full Kitchen | W & D | 1.5Bath | 🌵
Anthony was a great host and was very responsive. The home is nice and comfy and perfect for small families especially if you have little ones. The location of the home is perfect. It’s within driving distance to San Diego’s popular spots such as Old Town, zoo, Belmont Park etc. We were able to walk over to Logan Ave. with our little one to check out the arts, small boutiques, and cafes. It was also very helpful to have a parking spot on the property since there’s hardly any parking on the street. My family and I enjoyed our stay and would definitely stay here again.

Your Trendy San Diego Home, 2-Car Garage
Absolutely fantastic experience! When emergency repairs forced us out of our home at the last minute, Nathan and Abby were absolute lifesavers. They responded quickly and were incredibly accommodating, allowing us to book their lovely home with virtually no notice. We spent a week there, and it truly felt like a home away from home. The location is amazing so many cute shops and restaurants within walking distance! And the two-car garage was a HUGE bonus, as street parking seemed limited. We highly recommend staying here. Nathan and Abby are amazing hosts, and their home is comfortable, well located, and just what we needed during a stressful time. Thank you both for everything!
House rentals with a pool

3 BR Urban Oasis with Pool and Spa in Great Area
Loved everything about our stay at this amazing house! Comfortable beds, awesome backyard with pool and hot tub, great location- walking distance to restaurants, coffee shops, park and very close to lots of site seeing. Our family of 5 had a wonderful time - thank you for sharing your lovely house with us!

Private 3 bedroom block to Bay New Pool Spa, Bikes
Vanessa's place is in a very very quiet neighborhood just steps from the bay. I am a SD native, I know the city very well. I actually lived in the area for many years. This place is totally worth it if your traveling with a family with kids. Plenty to do, plenty of space to sit and relax inside and outside. It has plenty of things to keep kids busy from books to toys very very nice touch. If available when we return definitely will be staying here. The short walk to watch the sunset in the ocean is worth every penny..

Fletcher Hills luxury, Sunset View, 4 BR, Pool/Spa
A Perfect Getaway in El Cajon! From the moment we arrived, this stunning Airbnb exceeded all expectations. Nestled in the scenic hills of El Cajon, the property is peaceful, beautifully maintained, and feels like a true retreat. The home itself is immaculate—thoughtfully decorated with a blend of modern touches and cozy charm. Every detail, from the plush linens to the fully stocked kitchen, made us feel pampered and at home. Waking up to the golden California sun streaming through the windows and enjoying coffee on the patio with panoramic views was a daily highlight. The outdoor space is a dream—lush landscaping, a relaxing seating area, and the kind of quiet that lets you truly unwind. Our host was incredibly welcoming and responsive. Whether you’re looking to explore San Diego or just relax in a serene setting, this is the perfect place. We left feeling refreshed, grateful, and already planning our next trip!

San Diego Retreat / Cal King x 2 / Pool, Parking!
House was clean and comfortable. Check in and check out went smoothly. Communication was great with the owner. Perfectly accommodated our family and location was great. We loved that Better Buzz was within walking distance for a coffee! Grocery store and restaurants also close by. Would highly recommend this rental!

Lionhead - Private Boutique Home
What a lovely home! We spent 5 days here with our family of 5 and it was absolutely wonderful. The home is spacious and open, very clean, and beautifully decorated. We loved the pool and watching airplanes take off and land in the distance. The neighborhood is very quiet and peaceful. Would stay here again!

Centrally located Home w/Guest House, Pool & Spa!
We had a great stay over spring break! Our group was 5 adults & 4 children, but we never felt cramped! The neighborhood is charming and felt safe, even to this small town family. We walked into the Kensington main street area most days - for coffee (Starbucks), acai bowls & organic groceries (Stehly Farms Market), pizza, burgers (kids eat free on Tuesday!), and ice cream (you MUST try the Ube & Toffee flavor at Stella Jeans)! :) The kids loved the pool/ hot tub, although it was a shame the pool guy never checked in over our weeklong stay. With 4 children in the pool every day, the water was cloudy by the time we left. I blame myself for not letting Zeina and Mo know, as they were responsive for all my other queries. The casita was a blessing for grandma and grandpa, who needed their quiet time. The only real complaint I heard from our group was that the house smells stale (like the charming old house it is) and the laundry/pingpong area smells of mildew. Opening doors helped!

Modern Oasis - Pool, Spa, Great Location 5BR/4BA
We had a wonderful stay! The house and backyard were incredibly spacious—plenty of room for both kids and pets to play and enjoy themselves. It was such a treat to have both a hot tub and a pool, especially since the weather was on the chillier side during our weekend. The neighbors have dogs, but they were friendly and didn’t bother us or our pup, which we appreciated. We loved that the home was walking distance to a grocery store, a pharmacy, and Hilltop Park which is dog-friendly. The neighborhood itself is very walkable and pet-friendly, something our whole family truly enjoyed. Overall, this was a memorable and comfortable place to stay for our multigenerational family vacation. We’d definitely return!

5BR | Salt Water Pool | Hot Tub | Fire Pit| BBQ
I love that the kitchen was very well stocked! If you like to cook it’s great! The backyard was beautiful my kids loved the resort feel. We visited for a graduation for my nephew from the Marines boot camp. The location was about 20-25 minutes from base which was so easy because you’re close to the freeway! The house was perfect for our stay! The box truck in the front yard was a throw off when we arrived but once inside you didn’t notice it was there. The house is very cute and full of everything you need to have a great stay! Thank you Brian for being a great host!
Quick stats about house rentals in La Mesa
Total rentals
290 properties
Total number of reviews
12K reviews
Family-friendly rentals
180 properties are a good fit for families
Pet-friendly rentals
90 properties allow pets
Rentals with a pool
70 properties have a pool
Rentals with dedicated workspaces
170 properties have a dedicated workspace
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- Windansea Beach
- SeaWorld San Diego
- University of California San Diego
- Santa Monica Beach
- Playas Los Buenos
- San Diego Zoo Safari Park
- Balboa Park
- LEGOLAND California
- Pechanga Resort Casino
- Belmont Park
- Liberty Station
- Moonlight Beach
- Sesame Place San Diego
- Playa Popotla
- Silver Strand State Beach
- Law Street Beach
- South Mission Beach, San Diego
- USS Midway Museum
- Hillcrest
- Temecula Creek Inn
- Buccaneer Beach
- Aviara Golf Club
- Swami's Beach
- Strand Beach