House vacation rentals in Santo Domingo

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Top-rated house rentals in Santo Domingo

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favorite

Home in Pedasí

Casa - Domaine De La Rose

Welcome to paradise ! Beautiful home with private pool and a large yard - amazing for entertaining family/ friends 1 master bedroom with full bath with jacuzzi, french doors to terrace 1 queen bed with full bath -1 double/ single bunk bed with full bath Open dining , kitchen and living room Full access to Andromeda Beach Club Full restaurant & bar - always something to do! Massive infinity pool with steps to the Pacific Ocean !! Beach is very beautiful and private and miles to explorer

LocationFamilyPool

4.89 out of 5 average rating, 19 reviews

Top guest favorite

An open-concept living area showcases a modern design with a neutral color palette. A plush gray sofa faces a minimalist coffee table, complemented by a decorative plant. Large windows invite natural light, while soft curtains frame the views of the surrounding greenery.

Home in Playa Venao

Nearly Oceanfront: Blue 3 Bedroom Spacious Villa

Villa-33, your exquisite retreat nestled within Blue Playa Venao. Discover a tropical paradise of stunning beaches. Embark on endless adventures just a short walk away. This beautiful Villa offers 3 bedrooms and 3 baths. Two of the bedrooms feature queen beds, while the third bedroom has 2 twin beds, ensuring a restful night's sleep for everyone. The living area, kitchen, and terrace are thoughtfully equipped with everything you need to make yourself at home during your fun family getaway.

LocationFamilyCleanliness

5.0 out of 5 average rating, 40 reviews

Superhost

A welcoming entrance is framed by vibrant tropical plants, with a pathway leading to a covered porch. The structure features a tiled roof and red steps, providing an inviting transition from the outdoors to the interior space.

Home in Pedasí

Peaceful Pedasi

Peaceful Pedasi. Get completely away from the city and forget the rest of the world exists. Pedasí is a town and corregimiento situated on the south-eastern tip of the Azuero Peninsula on Panama’s Pacific coast. And although remote enough to feel protected from the stresses of life, Pedasi offers wonderful dining and shopping. Our home offers a full functioning kitchen, large dining space, 5 Bedrooms, 4 Bathrooms, 2 car garage, private pool, and cabana with your own view of the ocean.

FamilyLocationKitchen

4.87 out of 5 average rating, 23 reviews

Guest favorite

The house exterior features a warm peach-colored facade with a large white-framed window. Tropical palm trees and vibrant flowering shrubs border the front, providing a refreshing touch to the entrance.

Home in Chitré

NinaHouse, casa amplia y fresca en Chitré.

Casa solo para ti, ahora con tanque de agua!hasta 7 p, amplia y en una de las mejores zonas de Chitré, tranquila y familiar, acceso a la piscina del area social, parques y canchas, cerca de todo: supermercados, casino, bus; ven a Chitre y disfrutar de comidas típicas, artesanía; planifica tus paseos y visita las mejores playas: Pedasi, Venao, Isla Iguana, podrás trabajar desde NinaHouse contando con un rápido internet. Ahora contamos con aire acondicionado en la sala para tu confort.

FamilyLocationCheck-in

4.82 out of 5 average rating, 84 reviews

Guest favorite

A modern tropical home is set amid lush greenery, featuring an expansive deck that connects to a serene pool. Large glass doors provide a view of the inviting interior and allow natural light to fill the space. Mountains and trees frame the backdrop.

Home in Playa Venao

Casa Samambaia - sea view tropical paradise w pool

With a modern tropical design, this home features a cozy living room and a stylish kitchen at the center of the social area. Open the glass doors to immerse yourself in open-concept living, seamlessly blending the indoors with the main terrace and the pool, all oriented towards the ocean view. With two en-suite bedrooms with AC and fans, the house is immersed in nature, green mountains, and a lovely garden, everything 5 minutes from the beach center.

ValueLocationIndoor spaces

4.98 out of 5 average rating, 84 reviews

Guest favorite

Home in Playa Venao

Casa Pelicano - Tropical house w pool and seaview

Welcome to Casa Pelicano! Indulge yourself in a retreat with breathtaking views of the ocean and mountains from every corner. Unwind in the private refreshing pool, where the turquoise waters seem to blend seamlessly with the horizon. The stylish interior features open-plan living spaces, perfect for entertaining or relaxing. Whether you're soaking up the sun or gazing at the moonlit ocean under the stars, this home is your ultimate escape.

ValueLocationIndoor spaces

4.9 out of 5 average rating, 84 reviews

Guest favorite

The outdoor area features a spacious infinity pool surrounded by a sun deck, complete with lounge chairs. Lush greenery and palm trees can be seen in the background, under a bright blue sky with fluffy clouds, creating a serene outdoor retreat.

Home in Pedasí

Villa La Jungla

Escape to this serene, private retreat just minutes from Pedasí, Playa Venao, and stunning beaches. Perfect for 4–8 guests, the home features spacious en-suite bedrooms with quality linens, a fully equipped kitchen, and a newly resurfaced infinity pool. Enjoy total privacy, comfort, and easy access to local adventures. Whether you're here to surf, explore, or relax, this is your ideal home base for a peaceful and memorable stay.

LocationValueWalkability

4.96 out of 5 average rating, 27 reviews

Guest favorite

Home in Chitré

Casa Blu Central Chitre| Sleeps 6| Private Parking

Stay in a newly renovated private home in the center of Chitré with free gated parking, a large backyard, fast Wi-Fi, and space for the whole family. Walk to restaurants, supermarkets and the cathedral while enjoying the comfort of an entire home to yourselves. It combines comfort, spaciousness, and natural light in every corner — perfect for families or groups of friends looking for a place that feels just like home.

LocationFamilyParking

5.0 out of 5 average rating, 11 reviews

Guest favorite

Home in Las Escobas del Venado

Tropical Cozy Cabin / Playa venao

Welcome to our tropical & cozy private cabin, fully furnished and equipped with everything you need for a comfortable stay in Playa Venao. Central location (2 min drive from the beach) Features two bedrooms with 2 single beds each, cozy living room with TV and sofa, fully equipped kitchen, AC in all the rooms, one bathroom and outdoor shower. Also have a nice terrace area with a deck and a comfy dining lounge.

ValueLocationQuiet

5.0 out of 5 average rating, 14 reviews

Top guest favorite

The exterior of a casita is displayed, featuring a light-colored facade with a red-tiled roof. A silver SUV is parked on a stone pathway that leads to a wooden front door. Lush greenery and palm trees are visible in the background under a partly cloudy sky.

Home in Pedasí

A minimalist Casita in Pedasi

Imagine a peaceful casita with ocean views and a nearby pool house boasting an edgeless pool overlooking the ocean. Plus, you have your own private beach. Inside, you will find an open-concept living space adorned with simple yet stylish furnishings, designed for relaxation and comfort. It's the perfect blend of tranquility, peaceful seclusion and breathtaking natural beauty. Gated community, 24 hour security

LocationFamilyGetting around

4.91 out of 5 average rating, 35 reviews

Guest favorite

A colorful hammock hangs between two posts on a wooden terrace, overlooking a vast landscape. The sun sets in the distance, casting a warm glow over the scene, framed by lush greenery and bamboo fencing that adds privacy.

Home

Casa Inito - Romantic Getaway

Indulge in the charm of Casa Inito, a thoughtfully crafted haven that invites you to experience a one-bedroom retreat like no other. This well-designed space seamlessly blends modern comfort with an intimate setting, creating the perfect atmosphere for your getaway. The Villa is located just 7 minutes from Playa Venao Beach (by car). ****(Vehicle a MUST, preferably SUV due to steep paved access road)****

LocationCleanlinessBathroom

4.95 out of 5 average rating, 22 reviews

Guest favorite

The exterior of the house is displayed, featuring a wooden door and a lattice fence. Windows are fitted with security bars, allowing natural light to enter while maintaining privacy. Lush greenery surrounds the entrance, contributing to the inviting appearance of the home.

Home in Las Tablas

Casa en Plaza Praga - Las Tablas

Céntrica y encantadora casa, ubicada frente a la Plaza Praga, a solo pasos del Parque Belisario Porras y la histórica Iglesia de Santa Librada. Cuenta con 2 habitaciones, cada una con una cama doble, aire acondicionado, agua caliente y tanque de agua y cocina básica. Ideal para alojarte durante Mil Polleras, Carnavales y Semana Santa.

LocationWalkabilityCleanliness

5.0 out of 5 average rating, 6 reviews