Guesthouse vacation rentals in San Luis Obispo

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Quick stats about guesthouse rentals in San Luis Obispo

  • Total vacation rentals

    Explore 30 vacation rentals in San Luis Obispo

  • Nightly prices starting at

    San Luis Obispo vacation rentals start at ﺩ.ﺇ 257 per night before taxes and fees

  • Verified guest reviews

    Over 5,820 verified reviews to help you choose

  • Rentals with dedicated workspaces

    10 properties have a dedicated workspace

  • Wi-Fi availability

    30 of San Luis Obispo vacation rentals include wi-fi access

  • Popular amenities for guests

    Guests love Kitchen, Wifi, and Pool across San Luis Obispo rentals

  • 4.9 Average rating

    San Luis Obispo stays are highly rated by guests—averaging 4.9 out of 5!

Top-rated guesthouse rentals in San Luis Obispo

Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.

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Top guest favorite
A charming garden area is framed by brick pathways, with a wooden table and chairs positioned nearby. Lush greenery and various plants create a serene outdoor atmosphere, while a wooden gate provides privacy and access to the space. The ground appears damp, suggesting recent rain.
Guesthouse in San Luis Obispo
4.97 out of 5 average rating, 673 reviews

SLO Guesthouse - quiet - near downtown - #115545

Private studio with it's own entrance located in lovely SLO. Includes a queen size Murphy bed (people rave about the comfort of this bed), 3 piece bathroom, table & two chairs, desk, closet, TV, WiFi & kitchenette. Coffee, tea with fixings are provided. 4 blocks from the downtown cultural-hub, hip restaurants, Farmer's Market, the Historic Mission and more. The Edna Valley wine country is 5 minutes away and the Beach is 10 minutes away. The Perfect Location to come experience the "SLO Life"!

Guest favorite
A bright sleeping area features a spacious bed dressed in soft green bedding, flanked by two stylish bedside lamps. The wall is adorned with tropical foliage wallpaper, and a mirror is visible beside the door leading to an adjacent room.
Guesthouse in San Luis Obispo
4.93 out of 5 average rating, 1,064 reviews

Modern Private Cottage+walkable+views+patio w/ BBQ

This adorable cottage is located 1 mile from downtown SLO and is equidistant to local wineries! Clean and tastefully decorated- equip with a full kitchen, comfortable sleeping accommodations and all the modern luxuries of home. This private studio is nestled on the backside of a beautifully landscaped property with a separate entrance and secluded patio area distanced from the main home offering you peace and serenity. Just a short stroll to Taste, SLO Co-Op, Del Monte's, Sally Loo's & many more

Guest favorite
A wood-finished pathway leads to a modern studio entrance, flanked by a bench with cushions. Lush greenery is present on one side, while an open field extends on the other, with distant hills visible under clear blue skies.
Guesthouse in Atascadero
4.95 out of 5 average rating, 463 reviews

Oak Country Cottage

Soak up the country in this newly remodeled modern STUDIO. Fully self contained with BBQ and all the essentials for cooking meals. Centrally located on the central coast of San Luis Obispo you can enjoy popular hot spots like Avila, Pismo, Morro Bay, Hearst Castle, Slo, & Paso Robles wine country all within 10-30 minutes. The cottage is located on a family owned Ranch just minutes from the 101. Come visit our horses, goats, chickens, cows, and pigs. Or get a Christmas tree during the season .

Top guest favorite
The guesthouse is framed by blooming trees and colorful flowers, set amidst natural landscaping. A pathway leads to the entrance, with a soft blue sky and gentle hills visible in the background, creating a harmonious connection with the surroundings.
Guesthouse in Arroyo Grande
5 out of 5 average rating, 175 reviews

Central Coast Country Retreat

My husband Mike and I are artists. We searched for 10 years to find the perfect spot for our retirement years. We found 7 1/2 acres here, on the Central Coast, with spectacular views of verdant trees covering rolling hills that reach all the way to the distant mountains south and east of Arroyo Grande Village. Come and stay in our Guesthouse, relax, explore the property, walk the quiet country lanes. For a rural setting, we are surprisingly close to all amenities, beaches, and wineries.

Top guest favorite
A light-filled studio is presented with a spacious bed, blue cabinetry, and a full kitchen that includes a microwave and stove. A small dining table with black chairs is positioned near the windows, providing a view of the room's warm wooden flooring.
Guesthouse in Downtown SLO
4.97 out of 5 average rating, 616 reviews

Downtown Historic District Sunset Studio

Enjoy a hotel quality stay, professionally cleaned prior to each guest, located in the beautiful downtown historic district. Studio is equipped to provide you with everything you need for an enjoyable stay; including washer/dryer, AC/ Heat. From the deck enjoy magnificent sunset views framed by San Luis Mountain and Bishop's Peak while enjoying dining al fresco. We are 4 walkable blocks to downtown and a mile to Cal Poly. The beach is about a 10 min drive away. You can't beat the location!

Top guest favorite
A welcoming entrance is framed by lush green foliage and vibrant purple flowers. A rustic wooden sign reading 'Welcome' adorns the fence, complemented by a small mat leading to the entrance. Soft sunlight filters through the leaves, creating a serene atmosphere.
Guesthouse in Downtown SLO
4.97 out of 5 average rating, 678 reviews

Cottage in SLO / Historic Downtown District

“Cottage in SLO” is located in the historic district of San Luis Obispo with its century old homes and buildings. Enjoy the three block walk to downtown with all its amenities: Restaurants to please every pallet, from BBQ to gourmet. Coffee shops, theaters, galleries, and the world famous Farmers Market event every Thursday night. Bike paths are on the same street that will take you anywhere in SLO and beyond. . (Bikes provided) Perfect for two. Homestay permit # -0606-2019

Top guest favorite
A bright living area features a white sofa adorned with throw pillows and a cozy blanket. A round wooden coffee table sits at the center, surrounded by a jute area rug. Natural light floods in through large windows, framing views of lush greenery outside.
Guesthouse in San Luis Obispo
4.98 out of 5 average rating, 122 reviews

Near Cal Poly, Down Town & Mt Hikes; Easy Prking

When you arrive in sunny San Luis Obispo, you’ll be surrounded by beautiful mountains in a quiet neighborhood. You will be close to downtown and Cal Poly, and just 15 minutes to the beach. Enjoy wine tasting in gorgeous vineyards, hiking and biking stunning mountain trails, and savoring farm-to-table eateries or craft cocktail lounges. You can cook in our Art Deco kitchen with hand-painted floors and relax at the outdoor bar/patio. Enjoy life on the SLO Lane. You’ll love it!

Top guest favorite
A welcoming living area features a gray sofa adorned with decorative pillows. Large windows with wooden accents allow natural light to illuminate the rustic wood paneling behind the couch. A coffee table sits at the center of the space, displaying a small vase of flowers.
Guesthouse in Arroyo Grande
4.97 out of 5 average rating, 517 reviews

Wine Country Tiny Home with a Gas Fire Pit and Hammock

Skylight windows, rustic wood paneling, and elegant tiling are just a few of the refinements within this charming tiny home. Lie in an outdoor hammock for an afternoon nap, then gather around the gas fire pit at night to pair the stars with wine. Sorry, no animal guests allowed. Dates not available? See our newest tiny home at: Modern Wine Country Tiny Home This quiet cozy tiny house is 285 square feet with an open floor plan including a queen bed and a sleeper sofa.

Top guest favorite
A comfortable sleeping area features a queen bed with crisp white linens and gray-striped accent pillows. Next to the bed, a dark nightstand displays a decorative lamp and a collection of books. A closet with sliding doors is visible beside the bed.
Guesthouse in Pismo Beach
4.98 out of 5 average rating, 610 reviews

Shell Beach Hideaway

Welcome to picturesque Shell Beach Hideaway. This charming studio cottage offers privacy and seclusion, yet walking distance to restaurants, cafes, a private small beach, and to numerous points of interest This is a NO SMOKING cottage.This private studio is located behind our home in a quiet neighborhood with a full bath, queen bed, wifi, and a full kitchen. No pets allowed. Maximum guest two (2). Not suitable for children. License 19951

Top guest favorite
A well-appointed sleeping area features a spacious bed dressed in a light-colored patterned coverlet. Stylish decorative pillows are arranged neatly at the head of the bed. A round table with a single chair sits nearby, surrounded by floral drapes that frame the window.
Guesthouse in Santa Maria
4.99 out of 5 average rating, 1,706 reviews

French Country Casita - Breakfast Included

This stand-alone casita sits in the privacy of our rear yard and has a separate entrance. We are three minutes from highway 101 in the newer La Ventana community. Surrounded by beautiful mountain views on the Central Coast and close to many flourishing wineries, this residence is 20 minutes south of Pismo Beach, 30 minutes from San Luis Obispo, one hour north of Santa Barbara, close to the beautiful Danish city of Solvang and Santa Ynez.

Top guest favorite
A cozy interior space is divided into a sleeping area and a living area. A spacious bed is situated in the background, complemented by a contemporary design. A comfortable couch and a coffee table are positioned in front of a kitchen area featuring a refrigerator and workspace.
Guesthouse in San Luis Obispo
4.94 out of 5 average rating, 251 reviews

SLO Casita, a short walk to everything!

Visit our sweet casita at the foot of Cerro San Luis mountain in San Luis Obispo! This cozy little spot is around the corner from an incredible deli, a short walk to a beautiful hike, and a 15 minute walk to downtown. This is an ideal spot for a couple looking to soak up the best San Luis has to offer or a group of up to three to stay in the perfect location.

Top guest favorite
Guesthouse in San Luis Obispo
5 out of 5 average rating, 135 reviews

Private Creekside Cabin • Gated • Near Avila Beach

Castlebrook Cabin is a private retreat tucked into the quiet beauty of See Canyon, surrounded by apple orchards, vineyards, and towering oaks. Just minutes from Avila Beach, Pismo Beach, and downtown San Luis Obispo, you’ll feel completely immersed in nature while staying effortlessly close to it all. Unplug to recharge, with a side of WiFi if you need it.

Popular amenities for San Luis Obispo guesthouse rentals

When is the best time to visit San Luis Obispo?

MonthJanFebMarAprMayJunJulAugSepOctNovDec
Avg. priceﺩ.ﺇ 558ﺩ.ﺇ 569ﺩ.ﺇ 525ﺩ.ﺇ 588ﺩ.ﺇ 580ﺩ.ﺇ 643ﺩ.ﺇ 617ﺩ.ﺇ 555ﺩ.ﺇ 555ﺩ.ﺇ 606ﺩ.ﺇ 606ﺩ.ﺇ 602
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