
Guesthouse vacation rentals in La Mesa
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Top-rated guesthouse rentals in La Mesa
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for La Mesa guesthouse rentals
Family-friendly guest house rentals

Adorable San Diego Guesthouse

Fig Tree Bungalow

Private Family Friendly Casita/Guesthouse

Pacific Beach Guest House With Garage and A/C

The BEST NEST Clean, peaceful, private, affordable

Retreat house. Nature, Hot Tub, Views!

Vineyard & Winery Guest House

Cosy quiet Guesthouse near SDSU
Guest house rentals with a patio

Golden Hour Guesthouse

Adorable cottage in Talmadge

Private 1 BR Paradise retreat

La Jolla Oasis: Ocean, City and Fire Works Views

New! Beautiful Private Casita- King Bed & Office

Cozy, Quiet and Private Backyard Studio Escape

Casita with private yard and separate entrance

New (2022) North Park Abode w/ Roof Deck
Guest house rentals with a washer and dryer

Beautiful Private Villa walk to beach

San Diego Shangri-La

La Casita Private Resort Spa and Mini Golf Course

❤ Cozy Private Studio w/ WD 2 Minutes from Freeway

Law Street Retreat

Indoor/Outdoor Sanctuary in Ocean Beach

Beautiful Historic Home and Gardens Near Downtown!

Cozy Coop with a View
Quick stats about guesthouse rentals in La Mesa
Total rentals
80 properties
Nightly prices starting at
ﺩ.ﺇ184 before taxes and fees
Total number of reviews
5.2K reviews
Family-friendly rentals
10 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with a pool
10 properties have a pool
Destinations to explore
- San Diego Vacation rentals
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- Rentals with a washer and dryer La Mesa
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- Rentals with a patio La Mesa
- Family-friendly rentals La Mesa
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- Rosarito Beach
- La Jolla Shores Beach
- Oceanside City Beach
- Tijuana Beach
- South Coronado Beach
- Torrey Pines State Beach
- Pacific Beach
- Tamarack Surf Beach
- La Misión Beach
- Coronado Shores Beach
- Oceanside Harbor
- San Elijo State Beach
- Black's Beach
- SeaWorld San Diego
- Windansea Beach
- University of California San Diego
- Santa Monica Beach
- Fletcher Cove Beach Park
- Marine Street Beach
- San Diego Zoo Safari Park
- Playas Los Buenos
- Balboa Park
- LEGOLAND California
- Pechanga Resort Casino