House vacation rentals in Seneca

Find and book unique houses on Airbnb

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Popular amenities for Seneca house rentals

House rentals with a pool

Superhost
Home in Sky Valley
4.88 out of 5 average rating, 8 reviews

VIEWS! 100+MB WIFI! firepit, private, convenient

CarrollRating, 5 stars65 months ago
Gorgeous mountain retreat is a perfect way to describe this property. I found everything in the description of this property to be true. In my opinion Karla’s description was very humble and we found the property to be much better than expected. Entire family celebrated my father’s 90th birthday, and found the house plenty spacious for all of us. With full living space on the main level and downstairs we never felt crowded.The house was immaculate and very well stocked with items that were above and beyond any other property I’ve ever stayed in right down to the firewood. Directions were easy to follow and communication was always done in a timely fashion. If you want to relax, do nothing, enjoy the views this is the place for you. If you want to be active, go hiking, play golf, tennis, etc. this is the place for you. If you want to grill out and watch football with the gang, this place is for you. So if you have a large group, and you are looking for a mountain getaway, I recommend that you stop looking and book this property NOW!!
Top guest favorite
Home in Salem
4.99 out of 5 average rating, 127 reviews

Keowee Key Luxury Condo - Stunning Views!

ChuckRating, 5 stars3 weeks ago
Stayed at tall ships numerous times, best unit so far. Enjoy all the amenity’s. Golf,tennis,gym, walking trails. Will rent from Michael next trip. Chuck B.
Guest favorite
Home in Martin
4.9 out of 5 average rating, 30 reviews

Lake Hartwell: Private Pool, Dock, Pets, Fire Pit

JasmineRating, 5 stars1 week ago
The lake house is beautiful. Very private and peaceful. The house looks even better than the photos. Our children loved the pool. We are already planning to return some time this summer. Thanks Ellen for being a great host.
Superhost
Home in Dillard
4.83 out of 5 average rating, 24 reviews

Big House with Big Mtn Views, Golf & Pool Access

MicheleRating, 5 stars5 days ago
We needed a place for our blended family to finally meet and have time together. One of the bedrooms had bunks which became the kids room. They loved it. They also loved the game room, playground and bathing in the heart shaped jacuzzi. The view is amazing, overlooking a pond with the mountains in the background. We had groups playing golf and tennis. It was too cold for the pool but I’m sure the kids would have been there if it was warm. There is a beautiful waterfall closer than I thought. There was plenty of room for everyone to dine and just be together. It is definitely a place we will keep in mind for future gatherings.
Superhost
Home in West Union
4.83 out of 5 average rating, 12 reviews

Peninsula Sunset View of Keowee

EricRating, 5 stars19 months ago
Great stay. Everything worked out great. Would recommend to friends.
Superhost
Home in Salem
4.85 out of 5 average rating, 20 reviews

Lake Keowee Home near Clemson, boating, and hiking

ConnorRating, 5 stars8 months ago
Keith was very responsive and helpful from the moment I booked the BNB for the weekend. Very simple process and the details and instructions were very clear and easy to understand. The house is beautiful in a great location with perfect sleeping arrangements for a group of 8-9. Highly recommended booking this location for your next trip to the lake
Top guest favorite
Home in Highlands
4.95 out of 5 average rating, 101 reviews

Mountain Laurel Retreat

JordanRating, 5 stars1 month ago
Mary Jo and Lina’s place was perfect for our family! It had so many kid friendly accommodations and was well kept and just a short walk to shops and restaurants! We loved our stay!
Guest favorite
Home in Seneca
4.89 out of 5 average rating, 9 reviews

Enchanting 1906 Farmhouse

RhondaRating, 5 stars5 months ago
We rented the spacer for a wedding rehearsal dinner and bridesmaids stay. It was a beautiful older home that had such a warm feel. The setting was just perfect!

Weekly house rentals

Guest favorite
Home in Lavonia
4.97 out of 5 average rating, 120 reviews

The Skyline Way Lake House w/ Hot Tub & Dock!

AnthonyRating, 5 stars2 weeks ago
From the moment we walked in, everything was perfect and perfect location/setup for our getaway. Everything we needed with plenty of room, perfect for four guys on a golf trip!! Even had a brand new grill, updated appliances and perfect theater room to watch the Final Four games!! Can’t say enough about this place and the owners were very responsive and communicative throughout our stay. Five stars all around and would highly recommend!!
Top guest favorite
Home in Anderson
4.97 out of 5 average rating, 107 reviews

Sunset Point-Best view on Broadway - HOT TUB!

MarisaRating, 5 stars3 weeks ago
Can’t say enough great things about Sunset Point! Beautiful and Spotless inside, they thought of every detail. The livingroom had a large comfy couch and the beds and bedding top notch! Bonus- it is decorated so cute-LOVED the color coded beautiful bookcase! My son plays lacrosse at Anderson university, we were spending the week to catch a few of his games-I wanted a place that felt like vacation but also be able to cook some homemade meals. Sunset point exceeded my expectations! The kitchen had everything needed including a crockpot and the outdoor grill was a great addition! Outside we were able to enjoy the beautiful lake-the views and the sunsets stunning! Marvin has a shed fully stocked w beach chairs, cornhole, paddle boards, floats and there is also kayaks! They truly thought of everything. I am so glad to have found this gem.. don’t hesitate to book it-you’ll be so glad you did! I can’t wait to go back! Thank you Marvin and Angela for a wonderful week in your beautiful home!
Guest favorite
Home in Martin
4.95 out of 5 average rating, 84 reviews

Red Door Retreat on the Lake

AllisonRating, 5 stars2 months ago
Had a wonderful stay at this lake house. It was perfectly clean and very cozy. Our group felt right at home. The lake was beautiful and we got to enjoy some time relaxing on the dock. Hosts were very communicative and helpful. Would absolutely recommend and stay here again!
Guest favorite
Home in Anderson
4.96 out of 5 average rating, 112 reviews

Clemson ,Lake Hartwell, Waterfront, pontoon rental

LaurenRating, 5 stars3 weeks ago
Very nice big house with beautiful kitchen and lovely backyard. Neighbors were quiet, and an overall peaceful stay.
Top guest favorite
Home in Starr
5 out of 5 average rating, 25 reviews

lakefront Home with million dollar view

JenniferRating, 5 stars6 months ago
Bruce was amazing!! The house on the lake was peaceful and relaxing.
Guest favorite
Home in Highlands
4.81 out of 5 average rating, 74 reviews

6+BR home with Mountain Views

ErinRating, 5 stars4 months ago
The home and Tara were great! The space was perfect for our large family - the loft playroom in particular was wonderful for 7 kids to play in and allow the adults to still have a separate space where there was some relative calm. It is remote but still accessible to Cashiers, and we went on several excursions to nearby hikes and waterfalls. We very much enjoyed our holiday there.
Top guest favorite
Home in Anderson
4.97 out of 5 average rating, 132 reviews

Westwind Retreat Lake House

RobertaRating, 5 stars6 days ago
Beautiful and spacious house in a serene setting. Comfortable beds. Responsive, flexible hosts who are not overbearing or intrusive. Great accommodations! Highly recommend this home.
Guest favorite
Home in Pickens
4.98 out of 5 average rating, 40 reviews

Happy Trails: Jacuzzi, Lookout Tower, Views!

JenniferRating, 5 stars1 week ago
We rented the Airbnb for a wedding weekend! The house exceeded our expectations and was a wonderful place for the bridal party to stay! Plenty of space and excellent communication for the host! Would definitely recommend!!

Private house rentals

Top guest favorite
Home in Scaly Mountain
5 out of 5 average rating, 32 reviews

*Gorgeous Mtn Views, Fire Pit & Wine Cellar*

BrettRating, 5 stars3 months ago
Thank you so much for sharing your beautiful home with our family. Even with the rain we had a wonderful time. We loved the smaller cottage for us older folks. Some peace and quiet from the grands! Plenty of room for everyone to spread out and have their own space. We thoroughly enjoyed the large fireplace. So warm and cozy! The large Christmas tree and decorated mantle was a beautiful addition to the holiday spirit. Thank you again for sharing such a special place!
Superhost
Home in Walhalla
4.9 out of 5 average rating, 41 reviews

aunt helen's house

MyraRating, 5 stars6 days ago
I’m thrilled we found Aunt Helen’s place in Walhalla, SC. Home is perfect for a long weekend with friends and family. You feel at home when you walk in and it’s a very comfortable stay. We spent a lot of time on the porch swing enjoying the perfect weather. Did some walking around Walhalla shopping and eating in local restaurants. Great place to visit we’ll be back. We’ll be back the host are wonderful!!
Superhost
Home in Hartwell
4.87 out of 5 average rating, 55 reviews

Relaxing On Riviera

GabrielRating, 5 stars6 months ago
Great stay! Beautiful house and very nice lake.
Top guest favorite
Home in Highlands
5 out of 5 average rating, 10 reviews

<10 min to Main St~Hot Tub Coming May 2025~Pets

DebbiRating, 5 stars4 months ago
We loved this home and the hosts! The 3 bedrooms and extra family room downstairs meant we all had room to spread out. At the same time, the family room and kitchen was a cozy gathering space and all the fireplaces were so fun! This was a great place for a chilly Thanksgiving week and we loved every second! And our dog was so happy here. The crate was perfect for the few times we ventured out without her. Love all the doggie details - bowls, poop bags, everything we needed!
Guest favorite
Home in Easley
4.79 out of 5 average rating, 33 reviews

Jess & Bailey's Easley Escape

JulieRating, 5 stars3 weeks ago
This was my second stay at this lovely home because I liked it so much the first time. As long as my family is in the area and I haven’t moved to the area, I’ll stay again if it’s available!
Guest favorite
Home in Hartwell
4.93 out of 5 average rating, 30 reviews

Lake Hartwell Hideaway

PattiRating, 5 stars1 month ago
Beautiful spacious home in an exceptionally tranquil setting. The amenities available in the home exceeded expectations. I would highly recommend this home and would love to return there if ever in the area again.
Top guest favorite
Home in Westminster
4.98 out of 5 average rating, 46 reviews

Tugaloo Hideaway

DonielleRating, 5 stars3 months ago
Very beautiful and peaceful home. Perfect for our mini surprise family reunion. The game room was a bonus and kept the kids occupied. The fire pit was also a great addition, who doesn't love s'mores! We absolutely loved it and will be coming back.
Guest favorite
Home in Anderson
4.97 out of 5 average rating, 99 reviews

Cozy 3 bedroom house. convenient location!

TammyRating, 5 stars1 month ago
We had a great stay at Everett’s place! The dog loved the independence that he had on and in the property! Totally fenced in so we didn’t have to worry about him getting loose! We spent a lot of time outside just grilling out and sitting on the patio. Very cute little house!

Quick stats about house rentals in Seneca

  • Total rentals

    30 properties

  • Nightly prices starting at

    ﺩ.ﺇ147 before taxes and fees

  • Total number of reviews

    1.5K reviews

  • Family-friendly rentals

    20 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

Destinations to explore

  1. Airbnb
  2. United States
  3. South Carolina
  4. Oconee County
  5. Seneca
  6. House rentals