
Vacation rentals in Panama City
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Panama City
Guests agree: these stays are highly rated for location, cleanliness, and more.

Modern apartment in the heart of Obarrio
This apartment stands out for its privileged location in Obarrio, with a modern and cozy design. Located on the 14th floor, it offers a spectacular view, its decoration in neutral tones conveys serenity. The convenience of having two bathrooms makes it unique. Ideal for travelers looking for tranquility and functionality. Located within walking distance of 50th Street and the iconic El Tornillo building. You're surrounded by casinos, hotels, and restaurants. Safe area for walking and enjoying the city.

Luxury apt in Panama City 2 Rooms 3 Baths
El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

The Penthouse Annex
Inspired by Panama's rich history with France and located in one of the oldest watch towers in Panama, this chic apartment combines original features of this historically important building with the elegance and style of Europe. Perfectly situated to indulge in the restaurants, cafes, museums and boutique stores of Casco Viejo, and equipped with everything you expect from a home-from-home base, the annex is the perfect combination of comfort and style for couples and small groups of friends.

Modern apt ocean view in heart of Panamá yoo tower
Este lugar tiene una ubicación estratégica: ¡será muy fácil planear tu visita! Ph Yoo and Arts, ubicado en Av. Balboa, súper céntrico Esta hermosa y moderna propiedad cuenta con un estilo único y una vista al mar increíble, piso alto, 2 habitaciones, 2.5 baños completos, Lavanderia, amplia terraza, luces dimeables en todo el espacio, sala comedor, sala de películas, espacio de trabajo, 3 smart tvs, 3 aires acondicionados céntrales, cocina full equipada, cristalería moderna.

Cozy apartment near Casco Viejo
Enjoy a stay in one of the most exclusive areas in the center of Panama, few minutes from Casco Viejo the Cozy Apartment City Center offers free WiFi, air conditioning and stunning views amidst skyscrapers. The apartment has one bedroom with a queen-size bed, a bath and shower, a sofa bed, two smart TV, a fully equipped kitchen, a washer and dryer, and a half bath. On the property there is a work area, a gymnasium, a community pool, and a barbeque area FREE PARKING

Escape to the Heart of Casco with a Private Balcony
Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Elegance and Comfort with a Panoramic Ocean View
Experience the luxurious oceanfront PH Yoo experience in this stylish apartment with king bed and floor-to-ceiling windows. Enjoy top-notch amenities: a swimming pool, gym, squash court, spa, and more. Prime location, close to tourist areas, restaurants, bars, and malls. Inside the building you can find gastronomic options with exclusive discounts and free valet parking. A modern, spacious and sophisticated space, ideal for an unforgettable getaway.

Beautiful Apartment 3 guests
Moderno, elegante y cómodo departamento, cerca de todo! Restaurantes, farmacias, supermercados, canchas de padle, a pocos minutos del centro comercial Multiplaza. Totalmente amoblado, 1 recamara, 1 baño completo, walking closet, cocina, sala, área de desayunador, lavadora-secadora y balcón. Para su disfrute, piscina de agua salada en el último piso, gimnasio, espacio de co-working, incluye un espacio de estacionamiento con valet parking.

Luxury apartment in downtown Panama, banking area
We have a strategic location right on the main road of Panama (Calle 50) Bella Vista. You will find yourself located in the heart of the banking area. Whether you're coming for work or vacation, this is the ideal place. You'll find all kinds of restaurants, shops, and shopping malls nearby. You'll have the Cinta Costera just a 10-minute walk away where you can walk or exercise. Fun and enjoyment within walking distance

Exceptional three-story building with sea view
This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Full apartment in Panama
This charming apartment is located in one of the best neighborhoods in Panama, San Francisco, a downtown location where you will find ample cuisine, entertainment venues, close to bus stations, and the city's most important shopping mall, Multiplaza. This central and quiet apartment is an opportunity you won't want to miss. It offers the perfect combination of comfort, beauty, and a convenient location.

Patty’s Cozy Studio with K bed in Casco Viejo
Best location by the “El Rey" Supermarket...Casco's only grocery store! Prime location steps away from restaurants, bars, cafes, plazas and great little breakfast places with the lovely water front promenade around the corner making it the perfect “pied-à-terre!” The studio has a fully stocked kitchen aside from the main living space. It is spacious, comfortable and tastefully decorated!
Popular amenities for Panama City vacation rentals
Other great vacation rentals in Panama City

Elegant apartment with a view & the warmth of home

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

Chic & Modern 1BD Yoo Panama City

Unique Luxury 3-story Loft at the Yoo

YOO Panama · Luxury signature ocean view. 57th fl

Tropicool Loft w/rooftop steps from Casco

Luxury Mid-Century Apartment In Casco Viejo

Amazing loft with an iconic view of Casco Viejo
Frequently Asked Questions
How is the weather in Panama City?
Panama City has a tropical climate with high temperatures throughout the year, usually ranging from 75°F to 88°F (24°C to 31°C). Rainy season occurs between May and December, while the dry season extends from January to April.
What are some of the best things to do in Panama City?
Popular activities in Panama City include exploring the historic Casco Viejo district, visiting the Panama Canal Museum, and strolling along the Cinta Costera. Birdwatching in the Metropolitan Natural Park and shopping in the Mercado de Mariscos are also often recommended.
What is the best time of year to visit Panama City?
The most frequented time to visit Panama City is between January and April. This period coincides with Panama's dry season, which enables more comfortable exploration of the city's many attractions. During this time, the vibrant and lively Carnival of Panama, typically held in February, draws a sizable crowd.
What are the best places to stay in Panama City?
Casco Viejo, the city's historic district, is a popular area to stay in Panama City due to its colonial architecture and range of dining options. The modern neighborhood of Punta Paitilla is often recommended for its skyscrapers and shopping centers, while Costa del Este appeals to those seeking a quieter, residential ambiance.
What are the best places to visit in Panama City?
Many visitors to Panama City enjoy the historic district of Casco Viejo, the Panama Canal, and the Metropolitan Natural Park. Other frequently suggested places include the Amador Causeway for its stunning views, and the Biomuseo for its distinct architecture and exhibits on biodiversity.
What are some hiking trails in Panama City?
The Metropolitan Natural Park, located within Panama City, has several hiking trails, such as the Mono Titi Road and the Los Momotides trail. Just outside the city, you can explore the trails of the Soberania National Park, including the Pipeline Road, known for its diverse birdlife.
What are some family activities to do in Panama City?
Families in Panama City often enjoy a visit to the Biomuseo, a museum renowned for its exhibits on biodiversity. The Panama Canal, particularly the Miraflores Locks, provides an educational experience. The Metropolitan Natural Park and Summit Botanical Gardens and Zoo are also popular destinations for families.
What are some of the best day trip ideas in Panama City?
A day trip to the Panama Canal, specifically the Miraflores Locks, is frequently suggested. The beautiful Pearl Islands are also accessible for a day trip from the city. Within the city, exploring the historic district of Casco Viejo, or the biodiversity of the Metropolitan Natural Park, make for enjoyable day trips.
Are there family-friendly apartment rentals in Panama City?
Panama City has more than 870 family-friendly apartment rentals. Amenities on the property may include high chairs, travel cribs, or strollers.
How much does it cost to stay in bed and breakfast rentals in Panama City?
Experience the best of Panama City with our bed and breakfast rentals, starting at about $10 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Quick stats about vacation rentals in Panama City

Total vacation rentals
Explore 4,740 vacation rentals in Panama City

Nightly prices starting at
Panama City vacation rentals start at ﺩ.ﺇ37 per night before taxes and fees

Verified guest reviews
Over 114,280 verified reviews to help you choose

Family-friendly vacation rentals
1,480 properties offer extra space & kid-friendly amenities

Pet-friendly vacation rentals
Find 1,680 rentals that welcome pets

Vacation rentals with a pool
2,570 properties feature pools

Rentals with dedicated workspaces
2,880 properties have a dedicated workspace

Wi-Fi availability
4,490 of Panama City vacation rentals include wi-fi access

Popular amenities for guests
Guests love Gym, BBQ grill, and Laptop-friendly workspace across Panama City rentals

4.7 Average rating
Panama City stays receive an average rating of 4.7 out of 5 from guests

Nearby attractions
Panama City's top spots, include Miraflores Locks, Museo de Arte Contemporáneo, and Santo Tomas (Panama Metro)
Destinations to explore
- Cartagena Vacation rentals
- San Andrés Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Uvita Vacation rentals
- Boquete Vacation rentals
- Coveñas Vacation rentals
- Playa Blanca Vacation rentals
- Bahía Ballena Vacation rentals
- Ancón Vacation rentals
- Limón Vacation rentals
- David Vacation rentals
- Valle de Antón Vacation rentals
- Rentals with a washer and dryer Panama City
- Pet-friendly rentals Panama City
- Rentals with lake access Panama City
- Rentals with outdoor seating Panama City
- Hostel rentals Panama City
- Fitness-friendly rentals Panama City
- Rentals with a fire pit Panama City
- Apartment rentals Panama City
- Beachfront rentals Panama City
- Guesthouse rentals Panama City
- Smoking-friendly rentals Panama City
- Boutique hotel rentals Panama City
- Hotel rentals Panama City
- Serviced apartment rentals Panama City
- Rentals with beach access Panama City
- Rentals with a sauna Panama City
- Loft rentals Panama City
- Rentals with a hot tub Panama City
- Rentals with an EV charger Panama City
- Private suite rentals Panama City
- Rentals with pools Panama City
- Villa rentals Panama City
- Rentals with an accessible height bed Panama City
- Bed and breakfasts Panama City
- Ski-in/ski-out rentals Panama City
- Family-friendly rentals Panama City
- Rentals with a fireplace Panama City
- Rentals with a home theater Panama City
- Rentals with a patio Panama City
- Townhouse rentals Panama City
- Condo rentals Panama City
- Rentals with breakfast Panama City
- Cabin rentals Panama City
- Waterfront rentals Panama City
- House rentals Panama City
- Things to do Panama City
- Food and drink Panama City
- Art and culture Panama City
- Tours Panama City
- Sightseeing Panama City
- Nature and outdoors Panama City
- Sports activities Panama City
- Things to do Panamá Province
- Food and drink Panamá Province
- Nature and outdoors Panamá Province
- Tours Panamá Province
- Sightseeing Panamá Province
- Art and culture Panamá Province
- Sports activities Panamá Province
- Things to do Panama
- Sightseeing Panama
- Food and drink Panama
- Sports activities Panama
- Nature and outdoors Panama
- Entertainment Panama
- Art and culture Panama
- Tours Panama

