Luxury rentals in Isle of Palms

Find and book unique accommodations on Airbnb

Top-rated luxury vacation rentals in Isle of Palms

Guests agree: these stays are highly rated for location, cleanliness, and more.

0 of 0 items showing

1 of 3 pages

Luxe

Villa in Isle of Palms

5 out of 5 average rating, 3 reviews

Villa Las Palmas

It’s an easy walk to the beach at this gorgeous oceanfront villa in the Isle of Palms. Just follow your private walkway down to the sand. Rather enjoy the view from home? Set yourself up in the pool, hot tub, or around the fire pit. When the sun begins to set, fire up the barbeque and grill up something from a local market. Then, dine alfresco as waves gently wash along the shore. Copyright © Luxury Retreats. All rights reserved. BEDROOM & BATHROOM First floor • Bedroom 1: King size bed, Ensuite bathroom with stand-alone shower • Bedroom 2: 2 Twin size bunk beds, Ensuite bathroom with stand-alone shower Second floor • Bedroom 3: King size bed, Ensuite bathroom with stand-alone shower, Ocean view • Bedroom 4: King size bed, Ensuite bathroom with stand-alone shower, Ocean view • Bedroom 5: Queen size bed, Ensuite bathroom with stand-alone shower • Bedroom 6: Queen size bed, Ensuite bathroom with shower/bathtub combo • Bedroom 7: 2 Twin over queen size bunk beds, Ensuite bathroom with stand-alone shower STAFF & SERVICES Extra Cost (advance notice may be required): • Activities and excursions

Luxe

An aerial view of The Pelzer House showcases the striking marble checkerboard pool with an elevated spa. White umbrellas provide shade over lounge chairs, surrounded by landscaped greenery, while the stylish design elements create a harmonious outdoor retreat.

Home in Mount Pleasant

5 out of 5 average rating, 13 reviews

The Pelzer House

Luxe coastal retreat! Cooper Estates - known as Mount P's most desirable neighborhood for its unbeatable proximity and charm. Dual primary suites, 2 king guest rooms, twin room, 3 full baths, designer kitchen w/Thermador appliances, and soaring ceilings. 7 mins to downtown Charleston, 3 mins (walkable) to Shem Creek, 10 mins to Sullivans Island Beach, 5 mins to boat landing. Marble pool, spa, fireplace, grill & boat parking. NO BACH PARTIES ALLOWED. STR Permit: ST250378 | TOMP License: 20122311

Luxe

The oceanfront home features a spacious deck overlooking a private pool, framed by lush landscaping. The two-story structure is adorned with large windows and elegant architectural details, while soft evening light enhances the inviting atmosphere of the outdoor living space.

Home in Isle of Palms

New Listing! 3900 Palm Blvd. Oceanfront 5 bd, pool

New to our luxury collection, 3900 Palm Blvd. is a stunning five bedroom oceanfront home. Welcome to your dream vacation home on the pristine shores of Isle of Palms, South Carolina. This magnificent five bedroom, four bathroom and two half bath, oceanfront property combines luxury, comfort, and convenience, offering an unforgettable getaway for families and groups alike. Wake up to breathtaking ocean views and the sounds of the waves crashing from every corner of this stunning home.

Luxe

An aerial view showcases the luxurious oceanfront home, featuring multiple outdoor seating areas on extensive porches. A large private pool invites relaxation, surrounded by sun loungers and a shaded umbrella. Lush greenery and palm trees enhance the inviting outdoor space.

Home in Isle of Palms

5 out of 5 average rating, 7 reviews

Sea Spray- 400 Ocean Blvd.Oceanfont! 6BD, Pool/spa

New to our Luxury collection, Sea Spray- 400 Ocean Blvd., is a exquisite six bedroom, six bathroom, oceanfront home that is nestled in the most coveted Isle of Palms area. The home sits right on the ocean and offers unrivaled beachfront views. The home has recently been fully renovated and no expense was spared- including a private pool and hot tub (both heatable for extra charge), putting green, multiple porches and Chef's kitchen and four bedrooms with ocean views.

Luxe

Villa in Isle of Palms

5 out of 5 average rating, 6 reviews

Ocean View

4,000 sqft of luxury featuring a three sided infinity edge pool and hot tub (heatable for an additional fee), glass elevator, wrap around porches, rooftop deck and Wolf stainless steel appliances. Located directly across from the beach on Ocean Boulevard with a short beach access right across the street. Enjoy a spectacular view of the island from the large wrap-around porches or widow's walk. Walk to shops and restaurants on Front Beach. Sleep 16 max.

Luxe

An elegant coastal home features multiple levels with a red metal roof. The exterior is adorned with white railings and balconies. A shimmering pool is situated in the backyard, surrounded by lush palm trees and greenery, enhancing the inviting atmosphere of beachside living.

Place to stay in Wild Dunes

5 out of 5 average rating, 8 reviews

Isle be back

Savor a taste of beachside living at this 6-bedroom Isle of Palms home. Cherry hardwood, granite counters, and white linens are drenched in streaming sunlight inside. The radiant pool is the perfect place to sip a cocktail. Work up an appetite cycling along a variety of scenic trails or playing a serene round of golf on the vibrant green course before treating yourself to a mouth-watering dinner. Copyright © Luxury Retreats. All rights reserved.

Luxe

A two-story home is surrounded by lush greenery, featuring palm trees and a landscaped front yard. The exterior is painted in light colors with white railings along the balconies. Two garage doors are visible, providing convenient access.

Home in Isle of Palms

5 out of 5 average rating, 3 reviews

Saint Somehwhere

Nestled amongst greenery in Isle of Palms, this home features everything you need for a laid-back getaway. The heart of town is nearby where you’ll discover restaurants, shops, and must-try ice cream. Heat up in the midday sun before plunging into the ample pool. A short stroll is all it takes to land you at the beach. Perhaps you’ll catch a glimpse of sea turtles as you meander along the shore. Copyright © Luxury Retreats. All rights reserved.

Luxe

A well-appointed bathroom features a dark wood vanity with a white countertop and a circular mirror above. Soft lighting is provided by modern sconces. An art piece displaying a shell design adds a decorative touch. Clean lines and neutral colors create a spacious feel.

Home in Isle of Palms

The Sea Herring

A few minutes walk from the beach, and the entertainment district, this brand-new rental in the Isle of Palms enjoys views of Hamlin Creek and the waterway from the secluded terrace. On sunny afternoons, settle into a poolside lounge chair, lean back, and catch up on some reading. When you’re ready for dinner or a night of dancing, simply walk to the Front Beach area just 5 blocks from home. Copyright © Luxury Retreats. All rights reserved.

Luxe

A three-story retreat features multiple balconies and outdoor seating areas, set against a vibrant sunset. The foreground is framed by a secure fence, while lush greenery surrounds the property, enhancing the inviting atmosphere.

Villa in Isle of Palms

Port of Call

Rocking chairs line the porch and palms line the boardwalk at this Isle of Palms retreat. Stone lines a pool, firepit, and outdoor wet bar, and there’s a private chipping green just beyond the terrace. In the great room, shades of white and blue echo the colors of the waves cresting in front of the house. It’s a short walk down to the shore, and a short drive into Charleston for dining and more. Copyright © Luxury Retreats. All rights reserved.

Luxe

An elegantly designed oceanfront home is highlighted under a colorful sunset. The two-story structure features multiple decks overlooking a landscaped yard with a pool. White lounge chairs are positioned beside the pool, and lush greenery surrounds the area, creating a serene setting.

Home in Isle of Palms

Dolphin Manor

This 6-bedroom oceanfront home is nestled mere steps from your own private, powdery slice of beach. Vaulted ceilings and soaring windows allow sunlight to stream inside, highlighting the elegant décor. Champagne in the bubbling hot tub takes stargazing to a new level. Give your best shot on the small putting green. Shops and mouth-watering eateries in Isle of Palms are just a few blocks away. Copyright © Luxury Retreats. All rights reserved.

Luxe

Home in Isle of Palms

3108 Palm by AvantStay | Oceanfront Pool + Views

★ Recognized as one of our best. This home was a finalist in the 2025 AvantStay Awards, our annual celebration of top-tier stays. - Stunning oceanfront estate with private beach access - Infinity pool and hot tub with panoramic views - Luxurious, newly built interiors - Outdoor kitchen and multiple outdoor living areas - Spacious yard with a fire pit

Luxe

Home in Kiawah Island

5 out of 5 average rating, 4 reviews

Brand New Pool, Spacious Kiawah 5 Bed w/ views

Welcome to this incredible new home at 67 Otter Island Road on Kiawah Island! This 5 bedroom luxury beach vacation rental, located just off of the famed Ocean Course Drive, boasts lagoon and marsh views, a new private pool, and is just a short stroll or bike ride to the beach. It truly is an ideal island and golf getaway!