House vacation rentals in Santee

Find and book unique houses on Airbnb

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Popular amenities for Santee house rentals

House rentals with a hot tub

Superhost
Home in Camden
4.92 out of 5 average rating, 49 reviews

Lake Wateree Sunsets: 6000SF, Dock/Ramp & HOT TUB!

KarlRating, 5 stars2 weeks ago
Huge house! Very private. Has a dock and boat launch. Beautiful view of the lake from all levels of the house. Plenty of rooms and common space. Would definitely stay here again!
Guest favorite
Home in Chapin
4.95 out of 5 average rating, 96 reviews

Lake Murray: Panoramic Views, Kayaks & Hot Tub

TimRating, 5 stars3 weeks ago
We had such a lovely little getaway at Jessica’s place. It’s in a perfect spot for families with kids—my children had the best time playing in the playhouse, and the hot tub was such a relaxing treat. The kayaks were a great bonus! Our family of five, with two school-aged children and a toddler, fit comfortably between the two kayaks, so we were all able to go out on the water together. Jessica was incredibly kind and responsive, answering all my questions before we booked and going out of her way to make sure we felt welcome and at home. The gift basket was such a thoughtful touch. My daughter quickly claimed the tumbler and now brings it to school every day—she says she never wants to forget “sunshine and nap time.” It’s those little details that made our stay feel extra special.
Top guest favorite
Home in Chapin
5 out of 5 average rating, 8 reviews

LakeMurray-Pool-HotTub-GameRm-Beach-FirepitPlaySet

GarrettRating, 5 stars2 weeks ago
This is a wonderful house and a great location! Varun (host) was friendly and very responsive! The house had everything we needed to enjoy our stay. We would rent this house again. Thank you, Varun!
Guest favorite
Home in Bonneau
5 out of 5 average rating, 39 reviews

Lake Moultrie retreat

DavidRating, 5 stars2 weeks ago
We had an amazing stay at this Airbnb near the lake! From the moment we arrived, we were captivated by the stunning natural beauty surrounding the property. The accommodations were comfortable and well-equipped, making it a perfect home base for our family getaway. There was so much to do! We spent our days exploring the lake, having karaoke nights, and enjoying quality time together. The highlight for us was definitely the hot tub—what a fantastic way to unwind after a day of adventures! The host was incredibly welcoming and flexible with our stay. We truly felt at home and can't wait to return. This place is a gem for anyone looking to enjoy nature and create lasting family memories. Highly recommend!
Guest favorite
Home in Ridgeway
4.91 out of 5 average rating, 47 reviews

6 Bedroom Lake House with a heated pool

BradRating, 5 stars2 weeks ago
Clean, plenty of entertainment, minimal cleaning request for check out. The house is stunning and so is the view of the lake. It is BEAUTIFUL. I would absolutely stay here again.
Guest favorite
Home in Summerville
4.92 out of 5 average rating, 12 reviews

Pickleball/Basketball Court - Movie Room - Hot Tub

KeithRating, 5 stars2 weeks ago
John and Maria were great hosts and the Pickle Pad had something for everyone. While we chose to explore the area, we could have stayed busy without ever leaving the house. The theatre, pickleball/Basketball court and the hot tub were all a huge hit with our family. We would absolutely stay here again!
Superhost
Home in Chapin
4.76 out of 5 average rating, 50 reviews

Lake Murray Escape with private boat launch & dock

CRating, 5 stars1 week ago
Everything was amazing when I had a problem they were quick to respond. Even accommodated us an extra day, would love to return when I have more time to enjoy it! Thank you!!
Guest favorite
Home in Gilbert
4.95 out of 5 average rating, 168 reviews

10 Mile View on Lake Murray w/ Dock and Ramp

MeganRating, 5 stars1 week ago
We had a great stay on the lake! Gorgeous views. Would stay again!

Family-friendly house rentals

Superhost
Home in West Columbia
4.84 out of 5 average rating, 444 reviews

Quiet & Cozy~ Near Downtown/USC/Zoo/Ft. Jackson!

AllieRating, 5 stars1 month ago
This house is great for family with everything you need for young kids in a quiet neighborhood with great park just a 2 minute walk away!
Guest favorite
Home in Hanahan
4.88 out of 5 average rating, 65 reviews

May dates avail/Pet Friendly

VickieRating, 5 stars2 weeks ago
Upon arriving in Charleston, we found the home we booked on another site had been double booked. It was late and we were tired. I had 2 of my puppies with me so I found a hotel for the night. I began looking on AirBNB and found several homes but the owners/host were not willing to accommodate us. On my last attempt before deciding to just stick it out in a hotel, I reached out to Allison's listing. She responded quickly, was willing to waive the 3 night minimum and worked to get us into her home quickly. I cannot thank her enough. We got to the home and it was awesome, clean and as described. A bonus - Allison is a lover of animals and had toys, beds and even snacks for the pups. The small fenced in backyard was perfect for my little 4 legged babies. I highly recommend staying with Allison. She is da' bomb.
Guest favorite
Home in Columbia
4.94 out of 5 average rating, 54 reviews

1930's Cape Cod Style Home On Pond

AdelaideRating, 5 stars5 months ago
Ellen and Arnold’s home was absolutely perfect for our family. The home was so charming and we felt immediately at home! From the welcome treats to the delightful sunroom, everything was wonderful. I highly recommend for a beautiful, cozy, and charming stay!
Superhost
Home in Columbia
4.74 out of 5 average rating, 163 reviews

Forest Acres Charm - Ft.J 5min, USC/DT 10 min.

JenniferRating, 5 stars4 months ago
Nice clean house. Rich was responsive and pleasant, even when we (honestly) accidentally stayed too long. (I know it sounds impossible, but I managed to do it.) Luckily, no one else was scheduled to stay the night we overstayed, and Rich was very flexible and understanding.
Top guest favorite
Home in Columbia
4.98 out of 5 average rating, 313 reviews

Exceptional Heathwood Gem Near USC & Fort Jackson!

MichaelRating, 5 stars2 weeks ago
We had a fantastic stay at Robert’s place! The home is spotless, stylish, and full of charm, nestled in a peaceful, historic neighborhood. It’s about a mile walk to Devine Street, with great restaurants and boutiques along the way. We loved the front porch, quiet surroundings, and thoughtful touches throughout the house. Robert was a responsive, proactive host—everything went smoothly. Highly recommend and would happily stay again!
Top guest favorite
Home in Summerville
4.91 out of 5 average rating, 272 reviews

~ NEWLY RENOVATED 3BR/2BA HOME IN SUMMERVILLE SC ~

KatiRating, 5 stars3 weeks ago
This is a great home and actually had more space and storage than we needed for our 4 night stay. Perfect for a Summerville stay and we loved our visit. Very close to Charleston, the beaches, drivable to Columbia and other end of SC as well. Great host, attentive and responsive. Ve
Guest favorite
Home in Moncks Corner
4.81 out of 5 average rating, 144 reviews

Lake Moultrie, Lake front with private dock

LindseyRating, 5 stars1 month ago
Some might call Kellie's place dated, I prefer nostalgic. I felt like I was somewhere that used to belong to my family and enjoyed that familiarity. The location is spectacular, the lake was perfect, and the yard is huge. There were also plenty of pillows and towels which is a plus when you have 7 or 8 people running around. Some said the house was small, but the back screened in porch is huge and we spent most of our time outside and when we were inside we weren't tripping all over each other, so I would say it's just right. We had a wonderful stay and will probably try to go back again!
Superhost
Home in Columbia
4.77 out of 5 average rating, 258 reviews

Walk to USC Devine Street - Cool Blue Bungalow

NatalieRating, 5 stars2 weeks ago
The home is beautiful and full of original character. The neighborhood is quiet and easily accessible. Dane was absolutely amazing to deal with. He is quick in responses and goes beyond to accommodate any special requests or needs if possible. Our trip was a lot less stressful with him as our host!

House rentals with a pool

Superhost
Home in Columbia
4.76 out of 5 average rating, 46 reviews

Serenity at Marsh Pointe, Private Pool! 5bd

LoryRating, 5 stars6 months ago
We had a wonderful stay. The house was beautiful and clean and perfect size for 12 people. Thank you!
Guest favorite
Home in Summerville
4.96 out of 5 average rating, 90 reviews

Share-in Dipity Refined 4 bedrooms pool not heated

Daniel And MelissaRating, 5 stars1 week ago
Great place near lots of restaurants and resources. Jon and team are great and responsive
Guest favorite
Home in Orangeburg
4.96 out of 5 average rating, 80 reviews

Colonial Farmhouse - 6 bedroom with a pool

VirginiaRating, 5 stars1 day ago
Gorgeous home! Spacious, nicely appointed, comfortable. The pool was relaxing and a nice bonus for this area. Our family really enjoyed it.
Guest favorite
Home in North Charleston
4.9 out of 5 average rating, 50 reviews

North Charleston 4BR w/ POOL!

ChwanJyeRating, 5 stars1 week ago
This is our second stay with them and it’s always the best- They are so on point with responding quickly and taking care of any questions that it makes everything easy and seamless We are already looking to rebook 🫶
Guest favorite
Home in Lexington
4.88 out of 5 average rating, 175 reviews

Lavish Home 4BR/3BA, King, Games, Grill, Pool!

JessicaRating, 5 stars2 weeks ago
Trevor's place is great. Clean, comfortable, and not hard to get too. My only complaint would be the lack of a hair dryer. And in the big scheme of things this is nothing. I would stay again if I was in the area.
Superhost
Home in Charleston
4.76 out of 5 average rating, 34 reviews

The Lowcountry Pool Retreat/Tanger Outlet/Top Golf

RayanneRating, 5 stars2 weeks ago
Stayed here for my bachelorette weekend and it was perfect. Plenty of beds, safe neighborhood, beautiful home, and great pool. Everything was clearly listed in the rules and instructions so we had no questions! 20 min uber ride to downtown and great food nearby. For girls my only recommendation was a full body mirror would have been amazing lol! No complaints 10/10!!
Guest favorite
Home in North Charleston
4.95 out of 5 average rating, 362 reviews

Gorgeous Executive Home on Pond *5 beds*

TriciaRating, 5 stars3 weeks ago
Jen and Loren were incredibly gracious. My group of 10 women flew to SC to surprise my daughter who was expecting my first grand baby. We flew through the night so we could be in SC when my daughter got off of work. I asked many weeks in advance if we could check in early so we could rest up and get ready to surprise my daughter. Since no one had rented the house the day prior, they were so so kind to let us come in early. This was extremely kind of them and so appreciated . On the last day, we were flying out late in the evening and once again, with no expectations, I asked for late check our and they again, so graciously, let us stay as long as we needed until we had to leave for the airport. Kindness goes a long way. We traveled from California and this just made the trip so much more enjoyable. The property was nice, beds were comfy and can’t thank them enough for a lovely stay. With my daughter and grand there, I’m sure to be back in a heartbeat The best hosts ever
Top guest favorite
Home in North Charleston
4.98 out of 5 average rating, 140 reviews

Family Retreat | Pool | Game Room | Fenced Yard

ErinRating, 5 stars2 days ago
The house was exactly what we needed for two families staying together with a teen and a toddler. The activities in the house were fun and then the pool outside allowed something for everyone. Steve was a great host and communicated with us quickly! We would stay here again if we were looking for a great place outside of the hustle and bustle of the city.

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