Vacation rentals in Seneca

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Top-rated vacation rentals in Seneca

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A charming cottage with a distinctive A-frame structure is set amidst lush greenery. The front yard features well-maintained flower beds, and two benches flank the entrance. An American flag is displayed beside the front door, which is framed by two inviting windows.
Cottage in Anderson
4.96 out of 5 average rating, 114 reviews

A-Frame Lake Hartwell Cottage w/ Hot Tub

No lake water till it substantially rains Lake Hartwell cottage w/ Hot Tub ! Clemson 9 mi. away! 2 bdrm, 2 full bath, hot-tub, canoe, 2kayaks, 🎣 poles, life-vests, dining & patio table, grill+charcoal, 3tv, Netflix/2DVDplayers/DVDs, kitchen, pots/pans, 2crockpot, microwave, dishwasher+pods, keurig+coffee, washer+detergent, dryer, spices, shampoo/cond, hair dryer, curler, straightener, linens, towels, 3bikes, helmet, Karaoke, firepit+wood, wall of fun! (Boat-landing 1 mi. away! Cateechee Shores

Top guest favorite
A spacious outdoor dining area is visible through a large hinge window. The wooden table is surrounded by four folding chairs, with a scenic view of the lake and trees in the background. Sunlight filters through, enhancing the seamless indoor-outdoor connection.
Cottage in Seneca
4.99 out of 5 average rating, 114 reviews

Destination Keowee

A rustic industrial style Lake Keowee lakefront escape that places you right on a panoramic point in a private cove. Welcome the outdoors in with the 6ft kitchen hinge bar window to the upper deck or enjoy the 6-seat hot tub on lower deck. Deep water dock tie off space is available. Guests enjoy the use of 2 standup paddle boards, and lakeside fire pit (guest provide firewood). Great cove sunsets! 15 minutes to Clemson and 1 min Lighthouse Restaurant. Please read all details prior to booking!

Top guest favorite
The cottage exterior displays warm wood siding with large windows allowing natural light. A welcoming front porch features two chairs and a small plant, while a grill stands nearby. Surrounding landscaping creates a serene atmosphere in a private setting.
Cottage in Central
4.99 out of 5 average rating, 197 reviews

The Wildflower

Enjoy a relaxing experience at this centrally-located spot, away from the hustle and bustle but only 6 min from Clemson (10 min from Clemson University), nestled in the country in a peaceful, safe neighborhood with lots of privacy surrounding. The cottage has a front porch with 2 chairs, a 2 person hammock, grill, and a fire pit (wood is provided) with three lawn chairs. There’s a queen bed and also a CordaRoy beanbag (*bed #2) that opens up to a soft bed that sleeps 1 adult or two children.

Guest favorite
A cozy bedroom is highlighted by a spacious bed with a patterned blanket. Two bedside lamps provide soft illumination on either side. A wooden dresser is positioned against the wall, and a window allows natural light to fill the space, complemented by cream-colored walls.
Apartment in Seneca
4.94 out of 5 average rating, 176 reviews

Clemson Mom Apartment

Roomy 1 bedroom, 1 bath apartment in Seneca, SC. Approximately 2.5 miles from Wal-Mart and 2 miles from Waffle House. 9 miles from Clemson football stadium. Excellent location with a short drive to restaurants, shopping, 3 24-hour gyms, and grocery stores. Located in a quiet subdivision with minimal traffic. This is the perfect spot, close to Seneca, but away from highly trafficked areas. Great for a working adult and quiet enough during the day for someone working third shift to sleep.

Top guest favorite
A charming cabin is nestled among tall trees, accessed by a stone path. Warm string lights adorn the porch area, creating a welcoming glow. Fallen leaves blanket the ground, complementing the natural surroundings and inviting a sense of tranquility.
Cabin in Pickens
4.98 out of 5 average rating, 246 reviews

The Romantic Greystone Cottage

Follow the enchanting stone path to a private getaway where romance and connection await. Enjoy the ambiance of the starlit sky while cuddled up on the hammock or around the fire. Cozy up on the king-size bed and relish every moment of your stay. Indulge in a bottle of wine and relax by soaking in the luxurious claw-foot tub. Wake up to the tranquil sounds of the forest, savoring the morning with coffee on the porch. Escape the everyday and embrace what matters most at The Greystone Cottage.

Guest favorite
A modern cottage features a spacious covered porch with string lights, surrounded by a lush green lawn. Large glass doors invite natural light into the interior, while tall trees provide shade in the background against a colorful sunset sky.
Cottage in Anderson
4.96 out of 5 average rating, 216 reviews

Lakefront dock *hot tub* Anderson/Clemson king bed

Relax & enjoy the beautiful views of lake Hartwell from the front porch daybed swing, hot tub, or private dock. Sleep in a king size bed wrapped in cool cotton linens, a towel warmer, soaking tub with TV, & a breville espresso maker. Located w/i 10 minutes of many restaurants. Less than 20 min. to downtown Anderson Pendleton or Clemson. This prime location on lake Hartwell is a 10 minute boat ride to Portman Shoals Marina, the Galley restaurant, & Green Pond Landing.

Top guest favorite
A view capturing the entryway leading to a cozy bedroom space. The warm wooden accent wall complements the inviting bedding. A small side table holds a decorative item, while light fills the room through a ceiling fixture, creating a serene atmosphere.
Camper/RV in Pendleton
4.95 out of 5 average rating, 103 reviews

The Pendle-Tin

At the Pendle-tin, you’re close to it all, yet feel tucked away in the west end of downtown Pendleton. You’re 5-8 min from Clemson’s Death Valley, and 2 blocks from downtown Pendleton where you’ll find eateries, and shops. About 5 min from the lake and about 45-50 min from the mountains. Inside you’re Equipped with a kitchen, full bath, WiFi, smart tv , queen bed and separate work space . Outside you have seating for 4 and a propane fire pit.

Top guest favorite
The exterior of a modern tiny house is depicted, featuring a dark blue façade and large windows allowing natural light to fill the interior. The covered porch is accessible from the gravel pathway, and greenery surrounds the property, enhancing the wooded setting.
Cottage in Westminster
4.97 out of 5 average rating, 617 reviews

Tiny house

BRAND NEW 490 sq ft tiny house/cottage nestled in the woods in a country setting. Complete with a queen bedroom, a twin/day bed and then a queen bed in loft ( comfortably sleeps 4 adults and one child). We are conveniently located 10 miles from I-85 exit 1 on S Hwy 11. 20 minutes from Clemson, 8 minutes from Seneca, and just a short drive to many hiking trails, lakes and parks in the beautiful foothills of the Blue Ridge mountains.

Top guest favorite
The charming house, surrounded by lush greenery, features a screened-in front porch that invites relaxation. A flag gently flutters on the porch, while well-maintained landscaping frames the entrance. Large trees provide ample shade, enhancing the tranquil outdoor environment.
Home in Westminster
4.93 out of 5 average rating, 126 reviews

Shady Rest

As you enter the screened in front porch you will instantly relax, experience a peaceful and quiet tree lined front yard. The house has plenty of shade and old oaks, built in 1935 has the charm of visiting great grandmother’s farm house without the wallpaper. Large side deck with grill, hot tub and plenty of shaded sitting. Side yard has a fire pit for evening campfires and roasting marshmallows. The house has an open floor plan.

Top guest favorite
A charming tiny house is set amidst wooded surroundings, featuring a welcoming entrance with a white door and a light-colored roof. Two white chairs and a small table are positioned on a wooden porch, complemented by a grill nearby. Lush greenery enhances the tranquil setting.
Tiny home in Seneca
4.96 out of 5 average rating, 246 reviews

Windmill Cottage

You’ll treasure your time at this cute little cottage. It is 295 sq feet and was built in 2023 at the edge of the woods on our property. It has a full kitchen, bedroom with a queen bed, bathroom and living room. It is perfect for one or two people, for either a quiet get-away in the country or for someone who is in town for work and is looking for a more extended stay. We offer discounts for weekly/monthly stays!

Top guest favorite
A bright and spacious kitchen features a central island with a granite countertop, surrounded by blue upholstered chairs. A dining table with wicker chairs is located nearby, and natural light fills the room through sliding glass doors leading to the outdoor area.
Home in Seneca
4.96 out of 5 average rating, 125 reviews

5 Min to Clemson | Large Driveway & Self Check-In

Welcome to your Cozy Family Home! Escape to this charming 3-bedroom, 2-bathroom home, just a short 3-mile drive from the iconic Clemson Memorial Stadium. Whether you're planning a trip to the lake, tailgating for the big game, catching up with friends, or exploring the local hiking trails, this quiet and convenient home is your ideal base. Can't wait for you to enjoy Clemson, SC. Go Tigers! Pet Fee of $100.

Top guest favorite
A charming cottage is surrounded by lush greenery and tall trees, featuring a welcoming front porch with seating. The exterior is clad in grey siding and highlights stylish architectural design elements. A gravel driveway leads up to the house, emphasizing its peaceful and private setting.
Home in Seneca
5 out of 5 average rating, 110 reviews

The Cottage

Come relax and refresh in peaceful surroundings. Relax and unwind on the front porch. Experience tranquility as the sun sets and the frogs start croaking. You are welcome to cast a line in the pond to try your skill at fishing. Fishing poles are not provided. The cottage is private but still has convenience of Walmart and Oconee Memorial Hospital within a 5 minute drive. We are 13 miles from Clemson.

Popular amenities for Seneca vacation rentals

When is the best time to visit Seneca?

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Frequently Asked Questions

  • Where should I stay in Seneca?

    Make yourself at home in Seneca by choosing from our most frequently booked neighborhoods. We have over 110 vacation rentals in Utica, and over 180 vacation rentals in Seneca.

  • Are there vacation rentals with a dedicated workspace in Seneca?

    Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • Are there pet-friendly vacation rentals in Seneca?

    Four-legged friends are welcome in Seneca. Choose from more than 20 vacation rentals for guests traveling with pets.

  • How much does it cost to stay in house rentals in Seneca?

    Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there family-friendly vacation rentals in Seneca?

    Seneca has more than 50 family-friendly stays. Amenities on the property may include high chairs, travel cribs, or strollers.

  • Do house rentals in Seneca have wifi?

    Absolutely! We offer over 40 house rentals with wifi in Seneca. Enjoy a tailored experience with all the comforts you desire.

  • Do house rentals in Seneca have air conditioning?

    Absolutely! We offer over 40 house rentals with air conditioning in Seneca. Enjoy a tailored experience with all the comforts you desire.

  • What are the most popular amenities for House Rentals in Seneca?

    Enhance your stay in our House Rentals with the most popular amenities: over 40 homes with air conditioning, over 40 homes with wifi, and more. Indulge in the ultimate retreat, tailored to your preferences.

Quick stats about vacation rentals in Seneca

  • Total vacation rentals

    Explore 60 vacation rentals in Seneca

  • Nightly prices starting at

    Seneca vacation rentals start at ﺩ.ﺇ184 per night before taxes and fees

  • Verified guest reviews

    Over 2,400 verified reviews to help you choose

  • Family-friendly vacation rentals

    50 properties offer extra space & kid-friendly amenities

  • Pet-friendly vacation rentals

    Find 20 rentals that welcome pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

  • Wi-Fi availability

    60 of Seneca vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Gym, BBQ grill, and Laptop-friendly workspace across Seneca rentals

  • 4.9 Average rating

    Seneca stays are highly rated by guests—averaging 4.9 out of 5!

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