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Guesthouse vacation rentals in Mission Bay, San Diego

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Mission Bay, San Diego guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
A cozy living area is highlighted by a large sectional sofa adorned with various cushions. Light filters through sheer white curtains, illuminating the space. A striped coffee table rests atop a soft area rug, while a TV and a stylish lamp add functionality.
Guesthouse in South Park
4.84 out of 5 average rating, 126 reviews

Adorable San Diego Guesthouse

AlauraRating, 5 stars3 weeks ago
I have never stayed in South Park before. This location was so fun! Lots of little places to walk to. No issues with parking.
Guest favorite
Guesthouse in La Jolla
4.83 out of 5 average rating, 155 reviews

Poolside Ocean View Studio

JeffRating, 5 stars5 months ago
I was looking for a peaceful and comfortable place to relax and recharge and this fit perfectly. Anita and Brian are great hosts, friendly and helpful but still respected my privacy. The setting is also beautifully landscaped and the deck was great to have for relaxing and enjoying the water view. I can highly recommend.
Guest favorite
The exterior of a two-story guesthouse is showcased, featuring a combination of wood paneling and painted walls. A bright white door and two small windows add contrast. The area is complemented by a compact patio set with two chairs and a table on a stone surface.
Guesthouse in La Mesa
4.93 out of 5 average rating, 236 reviews

Fig Tree Bungalow

LaurenRating, 5 stars1 week ago
This place was great for our quick weekend trip. Definitely worth the price.
Superhost
A welcoming living area features a futon and coffee table set on polished hardwood floors. Bright natural light fills the room through the window. A dining area with a table for four is visible, along with kitchen access through an open doorway.
Guesthouse in Pacific Beach
4.83 out of 5 average rating, 360 reviews

Pacific Beach Guest House With Garage and A/C

BillRating, 5 stars1 month ago
Had a great stay at this Airbnb. hist provided excellent instructions and the space was accurately described in the listing. Was a great basecamp for visiting San Diego friends and exploring the city.
Top guest favorite
A cozy bedroom is highlighted by a neatly made bed, featuring a patterned quilt and two pillows. A small tray with snacks sits attractively on the bed. Natural light pours in through a window adorned with light curtains.
Guesthouse in Allied Gardens
4.95 out of 5 average rating, 390 reviews

The BEST NEST Clean, peaceful, private, affordable

CatalinaRating, 5 stars3 weeks ago
Love Teri’s place! Feels just like home whenever we stay there. Walking distance to Better Buzz Coffee and Vons for groceries. Everything you need is there for you to make the place feel like home away from home. Teri was a great host too, can’t recommend her enough for anyone wanting to stay in San Diego.
Guest favorite
A quaint wooden counter is displayed, featuring a vintage cash register and an old-fashioned gramophone. Behind the counter, shelves are filled with various antique items and collectibles, creating a nostalgic atmosphere. A wooden chair sits invitingly in front of the counter.
Guesthouse in La Mesa
4.93 out of 5 average rating, 162 reviews

Granny Flat with Bedroom/Bathroom/Kitchen

VioletRating, 5 stars2 days ago
This has been my favorite place I have ever stayed. The home was cozy and beautiful and I loved the energy because it had so much history and love. My boyfriend and I enjoyed looking at all Janet’s memorabilia and felt it just made the home more special and we were grateful to be there. Janet was incredibly sweet and I enjoyed meeting her and having the opportunity to talk to her. She was kind, caring and had a warm presence. When we left she took the time to say goodbye and it meant a lot to me. Her dog was also very cute! She had a garden that was incredibly dreamy too. All in all it was a lovely experience and I hope to be back soon. Thank you so much Janet.🐶💜🦋
Guest favorite
A bright living area is highlighted by light-colored walls and warm wooden floors. Two blue chairs and a circular coffee table are positioned around a patterned area rug. A light green furniture piece holds a television, and natural light enters through sheer curtains.
Guesthouse in North Park
4.88 out of 5 average rating, 110 reviews

Charming North Park Cottage

LoraRating, 5 stars1 week ago
We thoroughly enjoyed our short stay at Patricia’s place. The location is within walking distance of numerous restaurants and bars and is a short drive to downtown San Diego, Little Italy etc. The home was clean and comfortable and perfect for two people. I met Patricia briefly as we were leaving. She was very friendly and had we been staying longer I would’ve asked her for local recommendations. I will absolutely stay there again when I’m back in California. Thank you, Patricia!
Superhost
A large, inviting swimming pool features a curved design with clear blue water. Stone accents outline the pool, and a jacuzzi is positioned nearby. Lush greenery and rock formations enhance the space, while lounge seating is arranged on the surrounding patio.
Guesthouse in Spring Valley
4.88 out of 5 average rating, 202 reviews

San Diego family bungalow!

EstrellaRating, 5 stars1 month ago
Everything and the hosts were amazing, can't wait to come back again ❤️

Guest house rentals with a patio

Top guest favorite
A comfortable outdoor seating area is visible, featuring two wooden chairs and a low table with potted plants. Brightly colored textiles decorate the table, while the door to the cottage is framed by greenery. Sunlight filters through the area, enhancing the inviting ambiance.
Guesthouse in Talmadge
4.99 out of 5 average rating, 201 reviews

Adorable cottage in Talmadge

KathyRating, 5 stars3 weeks ago
Another great visit! Convenient location coupled with wonderful amenities, along with Carlos’ hospitality makes this a top choice for us when visiting San Diego to see our son!
Top guest favorite
Guesthouse in La Mesa
4.99 out of 5 average rating, 105 reviews

Private 1 BR Paradise retreat

GinaRating, 5 stars2 days ago
Great stay & wonderful hosts. We'll be back for sure!
Top guest favorite
A broad view captures the coastal landscape of La Jolla, featuring the shimmering ocean, serene bay, and city lights under a clear sky. The horizon displays the iconic pier, with the vibrant residential area blended into the backdrop of rolling hills.
Guesthouse in La Jolla
4.98 out of 5 average rating, 199 reviews

La Jolla Oasis: Ocean, City and Fire Works Views

MarkoRating, 5 stars2 weeks ago
An absolute paradise!!! From the arrival to the attention to detail in every way, this place makes you feel right at home. We were greeted by a welcome basket even! The neighborhood is so peaceful… plenty to enjoy and relax just being at the home. We cannot wait to come back!
Guest favorite
A spacious studio features light-colored walls and wood flooring. A large bed is dressed in soft linens, accompanied by a side table with a lamp. A patio door opens to a private outdoor space, while a clothing rack and seating area are also visible.
Guesthouse in Serra Mesa
4.95 out of 5 average rating, 100 reviews

Cozy, Quiet and Private Backyard Studio Escape

SharonRating, 5 stars2 weeks ago
This was the perfect Air Bnb for our honeymoon in San Diego. It was in a great area, and the location was 15 minutes from everything we wanted to do! Couldn't recommend more
Guest favorite
A set of double glass doors is framed by light-colored walls, providing access to the private studio. Two comfortable chairs are positioned outside, offering a cozy spot to relax. Decorative string lights are visible overhead, creating a welcoming atmosphere.
Guesthouse in North Park
4.88 out of 5 average rating, 147 reviews

Casita with private yard and separate entrance

CamiRating, 5 stars2 months ago
This was the perfect place for a one night stay. It’s so close to a lot of good restaurants and stores. Also the perfect spot to stay if you’re looking for somewhere close to the observatory theater!
Top guest favorite
A ground-level patio features comfortable Adirondack chairs arranged around a fire pit, set on freshly laid pavers. Large sliding glass doors provide access to the interior space, illuminating the outdoor seating area.
Guesthouse in North Park
4.98 out of 5 average rating, 122 reviews

New (2022) North Park Abode w/ Roof Deck

SarahRating, 5 stars3 months ago
BOOK IT! Aesthetically well done, extremely comfortable, perfect location. Really enjoyed my stay here for 5 days. Unit has everything you may need during your stay. Love this neighborhood, so many great restaurants and shops. Parking was always available. Space is squeaky clean and bed is comfy. Next time I’m in SD I will stay here again.
Superhost
Guesthouse in Mission Beach
4.89 out of 5 average rating, 124 reviews

Seaside Sanctuary Studio with Shared Patio and AC!

ChaseRating, 5 stars3 weeks ago
Amazing Place, Amazing Location just steps from the Mission Beach Sand, and most Importantly an Amazing host. My Girlfriend left some clothes, and she was able to figure a way out to get them back for us in just 20 minutes! Cheers
Guest favorite
Guesthouse in La Mesa
4.95 out of 5 average rating, 107 reviews

Violet Oasis | hot tub, kitchen, no dog fee!

KaylaRating, 5 stars1 month ago
We had an amazing little staycation over the weekend at the Violet Oasis. Extremely clean, the bed was so comfy we never wanted to leave, both parking locations easy to find and Elizabeth and Paola were super responsive. Rather than feel like we were staying at an Airbnb it felt like staying over at a friend’s place. Their passion responding to their guests, making them feel at home and providing information on what to do in the area really shows in this listing. We will be back!

Guest house rentals with a washer and dryer

Guest favorite
An outdoor living space is featured, showcasing a stone fireplace with a flickering fire. A cozy seating arrangement is present nearby, and a television is visible through a glass door, contributing to a relaxed atmosphere perfect for gathering.
Guesthouse in La Jolla
4.98 out of 5 average rating, 415 reviews

Beautiful Private Villa walk to beach

SamanthaRating, 5 stars2 weeks ago
It’s was amazing staying a Kim’s guesthouse. Felt very private and peaceful. The birds sounded so beautiful in the morning, we thought it was fake at first. The flowers just outside are beautiful. The beach within walking distance was a perfect place to play, lay out, watch the sunset and surfers. We even saw dolphins one night! Just a magical time. We will definitely come back!
Top guest favorite
Guesthouse in North Park
4.99 out of 5 average rating, 159 reviews

Carrie’s North Park Casita, in Heart of San Diego

MichaelRating, 5 stars1 month ago
my wife and I had a wonderful time at Carrie's place. she thought of everything and we did not want for anything. lots of thoughtful touches throughout the Casita. when we checked in we were greeted by the cutest little white dog named Rose. she is getting on in years but was very friendly. if you need a quiet, clean, private and convenient place in San Diego you cannot go wrong with this rental. thank you Carrie for a great time. much luck to you on future rentals!
Guest favorite
The exterior of a multi-level house is shown, featuring a combination of warm stucco and wood elements. A white truck is parked in the driveway, with lush palm trees and landscaping surrounding the property. Large windows provide natural light, enhancing the inviting atmosphere.
Guesthouse in La Jolla
4.79 out of 5 average rating, 191 reviews

San Diego Shangri-La

JimRating, 5 stars4 weeks ago
This apartment is great for 2 people to enjoy the San Diego / La Jolla area. We stayed here for a full month. The apartment is very cozy and the hosts are absolutely fantastic! They have an office set up downstairs (in the garage) and work there most weekdays and occasionally on weekends, so you're not in a totally private house (you have your own entrance and space upstairs), but they are close by for questions. As is prevalent in the area our small dog was very welcome in this apartment. If you have a small dog be wary of coyotes that roam the area.
Superhost
Guesthouse in Pacific Beach
4.78 out of 5 average rating, 389 reviews

Law Street Retreat

MarissaRating, 5 stars2 weeks ago
Exactly as advertised and in a great location not far from the beach and boardwalk. The bikes were great for getting around as well. The bed was also very comfortable. Easily accessed and had no issues at all!
Superhost
A modern lounge area features a sectional sofa adorned with soft blue cushions. A wooden coffee table sits centrally, accompanied by a small potted plant. Large glass garage doors open to the outdoor space, allowing natural light to fill the room.
Guesthouse in Ocean Beach
4.88 out of 5 average rating, 321 reviews

Indoor/Outdoor Sanctuary in Ocean Beach

ShonnaRating, 5 stars2 weeks ago
The place was as described and Lori was responsive. Although, I did accidentally break a small plate while cleaning it. I let her know but didn't get a response. Oops! And it would have felt good hearing, "no worries it happens." Only because I felt bad. Overall, beautiful and relaxing. I'll definitely book there again when we're back to visit family!
Guest favorite
The bright living area features a spacious sofa accompanied by decorative pillows. Natural light floods in through large windows, complemented by wood blinds. A ceiling fan and light fixture enhance the comfort of the room, which also includes a bar-style counter with stools.
Guesthouse in Mission Beach
4.88 out of 5 average rating, 340 reviews

Rockaway North - Family Friendly, Garage Parking & Laundry

MarianneRating, 5 stars3 weeks ago
This is a great location - a one block walk to the beach and to restaurants, etc. We didn't have a car but it's great to have a location with a secure garage (we were visiting my daughter who could leave the car in the garage when staying for a short time). Very clean and comfortable. The shades are great to block out light in the morning so we slept well. Shower is fantastic. Kylee had snacks and coffee pods on hand for us which was a nice perk. Great value! There is ample seating for 5 in the living area. My only feedback is it would be nice to have a coffee table in there. A little challenging to find initially but instructions were very clear.
Top guest favorite
An inviting outdoor space is framed by lush palm trees and vibrant gardens. A circular fire pit with glowing flames creates a warm focal point, surrounded by comfortable lounge chairs. Soft lighting enhances the tranquil ambiance as dusk settles over the scenic landscape.
Guesthouse in Mission Hills
4.97 out of 5 average rating, 248 reviews

Beautiful Historic Home and Gardens Near Downtown!

PeterRating, 5 stars6 days ago
Sam's place was lovely. The house is as advertised , and well appointed throughout. The garden was tranquil, and a nice place to relax after a long day. Sam provided us with all the kids items (Stroller, Pack n play, high chair, etc.) I highly recommend this house for all things San Diego. The location and amenities can't be beat.
Guest favorite
The exterior of the cottage features a charming patio area with a small table and chairs. Lush green landscaping and vibrant flowers enhance the front yard, while palm trees and a clear blue sky create a serene backdrop.
Guesthouse in La Mesa
4.96 out of 5 average rating, 196 reviews

Cozy Coop with a View

DeanRating, 5 stars3 weeks ago
Corey's place definitely fit the bill as a relaxing and quiet destination in San Diego. We would recommend recommend this very nice place to any one. Thanks Corey for an awesome stay.

Quick stats about guesthouse rentals in Mission Bay, San Diego

  • Total rentals

    20 properties

  • Nightly prices starting at

    ﺩ.ﺇ441 before taxes and fees

  • Total number of reviews

    2.8K reviews

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wifi availability

    20 properties include access to wifi

  • Popular amenities

    Kitchen, Wifi, and Pool

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