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Guesthouse vacation rentals in Mission Bay, San Diego

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mission Bay, San Diego guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
A cozy living area is highlighted by a large sectional sofa adorned with various cushions. Light filters through sheer white curtains, illuminating the space. A striped coffee table rests atop a soft area rug, while a TV and a stylish lamp add functionality.
Guesthouse in South Park
4.84 out of 5 average rating, 126 reviews

Adorable San Diego Guesthouse

AlauraRating, 5 stars3 weeks ago
I have never stayed in South Park before. This location was so fun! Lots of little places to walk to. No issues with parking.
Guest favorite
Guesthouse in La Jolla
4.83 out of 5 average rating, 155 reviews

Poolside Ocean View Studio

JeffRating, 5 stars5 months ago
I was looking for a peaceful and comfortable place to relax and recharge and this fit perfectly. Anita and Brian are great hosts, friendly and helpful but still respected my privacy. The setting is also beautifully landscaped and the deck was great to have for relaxing and enjoying the water view. I can highly recommend.
Guest favorite
The exterior of a two-story guesthouse is showcased, featuring a combination of wood paneling and painted walls. A bright white door and two small windows add contrast. The area is complemented by a compact patio set with two chairs and a table on a stone surface.
Guesthouse in La Mesa
4.93 out of 5 average rating, 236 reviews

Fig Tree Bungalow

LaurenRating, 5 stars1 week ago
This place was great for our quick weekend trip. Definitely worth the price.
Superhost
A welcoming living area features a futon and coffee table set on polished hardwood floors. Bright natural light fills the room through the window. A dining area with a table for four is visible, along with kitchen access through an open doorway.
Guesthouse in Pacific Beach
4.83 out of 5 average rating, 360 reviews

Pacific Beach Guest House With Garage and A/C

BillRating, 5 stars1 month ago
Had a great stay at this Airbnb. hist provided excellent instructions and the space was accurately described in the listing. Was a great basecamp for visiting San Diego friends and exploring the city.
Top guest favorite
A cozy bedroom is highlighted by a neatly made bed, featuring a patterned quilt and two pillows. A small tray with snacks sits attractively on the bed. Natural light pours in through a window adorned with light curtains.
Guesthouse in Allied Gardens
4.95 out of 5 average rating, 390 reviews

The BEST NEST Clean, peaceful, private, affordable

CatalinaRating, 5 stars3 weeks ago
Love Teri’s place! Feels just like home whenever we stay there. Walking distance to Better Buzz Coffee and Vons for groceries. Everything you need is there for you to make the place feel like home away from home. Teri was a great host too, can’t recommend her enough for anyone wanting to stay in San Diego.
Guest favorite
A vibrant wall art piece features two alpacas, one with a light-colored fleece and the other with dark fur. They are depicted against a backdrop of green foliage, adding a touch of nature and whimsy to the space.
Guesthouse in San Diego
4.93 out of 5 average rating, 191 reviews

Cosy quiet Guesthouse near SDSU

AnthonyRating, 5 stars1 week ago
I think this place was well worth what it was advertised. Great location host was very responsive and I will book again if I’m in the area..
Guest favorite
A bright living area is highlighted by light-colored walls and warm wooden floors. Two blue chairs and a circular coffee table are positioned around a patterned area rug. A light green furniture piece holds a television, and natural light enters through sheer curtains.
Guesthouse in North Park
4.88 out of 5 average rating, 110 reviews

Charming North Park Cottage

LoraRating, 5 stars1 week ago
We thoroughly enjoyed our short stay at Patricia’s place. The location is within walking distance of numerous restaurants and bars and is a short drive to downtown San Diego, Little Italy etc. The home was clean and comfortable and perfect for two people. I met Patricia briefly as we were leaving. She was very friendly and had we been staying longer I would’ve asked her for local recommendations. I will absolutely stay there again when I’m back in California. Thank you, Patricia!
Superhost
A large, inviting swimming pool features a curved design with clear blue water. Stone accents outline the pool, and a jacuzzi is positioned nearby. Lush greenery and rock formations enhance the space, while lounge seating is arranged on the surrounding patio.
Guesthouse in Spring Valley
4.88 out of 5 average rating, 202 reviews

San Diego family bungalow!

EstrellaRating, 5 stars1 month ago
Everything and the hosts were amazing, can't wait to come back again ❤️

Guest house rentals with a patio

Top guest favorite
A comfortable outdoor seating area is visible, featuring two wooden chairs and a low table with potted plants. Brightly colored textiles decorate the table, while the door to the cottage is framed by greenery. Sunlight filters through the area, enhancing the inviting ambiance.
Guesthouse in Talmadge
4.99 out of 5 average rating, 201 reviews

Adorable cottage in Talmadge

KathyRating, 5 stars3 weeks ago
Another great visit! Convenient location coupled with wonderful amenities, along with Carlos’ hospitality makes this a top choice for us when visiting San Diego to see our son!
Top guest favorite
Guesthouse in La Mesa
4.99 out of 5 average rating, 106 reviews

Private 1 BR Paradise retreat

GinaRating, 5 stars4 days ago
Great stay & wonderful hosts. We'll be back for sure!
Top guest favorite
A broad view captures the coastal landscape of La Jolla, featuring the shimmering ocean, serene bay, and city lights under a clear sky. The horizon displays the iconic pier, with the vibrant residential area blended into the backdrop of rolling hills.
Guesthouse in La Jolla
4.98 out of 5 average rating, 200 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

MarkoRating, 5 stars2 weeks ago
An absolute paradise!!! From the arrival to the attention to detail in every way, this place makes you feel right at home. We were greeted by a welcome basket even! The neighborhood is so peaceful… plenty to enjoy and relax just being at the home. We cannot wait to come back!
Guest favorite
An outdoor living area features a comfortable seating arrangement on a wooden deck, adorned with orange cushions. Decorative wall art and greenery enhance the space, while a well-maintained lawn is visible in the background, creating a relaxing atmosphere for guests.
Guesthouse in Chula Vista
4.94 out of 5 average rating, 139 reviews

New! Beautiful Private Casita- King Bed & Office

ChrisRating, 5 stars4 weeks ago
Really enjoyed Alberto’s place, it’s nicely tucked away and provided a nice retreat from the busy area. We were able to relax and had all of the comforts of home. We really enjoyed the comfy couch and bed which allowed us to relax after a very busy few days. Off street parking was very nice as we had a busy agenda the few days we were in town and it was nice having our car in the driveway and secure off the street. Would absolutely stay again and recommend to anyone in the area.
Guest favorite
A spacious studio features light-colored walls and wood flooring. A large bed is dressed in soft linens, accompanied by a side table with a lamp. A patio door opens to a private outdoor space, while a clothing rack and seating area are also visible.
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 101 reviews

Cozy, Quiet and Private Backyard Studio Escape

ChristineRating, 5 stars3 days ago
Everything was great but the thing that stood out the most was how CLEAN everything was. I find most airbnb hosts are not keeping their rentals as clean as I would like, but this one was spotless. Not only organized, but also bathroom and kitchen tiles, counters and floors throughout were very clean and I appreciated that so much! Stephanie also graciously offered to help with a pricing issue I encountered before booking which was very kind. The guest house is quiet and peaceful and I found the bed to be very comfortable. Very nice all around.
Guest favorite
A set of double glass doors is framed by light-colored walls, providing access to the private studio. Two comfortable chairs are positioned outside, offering a cozy spot to relax. Decorative string lights are visible overhead, creating a welcoming atmosphere.
Guesthouse in North Park
4.88 out of 5 average rating, 147 reviews

Casita with private yard and separate entrance

CamiRating, 5 stars2 months ago
This was the perfect place for a one night stay. It’s so close to a lot of good restaurants and stores. Also the perfect spot to stay if you’re looking for somewhere close to the observatory theater!
Top guest favorite
A ground-level patio features comfortable Adirondack chairs arranged around a fire pit, set on freshly laid pavers. Large sliding glass doors provide access to the interior space, illuminating the outdoor seating area.
Guesthouse in North Park
4.98 out of 5 average rating, 122 reviews

New (2022) North Park Abode w/ Roof Deck

SarahRating, 5 stars3 months ago
BOOK IT! Aesthetically well done, extremely comfortable, perfect location. Really enjoyed my stay here for 5 days. Unit has everything you may need during your stay. Love this neighborhood, so many great restaurants and shops. Parking was always available. Space is squeaky clean and bed is comfy. Next time I’m in SD I will stay here again.
Guest favorite
Guesthouse in La Mesa
4.95 out of 5 average rating, 107 reviews

Violet Oasis | hot tub, kitchen, no dog fee!

KaylaRating, 5 stars1 month ago
We had an amazing little staycation over the weekend at the Violet Oasis. Extremely clean, the bed was so comfy we never wanted to leave, both parking locations easy to find and Elizabeth and Paola were super responsive. Rather than feel like we were staying at an Airbnb it felt like staying over at a friend’s place. Their passion responding to their guests, making them feel at home and providing information on what to do in the area really shows in this listing. We will be back!

Guest house rentals with a washer and dryer

Guest favorite
An outdoor living space is featured, showcasing a stone fireplace with a flickering fire. A cozy seating arrangement is present nearby, and a television is visible through a glass door, contributing to a relaxed atmosphere perfect for gathering.
Guesthouse in La Jolla
4.98 out of 5 average rating, 415 reviews

Beautiful Private Villa walk to beach

SamanthaRating, 5 stars3 weeks ago
It’s was amazing staying a Kim’s guesthouse. Felt very private and peaceful. The birds sounded so beautiful in the morning, we thought it was fake at first. The flowers just outside are beautiful. The beach within walking distance was a perfect place to play, lay out, watch the sunset and surfers. We even saw dolphins one night! Just a magical time. We will definitely come back!
Top guest favorite
Guesthouse in North Park
4.99 out of 5 average rating, 160 reviews

Carrie’s North Park Casita, in Heart of San Diego

BethRating, 5 stars2 weeks ago
Very sweet spot for me and my son to stay while on Spring Break. We mentioned my son loved tacos, and Carrie gave us several recommendations and even gave us a gift card for The Taco Stand! So thoughtful! 🙂❤️🌮
Guest favorite
An open living space features a comfortable seating area with light-colored furniture, a wooden coffee table, and a television mounted on the wall. Large glass doors allow natural light to fill the room, offering views of an outdoor area with greenery.
Guesthouse in La Jolla
4.79 out of 5 average rating, 191 reviews

San Diego Shangri-La

JimRating, 5 stars1 month ago
This apartment is great for 2 people to enjoy the San Diego / La Jolla area. We stayed here for a full month. The apartment is very cozy and the hosts are absolutely fantastic! They have an office set up downstairs (in the garage) and work there most weekdays and occasionally on weekends, so you're not in a totally private house (you have your own entrance and space upstairs), but they are close by for questions. As is prevalent in the area our small dog was very welcome in this apartment. If you have a small dog be wary of coyotes that roam the area.
Guest favorite
A white door with an arched window is set against a textured beige wall, marked with the letter 'J'. Lush green plants and bright yellow flowers frame the entrance, providing a welcoming touch to the exterior. A small mat is positioned at the door.
Guesthouse in Rancho Penasquitos
4.93 out of 5 average rating, 102 reviews

❤ Cozy Private Studio w/ WD 2 Minutes from Freeway

JenniferRating, 5 stars5 months ago
Wonderful stay! Home away from home! had everything I needed for an extended stay. Will be back for sure!
Superhost
Guesthouse in Pacific Beach
4.78 out of 5 average rating, 389 reviews

Law Street Retreat

MarissaRating, 5 stars2 weeks ago
Exactly as advertised and in a great location not far from the beach and boardwalk. The bikes were great for getting around as well. The bed was also very comfortable. Easily accessed and had no issues at all!
Superhost
An open indoor space features a comfortable sofa adorned with decorative pillows. A large glass garage door leads to a private outdoor lounge area with natural greenery, seating, and a dining table, creating a seamless transition between indoor and outdoor living.
Guesthouse in Ocean Beach
4.88 out of 5 average rating, 321 reviews

Indoor/Outdoor Sanctuary in Ocean Beach

ShonnaRating, 5 stars2 weeks ago
The place was as described and Lori was responsive. Although, I did accidentally break a small plate while cleaning it. I let her know but didn't get a response. Oops! And it would have felt good hearing, "no worries it happens." Only because I felt bad. Overall, beautiful and relaxing. I'll definitely book there again when we're back to visit family!
Top guest favorite
An inviting outdoor space is framed by lush palm trees and vibrant gardens. A circular fire pit with glowing flames creates a warm focal point, surrounded by comfortable lounge chairs. Soft lighting enhances the tranquil ambiance as dusk settles over the scenic landscape.
Guesthouse in Mission Hills
4.97 out of 5 average rating, 248 reviews

Beautiful Historic Home and Gardens Near Downtown!

PeterRating, 5 stars1 week ago
Sam's place was lovely. The house is as advertised , and well appointed throughout. The garden was tranquil, and a nice place to relax after a long day. Sam provided us with all the kids items (Stroller, Pack n play, high chair, etc.) I highly recommend this house for all things San Diego. The location and amenities can't be beat.
Guest favorite
Two white adirondack chairs are positioned on a stone patio, facing a vibrant sunset painted in shades of orange and pink. A small white table sits between the chairs, creating a serene outdoor seating area surrounded by gentle hills and greenery.
Guesthouse in La Mesa
4.96 out of 5 average rating, 196 reviews

Cozy Coop with a View

DeanRating, 5 stars3 weeks ago
Corey's place definitely fit the bill as a relaxing and quiet destination in San Diego. We would recommend recommend this very nice place to any one. Thanks Corey for an awesome stay.

Quick stats about guesthouse rentals in Mission Bay, San Diego

  • Total rentals

    20 properties

  • Nightly prices starting at

    ﺩ.ﺇ441 before taxes and fees

  • Total number of reviews

    2.8K reviews

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wifi availability

    20 properties include access to wifi

  • Popular amenities

    Kitchen, Wifi, and Pool

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