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Vacation rentals in La Mesa

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Top-rated vacation rentals in La Mesa

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Two red Adirondack chairs are positioned under a covered patio, facing a serene backyard with a pool. Lush greenery surrounds the area, creating a tranquil atmosphere. A BBQ room and various seating arrangements are visible beyond the pool, enhancing the outdoor retreat experience.
Guesthouse in La Mesa
4.99 out of 5 average rating, 141 reviews

Private 1 BR Paradise retreat

Private, yet central. It is your exclusive paradise retreat to enjoy from your spacious 1 bedroom guest house located on the lower level of our home. Hang out in the expansive and private backyard with pool, different sitting areas and covered BBQ room. Or maybe a workout in the gym. Centrally located in the Village of La mesa. Just a 1/4 mile jaunt into the quaint village with its numerous assortments of dining options, stores and trolley station. Freeway close to beaches, downtown and airport

Top guest favorite
A spacious deck is visible, furnished with a table and four wicker chairs. A decorative bowl sits at the center of the table. The panoramic view of the surrounding landscape and city skyline stretches into the distance under a clear blue sky.
Guesthouse in La Mesa
4.96 out of 5 average rating, 228 reviews

Da Hui Hut - La Mesa’s best view and spa

Da Hui Hut is a very private oasis uniquely situated at the top of San Diego county's magnificent Mt. Helix. At roughly 1,300 feet above sea level, Mt. Helix is the crown jewel of natural landmarks in the area. The landscape provides bountiful views, and the large deck is positioned perfectly to see it all. It feels like you're on top of the city! Inside, guests will encounter Californian and Hawaiian inspired decor as they collide with wooden walls to compose a symphony of color and good vibes.

Top guest favorite
An open layout studio is presented, featuring a cozy seating area with a grey couch and a rustic wooden coffee table. A dining space with a round table and chairs is visible. The kitchen area, equipped with modern appliances, is complemented by a ceiling fan with decorative light fixtures.
Guesthouse in La Mesa
5 out of 5 average rating, 103 reviews

NEW construction - Studio near the Village

New studio - Attached Dwelling Unit (ADU) with a private entrance. Walking distance to the Village of La Mesa which has several restaurants, shops and a Vons. Very close to SDSU and quick access to multiple freeways that take you to beaches, mountains, SD Zoo, the nightlife in downtown SD (8, 94, 125). Access to shared laundry room, 2 parking spaces and its own outdoor area. AC & heat. WiFi. Netflix, Hulu with live TV, Apple TV, Disney +, Prime Video and HBO Max. Crib and high chair upon request

Top guest favorite
The studio features exposed wooden beams and a spacious layout. A queen bed is positioned against the wall, while two comfortable chairs are set nearby. A well-equipped kitchen area with appliances and a counter is visible, alongside a door leading to the patio.
Tiny home in La Mesa
4.99 out of 5 average rating, 178 reviews

Casita de Pueblo - Private Yard, La Mesa Village

Enjoy a stylish experience at this centrally-located studio. Walking distance to La Mesa Village, where you can enjoy restaurants, coffee shops, boutiques, & more. With all the things you need in a kitchen to whip up any meal, and a patio to enjoy the San Diego sun. Hop on the trolley to get to anywhere. Bringing more friends or family along with you? We also have another listing, Casa de Pueblo at the same property. 20 min drive to the Beach or Downtown 15 min drive to Balboa Park or Old Town

Guest favorite
The exterior of a historic stone cottage showcases a rounded structure with large, circular windows. Native plants and decorative rocks surround the entrance, highlighting the natural landscape. The name 'Anna' is displayed on a rustic wooden sign, further enhancing the cottage's character.
Guesthouse in La Mesa
4.89 out of 5 average rating, 403 reviews

Anna's Historic Stone Cottage w/panoramic View!

Welcome to Anna's Historic Stone Cottage! The 110 year old cottage has been transformed into the perfect combination of romantic and rustic for a dream-worthy getaway. The 280sq ft cottage features stunning, panoramic views of the San Diego skyline while offering rooftop seating for sunrise and sunset viewing. The Cottage is conveniently located 20 minutes from the world famous San Diego zoo and most other must-see, tourist spots. Amenities for special occasions offered too. Check out our menu!

Top guest favorite
An outdoor patio area features a round table with four chairs, all adorned with colorful cushions. A large red umbrella provides shade, and a decorative rug adds vibrancy to the stone surface. Surrounding greenery and blooming plants create a serene environment.
Home in Rolando
4.98 out of 5 average rating, 331 reviews

Travel Writer's Pad

Hello, Bonjour, Hola, Ciao, Ni Hao! For the past two decades my career as a travel journalist has taken me around the globe. I’ve stayed at thousands of accommodations, where I learned personal touches create a comfortable home away from home. Certain places I visited offered extra special amenities, such as Green tea at a Japanese Ryokan & chardonnay infused bath salts at a Mexican posada. These kinds of touches are in the home. I welcome you, but no parties or events at the house. Thanks!

Top guest favorite
A private deck is shown, featuring a red umbrella over a round table with four chairs. The entrance to the guest house is framed by glass doors and accompanied by a vibrant red door. Lush greenery and flowerbeds enhance the outdoor space.
Guesthouse in La Mesa
4.99 out of 5 average rating, 208 reviews

Stunning Guest House 15 min. from Zoo, Downtown

Stunning guest house that's 15 minutes to San Diego Zoo + downtown San Diego. The cottage is decorated with mid-century and one-of-a kind furniture in a comfy living space overlooking a gorgeous garden. Enjoy the the garden on your private deck, watch TV while relaxing in the handcrafted Nicaraguan rocker or 1950s Danish slipper chair. The cottage also has a comfy queen-sized bed and a full kitchen that's stocked with what you'd need. Oh, and all guests arrive to a homemade loaf of bread.

Guest favorite
A welcoming living area features a spacious beige sectional sofa adorned with patterned throw pillows. Natural light filters through a large window, complemented by soft, flowing curtains. A dark ottoman with decorative details adds a contrasting element to the cozy space.
Home in La Mesa
4.98 out of 5 average rating, 115 reviews

Zen Retreat: 3-Bedroom Oasis near La Mesa Village

Relax in this charming 3-bedroom, 1-bathroom home located just 1 mile from the heart of Historic Downtown La Mesa Village. Nestled in a quiet, central neighborhood, this cozy retreat offers easy access to major freeways, top-rated restaurants, and the local trolley line making it a breeze to explore the best of San Diego. Within 10 to 15 miles, you’ll find yourself in iconic destinations like Downtown San Diego, Balboa Park, Coronado Island, scenic beaches, and beautiful mountain trails.

Top guest favorite
A cozy living area features a sectional sofa and wooden coffee table, complemented by a television mounted on the wall. Several light sources illuminate the space, including a ceiling fan. Decorative wall art adds a personal touch, while windows allow natural light to brighten the room.
Guesthouse in La Mesa
4.99 out of 5 average rating, 309 reviews

SDCannaBnB #1 *420 *parking *dog-friendly *hot tub

Welcome to SDCannaBnB - San Diego's premier cannabis-friendly rental!   Our casita is newly remodeled with luxury ammenities.  We proudly cater to the cannabis community and non-users alike.   Our casita has HEPA air purifiers, is fully ventilated and receives deep cleanings between each guest.  This ensures that every guest checks into a clean, fresh-smelling place that feels like home.   Our casita is located in our quiet, fully fenced in backyard, close to San Diego's attractions

Guest favorite
A modern loft space features warm wood flooring and a plush area rug. A gray sofa faces a sleek entertainment center. A desk and stool are situated by a window, offering views of the surrounding landscape. Natural light fills the room through large windows.
Guesthouse in La Mesa
4.94 out of 5 average rating, 201 reviews

Mountain top view getaway loft

This loft is completely sound proof! VIEWS, VIEWS, VIEWS!! Do not miss this stunning contemporary loft, located in the highly desired Mt. Helix community. The guest house faces west, giving you phenomenal 270-degree views of the ocean, Downtown, Point Loma, Coronado islands, Coronado bridge, and more! Designed and built by an acclaimed San Diego home designer, this property was featured in Dream Homes Magazine and is well known for its incredible design and construction.

Top guest favorite
Barn in La Mesa
4.95 out of 5 average rating, 383 reviews

Enchanting Barn San Diego/La Mesa

DESCRIPTION: Relax and enjoy my converted Barn that is safe, cozy & comfortable. Barn has its own private entrance secured with a keyless entry lock. Sleep on a Cal King therapy foam bed, TV & Blu-ray player, CD stereo USB connection. Extra space has a large desk area. Barn has a private bathroom that includes a walk in shower. Guests provided with Freshly washed towels & linens. *I have a pet Nigerian Dwarf Goat who would love to meet you!

Top guest favorite
A modern kitchen with white cabinetry and granite countertops is paired with a round dining table set for four. Sunlight fills the space through large windows, and a cozy seating area features a dark leather sofa, creating an inviting atmosphere.
Cottage in La Mesa
4.97 out of 5 average rating, 332 reviews

La Mesa House On a Hill With Mountain Views!

SUNRISE PERCH - A standalone guest house, perfect spot for your San Diego stay! Enjoy inspiring sunrise views from the deck or relax indoors with super fast WiFi and a 43" TV. Enjoy a full kitchen! The king bed is super comfy and the bathroom is stocked. The space is only for those looking for quiet. No partying/loud socializing. Families welcome! Located 20 min from downtown San Diego and 25 min from the nearest beach (Ocean Beach).

Popular amenities for La Mesa vacation rentals

When is the best time to visit La Mesa?

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Frequently Asked Questions

  • What are the best places to stay in La Mesa?

    La Mesa has a range of options, with many visitors choosing stays near the downtown village area for easy access to dining, local shops, and parks. Residential neighborhoods around Lake Murray are frequently suggested for a quieter experience and access to green spaces.

  • What are the best things to do in La Mesa with kids?

    Families often explore parks like Harry Griffen Park, enjoy playgrounds, and visit local community pools. Interactive activities such as public art walks or checking out seasonal farmers markets provide fun ways to engage with the area.

  • What are some of the best things to do in La Mesa?

    Explore the historic La Mesa Village, walk scenic trails at Mission Trails Regional Park, or relax by Lake Murray's shoreline. Local art galleries, regular outdoor markets, and annual festivals reflect the area's community spirit.

  • How is the weather in La Mesa?

    La Mesa has a mild, sunny climate with winter temperatures around 50–66°F (10–19°C) and summer warmth reaching 66–77°F (19–25°C). Rain is most common in winter, while summers tend to be dry and clear.

  • What are the best places to visit in La Mesa?

    La Mesa Village has locally owned shops and public art, while Lake Murray is popular for picnics and water activities. Mission Trails Regional Park is frequently suggested for hiking and nature experiences.

  • What are some hiking trails in La Mesa?

    Many hikers enjoy the trails at Mission Trails Regional Park, including the Cowles Mountain climb for broad views. Around Lake Murray, a paved path is suitable for walking, jogging, or cycling among natural surroundings.

  • What are some family activities we can do in La Mesa?

    Families often visit community parks for playgrounds and picnics, explore the interactive public art in the village, or attend local events like farmers markets and community festivals. Outdoor activities around Lake Murray are also popular among all ages.

  • What are some of the best day trip ideas from La Mesa?

    Many visitors spend a day exploring beaches along the Pacific coast, discover museums and gardens in Balboa Park, or hike in the Cuyamaca Mountains. Exploring neighboring neighborhoods known for food and local art is also frequently suggested.

  • Are there any pet friendly accommodations available in La Mesa?

    La Mesa has a number of stays that welcome pets, especially in neighborhoods with easy access to parks and trails. Public spaces, such as Lake Murray and local dog parks, can make visits enjoyable for guests traveling with animals.

  • What are some local tips for visiting La Mesa?

    Explore the farmers markets for fresh, local produce, and check for community festivals throughout the year. Comfortable walking shoes and sun protection are helpful, as much of La Mesa is best enjoyed outdoors.

  • What is La Mesa known for?

    La Mesa is known for its historic village atmosphere, regular community events, and scenic outdoor spaces such as Lake Murray. Its blend of independent shops, public art, and accessible parks appeals to locals and visitors alike.

  • What are the best hidden gems to explore in La Mesa?

    Seek out the Secret Stairs for a locally famous walking route through hillside neighborhoods. Pocket parks, mural art throughout the village, and lesser-known hiking trails around Lake Murray provide inviting ways to explore.

  • What are the best foods to try in La Mesa?

    La Mesa has a diverse dining scene, with Mexican cuisine, classic diners, and family-style restaurants frequently suggested. Visitors often enjoy local bakeries, craft coffee shops, and places featuring California-inspired dishes.

  • What should I bring for a trip to La Mesa?

    Light, breathable clothing is useful for sunny days, while a light jacket or sweater can be helpful in cooler evenings or during winter months. Sun protection, reusable water bottles, and comfortable walking shoes support outdoor exploration.

  • What is the nightlife in La Mesa like?

    La Mesa has a laid-back nightlife scene centered on relaxed bars, pubs, and a few live music venues in the village area. Many spots feature local craft beers and occasional events such as open mics or trivia nights.

  • What are the most popular events or festivals in La Mesa?

    La Mesa frequently hosts community street fairs in spring and autumn, a car show known as Back to the 50's, and Oktoberfest celebrations in the village. Seasonal farmers markets are also community favorites.

  • Are there family friendly vacation rentals in La Mesa?

    La Mesa has a variety of family friendly vacation rentals, including homes near parks, playgrounds, and local attractions. Many guests choose neighborhoods close to Lake Murray and the village for accessible amenities and outdoor activities.

  • When is the best time to visit La Mesa?

    Late spring and early autumn are often recommended for comfortable temperatures and minimal rainfall. Summer brings clear, sunny days, while winter is cooler and sometimes rainy.

Quick stats about vacation rentals in La Mesa

  • Total vacation rentals

    Explore 560 vacation rentals in La Mesa

  • Nightly prices starting at

    La Mesa vacation rentals start at ﺩ.ﺇ73 per night before taxes and fees

  • Verified guest reviews

    Over 31,000 verified reviews to help you choose

  • Family-friendly vacation rentals

    250 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 180 rentals that welcome pets

  • Vacation rentals with a pool

    140 properties feature pools

  • Rentals with dedicated workspaces

    340 properties have a dedicated workspace

  • Wi-Fi availability

    550 of La Mesa vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Gym, BBQ grill, and Laptop-friendly workspace across La Mesa rentals

  • 4.8 Average rating

    La Mesa stays are highly rated by guests—averaging 4.8 out of 5!

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