
Vacation rentals in Seneca
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Top-rated vacation rentals in Seneca
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Other great vacation rentals in Seneca

Clemson/Anderson Lake Hartwell
Pat was extremely communicative and the home fit our family of 10 perfectly. There are 2 large bedrooms on the main level, one, a King with small private bath and the other, a queen bed with large private bathroom. There were 2 additional full baths on the main level as well. The kitchen was extra large, very well stocked and accommodated our large family! There is an oversized family room with lots of seating and a bar area too! The family room off the kitchen faces the back deck and the lake and I enjoyed lots of time there reading books to my Grand baby. The back deck was oversized and the home literally sits on Lake Hartwell ! The back dock was a nice bonus as was the hot tub! The downstairs does have some steep stairs so I wouldn't advise elderly people sleeping down there. However, you will find a full bathroom, 2 bedrooms and a third bedroom/bonus/flex space with 2 full beds. We loved our family time there celebrating our daughter's wedding! We can't wait to go back!

Beautiful Highlands Cabin: Fun Game Room, Hot Tub
Thank you for letting us stay at your home. It was a great getaway for us and well worth the drive from Ohio! The location was perfect as it was close to hiking locations, great restaurants and fun activities. The game room was a big hit and my kids want to come back again soon! Thank you again for everything!

The Honey Pot- peaceful cabin -fireplace and deck
We love visiting sky valley and Jennifer’s place did not disappoint! It was a peaceful paradise nestled in the hills. We all had so much fun! Would book again for sure!

Jess & Bailey's Easley Escape
This was my second stay at this lovely home because I liked it so much the first time. As long as my family is in the area and I haven’t moved to the area, I’ll stay again if it’s available!

Her Redhead Cabin on Lake Hartwell w/ Private Dock
What a amazing place ! My wife and I came for a weekend getaway and were blown away by how accommodating Mimi and Gene were . The place was above and beyond what we expected ! Absolutely adorable place and perfectly equipped with everything you need for a great stay ! Can’t say enough about the place and the hosts ! We booked another stay here within hours of checking in ! We have stayed at a lot of air bnbs and this has to be up there with one of our favorites :)

Mountain house perfect for nature lovers!
Our family loved Pippas place! We spent the time in the more than expansive home celebrating a birthday, using the grill, sitting at the fire pit each night, having evening visits with the sweet donkey we got to feed some carrots, and endless fishing on the property for our son. Very safe for kids.

Dog friendly guesthouse near Clayton & Highlands
This place was stunning! Very clean and organized. The only issue we had was not reading the instructions that we would lose cell service halfway up the mountain. In her defense, Elizabeth did put that in the instructions that I did not read ahead of time. Everything was squeaky, clean, organized, well decorated…Beautiful!

Happy Trails: Jacuzzi, Lookout Tower, Views!
We rented the Airbnb for a wedding weekend! The house exceeded our expectations and was a wonderful place for the bridal party to stay! Plenty of space and excellent communication for the host! Would definitely recommend!!
Quick stats about vacation rentals in Seneca
Total rentals
50 properties
Nightly prices starting at
ﺩ.ﺇ147 before taxes and fees
Total number of reviews
2.1K reviews
Family-friendly rentals
30 properties are a good fit for families
Pet-friendly rentals
10 properties allow pets
Rentals with dedicated workspaces
20 properties have a dedicated workspace
Frequently Asked Questions
Are there vacation rentals with a dedicated workspace in Seneca?
Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.
How much does it cost to stay in house rentals in Seneca?
Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.
Are there pet-friendly vacation rentals in Seneca?
Four-legged friends are welcome in Seneca. Choose from more than 10 vacation rentals for guests traveling with pets.
Do house rentals in Seneca have wireless internet?
Absolutely! We offer over 30 house rentals with wireless internet in Seneca. Enjoy a tailored experience with all the comforts you desire.
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- Black Rock Mountain State Park
- Table Rock State Park
- Tallulah Gorge State Park
- Gorges State Park
- Bell Mountain
- Ski Sapphire Valley
- Jump Off Rock
- Mountaintop Golf & Lake Club
- Tugaloo State Park
- Don Carter State Park
- Old Edwards Club
- Funopolis Family Fun Center
- Helen Tubing & Waterpark
- Anna Ruby Falls
- Discovery Island
- Victoria Bryant State Park
- Wade Hampton Golf Club
- Haas Family Golf
- Victoria Valley Vineyards
- Carl Sandburg Home National Historic Site