
Boutique hotel vacation rentals in Southern United States
Find and book unique boutique hotel rentals on Airbnb
Top-rated boutique hotel rentals in Southern United States
Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Southern United States boutique hotel rentals
Family-friendly boutique hotels rentals

Cool, cozy, contemporary and romantic! Location!
Great, very new and well appointed. Nice access to the bay. Wonderful location. We will definitely be back.

The Coral Suite at Riverwood Suites
Excellent location. Easy to walk to everything downtown. Lovely garden for coffee in the mornings or wine in the evenings. Beautifully decorated and very clean. Monica and her team are very responsive. I highly recommend this spot. This was our second stay.

Gulf Front Suite - 2 Bedrooms with Kitchen
Place was in a great location with an awesome deck, check in was easy and host was very responsive. Great place to stay in Grand Isle.

#5 No Cleaning/Parking Fees! Walk to Games/Music!
Had a great stay. Jeff was very attentive. Loved the room.

The Happy Place
We thoroughly enjoyed our weekend in Bay St. Louis and our stay at this lovely place. There is a magical quality to the property, with its lush garden complete with a goldfish pond and the cats and dogs. The place was comfortable (for two people) and the location is great. It's an easy walk to the heart of the town and the beach.

Esmeralda - Hotel Luna Mystica
Great amenities in Esmerelda, easy access, super comfy bed! Wish we had more time there - would stay again!

The Little Inn with a Big ❤️
This place is wonderful! The property manager, Cindy was super attentive, and made our stay memorable! The property is spotless, close to everything, and within walking distance to the beach, and downtown area!

Cozy 1BR Retreat w/Full Kit- Steps to Clw Bch
The location and apartment were great! Walking distance to the beach and local restaurants and shops. The apartment was comfortable and clean. It was a nice and quiet area which was appreciated after a long day at the beach. Looking forward to coming back another time!
Boutique hotels rentals with a patio

Awesome spacious room, with pool & free parking
This space was exactly what I needed—clean, organized, and filled with positive energy. You can tell it’s cared for with intention, and that made a big difference in my stay. The environment felt inspiring and peaceful, perfect for grounding and creativity. Grateful for the warm vibes and welcoming atmosphere.

Victorian Carriage House Studio
Jennifer’s home is beautiful, Victorian charm and ambiance. The room is spacious and beautifully decorated with a large en suite bathroom. We felt very pampered. The location was easy to find and even though most restaurants in the village were closed because it was a Monday, there are other restaurants and shopping a couple of miles away. I would highly recommend the room at Jennifer’s.

New High Rise 2 Bedroom Condo Rainey District
We have stayed with Jason several times and are never disappointed! The place is in a great location, has all the amenities you need and he is very responsive and accommodating. The unit is clean and comfortable, I highly recommend booking, you will not be disappointed!

#4 Penny Farthing Le Velo Inn
It was an absolute joy. My fiancee and I booked at this location in Saint Charles on a whim because we were going horse back riding out in High Ridge. It was the first time either of us experienced St Charles and we loved it so much, we are talking about moving there. It is such a beautiful little town with all types of local restaurants and shops and plenty to do all within walking distance. The Velo Inn was perfect as well. It is so unique and beautiful. EXACTLY as described in the listing/pictures. 10/10 we will for sure be back in the future. My 1 and only minor issue was the cost. But on the other hand, you can see the amount of work and effort they put into making this hotel a wonderful experience for their guests.

Rustic 3 bed cabin with upscale hotel amenities
We enjoyed our stay while here! The owner was friendly and responsive. We enjoyed the ducks that came and visited us.

The Old Jail Inn the Bonnie and Clyde Suite
My daughter and I stayed in the Bonnie and Clyde cell. Very interesting place and experience. We are always looking for something new and different and it didn’t disappoint. We enjoyed Turkey Run nearby, and visited the old Indiana State Sanitarium. We also shopped at the stores on the square and ate at the Thirty six Saloon , both within walking distance, and enjoyed some good food and music. Great place to stay in a great little town.

Conch Key Villas #1. Fun, fishing & great sunsets
The pictures of this place do not do it justice! Beautiful sunsets every night, tons of sea life off the dock. Saw many parrot fish, nurse sharks and even a Loggerhead turtle! This place is clean and as described! Close drive to Marathon and Islamorada for day trips! Kayaks and paddle boards for use at anytime! We will definitely be back!

Downtown Boutique Bed & Bath w Balcony, Unit 3
This place was in a great location, spacious, and has a very comfortable bed with soft linens. Loved tub/shower combo in a very nice and clean bathroom. It was quiet but walkable to everything and the neighborhood seems very safe and friendly. The hosts are very responsive. Highly recommend and would return.
Monthly boutique hotels rentals

Hostal del Barrio/Habitación #09 cama individual
This place it’s by Barrio Antiguo. Great area easy check in .. Always polite and the place is clean. I really like to stay here . I will come back for sure !!

The Bonnie & Clyde room in historic hotel
Had a few mixups with checkin because they had lost power earlier but the host helped get me in another room that was nicer which was appreciated! Cool historic spot

Mandalay Motel #7 by Silver Dollar City
The Mandalay Motel is a beautiful, peaceful place to stay when in the Branson area! We needed a clean, convenient room after a fun night at Thunder Ridge Arena, and it was great option. It’s also a short drive into Branson for food and fun on the strip, and very close to Silver Dollar City. Self check-in is a breeze, and Emily is a friendly, proactive, and responsive host- thank you so much for your hospitality! :)

La Decima (clean rate / no hidden fees)
El lugar está súper bien ubicado, un precio bastante bueno y el desayuno de 10. Totalmente volvería. Relación calidad/precio muy buena

Adorable Efficiency Suite-2- Heart of Kenbridge!
Booked for one of our employees who was assisting a near by medical facility. Vanessa was responsive and took care of us so we can take care of others. Much appreciated.

#2 Coronado4veinte zonacentrochepe hotel boutique
Fue muy agradable hospedarnos con Rossina. Nos tenia un detalle el cual se aprecia mucho. Sin duda volveremos

1. Habitación privada c/clima. Céntrica ubicación
estuvo bien funcional para lo que requeríamos

Two Queen Economy Room - Shared Restrooms
Historic hotel in a rad town in the moutains. Historic Hotel like a boarding house back in the day. Many rooms have a shared bathroom down the hall. Some rooms have a private bath. Awesome old wood floors squeak and creak fairly loudly. I dug it and thought of it as the floors were talking story of all that's times past. If your sensitive to noise and the funky quirks of an Old time Historic hotel...... maybe stay on the main highway and hit up a holiday inn! If on the otter hand you like character, history, adventure and meeting random travelers in a cool, comfortable and inviting mountain cowboy hotel... Then this is a good spot to hang your hat and rest your head to be ready for the next days Adventure!
Destinations to explore
- Rentals with a hot tub Southern United States
- Resort rentals Southern United States
- Ski-in/ski-out rentals Southern United States
- Rentals with a kayak Southern United States
- Shipping container rentals Southern United States
- Smoking-friendly rentals Southern United States
- Rentals with a home theater Southern United States
- Rentals with a soaking tub Southern United States
- Ranch rentals Southern United States
- Condo rentals Southern United States
- RV rentals Southern United States
- Townhouse rentals Southern United States
- Rentals with an accessible height toilet Southern United States
- Rentals with outdoor seating Southern United States
- Farmstay rentals Southern United States
- Bungalow rentals Southern United States
- Earth house rentals Southern United States
- Family-friendly rentals Southern United States
- Rentals with breakfast Southern United States
- Loft rentals Southern United States
- Campsite rentals Southern United States
- Kid-friendly rentals Southern United States
- Yurt rentals Southern United States
- Rentals with a fire pit Southern United States
- Nature eco lodge rentals Southern United States
- Chalet rentals Southern United States
- Rentals with an accessible height bed Southern United States
- Tipi rentals Southern United States
- Tent rentals Southern United States
- Cabin rentals Southern United States
- Hostel rentals Southern United States
- Rentals with a patio Southern United States
- Houseboat rentals Southern United States
- House rentals Southern United States
- Rentals with a balcony Southern United States
- Tiny house rentals Southern United States
- Pet-friendly rentals Southern United States
- Aparthotel rentals Southern United States
- Rentals with a washer and dryer Southern United States
- Vacation home rentals Southern United States
- Dome rentals Southern United States
- Rentals with beach access Southern United States
- Fitness-friendly rentals Southern United States
- Rentals with lake access Southern United States
- Barn rentals Southern United States
- Rentals with an EV charger Southern United States
- Villa rentals Southern United States
- Beachfront rentals Southern United States
- Bed and breakfasts Southern United States
- Guesthouse rentals Southern United States
- Rentals with a fireplace Southern United States
- Hotel rentals Southern United States
- Private suite rentals Southern United States
- Boat rentals Southern United States
- Waterfront rentals Southern United States
- Train rentals Southern United States
- Cottage rentals Southern United States
- Apartment rentals Southern United States
- Rentals with pools Southern United States
- Rentals with a sauna Southern United States
- Serviced apartment rentals Southern United States
- Treehouse rentals Southern United States
- Luxury rentals Southern United States
- Island rentals Southern United States
- Boutique hotel rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Things to do Southern United States
- Food and drink Southern United States
- Wellness Southern United States
- Art and culture Southern United States
- Sightseeing Southern United States
- Sports activities Southern United States
- Entertainment Southern United States
- Nature and outdoors Southern United States
- Tours Southern United States
- Things to do United States
- Sports activities United States
- Nature and outdoors United States
- Art and culture United States
- Wellness United States
- Tours United States
- Food and drink United States
- Sightseeing United States
- Entertainment United States