
House vacation rentals in Santo Domingo
Find and book unique houses on Airbnb
Top-rated house rentals in Santo Domingo
Guests agree: these houses are highly rated for location, cleanliness, and more.

Breathtaking Views: Sleeps 13, Walk to Beach!
There’s something special about this place. Every guest says the same thing—they never want to leave. Imagine waking up to the sound of waves and birdsong, sipping coffee on the balcony with sweeping ocean views. This peaceful retreat in Venao is at the quiet end of the beach, away from the party scene—but close enough to dive into the action when you want. Swim, surf, and dine nearby, then come home to the tranquility of your private lodge, where the only nightlife is the glow of the stars.
LocationFamilyAir conditioning

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa
Villa-33, your exquisite retreat nestled within Blue Playa Venao. Discover a tropical paradise of stunning beaches. Embark on endless adventures just a short walk away. This beautiful Villa offers 3 bedrooms and 3 baths. Two of the bedrooms feature queen beds, while the third bedroom has 2 twin beds, ensuring a restful night's sleep for everyone. The living area, kitchen, and terrace are thoughtfully equipped with everything you need to make yourself at home during your fun family getaway.
LocationFamilyView

Casa - Domaine De La Rose
Welcome to paradise ! Beautiful home with private pool and a large yard - amazing for entertaining family/ friends 1 master bedroom with full bath with jacuzzi, french doors to terrace 1 queen bed with full bath -1 double/ single bunk bed with full bath Open dining , kitchen and living room Full access to Andromeda Beach Club Full restaurant & bar - always something to do! Massive infinity pool with steps to the Pacific Ocean !! Beach is very beautiful and private and miles to explorer
LocationFamilyCleanliness

Peaceful Pedasi
Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.
FamilyLocationCheckout

Casa Samambaia - sea view tropical paradise w pool
With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.
ValueLocationView

Casa Pelicano - Tropical house w pool and seaview
Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.
ValueFamilyBathroom

Villa La Jungla
Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.
LocationFamilyWalkability

Casa Blu Central Chitre| Sleeps 6| Private Parking
Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.
FamilyLocationCondition

Tropical Cozy Cabin / Playa venao
Welcome to our tropical & cozy private cabin, fully furnished and equipped with everything you need for a comfortable stay in Playa Venao. Central location (2 min drive from the beach) Features two bedrooms with 2 single beds each, cozy living room with TV and sofa, fully equipped kitchen, AC in all the rooms, one bathroom and outdoor shower. Also have a nice terrace area with a deck and a comfy dining lounge.
LocationValueAir conditioning

A minimalist Casita in Pedasi
Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security
LocationFamilyBathroom

Casa Inito - Romantic Getaway
Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****
LocationGetting aroundNearby

Private Pool · Fenced Yard · 5m to Beach & Town
Your private tropical oasis in Pedasí’s secure Roy’s Community. Stroll 10 min to the beach, unwind by your private pool, and enjoy a fully fenced yard with ice-cold A/C throughout. A proven 4.92-star Guest Favorite with 200+ reviews, featuring 2 en-suite bedrooms (King & Queen) and a fully equipped kitchen. Dogs welcome!
FamilyValueBeach
Popular amenities for Santo Domingo house rentals
House rentals with a pool

NinaHouse, spacious and cool house in Chitré.
ValueLocationAmenities

Tropical Oasis, Full House, Private Pool,
FamilyValueAmenities

Casa Ola – Steps from the Beach | Pool & BBQ Oasis
LocationValueHospitality

Casa Carolina: Spacious 3 Bedroom at Blue Venao
LocationFamilyCheckout

Lux Pedasi Pool & View Retreat
LocationAir conditioningHospitality

Casa Del Amor in Pedasi Panama Oceanfront paradise
Indoor spacesBeachComfort

Luxury Villa

Beachfront home on Playa Venao + private pool
LocationValueGrill
Weekly house rentals

Santa Clara Chitré
LocationValuePets

Los 4 Caminos Village # 2
LocationFamilyAccuracy

Guararé, Las Tablas, 3 Bedrooms, Sleeps 6
LocationComfortOutdoor spaces

Our Happy Place
LocationValueComfort

Pedasi Craftsman Home/Walk to Town
LocationFamilyComfort

Cozy country-style house.
FamilyLocationNearby

Spacious Condo Heart Playa Venao
LocationFamilyHospitality

Casa entera -7 min de Las Tablas
WifiComfortHospitality
Private house rentals

Beautiful house Olga in Las Tablas
LocationCleanlinessHospitality

Accommodation in Guarare near beaches and folklore
ValueLocationIndoor spaces

Cozy house available for rent-Las Tablas
FamilyLocationParking

House 8 minutes from Las Tablas.
LocationFamilyHospitality

Casa Amarilla-Cozy 2Bed/ 1Bath/ Pocri, Las Tablas
LocationValueDecor

Luxury Spanish-Style Beachfront Villa | Long Term
FamilyLocationNearby

Family house, spacious, central for vacationing
LocationComfortHospitality

A cozy house to enjoy and rest.
LocationFamilyAmenities
Destinations to explore
- Panama City Vacation rentals
- Cahuita Vacation rentals
- Quepos Vacation rentals
- Bahía Ballena Vacation rentals
- Puerto Viejo de Talamanca Vacation rentals
- Bocas del Toro Province Vacation rentals
- Uvita Vacation rentals
- Rio Hato Vacation rentals
- Boquete Vacation rentals
- El Valle Vacation rentals
- Valle de Antón Vacation rentals
- Cartago Vacation rentals





