
House vacation rentals in Isle of Palms
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Top-rated house rentals in Isle of Palms
Guests agree: these houses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Isle of Palms house rentals
House rentals with a pool

Isle of Palms Family Beach House

Private Entrance Suite w/ pool, 5 min from beach

Spacious Island Home with Private Pool & Spa!

Hammock Haus Snowbird rates for longer stays

Beautiful 2BD/2BA Seabrook Island Villa

SALTWATER OASIS AT THE BEACH, Isle of Palms, SC

debbie's dream | Magnificent Oceanfront-Golf View

Rates Lowered! New 6Bd, Pool, Steps to Beach!
Weekly house rentals

Serendipity By The Sea

Mt Pleasant Cottage-Downtown, Shem Creek & Beaches

Charleston Waterfront Retreat w/ Deep Water Dock

Fully renovated home- located 1 block from beach!

Little Boho Beach House ( Oceanfront Rental)

Cozy Beach Cottage just 3 min. walk to the beach!

The Palmetto Pool House | 4 BR + Arcade Room

Santorini Cottage
Private house rentals

Architecture* La Cabaña * Beach 8 min * 2 Bdrm

Wild Dunes Home Steps from Beach

Welcome to Ohana House!

Little Bit O' Heaven

Southern Oasis by AvantStay | Pool + Walk to Beach

Updated home private pool & 3 mi to beach!!

Stunning 4BR Oceanfront | Deck | W/D

Lee's Beach House
Quick stats about house rentals in Isle of Palms
Total rentals
760 properties
Nightly prices starting at
ﺩ.ﺇ110 before taxes and fees
Total number of reviews
11K reviews
Family-friendly rentals
740 properties are a good fit for families
Pet-friendly rentals
230 properties allow pets
Rentals with a pool
560 properties have a pool
Destinations to explore
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- Pet-friendly rentals Isle of Palms
- Condo rentals Isle of Palms
- Rentals with a fireplace Isle of Palms
- Rentals with a patio Isle of Palms
- Rentals with a kayak Isle of Palms
- Apartment rentals Isle of Palms
- Family-friendly rentals Isle of Palms
- Rentals with a washer and dryer Isle of Palms
- Rentals with an EV charger Isle of Palms
- Waterfront rentals Isle of Palms
- Beachfront rentals Isle of Palms
- Rentals with a hot tub Isle of Palms
- Luxury rentals Isle of Palms
- Rentals with a fire pit Isle of Palms
- Villa rentals Isle of Palms
- Rentals with beach access Isle of Palms
- Fitness-friendly rentals Isle of Palms
- Beach house rentals Isle of Palms
- Rentals with outdoor seating Isle of Palms
- Rentals with pools Isle of Palms
- House rentals Charleston County
- House rentals South Carolina
- House rentals United States
- Park Circle
- Hunting Island State Park Beach
- Sullivan's Island Beach
- Bulls Island
- Middleton Place
- Waterfront Park
- James Island County Park
- The Golf Club at Wescott Plantation
- Shem Creek Park
- Harbor Island Beach
- Hampton Park
- Angel Oak Tree
- The Charleston Museum
- Morris Island Lighthouse
- Isle of Palms Beach
- Seabrook Island Beach
- Charleston Aqua Park
- Gibbes Museum of Art
- White Point Garden
- Seabrook Beach
- Whirlin' Waters Adventure Waterpark
- Splash Zone Waterpark At James Island County Park
- Front Beach IOP
- Splash Island Waterpark