House vacation rentals in Orangeburg County

Find and book unique houses on Airbnb

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Popular amenities for Orangeburg County house rentals

House rentals with a pool

Guest favorite
Home in Orangeburg
4.96 out of 5 average rating, 83 reviews

Colonial Farmhouse - 6 bedroom with a pool

WillieRating, 5 stars1 month ago
Great place to stay. It was very economical compared to what we would have paid at a hotel.
Home in Summerton
5 out of 5 average rating, 3 reviews

The Sunset Chaser

SheyanneRating, 5 stars3 days ago
I had a wonderful stay at this Airbnb! The space was spotlessly clean, you can really tell the host puts care into keeping it welcoming and comfortable. The host was incredibly responsive and flexible, which made everything from check-in to check-out smooth and stress-free. Any questions I had were answered right away, and they were more than accommodating with my schedule. Overall, a fantastic experience, I’d definitely stay here again and highly recommend it to anyone looking for a reliable, cozy place to stay! We went for my bachelorette trip & it was perfect & exactly what I wanted!
Guest favorite
Home in Summerton
5 out of 5 average rating, 5 reviews

Lake House Retreat

StevenRating, 5 stars1 week ago
Wonderful place. Better than we could've immagined. Would definitely recommend!
Guest favorite
Home in Eutawville
4.88 out of 5 average rating, 16 reviews

Lakeview Leisure-Face to the Sun

AllysonRating, 5 stars3 days ago
Kimberly is the sweetest lady and their home is beautiful and CLEAN! The pool was the right call after being on the swamp all day. We are grateful to have stayed at this home and would highly recommend!
Guest favorite
Home in Williston
4.92 out of 5 average rating, 25 reviews

Out Aways House with a POOL on a POND

Millicent Lee Ann LyberthaRating, 5 stars1 month ago
Mrs Denise was welcoming, she makes you feel at home. She didn’t hesitate when asked a question. The home is so beautiful. My family loved it and it was kid friendly. The home was definitely a home away from home.
Top guest favorite
Home in Santee
5 out of 5 average rating, 14 reviews

The Merry Inn @ Lake Marion

KristenRating, 5 stars3 days ago
We absolutely loved our stay at Anthony’s! Our goal was to park the cars on Thursday and not have to leave all weekend, and we did just that. There was so much to do without even leaving the property- a fully stocked kitchen, super comfortable living-room seating, each bedroom equipped with exactly the same things- including a very comfortable bed & spacious bathrooms! The guys really loved fishing off the dock, (although the fish weren’t biting 😂) and the ladies enjoyed the pool, kayaks, lake tubes and cornhole! Anthony gives clear cut directions on all the house amenities, is super responsive if you have any questions, and really has outdone himself in setting up a true slice of heaven on lake Marion. The sunrises & sunsets were STUNNING- i cannot recommend this place enough. Thank you for a creating a space my closest friends and i were able to make lasting memories at! We will be back !
Guest favorite
Home in Eutawville
4.95 out of 5 average rating, 66 reviews

Heated Indoor Pool on Lake Marion with Dock

TomRating, 5 stars6 days ago
The home was absolutely perfect for our large family gathering! It was so nice to have plenty of space with wide open rooms. The kitchen had everything necessary for cooking meals for the large group and then a wonderful huge table to eat together. The pool was perfect for the younger ones while we all got to visit. We've stayed in many short term rentals and this is our favorite!
Superhost
Home in Summerton
4.88 out of 5 average rating, 16 reviews

Lake Marion Oasis with Pool

GassandraRating, 5 stars1 month ago
Our stay was great! The location was very peaceful and fun for the children. Fishing was great and the house was immaculate! Our host was only a call away if we needed anything. Would definitely stay again.

Weekly house rentals

Guest favorite
Home in Branchville
4.91 out of 5 average rating, 11 reviews

The Branchville Estate

JayRating, 5 stars1 day ago
Ara's place in Branchville was absolutely perfect! Our son was getting married at a local church, so the beautiful chef's kitchen was ideal as we were able to prepare and cook the food for the rehearsal dinner and then transport it to the church hot & ready to serve. The double fridge and double dishwashers were a dream! The 5 bedrooms accomodated us as well as extended family. We loved all of the historic character and thoughtful touches in the home. The beds and pillows were extremely comfortable!
Guest favorite
Home in Santee
4.97 out of 5 average rating, 156 reviews

Santee lakefront home, big water right off I-95

AaronRating, 5 stars1 month ago
awesome place with a beautiful view if your looking for a peaceful place to relax on the water this is it!
Guest favorite
Home in Summerton
4.95 out of 5 average rating, 42 reviews

Cozy 3 bed 2 bath on the waterfront

ElvinRating, 5 stars1 month ago
Kathy was an outstanding host very accommodating. We could not have asked for a better host and her property. Will definitely look her up when we return and as for there property we put our boats in the water when we arrive and never took it out the water other than to fuel out. The property was close enough to John C Landing that we went by water during practice and the tournament awesome place.
Guest favorite
Home in Denmark
4.91 out of 5 average rating, 111 reviews

Lowcountry river life

HeidiRating, 5 stars3 weeks ago
Mary Jane's place and location is absolutely beautiful. I haven't felt so relaxed in so long. Very peaceful. Mary Jane was easy to work with and very responsive. This was my first experience using an Airbnb and Mary Jane and her home was an abosolutely wonderful experience. Thank you so much Mary Jane!
Top guest favorite
Home in Summerton
4.9 out of 5 average rating, 52 reviews

SANTEE LAKE MARION GOAT ISLAND AREA NEWLY UPDATED

BrianRating, 5 stars2 months ago
Responsive host by text and phone. Super helpful with the questions I had about parking. The house was clean and everything we used worked as it should. We will be back next year for sure.
Guest favorite
Home in Eutawville
4.9 out of 5 average rating, 72 reviews

Relaxing Lake Marion Home, near 3 boat landings

JenniferRating, 5 stars3 weeks ago
We had a great stay! Great place and a great host! Thanks so much for hosting us!
Superhost
Home in Manning
4.9 out of 5 average rating, 10 reviews

Lake Marion Beauty w/ 5br/3ba

HeatherRating, 5 stars3 months ago
Nice big house with large screened in porch overlooking the lake. Enjoyed my stay!
Guest favorite
Home in Blackville
4.94 out of 5 average rating, 17 reviews

Cozy home near Healing Springs

LeroyRating, 5 stars4 days ago
From the moment we arrived, everything exceeded our expectations. Marisa and Ruth was incredibly welcoming and responsive, making the check-in process seamless. The space was spotless, beautifully decorated, and had all the amenities we could ask for — it truly felt like a home away from home. The location was ideal, close to everything yet peaceful and quiet. We especially appreciated the thoughtful little touches that made our stay extra special. We truly recommend this Airbnb to aLL and will definitely be back next time we’re in town!

Private house rentals

Guest favorite
Home in Bamberg
5 out of 5 average rating, 9 reviews

Charming Bamberg Home Near Medical Centers!

LauraRating, 5 stars3 months ago
Phyllis was a great host. The property was clean, comfortable, and what I expected. Well equipped, easy to find, and the nicest place in town!
Guest favorite
Home in Cameron
4.88 out of 5 average rating, 26 reviews

The Cypress House

KelliRating, 5 stars2 weeks ago
Beautiful, BEAUTIFUL, location. Cabin had all the amenities you could need and then some. Very quiet and clean. Best Air BnB that we have ever stayed in. Worth it in every way. 10/10 would recommend. Hosts were kind and responsive. Would definitely stay here again.
Home in Bowman
4.75 out of 5 average rating, 4 reviews

Beautiful brick home w/ large porch and 3 bedrooms

LoriRating, 5 stars2 months ago
We were just meeting up with my brother and his wife for the night. This was the halfway point for both of us. The front porch is where we spent basically the whole time. It was so peaceful and relaxing. It was close to the highway but far enough away from the hustle and bustle. The house was way bigger than we thought. We will be going back this summer!
Home in Orangeburg
4.64 out of 5 average rating, 33 reviews

RayneBow Royalty

BruceRating, 5 stars3 weeks ago
The host was extremely helpful and considerate. The place was very clean and spacious. Great surroundings and atmosphere. I would definitely return to that location on future visits.
Home in Summerton
5 out of 5 average rating, 4 reviews

Lake Marion Cottage

LeslieRating, 5 stars1 month ago
Wonderful stay, peaceful location, outstanding views. House was very clean, and had everything we needed for our weekend getaway. Loved the back porch, games, and private dock and boat ramp.
Home in Santee
4.64 out of 5 average rating, 80 reviews

Cozy 3 Bedroom Farmhouse

KimRating, 5 stars1 month ago
We enjoyed our stay. We were there for our daughter’s college tour at Claflin. The area was nice and our hostess was very nice and responsive.
Home in Cameron
4.86 out of 5 average rating, 7 reviews

Fisherman's Dream at Low Falls Landing-Lake Marion

TrishaRating, 5 stars2 weeks ago
I could write paragraphs about how much my husband and I enjoyed staying at Saundra's place! What a hidden gem. The location was incredible - very close to Low Falls Landing so it was convenient to put the boat in and out and a very short boat ride to Saundra's dock. The house - We have never felt more comfortable in a rental! Of course, we brought our own bed linens as requested, but everything else we needed and more was at the home. The home is very eclectic and cozy and has been very well taken care of. The fishing - wonderful! Such a beautiful and special area with the flooded cypress forests and Spanish moss. If you are looking to live like "Where the Crawdads Sing", this is the place - but bring bug spray! Thank you, Saundra, for being an incredible host. We will absolutely be back!
Home in Orangeburg
5 out of 5 average rating, 3 reviews

Renovated House & Huge Pond Close to Universities

JarvoressRating, 5 stars2 weeks ago
I loved staying at Criddle Pond! Ruthie was a great host and was very helpful even before the stay began. The house was convenient to local universities, and the rooms were spacious and exactly as advertised. WiFi was very good and streaming TVs and devices worked well. The kitchen was not only beautiful, but also quite functional with lots of kitchenware. Almost any pot, pan, utensil, etc. that you would need to make any meal or dessert was available. All amenities were great and I especially loved the well-stocked coffee / tea station that greeted us. The amazing views of Criddle Pond, native trees/plants and even ducks, were truly very special and unique elements of this stay. Can’t wait to visit again!

Destinations to explore