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Guesthouse vacation rentals in Panama

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Panama guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
Guesthouse in Nueva Gorgona
4.99 out of 5 average rating, 71 reviews

Beautiful Casita-Paradise in Panama, Nueva Gorgona

Mendee And AndresRating, 5 stars1 month ago
We absolutely LOVED our stay at Linda and Russ’s beautiful piece of paradise. Everything was just perfect! The house is darling, super comfortable, everything you could possibly need for a fully functional kitchen (scissors!), a nice big king-size bed. The grounds are AMAZING! We took advantage daily of their big, clean swimming pool. Linda and Russ are exceptional hosts! They are friendly, full of information but also give you lots of space and respect your privacy. There was nothing, I mean nothing that they didn’t think of that would make your stay perfect. There was thought put into every single detail. And Emma… oh sweet little Emma… the neighbor’s visiting cat that makes sure you get your daily dose of love. Please tell little Emma how much we miss her.
Guesthouse in Bocas del Toro Province
5 out of 5 average rating, 4 reviews

Las Palmas Casita at Bluff Beach Retreat

MarcRating, 5 stars25 months ago
We really enjoyed our vacation, and we can definitely renommend Bluff Beach Retreat. Karen and Steve were very helpful and took good care of us. The nature and the beautiful sorroundings were amazing. A boat trip with Luis, arranged by Karen, is something you shouldn’t miss out - a fantastic guy:)
Guesthouse in Coloncito
4.95 out of 5 average rating, 19 reviews

Beautiful Casita-Paradise in Panama, Nueva Gorgona

Dustin And GingerRating, 5 stars18 months ago
Love this place! Comfortable and close to everything. Russ and Linda are great to work with. We will be back!
Guesthouse in Jaramillo Arriba
4.92 out of 5 average rating, 38 reviews

Casita Caramelo

DavidRating, 5 stars15 months ago
A quiet apartment surrounded by a beautiful garden. The home was very clean, and we felt at home right away. Our host Pam was very welcoming to us. I cook and whatever I reached for, Pam had provided. No scratch teflon, a good set of knives and a sharpener, plenty of dishes and glassware, the list goes on. She was particularly considerate to our privacy (for example, by calling us when she’d have to be behind the house to refill a gas canister) but was always responsive when we’d reach out. And she’s a lovely friendly person too.
Top guest favorite
Guesthouse in Panamá
4.93 out of 5 average rating, 43 reviews

Cabaña privada y rio CasaMomote, Loma Limón.

JosuRating, 5 stars1 week ago
Excelente estadía, desde el primer momento Mariel nos hizo sentir en casa con su amabilidad y generosidad. El entorno, rodeado de naturaleza y lindas vitas, es tranquilo, silencioso y acogedor. El patio y la cocina exterior permiten hacer actividades al aire libre de forma muy cómoda. Recomiendo 100%. Muchas gracias Mariel y familia!
Guest favorite
Guesthouse in Mariato
4.96 out of 5 average rating, 80 reviews

Beachfront/Private Full floor Studio in Guesthouse

TealRating, 5 stars2 months ago
We had an absolutely magical stay at this incredible Airbnb! Nestled in the jungle with parrots and monkeys, it was only a short walk to a secluded beach. The sound of the waves from the deck was so peaceful and added to the charm of the place. We loved taking sunset walks on the beach, searching for shells, and simply enjoying the breathtaking views. The pool was a huge hit with our kids. The Airbnb itself was spotless, comfortable, and fully equipped with everything we needed for a wonderful stay. Michael and Lynn were fantastic hosts—super responsive, accommodating, and went above and beyond, even letting us have a late check-out so we could enjoy one last surf session before heading back to Panama City. The location was perfect, just a 15-minute drive to Playa Morrillo for daily surfing and another 15 minutes to the charming town of Torio. We loved this place and can’t wait to visit again one day soon. Highly recommend!
Guesthouse in Boquete
5 out of 5 average rating, 10 reviews

Vista a Baru

ElliotRating, 5 stars3 months ago
What a magical place! Lily and bob were warm, welcoming, and helpful hosts. We had a couple hiccups along the way and they were extremely responsive in helping us. Their property and the surrounds could not be any more beautiful. We hope to be back soon.
Guesthouse in Panamá
4.4 out of 5 average rating, 5 reviews

Mochila & Art Family House

Alba RosemarieRating, 5 stars75 months ago
Las personas súper atentas, nos dieron muchas recomendaciones para los traslados, y lugares para visitar, los desayunos muy ricos, recomendado.

Guest house rentals with a patio

Guesthouse in La Ermita
4.85 out of 5 average rating, 13 reviews

Casa Piedras Gordas

JorgeRating, 5 stars1 month ago
Lugar muy bonito, piscina suficiente para por lo menos 6-7 personas, asador de buen tamaño para hacer un asado. Cama bastante cómodas y bañas muy bonitos. El lugar esta aun en construcción por lo que no esta completamente cerrado, hay poca iluminación afuera (no se ve nada) y la refri es pequeña para varios días, del resto todo muy bien, recomendado el lugar sin importar lo mencionado. Si o si lleven repelente como dice el anuncio.
Guesthouse in Alto del Espino
5 out of 5 average rating, 3 reviews

Tropical Suburban Splendor.

GabyRating, 5 stars16 months ago
Spacious and just what we needed! The apartment is bigger than we expected and it has all your basic needs, including hot water and air conditioning. Emma-Lee was very kind and accommodating.
Guesthouse in Torio
4.83 out of 5 average rating, 6 reviews

Cozy cabin w/ Queen Bed & ensuite 10 mn from Beach

SereneRating, 5 stars14 months ago
Los Pinos is nestled among pine trees and palm trees as well as many others. Everything is well shaded for a comfortable experience. My cabina was clean, the bed was comfortable. This is a real bed and breakfast, I was treated to eggs cooked to order, served with “hojaldre” a puff pastry, an authentic specialty. The host Mike is personable and a wealth of information about the area
Guesthouse in Boquete
5 out of 5 average rating, 3 reviews

Mambú - Lantana guesthouse.

AlexisRating, 5 stars1 week ago
He tenido la oportunidad de alojarme en otro spot de Boquete y este de Marissa esta 10/10. Tiene un patio enorme con areas verdes, gacebos, y estan construyendo otras áreas de estar. Además, la hospedadora es muy amable, siempre esta al pendiente de tus necesidades y sin importar la hora te brinda lo que necesites. El area es super tranquila, por lo que puedes descansar a gusto, y cuenta con energía renovable, parte de su iluminaria utiliza paneles solares y algo importante a recalcar es que utilizan 3 filtros de agua, asi que es potable al 100% y no necesitaras comprar agua. El lugar cuenta con todas las amanenidades que se necesitan y más. Sin duda, recomendable.
Guesthouse in Cuesta de Piedra
4.75 out of 5 average rating, 8 reviews

Casita de Campo ideal para ti.

Elsi jeannetRating, 5 stars1 month ago
Es una excelente ubicación para alejarse de la ciudad , área muy tranquila, buen clima , instalaciones en buen estado y limpias ,buena atención y flexibilidad de acceso de chekin
Guest favorite
Guesthouse in Panama City
4.9 out of 5 average rating, 201 reviews

#1 MiniStudio personal 9 km Aeropuerto @tocumen

ZapataRating, 5 stars2 weeks ago
Tuve una excelente experiencia en el MiniStudio. El lugar es muy acogedor, limpio y perfecto para una escala cerca del aeropuerto. Lo que más destaco es la atención de Lily: siempre estuvo disponible, con muy buena disposición para ayudar y dar recomendaciones. Sin duda volvería. ¡Gracias por todo, Lily!
Guesthouse in Bocas del Toro
4.8 out of 5 average rating, 30 reviews

Studio w/pool access & near best surf spots.

MonyRating, 5 stars1 week ago
me gustó la tranquilidad no estaba en el centro pero si relativamente cerca lo que me pareció 👌 muy lindo el lugar coincidía con las fotos. sinceramente muy satisfecha con todo y Carolina siempre estuvo atenta.
Guesthouse in Torio
4.4 out of 5 average rating, 10 reviews

Olé #1 | Close the beach, restaurants, activities

PabloRating, 5 stars3 weeks ago
Je recommande ces Cabanas ! Le prix est très abordable et vous avez un petit logement entièrement fonctionnel et privé, avec beaucoup de restaurants et d'activités autour. La communication avec l'hôte est franchement très agréable et réactive. Merci pour ce moment :)

Guest house rentals with a washer and dryer

Top guest favorite
Guesthouse in Panamá Oeste
5 out of 5 average rating, 17 reviews

toma un descanso lugar tranquilo

VivianaRating, 5 stars1 month ago
Encantada con el lugar, muy bello, una estadía tranquila y la atención súper chevere y muy querida, super recomendado y espero volver pronto
Guest favorite
Guesthouse in Boquete District
4.95 out of 5 average rating, 20 reviews

Casa Tropical Boquete Duplex 1

HannahRating, 5 stars1 month ago
We had a great stay! The location felt private and immersed in nature, yet also a very quick drive away from the downtown area. There was a delicious strawberry stand across the street that we enjoyed, and little animals called neque hanging out in the gardens behind the home. Jhayat was kind and accommodating in her communication with us. The place itself felt like a cabin, but with modern amenities like hot showers and a well-equipped kitchen. It was a cute little mountain retreat.
Top guest favorite
Guesthouse in David
5 out of 5 average rating, 62 reviews

Pool House with Shared Pool Access

VickyRating, 5 stars1 month ago
On vous recommande ce logement à 1000%. Couple super gentil. ils nous ont donné pleins de conseils et de bons endroits à visiter. Le logement est spacieux et bien équipé ! Nous allons y retourner c'est certain 🤩
Superhost
Guesthouse in La Chorrera
5 out of 5 average rating, 3 reviews

Rincón encantado en La Chorrera

AjotaRating, 5 stars3 months ago
Casita acogedora tipo apartamento estudio dentro de una propiedad principal. La sala comedor tiene pisos de baldosas de terracota con muebles cómodos y funcionales. Sus áreas están iluminadas por luz natural y decoradas con plantas. Se encuentra en una zona muy tranquila, fuera del centro.
Superhost
Guesthouse in David
5 out of 5 average rating, 7 reviews

Acogedor, tranquilo y excelente ubicación!

BlaneRating, 5 stars11 months ago
Staying here was an outstanding experience in more ways than one. This is a good location for exploring other parts of Panama. Look up "Villa del Carmen, David, Panama" on Google Maps to get an idea. Tranquil is a good way to describe the area also. Apt. Isn't big, but is plenty good for 1 or 2 people. Kitchen & sitting areas are outside, with everything you need. If it gets too hot in the afternoon, just take a little siesta inside & you'll be fine. Very relaxing! Lina was an excellent host, & I had the pleasure of spending time with her. The apt. itself is behind the home of a nice, sweet, kind, helpful, generous woman named Amarilis. Get to know her! Amarilis turned a good experience into a great one! We had many good conversations (using Google Translate), she was patient with my lousy Spanish & I enjoyed her company very much. She & Lina helped make my decision to move to Panama an easy one, & I look forward to seeing them both again. Wish I could write more! I highly recommend!
Guest favorite
Guesthouse in Los Naranjos
4.71 out of 5 average rating, 70 reviews

Cabañas de Alicia 1

VeroniqueRating, 5 stars1 month ago
Clean and nice place, fits described bedrooms. Ezequiel was very friendly and helpful. Well placed, a bit further from Boquete but still close and close to the Lost falls that was a great hike. Washington machine was not in the unit but easy to wash clothes asking Ezequiel. Beds were comfortable.
Superhost
Guesthouse in La Concepcion
4.29 out of 5 average rating, 7 reviews

New tropical guesthouse

GrainneRating, 5 stars2 weeks ago
Donald is very friendly and helpful. The place was lovely, nice swimming hole when it got hot. Lots of birds and other travelers around to share your day with or not as you choose. A little hidden gem in a lovely town with lots to do. Well done Donald. We will be back!

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