Vacation rentals in Seneca

Book unique vacation rentals, houses, and more on Airbnb

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Popular amenities for Seneca vacation rentals

Stay near Seneca's top sights

Paesano's Italian Restaurant44 locals recommend
Solé Grill and Sushi Bar26 locals recommend
South Cove County Park26 locals recommend
The Tiki Hut Lakeside Grill22 locals recommend
Keowee Brewing Company22 locals recommend
Lake Keowee Marina19 locals recommend

Other great vacation rentals in Seneca

Superhost
Vacation home in Anderson
4.94 out of 5 average rating, 18 reviews

Clemson/Anderson Lake Hartwell

AmyRating, 5 stars1 month ago
Pat was extremely communicative and the home fit our family of 10 perfectly. There are 2 large bedrooms on the main level, one, a King with small private bath and the other, a queen bed with large private bathroom. There were 2 additional full baths on the main level as well. The kitchen was extra large, very well stocked and accommodated our large family! There is an oversized family room with lots of seating and a bar area too! The family room off the kitchen faces the back deck and the lake and I enjoyed lots of time there reading books to my Grand baby. The back deck was oversized and the home literally sits on Lake Hartwell ! The back dock was a nice bonus as was the hot tub! The downstairs does have some steep stairs so I wouldn't advise elderly people sleeping down there. However, you will find a full bathroom, 2 bedrooms and a third bedroom/bonus/flex space with 2 full beds. We loved our family time there celebrating our daughter's wedding! We can't wait to go back!
Guest favorite
Cabin in Highlands
4.97 out of 5 average rating, 77 reviews

Beautiful Highlands Cabin: Fun Game Room, Hot Tub

KellyRating, 5 stars1 month ago
Thank you for letting us stay at your home. It was a great getaway for us and well worth the drive from Ohio! The location was perfect as it was close to hiking locations, great restaurants and fun activities. The game room was a big hit and my kids want to come back again soon! Thank you again for everything!
Guest favorite
A spacious deck is adorned with hanging string lights, creating a warm gathering space. It features comfortable seating with two armchairs and a loveseat surrounding a glass coffee table. Large windows provide views of the surrounding greenery, enhancing the serene atmosphere.
Cabin in Sky Valley
4.95 out of 5 average rating, 20 reviews

The Honey Pot- peaceful cabin -fireplace and deck

AnaRating, 5 stars3 months ago
We love visiting sky valley and Jennifer’s place did not disappoint! It was a peaceful paradise nestled in the hills. We all had so much fun! Would book again for sure!
Guest favorite
A panoramic view showcases a serene lake surrounded by lush mountains under a colorful sunset. The still water reflects shades of purple and orange, complemented by an expansive sky filled with clouds.
Home in Easley
4.79 out of 5 average rating, 33 reviews

Jess & Bailey's Easley Escape

JulieRating, 5 stars3 weeks ago
This was my second stay at this lovely home because I liked it so much the first time. As long as my family is in the area and I haven’t moved to the area, I’ll stay again if it’s available!
Guest favorite
A charming cabin is nestled among lush greenery, featuring a welcoming porch with seating. The rustic yellow exterior complements the natural surroundings, while a winding gravel pathway leads to the entrance, offering glimpses of Lake Hartwell in the background.
Cabin in Fair Play
4.97 out of 5 average rating, 90 reviews

Her Redhead Cabin on Lake Hartwell w/ Private Dock

SeanRating, 5 stars1 month ago
What a amazing place ! My wife and I came for a weekend getaway and were blown away by how accommodating Mimi and Gene were . The place was above and beyond what we expected ! Absolutely adorable place and perfectly equipped with everything you need for a great stay ! Can’t say enough about the place and the hosts ! We booked another stay here within hours of checking in ! We have stayed at a lot of air bnbs and this has to be up there with one of our favorites :)
Guest favorite
Farm stay in Clayton
4.95 out of 5 average rating, 82 reviews

Mountain house perfect for nature lovers!

AudreyRating, 5 stars5 days ago
Our family loved Pippas place! We spent the time in the more than expansive home celebrating a birthday, using the grill, sitting at the fire pit each night, having evening visits with the sweet donkey we got to feed some carrots, and endless fishing on the property for our son. Very safe for kids.
Top guest favorite
Cottage in Scaly Mountain
5 out of 5 average rating, 24 reviews

Dog friendly guesthouse near Clayton & Highlands

DarleneRating, 5 stars4 weeks ago
This place was stunning! Very clean and organized. The only issue we had was not reading the instructions that we would lose cell service halfway up the mountain. In her defense, Elizabeth did put that in the instructions that I did not read ahead of time. Everything was squeaky, clean, organized, well decorated…Beautiful!
Guest favorite
An expansive deck area is framed by trees, providing a natural backdrop. A circular table with a tablecloth is set for outdoor dining, accompanied by white chairs. Two lounge chairs are positioned nearby, inviting relaxation under the blue sky.
Home in Pickens
4.98 out of 5 average rating, 40 reviews

Happy Trails: Jacuzzi, Lookout Tower, Views!

JenniferRating, 5 stars1 week ago
We rented the Airbnb for a wedding weekend! The house exceeded our expectations and was a wonderful place for the bridal party to stay! Plenty of space and excellent communication for the host! Would definitely recommend!!

Quick stats about vacation rentals in Seneca

  • Total rentals

    50 properties

  • Nightly prices starting at

    ﺩ.ﺇ147 before taxes and fees

  • Total number of reviews

    2.1K reviews

  • Family-friendly rentals

    30 properties are a good fit for families

  • Pet-friendly rentals

    10 properties allow pets

  • Rentals with dedicated workspaces

    20 properties have a dedicated workspace

Frequently Asked Questions

  • Are there vacation rentals with a dedicated workspace in Seneca?

    Yes! Work meets play with ease at over 20 vacation rentals in Seneca featuring dedicated workspaces. Stay connected and productive in your home away from home.

  • How much does it cost to stay in house rentals in Seneca?

    Experience the best of Seneca with our house rentals, starting at about $40 per day, before taxes and fees. Embrace comfort and style while staying within your budget in your home away from home.

  • Are there pet-friendly vacation rentals in Seneca?

    Four-legged friends are welcome in Seneca. Choose from more than 10 vacation rentals for guests traveling with pets.

  • Do house rentals in Seneca have wireless internet?

    Absolutely! We offer over 30 house rentals with wireless internet in Seneca. Enjoy a tailored experience with all the comforts you desire.

Destinations to explore

  1. Airbnb
  2. United States
  3. South Carolina
  4. Oconee County
  5. Seneca