Apartment vacation rentals in Santee

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Top-rated apartment rentals in Santee

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Guest favorite

Apartment in Downtown Columbia

4.89 out of 5 average rating, 113 reviews

*Tuscan Sun KING suite downtown FREE parking*

Perfectly situated in the heart of downtown! This studio is within walking distance of Main Street, The State House, USC campus and just a short drive to Williams Brice Stadium, Colonial Life Arena, medical facilities and so much more. The perfect stay for both long and short term guests. Wake up from a great night's sleep in our comfy KING bed to explore downtown, head out to see the Gamecocks play, or just sleep in! You’ll love staying at this stylish apartment! Permit No. STRN-004218-10-2023

Guest favorite

Apartment in Florence

4.93 out of 5 average rating, 15 reviews

“Cozy Escape | Relax & Recharge”

Discover your perfect getaway in this beautifully furnished 2-bedroom, 1.5-bathroom retreat. Featuring sleek, updated appliances and the convenience of an in-unit washer and dryer, this space blends style and comfort effortlessly. Nestled in a prime, sought-after neighborhood, you’ll enjoy both tranquility and easy access to local hotspots. Conveniently located near Magnolia Mall. A perfect blend of shopping, dining. Book your stay and experience the best of home living with a touch of luxury!

Guest favorite

Apartment in Lake City

4.84 out of 5 average rating, 194 reviews

Home away from Home #5 - Stay Smart-Save

Located on Main Street in a family home that has been updated to be like brand new. 5 has one bedroom with door, a private entrance, bath and dressing area, micro- kitchen, living & dining combination. An optional lockout bedroom(R7) with private entrance can be added, making this a 2 bed, 2 bath apt. Amenities include 2 CABLE & ROKU TVs, wifi, front door parking, Fresh brewed In Room Coffee. Uptown is a one mile walk along Main Street. 1/2 way from New York to Miami. Hablamos Espanol.

Guest favorite

Apartment in Columbia

4.81 out of 5 average rating, 134 reviews

One SUITE Deal

The guest suite is located on the lower level of our tri-level home, with a private driveway, patio, and entrance. The queen bed and pull-out sofa sleep 4 guests comfortably. It is within 15 minutes of downtown, which is home to USC and the Colonial Life Arena. It is 10 minutes from Lake Murray, Riverbanks Zoo, shopping, movies, and great dining experiences. This suite is spacious and cozy. It's great for business travelers, traveling nurses, and small groups looking to enjoy local events.

Superhost

Apartment in Downtown Columbia

4.8 out of 5 average rating, 459 reviews

Historic Downtown Lofts #2

Historic building located right between the Vista and Main St! Walking distance to all your needs and the cities best amenities. Work, delicious food/bev, museums, shops and entertainment! Located on the 3rd floor of a nationally protected historic site. It offers neat views of the capitol city and everything you'll need for your stay! 13 minute walk to Convention Center, Colonial Life Arena & Koger Center. Click my profile to see other options in the area! Permit No. STRN-000211-02-2024

Guest favorite

Apartment in Hanahan

4.89 out of 5 average rating, 128 reviews

Waterfront Private Hot Tub Fire Pit Dock Fishing A

🔥Hot Location only 9 MINS from Park Circle ⭕️ Restaurants, Bars, and Shops! ✅ NO Cleaning Fees! ✅ River-Frontage with Shared Dock ✅ Indoor Private Hot Tub 💦 ✅ Covered Patio ✅ Fire🔥Pit ✅ Hammock 🌴 ✅ Picnic Table ✅ Weber Gas BBQ🍔gril ✅ Pond ✅ K Cup/Coffee Pot ✅ 6 mins from I26 ✅ 15 mins from Downtown Charleston and Beaches🏖 ✅ 10 min to Airport/Convention & Performing Arts Center ✅ 6 min from Bettis Boat Landing ✅ Children 2-12 years old not allowed ✅ Outdoor shared amenities

Top guest favorite

Apartment in West Columbia

4.99 out of 5 average rating, 101 reviews

Brookhaven West

Newly renovated open floorplan lower lever apartment, 2 bedrooms, sleeps 6 comfortably with 2 king beds/1 queen bed, 1 bath (tankless hot water system), private entrance & keyless access, plenty of parking space for 3 cars. Full kitchen with coffee, easy breakfast snacks, popcorn, a W/D, sheets, towels. A private fire pit/smores! Close to everything! 4 miles to downtown. This is a quiet family neighborhood...NO smoking in the unit, no pets and NO parties permitted!

Guest favorite

Apartment in Downtown Columbia

5 out of 5 average rating, 9 reviews

Historic Charm,Modern Living Apartment 301

"Experience downtown luxury in a 2-BR, 2-BA haven spanning 2038 sq. ft. Breathtaking views, indulge in a chef’s kitchen and the master suite offers elegance and comfort, while the guest retreat boasts its own full bath. Custom 15ft wood trim ceilings add a touch of class. The living room, facing Main Street and the Courthouse, sets the stage for urban living. Step onto your private balcony and immerse yourself in luxury, while embracing downtown living at its finest.

Superhost

Apartment in Columbia

4.88 out of 5 average rating, 150 reviews

Modern Renovated Apartment in the Heart of Cola

This is Unit A at The Grove at Cherry, an updated tri-plex located in the Old Shandon area in the heart of Columbia. You'll have the entire 2 bed / 1 bath unit to yourself with all of the amenities needed for a comfortable stay. The location is very convenient to USC, Five Points, The Vista, Downtown, Edventure, Riverbanks Zoo, Fort Jackson, etc. Great for a quick weekend getaway as well as for business professionals looking for an extended stay.

Guest favorite

Apartment in Downtown Columbia

4.94 out of 5 average rating, 151 reviews

Apartment in heart of Columbia

This NEWLY RENOVATED apartment in the heart of Columbia's Vista neighborhood is the perfect spot for your stay. Bright and spacious with a comfortable queen-sized bedroom with flat-screen smart TV; large and spacious living area with full kitchen and big screen smart TV, AND a super comfortable couch that can be used as second bed. Located in the heart of The Vista, you'll have access to scores of restaurants, bars, and retail. Plenty of parking!

Guest favorite

Apartment in Summerville

4.9 out of 5 average rating, 199 reviews

Full Kitchen, 2 Bed, 2 Bath W/ Laundry & Fish Pond

Hosted by a Superhost with multiple listings in Summerville, this charming, two bedroom, two bathroom apartment features a full kitchen, a washer/dryer combo, and a picturesque 1 acre fishing pond. Resting on a small farm on the outskirts of Summerville, this one-of-a-kind shabby-chic suite will have you in a southern state of mind in no time. Just don't be surprised if you see a chicken or two running around...

Guest favorite

Apartment in Columbia

4.88 out of 5 average rating, 109 reviews

Cozy 1 Bed Historic Downtown Columbia

Our guests will enjoy easy access to everything from this centrally located place. We are in the heart of the City of Columbia, easy commute to all the great attractions. This lovely place is strategically located in Elmwood Park. Our space is designed for you to feel at home, we offer a complete set of appliances that will make your stay very convenient

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What guests are saying

Urban Oasis w/Sunroom-Downtown Columbia

4.98 out of 5 average rating, 80 reviews2 weeks ago

This was one of my husband and I’s favorite places we have ever stayed! The apartment itself was incredibly lovely and clean and I was obsessed with sitting in the chair in the sunroom reading. There are a lot of restaurants that are walkable. We stayed for The Masters and the drive to Augusta was not bad. The only thing I would recommend would be earplugs to sleep with at night if you are a light sleeper because the apartment is next to a hospital so you occasionally hear ambulances during the night.

Apartment in Downtown Columbia

What guests are saying

King Bed-Pool and Gym-Kitchen

4.83 out of 5 average rating, 6 reviews1 month ago

Awesome Host! We were very pleased with the property. The furnishings were well thought out. It was minimalist while feeling warm and inviting at the same time. It was well-maintained and the surrounding property was very nice. We felt at home in the property and area. Small convenience stores (DT, FD, DG) were all within 1-2 minutes driving and so much more anywhere from 5 minutes or more. It worked out very well for us. *It is on the second floor (we liked that), but just a heads up in case stairs are challenging for you or someone traveling with you. As a host - very responsive, great instructions and clear rules. We definitely recommend this property and host, and we would book again.

Apartment in Ladson

What guests are saying

Lakefront Luxury Apartment ~ Lake Murray by Marina

4.98 out of 5 average rating, 42 reviews1 week ago

We booked a last minute stay because we were in town for a funeral..Mark & Ruth were very accommodating. As for cleanliness probably one of the cleanest places I’ve stayed..the beds super comfy & just the best hosts! I hope we can come back again some time for a more relaxing reason :)

Apartment in Gilbert

What guests are saying

Quaint One-Bedroom Apartment

4.89 out of 5 average rating, 46 reviews1 week ago

I had a wonderful stay in Orangeburg, and I can’t say enough good things about Annette and her place. She’s an exceptional host—thoughtful, responsive, and genuinely welcoming. The space is always spotless and well-maintained, making it feel like a home away from home. If you’re ever in the area, I highly recommend staying at her spot. You won’t be disappointed!

Apartment in Orangeburg

What guests are saying

Downtown Modern Industrial Oasis

5 out of 5 average rating, 76 reviews2 weeks ago

This Airbnb was fantastic! Ashely was incredibly kind and responsive, making check-in super easy. The apartment was spotless, stylish, and well-equipped with everything I needed—including a great gym. The views were stunning, especially at sunset, and the location couldn’t have been better—just a short walk to amazing restaurants and cafes. It was quiet, comfortable, and felt like a true home away from home. I’d absolutely stay here again and highly recommend it to anyone visiting the area!

Apartment in Downtown Columbia