
Guesthouse vacation rentals in Panama
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Panama
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

Sunshine Cottage at Finca Katrina
Sunshine Cottage is a little cottage in the back garden of Finca Katrina. It is set on a hill with views of Palo Alto and Jaramillo with a coffee plantation in the foreground. There is a full (double) bed, room to hang your clothes and to store your belongings. You have a small fridge, toaster oven, sink, coffee maker, and cupboard space for food, but no stove top. If you are looking for more bedrooms, there are additional units on Finca Katrina that compliment Sunshine Cottage. Send us a note!

Spacious Casita with Bamboo View
Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

The Retreat in El Valle - Garden House
Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Torio guesthouse with panoramic view; Kokomo
Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

Gamboa - Ñeque Studio, house # 126
Welcome to Gamboa! Only 35 minutes from downtown Panama, Gamboa. Situated in Soberanía National Park and on the shores of the Panama Canal, is a Mecca for Birdwatchers and Nature enthusiasts! Watch the wildlife right from the backyard of your fully equipped apartment. Feel the magic songs of thousands of birds welcoming the twilight of sunrise and dusk in this century old community. Easily explore wildlife on trials through the surrounding old growth jungle and by boat on the Panama Canal.

Sustainable Guest house with Pool in Rio Hato
Discover Rancho Ahome, a serene 2BR 1Bath guesthouse in Rio Hato. Escape to tranquility, 5 mins from stunning beaches, and enjoy our private pool with a waterfall. Immerse in nature on our sustainable farm, home to fruits, rabbits and chickens. Perfect for those seeking peace and an eco-friendly retreat, Rancho Ahome offers a blend of comfort and adventure amidst breathtaking landscapes. Experience a peaceful sanctuary that’s close to nature yet filled with comfort. We are pet friendly.

Rural+comfy: AC, WiFi, hot water, pool, private
The Sky Cabin is part of 5 cabins “A Piece of Paradise” With registration in the Panamanian Tourism Authority Bureau. ✸ Ideal for a couple or a single person ✸ Outdoor dining area and kitchen ✸ Spacious terrace with a hammock ✸ Very quiet neighborhood ✸ Private and public transportation available, just ask and we will help you ✸ 7-10 minutes, by car, from Playa La Ermita and 10 minutes from Playa El Palmar (great spot for surfing) ✸ Breakfast for an additional $7.00, for each guest.

Bamboo Cabin
Take it easy at this unique and tranquil getaway. The Bambu Cabana is surrounded by bamboo and features a unobstructed view of Vulcan Baru. Wake up to see the sun reflecting off of the mountain, visible clearly through large floor to ceiling wrap around windows. Do some work at the desk or relax in the recliners or outdoor balcony chairs. Enjoy a refreshing shower or long soak in the large bathtub. The cabana includes a well stocked kitchenette, and washer dryer combo.

Ginger House/House for a violinist
Relax in this unique and peaceful getaway in a private neighborhood. Just a 5-minute walk to the beach, from the house you can hear the water of the creek and the birds singing in the trees, allowing you to enjoy the nature and tranquility of the surroundings. The accommodation features a large terrace with a barbecue area, an outdoor bathroom and shower, and a deck overlooking the creek. Ideal for nature lovers, remote work, surfing, yoga, meditation, hiking, and fishing.

Mountain cabin with private pool
Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and spectacular views, here you can breathe fresh air and gaze at the stars. ✔️ Ideal for couples, families or adventurers. ✔️ Trails, rivers and viewpoints nearby. ✔️ Comfortable and equipped spaces for your comfort. - Sleeps 4 people. - Possibility of having 1 double bed and 2 single beds or 4 single beds. - Discount for two nights or more.

Beachfront Nature Rentals, Full floor Studio
At Beachfront Nature Rentals, we have a 1km beautiful sandy beach. STARLINK internet. Peace & Quiet. 4 wheel drive car is not required. Soft rhythmic sound of the waves. Every week; new birds, turtles nesting, dolphins, whales or monkeys. See the stars without light pollution. Ocean is perfect for swimming and sometimes body-boarding. Swim in our pool anytime you like. If you surf, we have walking or driving access to a surfing beach.

Private guest house in Ancón
Enjoy the simplicity of this cozy, quiet, and centrally-located accommodation. Close to places of interest such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; yet it maintains the desired privacy and tranquility.
Popular amenities for Panama guesthouse rentals
Family-friendly guest house rentals

Rare find: central+urban+ private green yard

Guest casita with pool, 2 min walk to the beach!

Smart Stay by SS • Budget Studio 3+ Airport & Mall

A Remote Paradise in nature - Ocean View

Toucan Bay Lodging & Holistic Services

Our green house

Efficiency Bungalow - Metropolitan Natural Park

Casita Verde 411
Guest house rentals with a patio

Reef to Ridge Island Living - 2 Private Casitas

Casa de Meca

Q&B Inn Cozy One-Room Apartment #2

A beautiful beachfront guest house

Rustic Private Studio Near Downtown

Villa Alber Mari

Casita Colibri, new 2025. Near Beach, great pool

(5) The Beach House Inn - The Santa Cruz Room
Guest house rentals with a washer and dryer

Beautiful Casita-Paradise in Panama, New Gorgona

Cozy cabin w/ Queen Bed & ensuite 10 mn from Beach

Casa Tropical Boquete, Duplex #1 2R /2BR

Pool House with Shared Pool Access

Peaceful Contadora Island Guest Home w/Garden View

Studio with Pool Near Beaches in Bocas del Toro

Private cabin and CasaMomote river, Loma Limón.

Alicia's Cabins 1
Destinations to explore
- Beach condo rentals Panama
- Lakehouse rentals Panama
- Rentals with breakfast Panama
- Rentals with a home theater Panama
- Rentals with a washer and dryer Panama
- Smoking-friendly rentals Panama
- Rentals with a hot tub Panama
- Rentals with pools Panama
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Nature eco lodge rentals Panama
- Aparthotel rentals Panama
- Hotel rooms Panama
- Cottage rentals Panama
- Rentals with lake access Panama
- House rentals Panama
- Tent rentals Panama
- Boutique hotels Panama
- Farmstay rentals Panama
- Beach house rentals Panama
- Rentals with beach access Panama
- Condo rentals Panama
- Bed and breakfasts Panama
- Rentals with an accessible height bed Panama
- Treehouse rentals Panama
- Rentals with a fireplace Panama
- Shipping container rentals Panama
- Townhouse rentals Panama
- Rentals with a sauna Panama
- Dome rentals Panama
- Serviced apartment rentals Panama
- Ski-in/ski-out rentals Panama
- Earth house rentals Panama
- Mansion rentals Panama
- Private suite rentals Panama
- Waterfront rentals Panama
- Chalet rentals Panama
- Pet-friendly rentals Panama
- Rentals with a fire pit Panama
- Boat rentals Panama
- Fitness-friendly rentals Panama
- Rentals with a patio Panama
- Family-friendly rentals Panama
- Vacation home rentals Panama
- Cabin rentals Panama
- Rentals with outdoor seating Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Villa rentals Panama
- Tiny house rentals Panama
- Loft rentals Panama
- Apartment rentals Panama
- Bungalow rentals Panama
- Island rentals Panama




