Vacation rentals in Santee

Book unique vacation rentals, houses, and more on Airbnb

0 of 0 items showing
1 of 3 pages

Popular amenities for Santee vacation rentals

Other great vacation rentals in Santee

Guest favorite
Home in Summerton
5 out of 5 average rating, 5 reviews

Lake House Retreat

StevenRating, 5 stars1 week ago
Wonderful place. Better than we could've immagined. Would definitely recommend!
Guest favorite
A cozy living area features large windows allowing natural light and showcasing views of the outdoors. A modern television is mounted above a stone fireplace, which is complemented by a wooden mantel. A decorative ottoman sits nearby, and a lamp provides additional lighting.
Home in Santee
4.97 out of 5 average rating, 156 reviews

Santee lakefront home, big water right off I-95

AaronRating, 5 stars2 months ago
awesome place with a beautiful view if your looking for a peaceful place to relax on the water this is it!
A wooden dock extends over calm waters, featuring a black dog standing attentively. Surrounding trees provide a natural backdrop, while houses can be seen in the distance, adding a sense of community to the scene.
Cottage in Manning
4.74 out of 5 average rating, 141 reviews

A Great Lake house. Near Manning, SC and I-95.

KellyRating, 5 stars2 weeks ago
Ben was a super-responsive host. We had a great stay, and the cabin is peaceful. Perfect for a quiet restful vacation!
Top guest favorite
The kitchen area features a combination of modern appliances and warm cabinetry. A white farmhouse sink is a focal point, surrounded by dark countertops and black appliances. A wooden dining table stands in the foreground, offering an inviting space for meals and gatherings.
Home in Cross
5 out of 5 average rating, 10 reviews

Fish Haven

KatieRating, 5 stars2 days ago
We loved everything about this place! Have already requested to book again!
Top guest favorite
An outdoor balcony is furnished with a round table and four matching chairs, accompanied by a small side table. A ceiling fan is visible overhead, while a view of the lake and surrounding trees creates a serene atmosphere.
Apartment in Santee
5 out of 5 average rating, 11 reviews

Relaxation is the plan

WilliamRating, 5 stars3 weeks ago
We stopped here overnight on our road trip to Florida and found it to be very accommodating. Would stay here again if visiting Lake Marion. The place was spacious and had a great view of the lake.
Guest favorite
A compact bathroom is highlighted with natural wood paneling. A white toilet is positioned next to a small sink, equipped with a gold faucet. A mirror and a towel are mounted on the wall, while a wastebasket sits discreetly nearby.
Home in Manning
4.87 out of 5 average rating, 52 reviews

Cozy Church Branch Cabin

JackieRating, 5 stars1 week ago
The house was very nice. Exactly as described. The welcome book was helpful and the history of the house was also a nice touch.
Guest favorite
A smooth, round stone is placed on an open guestbook, featuring handwritten text inviting visitors to share their experiences. The guestbook has a leather cover, resting on a polished wooden table, which adds a rustic touch to the setting.
Cottage in Bonneau
4.94 out of 5 average rating, 198 reviews

Relax at the Lakehouse with a dock

HeatherRating, 5 stars2 weeks ago
My family loved having a quiet weekend at the lake. We felt perfectly at home during our stay. Personally, I loved that there were memory foam pillows. This is one of the comfier beds I've stayed in with an AirBnB. My kids loved jumping off the dock and swimming in the lake. I loved how peaceful it was to sit on the porch swing and watch the sunrise come up over the lake in the morning or listen to the frogs in the evening. I highly recommend staying here if you have 4 or less people.
Guest favorite
A view from the enclosed porch reveals Lake Marion with its calm waters and a distant bridge. Outdoor furniture, including a table and chairs, is visible on the deck, providing seating to enjoy the scenic surroundings.
Home in Santee
4.93 out of 5 average rating, 55 reviews

Lakefront Lookout

AmyRating, 5 stars1 day ago
This is the 2nd year we have stayed at the Condo. Very nice being able to dock our boat right near the Condo. Already looking to next year!

Quick stats about vacation rentals in Santee

  • Total rentals

    20 properties

  • Nightly prices starting at

    ﺩ.ﺇ367 before taxes and fees

  • Total number of reviews

    170 reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Rentals with a pool

    20 properties have a pool

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Santee?

    Yes! Work meets play with ease at over 10 vacation rentals in Santee featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • How much does it cost to stay in apartment rentals in Santee?

    Experience the best of Santee with our apartment rentals, starting at about $190 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • What are the most popular amenities for Apartment Rentals in Santee?

    Enhance your stay in our Apartment Rentals with the most popular amenities: over 10 homes with wifi, over 10 homes with a gym, and more. Indulge in the ultimate retreat, tailored to your preferences.

  • Are there Santee vacation rentals on Airbnb with pools?

    Yes! Dive into the perfect getaway at one of over 20 vacation homes with pools in Santee, available on Airbnb. Make a splash and soak up the sun in style!

  • Do apartment rentals in Santee have a gym?

    Absolutely! We offer over 10 apartment rentals with a gym in Santee. Enjoy a tailored experience with all the comforts you desire.

  • Do apartment rentals in Santee have wifi?

    Absolutely! We offer over 10 apartment rentals with wifi in Santee. Enjoy a tailored experience with all the comforts you desire.

Destinations to explore