Lake house vacation rentals in Santee

4.87 out of 5 average rating, 175 reviews

Home in Lake Murray

Lake Murray Paradise~2 BR, 1 Bth, Kit/Living area.

Enjoy the full lake adventure with 4 kayaks included. Our property is a lake front paradise w/ about 1 acre on Lake Murray near the dam on the Lexington side of the lake. Close to Columbia, USC and Ft. Jackson. 3 Decks, 1 dock, hot tub & fire pit w/ wood. Private upper deck to the 2 Bedroom, 1 Bath suite with Open Kitchen, Living & Game Area w/ large flat screen TVs, Pool, Ping Pong & Foosball table. The entire upstairs is your private area w/ views of the lake. We offer boat tours. Fees apply.

4.88 out of 5 average rating, 58 reviews

A wooden dock extends over still waters, showcasing a tranquil lakefront scene. An umbrella provides shade, while lush green trees surround the area, reflecting gently on the water's surface. Several boats can be seen nearby, highlighting the access to recreational activities.

Home in Manning

Cozy Church Branch Cabin

A cozy lakefront cottage made by family, for family. This was our parents home away from home, their favorite getaway. Now that they're gone, we want to share what they enjoyed. Traditionally constructed lake cabin with all the comforts of home. Large partially covered deck, large pier for fishing, plenty of room to bring your boat, canoes, or kayaks. Extremely close proximity to large landings where national fishing tournaments are held on Lake Marion. Prime hunting, near great hunting clubs.

Superhost

4.94 out of 5 average rating, 166 reviews

Luxurious Lakefront Log Home W/Pool & hot tub

Stunning luxury log home on the big waters of Lake Marion, featuring a private fishing pier, boat dock, brand-new saltwater pool, hot tub, and more. This custom-designed retreat offers 3 spacious bedrooms, a loft, and 2 elegant bathrooms—one with a clawfoot soaking tub and separate water closet. Enjoy dining and entertaining on the expansive screened-in porch with a custom 12’ outdoor bar. Just 6 minutes from I-95, this serene lakeside escape blends rustic charm with upscale comfort.

4.97 out of 5 average rating, 163 reviews

Home in Santee

Santee lakefront home, big water right off I-95

Lakefront home on the big water of Lake Marion. This home is on the Santee side of the lake in a quiet neighborhood, 1-2 miles from restaurants, grocery stores, golf courses and I-95. Starbucks is less than 2 miles away. *Home can accommodate 10 guests max. *Indoor hot tub is available October through March. *Only registered guests listed on the booking are authorized at the property unless prior approval has been granted. *STRICT no pet policy. *PARTIES ARE STRICTLY PROHIBITED*

5 out of 5 average rating, 25 reviews

An aerial view captures the lakeside property surrounded by lush greenery and mature trees. The mobile home sits adjacent to the water, featuring a landscaped yard and access to a private boat launch. Nearby structures and pathways are also visible.

Home in Cross

Fish Haven

Looking for a quiet, yet charming lakeside property? Look no further! Come enjoy this three-bedroom home with direct access to the diversion canal and a private boat launch. Great space for fisherman, families or couples. Ample space for your boat and hitch. Enjoy your days fishing, savor your afternoon by having a beverage and grilling out on the back patio. Spend the evenings playing cornhole and relaxing by the fire pit. It is the perfect setting to create wonderful memories!

4.92 out of 5 average rating, 128 reviews

A spacious wooden deck features a round glass table surrounded by four chairs, with an umbrella providing shade. Leaves are scattered across the surface, and greenery from the surrounding trees creates a natural backdrop.

Home in Earlewood

KING Beds - Bungalow Downtown Cola

* KING Beds in both bedrooms * PET FRIENDLY * EV CHARGER PLUG (4 Prong outlet ONLY, no cord or adapter) * TVs in both bedrooms and living room * 1.4 miles from PRISMA Hospital (4-minute drive) * BLACKOUT CURTAINS in all the bedrooms * 15 minutes to Fort Jackson * 7 minutes to Riverbanks Zoo * 5 minutes to the Columbia Museum of Art and Soda City Market * HUGE Deck with table and small covered area * Off-street parking pad for 5+ cars * 11-minute drive to Lexington Medical Center

A lush green yard features a shaded gazebo with seating, overlooking a serene lake. In the distance, a dock extends into the water, surrounded by trees. The scene captures a tranquil outdoor space ideal for relaxation and family gatherings.

4.83 out of 5 average rating, 110 reviews

Perfect family vacation retreat at Lake Marion, SC

Great family escape! Enjoy our beach, dock and boat ramp as well as our game room and fully stocked kitchen. This is the complete family reunion location! We purchased our lake home, built in 1980, in 2009 and began renovation. We updated the kitchen and baths, plus new carpet, tile, windows, appliances, and a complete update to the exterior with new landscaping. We also replaced the dock and the seawall. It has been a journey and we hope you love our house as much as we do!

4.91 out of 5 average rating, 116 reviews

Ultimate Lake Marion Dream Home W/Pool & Swim Spa

Welcome to The White House—a stunning lakefront retreat on Lake Marion. This luxurious home features 4 spacious bedrooms, 3.5 baths, a chef’s kitchen, private dock, gas grill, and HDTVs throughout. Relax in the infinity pool or unwind in the swim spa as you take in the tranquil views. The master suite is a true sanctuary, offering unmatched comfort and elegance. Hosted by Lake Marion Luxury Vacations, this home is your gateway to peace, luxury, and unforgettable memories.

A spacious deck overlooks a serene cove, featuring a dining table surrounded by six chairs. Lounge seating is positioned nearby, inviting relaxation. Lush trees frame the area, with views of water and nearby boats visible, creating a calm retreat.

4.99 out of 5 average rating, 118 reviews

Cheerful 3 bedroom home on the lake

Great 3 bedroom home on the water. Perfect for family vacations, a weekend getaway or a stay for local fishing tournaments. This home is on a quiet cove that opens up to the larger lake. Get the best of both worlds. The cove is perfect for paddle boating, kayaking, fishing off the dock, grilling on the deck, or just relaxing on the screened porch enjoying the view. But, with the private dock you can bring your boats and jet skis to enjoy the entire lake.

4.97 out of 5 average rating, 29 reviews

The Heron Lake House

Waterfront home on Lake Marion that boasts amazing views throughout. Large Deck and newly landscapede yard. There are 4 bedrooms and 2 bathrooms with common areas both indoor and outdoor. Enjoy the fire pit at night and water time during the day. Your stay includes 2 adult and 2 child kayaks. Enjoy your meals on the deck, screened in porch or handmade farm table in the kitchen nook. Private dock so bring your boat or water toys!

4.95 out of 5 average rating, 60 reviews

A wooden staircase leads to the elevated structure with a deck surrounded by trees. An American flag is displayed nearby, with wooden slats providing a rustic feel. The natural setting includes a mix of foliage and dirt pathways, indicating a secluded environment.

Home in Branchville

Edisto River Turnhole Getaway

Our getaway is on the Edisto River, located on a secluded bluff with breath taking views overlooking the longest black river in SC . Relax to a quiet and peaceful evening on the deck while enjoying the hot tub. Perfect for couples celebrating a birthday or anniversary. Boat access available. Located only one hour from Charleston and an hour and a half from Columbia. No pets please. WE NOW HAVE WIFI!