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Boutique hotel vacation rentals in Southern United States

Find and book unique boutique hotel rentals on Airbnb

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Popular amenities for Southern United States boutique hotel rentals

Family-friendly boutique hotels rentals

Guest favorite
Hotel room in Fairhope
4.92 out of 5 average rating, 142 reviews

Cool, cozy, contemporary and romantic! Location!

LaurenRating, 5 stars1 month ago
Great, very new and well appointed. Nice access to the bay. Wonderful location. We will definitely be back.
Guest favorite
Hotel room in Apalachicola
4.92 out of 5 average rating, 151 reviews

The Coral Suite at Riverwood Suites

JodyRating, 5 stars3 weeks ago
Excellent location. Easy to walk to everything downtown. Lovely garden for coffee in the mornings or wine in the evenings. Beautifully decorated and very clean. Monica and her team are very responsive. I highly recommend this spot. This was our second stay.
Hotel room in Grand Isle
4.9 out of 5 average rating, 30 reviews

Gulf Front Suite - 2 Bedrooms with Kitchen

EthanRating, 5 stars4 weeks ago
Place was in a great location with an awesome deck, check in was easy and host was very responsive. Great place to stay in Grand Isle.
Top guest favorite
Hotel room in Newport
4.96 out of 5 average rating, 550 reviews

#5 No Cleaning/Parking Fees! Walk to Games/Music!

SherryRating, 5 stars1 week ago
Had a great stay. Jeff was very attentive. Loved the room.
Top guest favorite
Hotel room in Bay St. Louis
4.97 out of 5 average rating, 233 reviews

The Happy Place

AlexanderRating, 5 stars1 week ago
We thoroughly enjoyed our weekend in Bay St. Louis and our stay at this lovely place. There is a magical quality to the property, with its lush garden complete with a goldfish pond and the cats and dogs. The place was comfortable (for two people) and the location is great. It's an easy walk to the heart of the town and the beach.
Hotel room in El Prado
4.8 out of 5 average rating, 20 reviews

Esmeralda - Hotel Luna Mystica

KellyRating, 5 stars46 months ago
Great amenities in Esmerelda, easy access, super comfy bed! Wish we had more time there - would stay again!
Top guest favorite
Hotel room in Lauderdale-by-the-Sea
4.97 out of 5 average rating, 105 reviews

The Little Inn with a Big ❤️

DouglasRating, 5 stars1 week ago
This place is wonderful! The property manager, Cindy was super attentive, and made our stay memorable! The property is spotless, close to everything, and within walking distance to the beach, and downtown area!
Guest favorite
Hotel room in Clearwater Beach
4.9 out of 5 average rating, 401 reviews

Cozy 1BR Retreat w/Full Kit- Steps to Clw Bch

KristinaRating, 5 stars4 weeks ago
The location and apartment were great! Walking distance to the beach and local restaurants and shops. The apartment was comfortable and clean. It was a nice and quiet area which was appreciated after a long day at the beach. Looking forward to coming back another time!

Boutique hotels rentals with a patio

Superhost
Hotel room in Miami
4.79 out of 5 average rating, 284 reviews

Awesome spacious room, with pool & free parking

Anthony AlaroyRating, 5 stars1 month ago
This space was exactly what I needed—clean, organized, and filled with positive energy. You can tell it’s cared for with intention, and that made a big difference in my stay. The environment felt inspiring and peaceful, perfect for grounding and creativity. Grateful for the warm vibes and welcoming atmosphere.
Top guest favorite
Hotel room in Corrales
4.98 out of 5 average rating, 147 reviews

Victorian Carriage House Studio

SallyRating, 5 stars6 days ago
Jennifer’s home is beautiful, Victorian charm and ambiance. The room is spacious and beautifully decorated with a large en suite bathroom. We felt very pampered. The location was easy to find and even though most restaurants in the village were closed because it was a Monday, there are other restaurants and shopping a couple of miles away. I would highly recommend the room at Jennifer’s.
Guest favorite
Hotel room in Austin
4.94 out of 5 average rating, 251 reviews

New High Rise 2 Bedroom Condo Rainey District

KatherineRating, 5 stars1 week ago
We have stayed with Jason several times and are never disappointed! The place is in a great location, has all the amenities you need and he is very responsive and accommodating. The unit is clean and comfortable, I highly recommend booking, you will not be disappointed!
Guest favorite
Hotel room in Saint Charles
5 out of 5 average rating, 21 reviews

#4 Penny Farthing Le Velo Inn

TylerRating, 5 stars1 week ago
It was an absolute joy. My fiancee and I booked at this location in Saint Charles on a whim because we were going horse back riding out in High Ridge. It was the first time either of us experienced St Charles and we loved it so much, we are talking about moving there. It is such a beautiful little town with all types of local restaurants and shops and plenty to do all within walking distance. The Velo Inn was perfect as well. It is so unique and beautiful. EXACTLY as described in the listing/pictures. 10/10 we will for sure be back in the future. My 1 and only minor issue was the cost. But on the other hand, you can see the amount of work and effort they put into making this hotel a wonderful experience for their guests.
Guest favorite
Hotel room in Bandera
4.87 out of 5 average rating, 124 reviews

Rustic 3 bed cabin with upscale hotel amenities

ElizabethRating, 5 stars1 month ago
We enjoyed our stay while here! The owner was friendly and responsive. We enjoyed the ducks that came and visited us.
Guest favorite
Hotel room in Rockville
4.96 out of 5 average rating, 25 reviews

The Old Jail Inn the Bonnie and Clyde Suite

MelissaRating, 5 stars1 week ago
My daughter and I stayed in the Bonnie and Clyde cell. Very interesting place and experience. We are always looking for something new and different and it didn’t disappoint. We enjoyed Turkey Run nearby, and visited the old Indiana State Sanitarium. We also shopped at the stores on the square and ate at the Thirty six Saloon , both within walking distance, and enjoyed some good food and music. Great place to stay in a great little town.
Guest favorite
Hotel room in Duck Key
5 out of 5 average rating, 30 reviews

Conch Key Villas #1. Fun, fishing & great sunsets

CorrieRating, 5 stars2 months ago
The pictures of this place do not do it justice! Beautiful sunsets every night, tons of sea life off the dock. Saw many parrot fish, nurse sharks and even a Loggerhead turtle! This place is clean and as described! Close drive to Marathon and Islamorada for day trips! Kayaks and paddle boards for use at anytime! We will definitely be back!
Superhost
Hotel room in St. Augustine
4.89 out of 5 average rating, 184 reviews

Downtown Boutique Bed & Bath w Balcony, Unit 3

PameleaRating, 5 stars3 days ago
This place was in a great location, spacious, and has a very comfortable bed with soft linens. Loved tub/shower combo in a very nice and clean bathroom. It was quiet but walkable to everything and the neighborhood seems very safe and friendly. The hosts are very responsive. Highly recommend and would return.

Monthly boutique hotels rentals

Guest favorite
Hotel room in Monterrey
4.82 out of 5 average rating, 17 reviews

Hostal del Barrio/Habitación #09 cama individual

MarlenRating, 5 stars3 weeks ago
This place it’s by Barrio Antiguo. Great area easy check in .. Always polite and the place is clean. I really like to stay here . I will come back for sure !!
Hotel room in Brady
4.63 out of 5 average rating, 52 reviews

The Bonnie & Clyde room in historic hotel

KaleighRating, 5 stars3 months ago
Had a few mixups with checkin because they had lost power earlier but the host helped get me in another room that was nicer which was appreciated! Cool historic spot
Superhost
Hotel room in Branson
4.81 out of 5 average rating, 43 reviews

Mandalay Motel #7 by Silver Dollar City

ChristiRating, 5 stars1 week ago
The Mandalay Motel is a beautiful, peaceful place to stay when in the Branson area! We needed a clean, convenient room after a fun night at Thunder Ridge Arena, and it was great option. It’s also a short drive into Branson for food and fun on the strip, and very close to Silver Dollar City. Self check-in is a breeze, and Emily is a friendly, proactive, and responsive host- thank you so much for your hospitality! :)
Hotel room in Chihuahua
4.67 out of 5 average rating, 257 reviews

La Decima (clean rate / no hidden fees)

Víctor FranciscoRating, 5 stars34 months ago
El lugar está súper bien ubicado, un precio bastante bueno y el desayuno de 10. Totalmente volvería. Relación calidad/precio muy buena
Guest favorite
Hotel room in Kenbridge
4.79 out of 5 average rating, 48 reviews

Adorable Efficiency Suite-2- Heart of Kenbridge!

AaronRating, 5 stars2 months ago
Booked for one of our employees who was assisting a near by medical facility. Vanessa was responsive and took care of us so we can take care of others. Much appreciated.
Guest favorite
Hotel room in Chihuahua
4.89 out of 5 average rating, 127 reviews

#2 Coronado4veinte zonacentrochepe hotel boutique

Jesus OctavioRating, 5 starstoday
Fue muy agradable hospedarnos con Rossina. Nos tenia un detalle el cual se aprecia mucho. Sin duda volveremos
Hotel room in Delicias
4.51 out of 5 average rating, 55 reviews

1. Habitación privada c/clima. Céntrica ubicación

MiguelRating, 5 stars2 months ago
estuvo bien funcional para lo que requeríamos
Hotel room in Kremmling
4.56 out of 5 average rating, 27 reviews

Two Queen Economy Room - Shared Restrooms

JohnRating, 5 stars9 months ago
Historic hotel in a rad town in the moutains. Historic Hotel like a boarding house back in the day. Many rooms have a shared bathroom down the hall. Some rooms have a private bath. Awesome old wood floors squeak and creak fairly loudly. I dug it and thought of it as the floors were talking story of all that's times past. If your sensitive to noise and the funky quirks of an Old time Historic hotel...... maybe stay on the main highway and hit up a holiday inn! If on the otter hand you like character, history, adventure and meeting random travelers in a cool, comfortable and inviting mountain cowboy hotel... Then this is a good spot to hang your hat and rest your head to be ready for the next days Adventure!

Destinations to explore